PharmaCoNets of Esketamine (SPCN: 6.78 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Esketaminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Esketaminehsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Esketaminehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Esketaminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Esketaminehsa03010Ribosome2.60E-088Q07020, P46778, P61513, Q02878, P35268, P63173, P27635, P62249RPL18, RPL21, RPL37A, RPL6, RPL22, RPL38, RPL10, RPS16More
Esketaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Esketaminehsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Esketaminehsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Esketaminehsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Esketaminehsa04024cAMP signaling pathway1.49E-025P42338, P0DP23, P23634, Q16566, O15399PIK3CB, CALM1, ATP2B4, CAMK4, GRIN2DMore
Esketaminehsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Esketaminehsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Esketaminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Esketaminehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Esketaminehsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Esketaminehsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Esketaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Esketaminehsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Esketaminehsa04724Glutamatergic synapse4.10E-023O15399, P63218, P50151GRIN2D, GNG5, GNG10More
Esketaminehsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Esketaminehsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Esketaminehsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Esketaminehsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Esketaminehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Esketaminehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Esketaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Esketaminehsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Esketaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Esketaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Esketaminehsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Esketaminehsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Esketaminehsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Esketaminehsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Esketaminehsa05171Coronavirus disease - COVID-196.67E-088P62249, Q02878, P27635, Q07020, P46778, P35268, P61513, P63173RPS16, RPL6, RPL10, RPL18, RPL21, RPL22, RPL37A, RPL38More
Esketaminehsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Esketaminehsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Esketaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Esketamine (SDC: 1.76)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
P13639EEF2Elongation factor 2Reported00.38850.00670.15580.3634
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)