PharmaCoNets of Eslicarbazepine-acetate (SPCN: 201.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Eslicarbazepine-acetatehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Eslicarbazepine-acetatehsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Eslicarbazepine-acetatehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Eslicarbazepine-acetatehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Eslicarbazepine-acetatehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Eslicarbazepine-acetatehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Eslicarbazepine-acetatehsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Eslicarbazepine-acetatehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Eslicarbazepine-acetatehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Eslicarbazepine-acetatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Eslicarbazepine-acetatehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Eslicarbazepine-acetatehsa00591Linoleic acid metabolism8.36E-041P11712CYP2C9More
Eslicarbazepine-acetatehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Eslicarbazepine-acetatehsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Eslicarbazepine-acetatehsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Eslicarbazepine-acetatehsa00740Riboflavin metabolism3.53E-021P24666ACP1More
Eslicarbazepine-acetatehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Eslicarbazepine-acetatehsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Eslicarbazepine-acetatehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Eslicarbazepine-acetatehsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Eslicarbazepine-acetatehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Eslicarbazepine-acetatehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Eslicarbazepine-acetatehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Eslicarbazepine-acetatehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Eslicarbazepine-acetatehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Eslicarbazepine-acetatehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa01522Endocrine resistance3.41E-026P14780, P22694, Q9UM47, P08069, P10415, Q13323MMP9, PRKACB, NOTCH3, IGF1R, BCL2, BIKMore
Eslicarbazepine-acetatehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Eslicarbazepine-acetatehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Eslicarbazepine-acetatehsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Eslicarbazepine-acetatehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Eslicarbazepine-acetatehsa03013RNA transport1.57E-0816O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FMR1, FXR1More
Eslicarbazepine-acetatehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Eslicarbazepine-acetatehsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Eslicarbazepine-acetatehsa03040Spliceosome3.35E-0714Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Eslicarbazepine-acetatehsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Eslicarbazepine-acetatehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Eslicarbazepine-acetatehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04014Ras signaling pathway1.13E-029P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Eslicarbazepine-acetatehsa04015Rap1 signaling pathway5.95E-039P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Eslicarbazepine-acetatehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Eslicarbazepine-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor3.57E-038Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Eslicarbazepine-acetatehsa04062Chemokine signaling pathway5.65E-0414P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Eslicarbazepine-acetatehsa04064NF-kappa B signaling pathway7.59E-1326P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Eslicarbazepine-acetatehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Eslicarbazepine-acetatehsa04071Sphingolipid signaling pathway9.23E-067P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Eslicarbazepine-acetatehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Eslicarbazepine-acetatehsa04080Neuroactive ligand-receptor interaction1.26E-0410P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Eslicarbazepine-acetatehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Eslicarbazepine-acetatehsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Eslicarbazepine-acetatehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Eslicarbazepine-acetatehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Eslicarbazepine-acetatehsa04140Autophagy - animal6.54E-026P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Eslicarbazepine-acetatehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Eslicarbazepine-acetatehsa04144Endocytosis4.42E-0511P0DMV8, Q9H444, O75351, Q9NZZ3, P62491, P42566, P61073, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, CHMP5, RAB11A, EPS15, CXCR4, SH3KBP1, PSCD1, GIT2, SNX12More
Eslicarbazepine-acetatehsa04145Phagosome8.88E-049O75015, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Eslicarbazepine-acetatehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Eslicarbazepine-acetatehsa04151PI3K-Akt signaling pathway4.77E-0315P42338, P43657, P09603, P20827, P49767, Q9GZP0, P08238, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, CSF1, EFNA1, VEGFC, PDGFD, HSP90AB1, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, CCND3More
Eslicarbazepine-acetatehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Eslicarbazepine-acetatehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Eslicarbazepine-acetatehsa04213Longevity regulating pathway - multiple species1.17E-048P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Eslicarbazepine-acetatehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Eslicarbazepine-acetatehsa04217Necroptosis4.76E-049P01568, P23458, Q13489, Q9NQC7, Q13546, P0C0S5, Q9H444, Q9NZZ3, O75351IFNA21, JAK1, BIRC3, CYLD, RIPK1, H2AFZ, CHMP4B, CHMP5, VPS4BMore
Eslicarbazepine-acetatehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Eslicarbazepine-acetatehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Eslicarbazepine-acetatehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Eslicarbazepine-acetatehsa04270Vascular smooth muscle contraction5.83E-047P0DP23, P0DP24, Q08828, P51828, P35579, P35749, P35318CALM1, CALM2, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Eslicarbazepine-acetatehsa04360Axon guidance2.47E-037P16333, P20827, O95631, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1More
Eslicarbazepine-acetatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Eslicarbazepine-acetatehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Eslicarbazepine-acetatehsa04380Osteoclast differentiation9.58E-0513Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Eslicarbazepine-acetatehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Eslicarbazepine-acetatehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Eslicarbazepine-acetatehsa04520Adherens junction1.04E-033P37173, P08069, P24666TGFBR2, IGF1R, ACP1More
Eslicarbazepine-acetatehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Eslicarbazepine-acetatehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa04610Complement and coagulation cascades1.14E-052P00734, P0C0L4F2, C4AMore
Eslicarbazepine-acetatehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Eslicarbazepine-acetatehsa04613Neutrophil extracellular trap formation3.78E-0723P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Eslicarbazepine-acetatehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Eslicarbazepine-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Eslicarbazepine-acetatehsa04621NOD-like receptor signaling pathway7.18E-0413Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4More
Eslicarbazepine-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Eslicarbazepine-acetatehsa04623Cytosolic DNA-sensing pathway3.05E-064P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Eslicarbazepine-acetatehsa04625C-type lectin receptor signaling pathway9.91E-049Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Eslicarbazepine-acetatehsa04640Hematopoietic cell lineage4.59E-0416P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Eslicarbazepine-acetatehsa04650Natural killer cell mediated cytotoxicity2.37E-0717P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Eslicarbazepine-acetatehsa04657IL-17 signaling pathway1.50E-059O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Eslicarbazepine-acetatehsa04658Th1 and Th2 cell differentiation2.95E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Eslicarbazepine-acetatehsa04659Th17 cell differentiation1.70E-0720P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Eslicarbazepine-acetatehsa04660T cell receptor signaling pathway2.85E-0517P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Eslicarbazepine-acetatehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Eslicarbazepine-acetatehsa04664Fc epsilon RI signaling pathway2.40E-037P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Eslicarbazepine-acetatehsa04666Fc gamma R-mediated phagocytosis2.97E-037O75015, P42338, P23528, P06396, O14494, P14598, P17252FCGR3B, PIK3CB, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Eslicarbazepine-acetatehsa04668TNF signaling pathway2.13E-0410P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9More
Eslicarbazepine-acetatehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Eslicarbazepine-acetatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Eslicarbazepine-acetatehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Eslicarbazepine-acetatehsa04726Serotonergic synapse2.37E-022P31645, P11712SLC6A4, CYP2C9More
Eslicarbazepine-acetatehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Eslicarbazepine-acetatehsa04730Long-term depression1.34E-023Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Eslicarbazepine-acetatehsa04750Inflammatory mediator regulation of TRP channels3.66E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Eslicarbazepine-acetatehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Eslicarbazepine-acetatehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Eslicarbazepine-acetatehsa04914Progesterone-mediated oocyte maturation9.67E-047P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Eslicarbazepine-acetatehsa04915Estrogen signaling pathway1.89E-036Q08828, P51828, P0DMV8, P0DP23, P0DP24, Q15788ADCY1, ADCY7, HSPA1A, CALM1, CALM2, NCOA1More
Eslicarbazepine-acetatehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Eslicarbazepine-acetatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Eslicarbazepine-acetatehsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Eslicarbazepine-acetatehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Eslicarbazepine-acetatehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Eslicarbazepine-acetatehsa04932Non-alcoholic fatty liver disease4.86E-047O43521, O75460, P01584, P13073, P12074, O15239, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Eslicarbazepine-acetatehsa04933AGE-RAGE signaling pathway in diabetic complications2.11E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Eslicarbazepine-acetatehsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Eslicarbazepine-acetatehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Eslicarbazepine-acetatehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Eslicarbazepine-acetatehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Eslicarbazepine-acetatehsa04970Salivary secretion3.57E-048P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Eslicarbazepine-acetatehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Eslicarbazepine-acetatehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Eslicarbazepine-acetatehsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Eslicarbazepine-acetatehsa05010Alzheimer disease1.94E-0316O15239, P13073, P12074, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, O95197, Q71U36, P67870, P09603, P21796, P28070NDUFA1, COX4I1, COX6A1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, RTN3, TUBA1A, CSNK2B, CSF1, VDAC1, PSMB4More
Eslicarbazepine-acetatehsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Eslicarbazepine-acetatehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Eslicarbazepine-acetatehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Eslicarbazepine-acetatehsa05034Alcoholism4.86E-048P0DP24, Q96RR4, P0C0S5, Q93077, P62807, O60814, P84243, P68431CALM2, CAMKK2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Eslicarbazepine-acetatehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Eslicarbazepine-acetatehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Eslicarbazepine-acetatehsa05132Salmonella infection1.74E-0414P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Eslicarbazepine-acetatehsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Eslicarbazepine-acetatehsa05134Legionellosis1.16E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Eslicarbazepine-acetatehsa05140Leishmaniasis3.10E-0613P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4More
Eslicarbazepine-acetatehsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Eslicarbazepine-acetatehsa05144Malaria1.74E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Eslicarbazepine-acetatehsa05145Toxoplasmosis4.06E-037P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Eslicarbazepine-acetatehsa05146Amoebiasis1.91E-0614P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Eslicarbazepine-acetatehsa05150Staphylococcus aureus infection2.68E-038P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMPMore
Eslicarbazepine-acetatehsa05152Tuberculosis8.50E-0410Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Eslicarbazepine-acetatehsa05161Hepatitis B1.61E-0310P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Eslicarbazepine-acetatehsa05162Measles2.57E-034P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Eslicarbazepine-acetatehsa05163Human cytomegalovirus infection2.68E-0516P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P04637, O00463TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Eslicarbazepine-acetatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Eslicarbazepine-acetatehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Eslicarbazepine-acetatehsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Eslicarbazepine-acetatehsa05200Pathways in cancer1.31E-0321Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6STMore
Eslicarbazepine-acetatehsa05202Transcriptional misregulation in cancer5.42E-0821Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Eslicarbazepine-acetatehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Eslicarbazepine-acetatehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Eslicarbazepine-acetatehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Eslicarbazepine-acetatehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Eslicarbazepine-acetatehsa05212Pancreatic cancer2.34E-045P42338, P42224, P84022, Q13485, O75293PIK3CB, STAT1, SMAD3, SMAD4, GADD45BMore
Eslicarbazepine-acetatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Eslicarbazepine-acetatehsa05214Glioma1.88E-034P08069, P0DP23, P42338, O75293IGF1R, CALM1, PIK3CB, GADD45BMore
Eslicarbazepine-acetatehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Eslicarbazepine-acetatehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Eslicarbazepine-acetatehsa05218Melanoma6.63E-031P08069IGF1RMore
Eslicarbazepine-acetatehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Eslicarbazepine-acetatehsa05220Chronic myeloid leukemia1.44E-036Q13547, Q13485, P25963, P84022, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Eslicarbazepine-acetatehsa05222Small cell lung cancer2.38E-036Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Eslicarbazepine-acetatehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Eslicarbazepine-acetatehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Eslicarbazepine-acetatehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Eslicarbazepine-acetatehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Eslicarbazepine-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.52E-0513P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Eslicarbazepine-acetatehsa05310Asthma2.14E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Eslicarbazepine-acetatehsa05321Inflammatory bowel disease1.21E-067O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Eslicarbazepine-acetatehsa05322Systemic lupus erythematosus2.54E-0513O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Eslicarbazepine-acetatehsa05332Graft-versus-host disease2.07E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Eslicarbazepine-acetatehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Eslicarbazepine-acetatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Eslicarbazepine-acetatehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Eslicarbazepine-acetatehsa05415Diabetic cardiomyopathy4.23E-022O14521, P37173SDHD, TGFBR2More
Eslicarbazepine-acetatehsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Eslicarbazepine-acetate (SDC: 8.64)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)