PharmaCoNets

PharmaCoNets of Eribulin (S_PCN: 17.48 )

Eribulin regulated-network (S_DN: 7.70)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Eribulin

hsa00010

Glycolysis / Gluconeogenesis

1.18E-02

P60174, P06744

TPI1, GPI

Eribulin

hsa00053

Ascorbate and aldarate metabolism

1.80E-02

P51648, Q9UEF7

ALDH3A2, KL

Eribulin

hsa00190

Oxidative phosphorylation

3.56E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Eribulin

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Eribulin

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Eribulin

hsa00310

Lysine degradation

4.27E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Eribulin

hsa00561

Glycerolipid metabolism

4.36E-03

O14494, P51648, P23743

PLPP1, ALDH3A2, DGKA

Eribulin

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Eribulin

hsa00630

Glyoxylate and dicarboxylate metabolism

2.42E-02

P40925, P15104

MDH1, GLUL

Eribulin

hsa01200

Carbon metabolism

1.99E-02

P06744, P60174

GPI, TPI1

Eribulin

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.90E-02

P17252, P10415, Q9NRA1

PRKCA, BCL2, PDGFC

Eribulin

hsa01524

Platinum drug resistance

4.02E-02

Q13315, P10415, Q13489, P43246

ATM, BCL2, BIRC3, MSH2

Eribulin

hsa03013

RNA transport

3.98E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Eribulin

hsa03040

Spliceosome

1.45E-04

Q14562, O43143, O60508, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142

DHX8, DHX15, CDC40, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8

Eribulin

hsa04020

Calcium signaling pathway

2.09E-02

Q16566, P17252, P25116, P0DP23, Q9NRA1

CAMK4, PRKCA, F2R, CALM1, PDGFC

Eribulin

hsa04064

NF-kappa B signaling pathway

3.04E-03

P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293

BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45B

Eribulin

hsa04071

Sphingolipid signaling pathway

2.03E-02

P17252, P21453, P10415, P01042

PRKCA, S1PR1, BCL2, KNG1

Eribulin

hsa04072

Phospholipase D signaling pathway

1.06E-02

P25116, P17252, O14494, P23743, Q9NRA1

F2R, PRKCA, PLPP1, DGKA, PDGFC

Eribulin

hsa04120

Ubiquitin mediated proteolysis

2.89E-02

O95071, P0CG47

UBR5, UBB

Eribulin

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Eribulin

hsa04141

Protein processing in endoplasmic reticulum

2.77E-02

P27824, P30101, P60604, P11142, P08238

CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1

Eribulin

hsa04145

Phagosome

1.69E-05

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB

Eribulin

hsa04217

Necroptosis

3.69E-05

P01568, Q13489, Q13546, P42224, P08238, Q6FI13, P10415, O43633

IFNA21, BIRC3, RIPK1, STAT1, HSP90AB1, H2AC18; H2AC19, BCL2, CHMP2A

Eribulin

hsa04371

Apelin signaling pathway

1.12E-03

P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Eribulin

hsa04520

Adherens junction

8.77E-03

Q13485, P84022, O95863, Q15223

SMAD4, SMAD3, SNAI1, PVRL1

Eribulin

hsa04540

Gap junction

5.44E-03

P17252, Q13509, P68371, Q9NRA1

PRKCA, TUBB3, TUBB2C, PDGFC

Eribulin

hsa04620

Toll-like receptor signaling pathway

7.24E-03

P51617, Q13546, P01568, P42224, P25963

IRAK1, RIPK1, IFNA21, STAT1, NFKBIA

Eribulin

hsa04621

NOD-like receptor signaling pathway

4.54E-02

P08238, P42224, P01568, P25963, Q13489, P10415, Q13546

HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1

Eribulin

hsa04623

Cytosolic DNA-sensing pathway

4.52E-05

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Eribulin

hsa04659

Th17 cell differentiation

1.64E-02

P19174, P84022, Q13485, P08238, P07766

PLCG1, SMAD3, SMAD4, HSP90AB1, CD3E

Eribulin

hsa04664

Fc epsilon RI signaling pathway

2.35E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Eribulin

hsa04666

Fc gamma R-mediated phagocytosis

1.76E-03

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Eribulin

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Eribulin

hsa04710

Circadian rhythm

1.79E-02

O15516

CLOCK

Eribulin

hsa04720

Long-term potentiation

2.05E-02

P17252, Q16566, P0DP23

PRKCA, CAMK4, CALM1

Eribulin

hsa04724

Glutamatergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Eribulin

hsa04725

Cholinergic synapse

8.04E-03

P17252, P62873, Q16566, P10415

PRKCA, GNB1, CAMK4, BCL2

Eribulin

hsa04727

GABAergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Eribulin

hsa04744

Phototransduction

2.95E-06

P62873, P0DP23

GNB1, CALM1

Eribulin

hsa04916

Melanogenesis

3.86E-03

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Eribulin

hsa04925

Aldosterone synthesis and secretion

3.91E-02

P0DP23, P17252, Q16566

CALM1, PRKCA, CAMK4

Eribulin

hsa04961

Endocrine and other factor-regulated calcium reabsorption

1.22E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Eribulin

hsa05032

Morphine addiction

4.43E-02

P63218, P50151, P43250

GNG5, GNG10, GRK6

Eribulin

hsa05132

Salmonella infection

3.40E-06

P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
Q13509	TUBB3	Tubulin beta-3 chain	O75369	FLNB	Filamin-B	0.914
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
P68371	TUBB2C	Tubulin beta-4B chain	Q13561	DCTN2	Dynactin subunit 2	0.715
Q13509	TUBB3	Tubulin beta-3 chain	Q13561	DCTN2	Dynactin subunit 2	0.74
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	Q13509	TUBB3	Tubulin beta-3 chain	0.78
Q13509	TUBB3	Tubulin beta-3 chain	Q13509	TUBB3	Tubulin beta-3 chain	1
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P68371	TUBB2C	Tubulin beta-4B chain	P68371	TUBB2C	Tubulin beta-4B chain	1
Q13509	TUBB3	Tubulin beta-3 chain	P68371	TUBB2C	Tubulin beta-4B chain	0.78

Eribulin

hsa05140

Leishmaniasis

4.05E-03

P14598, P42224, P25963, P29350, P51617, Q15080

NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4

Eribulin

hsa05145

Toxoplasmosis

1.95E-02

P51617, P25963, P10415, Q13489, P42224, P11142

IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8

Eribulin

hsa05152

Tuberculosis

1.40E-05

Q13488, P0DP23, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Eribulin

hsa05162

Measles

4.50E-03

P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415

IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2

Eribulin

hsa05166

Human T-cell leukemia virus 1 infection

1.77E-02

P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746

CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLB

Eribulin

hsa05168

Herpes simplex virus 1 infection

5.65E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2

Eribulin

hsa05170

Human immunodeficiency virus 1 infection

1.21E-06

P62873, P0DP23, P17252, Q13546, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, P23528, P10415, Q93034, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CFL1, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P68371	TUBB2C	Tubulin beta-4B chain	Q13315	ATM	Serine-protein kinase ATM	-0.772
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P23528	CFL1	Cofilin-1	-0.726
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
P68371	TUBB2C	Tubulin beta-4B chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.753
Q13509	TUBB3	Tubulin beta-3 chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.886

Eribulin

hsa05200

Pathways in cancer

2.19E-05

P04628, Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P14923, P30279, P10415, Q13489, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P01042

WNT1, LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, JUP, CCND2, BCL2, BIRC3, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	P04628	WNT1	Proto-oncogene Wnt-1	-0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13751	LAMB3	Laminin subunit beta-3	0.748
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
Q71U36	TUBA1A	Tubulin alpha-1A chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.866
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q71U36	TUBA1A	Tubulin alpha-1A chain	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.7
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.709
Q13509	TUBB3	Tubulin beta-3 chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.872
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
Q71U36	TUBA1A	Tubulin alpha-1A chain	P20585	MSH3	DNA mismatch repair protein Msh3	-0.745
P68371	TUBB2C	Tubulin beta-4B chain	P14923	JUP	Junction plakoglobin	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P14923	JUP	Junction plakoglobin	-0.937
Q71U36	TUBA1A	Tubulin alpha-1A chain	P30279	CCND2	G1/S-specific cyclin-D2	-0.721
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P68371	TUBB2C	Tubulin beta-4B chain	Q12778	FOXO1	Forkhead box protein O1	-0.895
P68371	TUBB2C	Tubulin beta-4B chain	P25116	F2R	Proteinase-activated receptor 1	-0.799
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
Q71U36	TUBA1A	Tubulin alpha-1A chain	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.818
Q71U36	TUBA1A	Tubulin alpha-1A chain	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.827
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.879
Q13509	TUBB3	Tubulin beta-3 chain	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.826
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.709
P68371	TUBB2C	Tubulin beta-4B chain	P01042	KNG1	Kininogen-1	-0.7