PharmaCoNets of Ergotamine (SPCN: 25.11 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dihydroergotaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dihydroergotaminehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Dihydroergotaminehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Dihydroergotaminehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Dihydroergotaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dihydroergotaminehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Dihydroergotaminehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Dihydroergotaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dihydroergotaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dihydroergotaminehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Dihydroergotaminehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Dihydroergotaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dihydroergotaminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dihydroergotaminehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Dihydroergotaminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dihydroergotaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Dihydroergotaminehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Dihydroergotaminehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Dihydroergotaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dihydroergotaminehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Dihydroergotaminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dihydroergotaminehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Dihydroergotaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dihydroergotaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dihydroergotaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dihydroergotaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dihydroergotaminehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dihydroergotaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dihydroergotaminehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dihydroergotaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dihydroergotaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dihydroergotaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dihydroergotaminehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dihydroergotaminehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dihydroergotaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dihydroergotaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dihydroergotaminehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Dihydroergotaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dihydroergotaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dihydroergotaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dihydroergotaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Dihydroergotaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dihydroergotaminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dihydroergotaminehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Dihydroergotaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dihydroergotaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dihydroergotaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Ergotaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Ergotaminehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Ergotaminehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Ergotaminehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Ergotaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Ergotaminehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Ergotaminehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ergotaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Ergotaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Ergotaminehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Ergotaminehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Ergotaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Ergotaminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ergotaminehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ergotaminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ergotaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Ergotaminehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ergotaminehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Ergotaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ergotaminehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Ergotaminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Ergotaminehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Ergotaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Ergotaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ergotaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Ergotaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Ergotaminehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Ergotaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Ergotaminehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ergotaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Ergotaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Ergotaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Ergotaminehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ergotaminehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Ergotaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ergotaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Ergotaminehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Ergotaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Ergotaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ergotaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Ergotaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Ergotaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ergotaminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Ergotaminehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Ergotaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Ergotaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ergotaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More

Community members of Ergotamine (SDC: 4.74)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
HTR1FP30939Ki169.82
HTR1FP30939Ki171