PharmaCoNets

PharmaCoNets of Erythromycin (S_PCN: 22.40 )

Erythromycin regulated-network (S_DN: 8.24)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Erythromycin

hsa00052

Galactose metabolism

6.39E-04

P06280, O43451

GLA, MGAM

Erythromycin

hsa00220

Arginine biosynthesis

4.88E-02

P49448

GLUD2

Erythromycin

hsa00250

Alanine, aspartate and glutamate metabolism

4.88E-02

P49448

GLUD2

Erythromycin

hsa00471

D-Glutamine and D-glutamate metabolism

1.65E-02

P49448

GLUD2

Erythromycin

hsa00500

Starch and sucrose metabolism

1.75E-03

O43451, P06737

MGAM, PYGL

Erythromycin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Erythromycin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Erythromycin

hsa00600

Sphingolipid metabolism

4.56E-02

Q9BX95, Q06136, P06280

SGPP1, FVT1, GLA

Erythromycin

hsa00730

Thiamine metabolism

1.50E-04

P05186, P24666

ALPL, ACP1

Erythromycin

hsa00830

Retinol metabolism

1.08E-02

Q9BPW9, O75911, P11712

DHRS9, DHRS3, CYP2C9

Erythromycin

hsa00910

Nitrogen metabolism

4.88E-02

P49448

GLUD2

Erythromycin

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Erythromycin

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Erythromycin

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Erythromycin

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Erythromycin

hsa03013

RNA transport

1.91E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Erythromycin

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Erythromycin

hsa03060

Protein export

3.28E-02

Q15070

OXA1L

Erythromycin

hsa04064

NF-kappa B signaling pathway

2.83E-02

P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45A

Erythromycin

hsa04071

Sphingolipid signaling pathway

5.28E-05

P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2, GAB2

Erythromycin

hsa04140

Autophagy - animal

3.72E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Erythromycin

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Erythromycin

hsa04152

AMPK signaling pathway

2.34E-02

Q96EB6, P36956

SIRT1, SREBF1

Erythromycin

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Erythromycin

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Erythromycin

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Erythromycin

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Erythromycin

hsa04612

Antigen processing and presentation

2.84E-02

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Erythromycin

hsa04613

Neutrophil extracellular trap formation

1.54E-04

O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P09958	FURIN	Furin	O60603	TLR2	Toll-like receptor 2	0.923
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P09958	FURIN	Furin	P05164	MPO	Myeloperoxidase	0.708
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P09958	FURIN	Furin	P08246	ELA2	Neutrophil elastase	0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P09958	FURIN	Furin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.78
P09958	FURIN	Furin	Q92769	HDAC2	Histone deacetylase 2	-0.798
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P09958	FURIN	Furin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.815
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P09958	FURIN	Furin	Q15080	NCF4	Neutrophil cytosol factor 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P09958	FURIN	Furin	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.775
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P09958	FURIN	Furin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P09958	FURIN	Furin	P21462	FPR1	fMet-Leu-Phe receptor	0.868
P09958	FURIN	Furin	O43315	AQP9	Aquaporin-9	0.795
P09958	FURIN	Furin	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.743

Erythromycin

hsa04640

Hematopoietic cell lineage

3.58E-02

P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Erythromycin

hsa04657

IL-17 signaling pathway

4.48E-03

P07900, P49841, P14780, P01375, P01584

HSP90AA1, GSK3B, MMP9, TNF, IL1B

Erythromycin

hsa04658

Th1 and Th2 cell differentiation

1.48E-02

Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOB

Erythromycin

hsa04660

T cell receptor signaling pathway

3.19E-03

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB

Erythromycin

hsa04668

TNF signaling pathway

4.96E-02

O00463, Q13546, Q13489, Q16539, Q13077, P14780

TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9

Erythromycin

hsa04672

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Erythromycin

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Erythromycin

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Erythromycin

hsa04924

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Erythromycin

hsa04927

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Erythromycin

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Erythromycin

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Erythromycin

hsa04940

Type I diabetes mellitus

3.64E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Erythromycin

hsa04964

Proximal tubule bicarbonate reclamation

4.88E-02

P49448

GLUD2

Erythromycin

hsa04970

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Erythromycin

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Erythromycin

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Erythromycin

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Erythromycin

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Erythromycin

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Erythromycin

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Erythromycin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.14E-02

Q16539, P25024, P25025

MAPK14, CXCR1, CXCR2

Erythromycin

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Erythromycin

hsa05144

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Erythromycin

hsa05146

Amoebiasis

1.48E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Erythromycin

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Erythromycin

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Erythromycin

hsa05202

Transcriptional misregulation in cancer

2.85E-04

Q15532, P41732, P14780, P27930, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q92769, P12980, P24522

SS18, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09958	FURIN	Furin	Q15532	SS18	Protein SSXT	-0.749
P09958	FURIN	Furin	P41732	TSPAN7	Tetraspanin-7	0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P09958	FURIN	Furin	P14780	MMP9	Matrix metalloproteinase-9	0.843
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P09958	FURIN	Furin	P27930	IL1R2	Interleukin-1 receptor type 2	0.763
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P09958	FURIN	Furin	Q16548	BCL2A1	Bcl-2-related protein A1	0.793
P09958	FURIN	Furin	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.714
P09958	FURIN	Furin	Q13077	TRAF1	TNF receptor-associated factor 1	-0.741
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P09958	FURIN	Furin	P35226	BMI1	Polycomb complex protein BMI-1	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P09958	FURIN	Furin	P35226	BMI1	Polycomb complex protein BMI-1	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P09958	FURIN	Furin	P05164	MPO	Myeloperoxidase	0.708
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P09958	FURIN	Furin	P08246	ELA2	Neutrophil elastase	0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P09958	FURIN	Furin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.811
P09958	FURIN	Furin	Q92769	HDAC2	Histone deacetylase 2	-0.798
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P09958	FURIN	Furin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.806