PharmaCoNets of Estazolam (SPCN: 298.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Estazolamhsa00030Pentose phosphate pathway2.27E-022P60891, P37837PRPS1, TALDO1More
Estazolamhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Estazolamhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Estazolamhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Estazolamhsa00190Oxidative phosphorylation6.67E-073Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Estazolamhsa00220Arginine biosynthesis2.40E-052P05089, P49448ARG1, GLUD2More
Estazolamhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Estazolamhsa00240Pyrimidine metabolism2.09E-063P31350, P21589, P04818RRM2, NT5E, TYMSMore
Estazolamhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Estazolamhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Estazolamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Estazolamhsa00500Starch and sucrose metabolism5.48E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Estazolamhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Estazolamhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Estazolamhsa00531Glycosaminoglycan degradation1.05E-032P15586, P34059GNS, GALNSMore
Estazolamhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate1.20E-031Q9Y2C2USTMore
Estazolamhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Estazolamhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Estazolamhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Estazolamhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Estazolamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Estazolamhsa00591Linoleic acid metabolism1.48E-031P11712CYP2C9More
Estazolamhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Estazolamhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Estazolamhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Estazolamhsa00670One carbon pool by folate1.23E-032P04818, Q99707TYMS, MTRMore
Estazolamhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Estazolamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Estazolamhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Estazolamhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Estazolamhsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Estazolamhsa00970Aminoacyl-tRNA biosynthesis2.41E-043O95363, P54136, P14868FARS2, RARS1, DARSMore
Estazolamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Estazolamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Estazolamhsa00983Drug metabolism - other enzymes2.57E-043P04183, P32320, P05164TK1, CDA, MPOMore
Estazolamhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Estazolamhsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Estazolamhsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Estazolamhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Estazolamhsa01522Endocrine resistance2.16E-021P04049RAF1More
Estazolamhsa01523Antifolate resistance3.45E-075P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Estazolamhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Estazolamhsa02010ABC transporters9.42E-063P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Estazolamhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Estazolamhsa03010Ribosome7.52E-032P46777, Q9UHA3RPL5, RSL24D1More
Estazolamhsa03013RNA transport7.07E-0417P62826, P52298, O14893, P61326, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O75822, P78345, Q9Y6A5, Q14232RAN, NCBP2, GEMIN2, MAGOH, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3J, RPP38, TACC3, EIF2B1More
Estazolamhsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Estazolamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Estazolamhsa03040Spliceosome2.09E-027Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5More
Estazolamhsa03050Proteasome3.47E-051P55036PSMD4More
Estazolamhsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Estazolamhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Estazolamhsa03410Base excision repair7.59E-031P27695APEX1More
Estazolamhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Estazolamhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Estazolamhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Estazolamhsa04014Ras signaling pathway9.96E-049P04049, P31751, P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174RAF1, AKT2, EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Estazolamhsa04015Rap1 signaling pathway1.85E-038P04049, P20827, Q9NRA1, P49767, P31751, P0DP23, P17252, P19174RAF1, EFNA1, PDGFC, VEGFC, AKT2, CALM1, PRKCA, PLCG1More
Estazolamhsa04020Calcium signaling pathway3.56E-0411Q08828, P17252, P19174, P0DP24, P0DP23, P05141, P51828, P20020, P23634, Q9NRA1, P49767ADCY1, PRKCA, PLCG1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Estazolamhsa04022cGMP-PKG signaling pathway6.51E-057P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Estazolamhsa04024cAMP signaling pathway5.02E-0610P63092, Q08828, P51828, P31751, P26678, P0DP24, P0DP23, P23634, P04049, P61586GNAS, ADCY1, ADCY7, AKT2, PLN, CALM2, CALM1, ATP2B4, RAF1, RHOAMore
Estazolamhsa04060Cytokine-cytokine receptor interaction1.91E-0519P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P01375, P09341, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNF, CXCL1, CCL8, IL1RN, CD4, TNFRSF25More
Estazolamhsa04061Viral protein interaction with cytokine and cytokine receptor2.72E-0811Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Estazolamhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Estazolamhsa04064NF-kappa B signaling pathway9.18E-1324P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Estazolamhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Estazolamhsa04070Phosphatidylinositol signaling system1.40E-0510P19174, P0DP23, Q14643, O14986, P23743, Q86XP1, Q16760, P48426, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKC, PRKCAMore
Estazolamhsa04071Sphingolipid signaling pathway8.91E-0610P04049, P17252, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Estazolamhsa04072Phospholipase D signaling pathway2.30E-0514P04049, P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Estazolamhsa04080Neuroactive ligand-receptor interaction5.14E-0410P08311, Q15722, P21453, Q9H228, P43657, P21462, P21730, P14416, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Estazolamhsa04110Cell cycle6.43E-089Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Estazolamhsa04114Oocyte meiosis3.12E-0712Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Estazolamhsa04115p53 signaling pathway1.39E-032P31350, P06493RRM2, CDK1More
Estazolamhsa04120Ubiquitin mediated proteolysis2.12E-058Q9UBT2, Q14145, Q13042, Q13191, P62837, Q15751, Q14669, Q7Z6Z7SAE2, KEAP1, CDC16, CBLB, UBE2D2, HERC1, TRIP12, HUWE1More
Estazolamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Estazolamhsa04140Autophagy - animal4.56E-0311P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Estazolamhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Estazolamhsa04142Lysosome8.21E-0511P43234, P06865, P15586, P34059, P38571, Q13510, P07602, P49281, P61916, Q04900, Q9Y227CTSO, HEXA, GNS, GALNS, LIPA, ASAH1, PSAP, SLC11A2, NPC2, CD164, ENTPD4More
Estazolamhsa04144Endocytosis1.38E-0310P0DMV8, Q9H444, O75351, P62491, P42566, Q15438, Q14161, Q96QK1, Q9UMY4, Q9UNH7HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, PSCD1, GIT2, VPS35, SNX12, SNX6More
Estazolamhsa04145Phagosome6.55E-0613O75015, P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Estazolamhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Estazolamhsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Estazolamhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Estazolamhsa04210Apoptosis1.39E-049P04637, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P63261, P04049TP53, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ACTG1, RAF1More
Estazolamhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Estazolamhsa04213Longevity regulating pathway - multiple species5.28E-047P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Estazolamhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Estazolamhsa04216Ferroptosis1.45E-022P04637, P49281TP53, SLC11A2More
Estazolamhsa04217Necroptosis5.03E-0619P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, Q9BTM1, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFJ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, VPS4B, PPIDMore
Estazolamhsa04218Cellular senescence3.00E-047P01106, P31751, P04049, O75293, P30304, P06493, P0DP23MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1More
Estazolamhsa04260Cardiac muscle contraction4.60E-033P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Estazolamhsa04261Adrenergic signaling in cardiomyocytes3.45E-0712P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP24, P0DP23, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, PRKCA, BCL2, ATP2B4More
Estazolamhsa04270Vascular smooth muscle contraction2.25E-026P24723, Q04759, Q14643, P04049, P22694, P35318PRKCH, PRKCQ, ITPR1, RAF1, PRKACB, ADMMore
Estazolamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Estazolamhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Estazolamhsa04340Hedgehog signaling pathway1.94E-033P49841, P22694, Q9Y496GSK3B, PRKACB, KIF3AMore
Estazolamhsa04360Axon guidance5.47E-048P16333, P20827, O95631, P17252, P23528, P04049, P19174, Q06124NCK1, EFNA1, NTN1, PRKCA, CFL1, RAF1, PLCG1, PTPN11More
Estazolamhsa04370VEGF signaling pathway2.36E-075P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Estazolamhsa04371Apelin signaling pathway6.08E-045P31751, P04049, Q08828, P51828, P0DP23AKT2, RAF1, ADCY1, ADCY7, CALM1More
Estazolamhsa04380Osteoclast differentiation2.07E-0510Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Estazolamhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Estazolamhsa04510Focal adhesion8.84E-034O14986, P61586, Q16363, P04049PIP5K1B, RHOA, LAMA4, RAF1More
Estazolamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Estazolamhsa04530Tight junction2.07E-046P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Estazolamhsa04540Gap junction1.44E-046P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Estazolamhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, P04049, Q02750, Q86SE9BMPR2, RAF1, MAP2K1, PCGF5More
Estazolamhsa04610Complement and coagulation cascades3.71E-082P00734, P0C0L4F2, C4AMore
Estazolamhsa04612Antigen processing and presentation4.93E-1010P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Estazolamhsa04613Neutrophil extracellular trap formation1.66E-0925P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Estazolamhsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Estazolamhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Estazolamhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Estazolamhsa04623Cytosolic DNA-sensing pathway7.34E-075P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Estazolamhsa04625C-type lectin receptor signaling pathway1.03E-069Q9ULY5, P04049, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Estazolamhsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Estazolamhsa04640Hematopoietic cell lineage6.77E-1117P13612, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Estazolamhsa04650Natural killer cell mediated cytotoxicity7.38E-2117P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Estazolamhsa04657IL-17 signaling pathway1.99E-0813P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9More
Estazolamhsa04658Th1 and Th2 cell differentiation6.97E-2113Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Estazolamhsa04659Th17 cell differentiation4.47E-1516P25963, Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, CD3E, CD3G, CD247More
Estazolamhsa04660T cell receptor signaling pathway5.37E-1620P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1More
Estazolamhsa04662B cell receptor signaling pathway1.12E-032P31751, P04049AKT2, RAF1More
Estazolamhsa04664Fc epsilon RI signaling pathway1.50E-035P01375, P31751, Q16539, Q9UQC2, P04049TNF, AKT2, MAPK14, GAB2, RAF1More
Estazolamhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Estazolamhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Estazolamhsa04672Intestinal immune network for IgA production3.36E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Estazolamhsa04713Circadian entrainment4.08E-058P0DP23, P17252, P62873, Q14643, Q08828, P51828, P63092, O15055CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7, GNAS, PER2More
Estazolamhsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Estazolamhsa04720Long-term potentiation6.77E-069P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Estazolamhsa04722Neurotrophin signaling pathway2.01E-046P31751, P04049, P49841, O43524, P48023, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1More
Estazolamhsa04723Retrograde endocannabinoid signaling2.51E-035Q14643, P17252, P48169, P62873, Q16718ITPR1, PRKCA, GABRA4, GNB1, NDUFA5More
Estazolamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Estazolamhsa04725Cholinergic synapse7.24E-048Q08828, P51828, Q14643, P17252, P62873, P18848, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2More
Estazolamhsa04726Serotonergic synapse2.93E-033P63092, P62873, P04049GNAS, GNB1, RAF1More
Estazolamhsa04728Dopaminergic synapse7.82E-058Q14643, P17252, P62873, P31751, P18848, Q13362, Q14738, P0DP23ITPR1, PRKCA, GNB1, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Estazolamhsa04730Long-term depression1.16E-021P04049RAF1More
Estazolamhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Estazolamhsa04744Phototransduction4.48E-052P62873, P0DP23GNB1, CALM1More
Estazolamhsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Estazolamhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Estazolamhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Estazolamhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Estazolamhsa04912GnRH signaling pathway6.90E-047P17252, Q08828, P51828, P18848, Q14643, P0DP23, P04049PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1, RAF1More
Estazolamhsa04914Progesterone-mediated oocyte maturation1.68E-045Q17RY0, Q9Y6D9, P51812, Q02750, P04049CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Estazolamhsa04915Estrogen signaling pathway3.57E-046P04049, P18848, Q08828, P51828, P31751, P0DP23RAF1, ATF4, ADCY1, ADCY7, AKT2, CALM1More
Estazolamhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Estazolamhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Estazolamhsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Estazolamhsa04920Adipocytokine signaling pathway3.41E-033Q06124, Q9Y478, P31751PTPN11, PRKAB1, AKT2More
Estazolamhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Estazolamhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Estazolamhsa04923Regulation of lipolysis in adipocytes5.39E-056Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Estazolamhsa04924Renin secretion1.31E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Estazolamhsa04925Aldosterone synthesis and secretion3.49E-046P18848, Q08828, P51828, P0DP24, P0DP23, P23634ATF4, ADCY1, ADCY7, CALM2, CALM1, ATP2B4More
Estazolamhsa04926Relaxin signaling pathway6.96E-035P31751, P18848, Q08828, P51828, P04049AKT2, ATF4, ADCY1, ADCY7, RAF1More
Estazolamhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Estazolamhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Estazolamhsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Estazolamhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Estazolamhsa04932Non-alcoholic fatty liver disease1.93E-0614P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Estazolamhsa04933AGE-RAGE signaling pathway in diabetic complications3.43E-058P84022, Q13485, P42224, P10415, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1More
Estazolamhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Estazolamhsa04935Growth hormone synthesis, secretion and action5.00E-035Q08828, P51828, P04049, P18848, P31751ADCY1, ADCY7, RAF1, ATF4, AKT2More
Estazolamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Estazolamhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Estazolamhsa04964Proximal tubule bicarbonate reclamation2.08E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Estazolamhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Estazolamhsa04970Salivary secretion2.57E-055Q08828, P51828, P23634, P0DP24, P0DP23ADCY1, ADCY7, ATP2B4, CALM2, CALM1More
Estazolamhsa04971Gastric acid secretion4.91E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Estazolamhsa04972Pancreatic secretion3.95E-045P23634, P63092, P51828, P62491, P61586ATP2B4, GNAS, ADCY7, RAB11A, RHOAMore
Estazolamhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Estazolamhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Estazolamhsa04976Bile secretion9.39E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Estazolamhsa05010Alzheimer disease7.98E-0620O15239, Q16718, O95298, O14521, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, O95197, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4More
Estazolamhsa05012Parkinson disease2.01E-037Q16718, O14521, Q14643, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, PLCG1, CALM1, TUBB3, TUBB2CMore
Estazolamhsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Estazolamhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Estazolamhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Estazolamhsa05022Pathways of neurodegeneration - multiple diseases1.26E-0621Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P19174, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Estazolamhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Estazolamhsa05031Amphetamine addiction4.78E-021P0DP23CALM1More
Estazolamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Estazolamhsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Estazolamhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Estazolamhsa05110Vibrio cholerae infection1.98E-044Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Estazolamhsa05120Epithelial cell signaling in Helicobacter pylori infection2.39E-056Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Estazolamhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Estazolamhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Estazolamhsa05132Salmonella infection4.49E-0514P25963, P08238, P04049, Q9UJU2, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, RAF1, LEF1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Estazolamhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Estazolamhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Estazolamhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Estazolamhsa05140Leishmaniasis4.34E-0812P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Estazolamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Estazolamhsa05143African trypanosomiasis7.36E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Estazolamhsa05144Malaria1.07E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Estazolamhsa05145Toxoplasmosis1.02E-037P25963, P10415, Q13489, P42224, P13765, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Estazolamhsa05146Amoebiasis7.89E-1412P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Estazolamhsa05150Staphylococcus aureus infection5.36E-057P0C0L4, P13646, Q14532, P59665, P59666, P12838, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Estazolamhsa05152Tuberculosis1.34E-0512P04049, Q13488, Q15075, P0DP23, P42224, O60603, P31751, P10415, P13765, Q13651, P01568, Q9UDY8RAF1, TCIRG1, EEA1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IL10RA, IFNA21, MALT1More
Estazolamhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Estazolamhsa05161Hepatitis B6.38E-045P04049, P25963, Q13485, P10415, P84022RAF1, NFKBIA, SMAD4, BCL2, SMAD3More
Estazolamhsa05163Human cytomegalovirus infection1.38E-0823P31751, P04049, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2MMore
Estazolamhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Estazolamhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Estazolamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Estazolamhsa05167Kaposi sarcoma-associated herpesvirus infection1.69E-0616P01568, P31751, P42224, P25963, P40189, P62873, P62879, P19174, P16298, Q14643, P04049, Q02750, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, IL6ST, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, CSF2, CALM1, UBB, LEF1More
Estazolamhsa05168Herpes simplex virus 1 infection7.17E-0415P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Estazolamhsa05169Epstein-Barr virus infection5.02E-0412P20023, P13765, P01106, Q13547, Q92769, O00463, P07948, Q13761, P24522, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Estazolamhsa05170Human immunodeficiency virus 1 infection1.25E-0616P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Estazolamhsa05171Coronavirus disease - COVID-192.67E-039P25963, P42224, P01568, Q9UHA3, P40189, P04141, P19174, P17252, O14786NFKBIA, STAT1, IFNA21, RSL24D1, IL6ST, CSF2, PLCG1, PRKCA, NRP1More
Estazolamhsa05200Pathways in cancer4.55E-0419P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Estazolamhsa05202Transcriptional misregulation in cancer2.66E-0719Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Estazolamhsa05203Viral carcinogenesis1.34E-047Q13547, Q15283, P58876, P62807, P33778, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12More
Estazolamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Estazolamhsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Estazolamhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Estazolamhsa05210Colorectal cancer1.46E-046Q9UKG1, P84022, Q13485, P04049, P10415, P37173APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2More
Estazolamhsa05211Renal cell carcinoma7.38E-064Q06124, Q99814, P31751, P04049PTPN11, EPAS1, AKT2, RAF1More
Estazolamhsa05212Pancreatic cancer4.44E-068P31751, P04049, Q15311, P23458, P84022, Q13485, P04637, P24522AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, TP53, GADD45AMore
Estazolamhsa05213Endometrial cancer3.60E-056O15169, P31751, Q02750, P04049, P04637, P24522AXIN1, AKT2, MAP2K1, RAF1, TP53, GADD45AMore
Estazolamhsa05214Glioma2.39E-068P0DP23, P17252, P04049, P31751, P04637, P19174, P24522, O75293CALM1, PRKCA, RAF1, AKT2, TP53, PLCG1, GADD45A, GADD45BMore
Estazolamhsa05215Prostate cancer1.33E-021P04049RAF1More
Estazolamhsa05216Thyroid cancer1.28E-034P01106, P04637, P24522, O75293MYC, TP53, GADD45A, GADD45BMore
Estazolamhsa05217Basal cell carcinoma2.03E-034Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Estazolamhsa05218Melanoma5.22E-054P04637, P31751, P04049, P24522TP53, AKT2, RAF1, GADD45AMore
Estazolamhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Estazolamhsa05220Chronic myeloid leukemia1.55E-068Q06124, P04637, Q13485, P25963, P84022, P31751, P04049, P24522PTPN11, TP53, SMAD4, NFKBIA, SMAD3, AKT2, RAF1, GADD45AMore
Estazolamhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Estazolamhsa05222Small cell lung cancer1.36E-034P31751, Q13489, P10415, P25963AKT2, BIRC3, BCL2, NFKBIAMore
Estazolamhsa05223Non-small cell lung cancer1.64E-0610P17252, O43524, P31751, P19174, P10826, P04049, Q9HC35, P04637, P24522, O75293PRKCA, FOXO3, AKT2, PLCG1, RARB, RAF1, EML4, TP53, GADD45A, GADD45BMore
Estazolamhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Estazolamhsa05225Hepatocellular carcinoma3.15E-034P04049, P04637, P24522, P63261RAF1, TP53, GADD45A, ACTG1More
Estazolamhsa05226Gastric cancer2.61E-057P04049, Q02750, P31751, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Estazolamhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Estazolamhsa05231Choline metabolism in cancer6.68E-0711P04049, P31751, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Estazolamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.28E-1017P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Estazolamhsa05310Asthma8.72E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Estazolamhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Estazolamhsa05321Inflammatory bowel disease2.75E-097O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Estazolamhsa05322Systemic lupus erythematosus1.76E-1017O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P12814FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Estazolamhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Estazolamhsa05330Allograft rejection6.97E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Estazolamhsa05332Graft-versus-host disease7.02E-105P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Estazolamhsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Estazolamhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Estazolamhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Estazolamhsa05415Diabetic cardiomyopathy2.07E-0610P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2, GAPDHMore
Estazolamhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Estazolamhsa05418Fluid shear stress and atherosclerosis3.43E-0610Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Estazolam (SDC: 10.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P00325ADH1BAllNonetransNoneretinol dehydrogenase [NAD(+)] ADH1BPredicted00.75050.04520.1530.6186
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P00441SOD1Superoxide dismutase [CuNoneZn]Predicted10.53850.07130.48710.8991
Q99814EPAS1Endothelial PAS domainNonecontaining protein 1Predicted00.23220.0620.24910.4892
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P49281SLC11A2Natural resistanceNoneassociated macrophage protein 2Predicted10.33250.05050.26620.5334
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)