PharmaCoNets of Esculin (SPCN: 19.94 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Esculinhsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Esculinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Esculinhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Esculinhsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Esculinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Esculinhsa01200Carbon metabolism2.91E-021P11413G6PDMore
Esculinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Esculinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Esculinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Esculinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Esculinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Esculinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Esculinhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Esculinhsa04612Antigen processing and presentation1.65E-038P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Esculinhsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Esculinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Esculinhsa04650Natural killer cell mediated cytotoxicity1.01E-0713P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Esculinhsa04658Th1 and Th2 cell differentiation6.40E-0810Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3More
Esculinhsa04659Th17 cell differentiation1.02E-0510Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Esculinhsa04660T cell receptor signaling pathway1.19E-0511Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Esculinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Esculinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Esculinhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Esculinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Esculinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Esculinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Esculinhsa05133Pertussis4.20E-021P0C0L4C4AMore
Esculinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Esculinhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Esculinhsa05144Malaria3.76E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Esculinhsa05145Toxoplasmosis3.96E-022P28068, Q16787HLA-DMB, LAMA3More
Esculinhsa05146Amoebiasis2.37E-059P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Esculinhsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Esculinhsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Esculinhsa05166Human T-cell leukemia virus 1 infection2.91E-023Q02930, P28068, Q13315CREB5, HLA-DMB, ATMMore
Esculinhsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Esculinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.32E-048P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQMore
Esculinhsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More
Esculinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Esculinhsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Esculin (SDC: 3.62)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)