PharmaCoNets

PharmaCoNets of Erdafitinib (S_PCN: 192.67 )

Erdafitinib regulated-network (S_DN: 24.83)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Erdafitinib

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Erdafitinib

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Erdafitinib

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Erdafitinib

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Erdafitinib

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Erdafitinib

hsa00310

Lysine degradation

1.31E-03

Q96KQ7, P51648

EHMT2, ALDH3A2

Erdafitinib

hsa00500

Starch and sucrose metabolism

5.48E-07

O43451, P46976, P06737

MGAM, GYG1, PYGL

Erdafitinib

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Erdafitinib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Erdafitinib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Erdafitinib

hsa00600

Sphingolipid metabolism

2.77E-02

Q9BX95, Q8TCT0, P15289

SGPP1, CERK, ARSA

Erdafitinib

hsa00630

Glyoxylate and dicarboxylate metabolism

3.69E-07

P40925, P40926, P15104

MDH1, MDH2, GLUL

Erdafitinib

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Erdafitinib

hsa00730

Thiamine metabolism

2.39E-05

P05186, P24666

ALPL, ACP1

Erdafitinib

hsa00750

Vitamin B6 metabolism

4.45E-02

O00764

PDXK

Erdafitinib

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Erdafitinib

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Erdafitinib

hsa00970

Aminoacyl-tRNA biosynthesis

9.57E-03

O95363, P54136, P14868

FARS2, RARS1, DARS

Erdafitinib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Erdafitinib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Erdafitinib

hsa00983

Drug metabolism - other enzymes

9.82E-04

P04183, P32320, P05164

TK1, CDA, MPO

Erdafitinib

hsa01040

Biosynthesis of unsaturated fatty acids

2.92E-02

P22307, Q9H5J4

SCP2, ELOVL6

Erdafitinib

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Erdafitinib

hsa01522

Endocrine resistance

4.48E-02

P22694, Q02750, Q9UM47, P46527

PRKACB, MAP2K1, NOTCH3, CDKN1B

Erdafitinib

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Erdafitinib

hsa01524

Platinum drug resistance

4.67E-02

Q13489, P98170, P78417, P43246

BIRC3, BIRC4, GSTO1, MSH2

Erdafitinib

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Erdafitinib

hsa03013

RNA transport

6.44E-05

P62826, P52298, Q09161, O14893, P38919, Q9UBU9, P37198, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O75822, P78345, Q14232, P51114

RAN, NCBP2, NCBP1, GEMIN2, EIF4A3, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3J, RPP38, EIF2B1, FXR1

Erdafitinib

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Erdafitinib

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Erdafitinib

hsa03040

Spliceosome

7.30E-09

Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742

Erdafitinib

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Erdafitinib

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Erdafitinib

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Erdafitinib

hsa04014

Ras signaling pathway

1.23E-03

Q02750, Q15389, Q9NRA1, Q13009, P17252, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694

MAP2K1, ANGPT1, PDGFC, TIAM1, PRKCA, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACB

Erdafitinib

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Erdafitinib

hsa04022

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Erdafitinib

hsa04024

cAMP signaling pathway

3.94E-02

Q08828, P51828, P31751, P0DP23

ADCY1, ADCY7, AKT2, CALM1

Erdafitinib

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Erdafitinib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.13E-04

Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Erdafitinib

hsa04062

Chemokine signaling pathway

5.92E-06

P25024, P09341, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCL1, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Erdafitinib

hsa04064

NF-kappa B signaling pathway

1.50E-06

P10415, O00463, Q13546, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, TRAF5, RIPK1, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q07912	TNK2	Activated CDC42 kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q07912	TNK2	Activated CDC42 kinase 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q07912	TNK2	Activated CDC42 kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q07912	TNK2	Activated CDC42 kinase 1	Q13315	ATM	Serine-protein kinase ATM	-0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Erdafitinib

hsa04066

HIF-1 signaling pathway

4.48E-02

P17252, Q15389, Q02750, P46527

PRKCA, ANGPT1, MAP2K1, CDKN1B

Erdafitinib

hsa04070

Phosphatidylinositol signaling system

8.17E-04

P19174, P0DP23, O14986, P23743, Q16760, P48426, P27987

PLCG1, CALM1, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB

Erdafitinib

hsa04071

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Erdafitinib

hsa04072

Phospholipase D signaling pathway

2.40E-03

P31751, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Erdafitinib

hsa04080

Neuroactive ligand-receptor interaction

1.20E-02

P08311, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318

CTSG, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADM

Erdafitinib

hsa04110

Cell cycle

8.83E-05

Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC

Erdafitinib

hsa04114

Oocyte meiosis

2.55E-04

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Erdafitinib

hsa04115

p53 signaling pathway

2.54E-02

O15151, Q13315, P10415

MDM4, ATM, BCL2

Erdafitinib

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Erdafitinib

hsa04140

Autophagy - animal

1.71E-02

P31751, Q7L523, O75460, Q96GC9, Q8TEV9

AKT2, RRAGA, ERN1, TMEM49, SMCR8

Erdafitinib

hsa04141

Protein processing in endoplasmic reticulum

1.22E-04

P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3

Erdafitinib

hsa04144

Endocytosis

2.81E-02

Q13191, P11142, P25024, P43250, P14784, Q9Y5X3

CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5

Erdafitinib

hsa04145

Phagosome

8.96E-04

P11215, P14598, Q71U36, Q13509, P68371, Q13488

ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1

Erdafitinib

hsa04151

PI3K-Akt signaling pathway

3.91E-03

P62753, P27348, P07900, P22105, Q99941, P18848, O00141

RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGK

Erdafitinib

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Erdafitinib

hsa04211

Longevity regulating pathway

1.32E-03

P31751, Q08828, P51828, Q99941, P18848

AKT2, ADCY1, ADCY7, CREBL1, ATF4

Erdafitinib

hsa04213

Longevity regulating pathway - multiple species

4.54E-02

P31751, Q08828, P51828

AKT2, ADCY1, ADCY7

Erdafitinib

hsa04217

Necroptosis

9.70E-04

P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, Q99878, P21796

TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, H2AC14, VDAC1

Erdafitinib

hsa04261

Adrenergic signaling in cardiomyocytes

2.38E-05

Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557

ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D

Erdafitinib

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Erdafitinib

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Erdafitinib

hsa04370

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Erdafitinib

hsa04371

Apelin signaling pathway

1.54E-07

P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Erdafitinib

hsa04380

Osteoclast differentiation

5.27E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Erdafitinib

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Erdafitinib

hsa04540

Gap junction

2.05E-05

P17252, P22694, Q13509, P68371, Q71U36, Q02750, Q9NRA1

PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, PDGFC

Erdafitinib

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Erdafitinib

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Erdafitinib

hsa04612

Antigen processing and presentation

5.27E-04

P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Erdafitinib

hsa04613

Neutrophil extracellular trap formation

1.49E-04

O60603, P05164, Q9UM07, Q13547, P04908, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, PADI4, HDAC1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O60603	TLR2	Toll-like receptor 2	0.762
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P05164	MPO	Myeloperoxidase	0.717
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.736
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q13547	HDAC1	Histone deacetylase 1	-0.759
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.706
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P08311	CTSG	Cathepsin G	0.715
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.892
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.923
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.779
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	O43315	AQP9	Aquaporin-9	0.918
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q16769	QPCT	Glutaminyl-peptide cyclotransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.839

Erdafitinib

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Erdafitinib

hsa04623

Cytosolic DNA-sensing pathway

1.25E-05

P01584, P01568, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2

Erdafitinib

hsa04625

C-type lectin receptor signaling pathway

1.14E-03

Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Erdafitinib

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Erdafitinib

hsa04640

Hematopoietic cell lineage

3.30E-05

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Erdafitinib

hsa04650

Natural killer cell mediated cytotoxicity

6.24E-06

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Erdafitinib

hsa04657

IL-17 signaling pathway

1.69E-05

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Erdafitinib

hsa04658

Th1 and Th2 cell differentiation

1.22E-07

Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Erdafitinib

hsa04659

Th17 cell differentiation

6.26E-09

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Erdafitinib

hsa04660

T cell receptor signaling pathway

8.91E-04

Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Erdafitinib

hsa04662

B cell receptor signaling pathway

4.07E-02

P42338, P60033, P07948, Q8N149

PIK3CB, CD81, LYN, LILRA2

Erdafitinib

hsa04664

Fc epsilon RI signaling pathway

7.09E-04

P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917

TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5

Erdafitinib

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Erdafitinib

hsa04713

Circadian entrainment

1.62E-05

O15399, P0DP23, P62873, P63218, P50151, Q08828, P51828

GRIN2D, CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7

Erdafitinib

hsa04714

Thermogenesis

6.01E-04

Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521

MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD

Erdafitinib

hsa04720

Long-term potentiation

6.40E-06

P17252, Q16566, P16298, P0DP23, P51812, P18848, O15399, P22694, Q08828, Q02750

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, PRKACB, ADCY1, MAP2K1

Erdafitinib

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Erdafitinib

hsa04724

Glutamatergic synapse

4.07E-06

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Erdafitinib

hsa04725

Cholinergic synapse

1.99E-06

Q08828, P51828, P22694, P17252, P62873, P62879, P63218, P50151, P18848, Q16566, Q13557, P31751, Q02750

ADCY1, ADCY7, PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK4, CAMK2D, AKT2, MAP2K1

Erdafitinib

hsa04726

Serotonergic synapse

1.47E-04

P22694, P17252, P62873, P62879, P63218, P50151, P09917, Q02750

PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, MAP2K1

Erdafitinib

hsa04727

GABAergic synapse

6.44E-07

P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252

GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCA

Erdafitinib

hsa04728

Dopaminergic synapse

1.01E-03

P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23

AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1

Erdafitinib

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Erdafitinib

hsa04744

Phototransduction

6.37E-05

P62873, P0DP23

GNB1, CALM1

Erdafitinib

hsa04750

Inflammatory mediator regulation of TRP channels

9.86E-03

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Erdafitinib

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Erdafitinib

hsa04911

Insulin secretion

4.09E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Erdafitinib

hsa04912

GnRH signaling pathway

7.81E-04

Q08828, P51828, P18848, Q13557, P0DP23

ADCY1, ADCY7, ATF4, CAMK2D, CALM1

Erdafitinib

hsa04914

Progesterone-mediated oocyte maturation

1.00E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Erdafitinib

hsa04915

Estrogen signaling pathway

2.27E-04

Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23

CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1

Erdafitinib

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Erdafitinib

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Erdafitinib

hsa04919

Thyroid hormone signaling pathway

6.35E-04

P17252, P49841, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47

PRKCA, GSK3B, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3

Erdafitinib

hsa04923

Regulation of lipolysis in adipocytes

5.15E-03

Q08828, P51828, P31751

ADCY1, ADCY7, AKT2

Erdafitinib

hsa04925

Aldosterone synthesis and secretion

5.46E-05

Q99941, P18848, Q08828, P51828, P0DP23, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D

Erdafitinib

hsa04926

Relaxin signaling pathway

2.12E-03

P31751, Q99941, P18848, Q08828, P51828

AKT2, CREBL1, ATF4, ADCY1, ADCY7

Erdafitinib

hsa04927

Cortisol synthesis and secretion

1.76E-04

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Erdafitinib

hsa04928

Parathyroid hormone synthesis, secretion and action

3.12E-03

P51828, P22694, Q02750, P17252, Q99941, P18848, Q9Y5Q3

ADCY7, PRKACB, MAP2K1, PRKCA, CREBL1, ATF4, MAFB

Erdafitinib

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Erdafitinib

hsa04932

Non-alcoholic fatty liver disease

5.67E-05

P31751, P01375, P49841, P18848, P48023, O75460, P01584, Q16718, O95298, O14521

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFA5, NDUFC2, SDHD

Erdafitinib

hsa04934

Cushing syndrome

2.20E-04

Q99941, P18848, Q08828, P51828, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CAMK2D

Erdafitinib

hsa04935

Growth hormone synthesis, secretion and action

1.32E-03

Q08828, P51828, Q99941, P18848, P31751

ADCY1, ADCY7, CREBL1, ATF4, AKT2

Erdafitinib

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Erdafitinib

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Erdafitinib

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Erdafitinib

hsa04970

Salivary secretion

1.83E-03

Q08828, P51828, P22694, P17252, P0DP23, P49913

ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMP

Erdafitinib

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Erdafitinib

hsa04976

Bile secretion

9.39E-06

O43315, Q08828, P51828, P22694, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Erdafitinib

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Erdafitinib

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Erdafitinib

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Erdafitinib

hsa05017

Spinocerebellar ataxia

2.86E-03

Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796

FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1

Erdafitinib

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Erdafitinib

hsa05022

Pathways of neurodegeneration - multiple diseases

4.63E-04

P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Erdafitinib

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Erdafitinib

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Erdafitinib

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Erdafitinib

hsa05034

Alcoholism

4.45E-05

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Erdafitinib

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Erdafitinib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

7.91E-05

Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN

Erdafitinib

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Erdafitinib

hsa05131

Shigellosis

1.80E-02

Q13546, Q9UDY8, Q12778, Q13315, P10415

RIPK1, MALT1, FOXO1, ATM, BCL2

Erdafitinib

hsa05132

Salmonella infection

4.00E-03

P25963, P08238, Q13546, P10415, O75369, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, RIPK1, BCL2, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41

Erdafitinib

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Erdafitinib

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Erdafitinib

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Erdafitinib

hsa05140

Leishmaniasis

4.62E-04

O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P49006, Q16539, Q15080

FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, NCF4

Erdafitinib

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Erdafitinib

hsa05144

Malaria

2.60E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Erdafitinib

hsa05146

Amoebiasis

5.44E-06

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Erdafitinib

hsa05150

Staphylococcus aureus infection

1.62E-03

P0C0L4, P21462, P13646, Q14532, P59665, P59666

C4A, FPR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3

Erdafitinib

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Erdafitinib

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Erdafitinib

hsa05163

Human cytomegalovirus infection

3.03E-09

P31751, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568

AKT2, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703

Erdafitinib

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Erdafitinib

hsa05165

Human papillomavirus infection

4.71E-03

P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315

CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM

Erdafitinib

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Erdafitinib

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.86E-06

P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Erdafitinib

hsa05168

Herpes simplex virus 1 infection

5.00E-03

P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, O75820, Q9NZL3

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF189, ZNF224

Erdafitinib

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Erdafitinib

hsa05170

Human immunodeficiency virus 1 infection

6.82E-04

P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174, P23528

GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1

Erdafitinib

hsa05200

Pathways in cancer

3.48E-06

Q13751, P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, Q13489, P98170, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, P01568, P14784, P01042

LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, BIRC3, BIRC4, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Erdafitinib

hsa05202

Transcriptional misregulation in cancer

3.76E-02

Q12778, Q13315, Q15744, P46527, P05164, P08246, Q9C0K0

FOXO1, ATM, CEBPE, CDKN1B, MPO, ELA2, BCL11B

Erdafitinib

hsa05203

Viral carcinogenesis

2.63E-03

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Erdafitinib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Erdafitinib

hsa05206

MicroRNAs in cancer

3.66E-02

P46527, Q9UM47, P16070, Q13315, P17252, Q02750

CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1

Erdafitinib

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Erdafitinib

hsa05212

Pancreatic cancer

2.33E-04

P31751, Q15311, P23458, P42224, P84022, Q13485, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B

Erdafitinib

hsa05214

Glioma

3.62E-03

P0DP23, Q16566, P19174, O75293

CALM1, CAMK4, PLCG1, GADD45B

Erdafitinib

hsa05215

Prostate cancer

3.03E-02

P10415, Q12778, Q9NRA1

BCL2, FOXO1, PDGFC

Erdafitinib

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Erdafitinib

hsa05222

Small cell lung cancer

3.80E-02

Q13751, Q13489, P98170, O75293

LAMB3, BIRC3, BIRC4, GADD45B

Erdafitinib

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Erdafitinib

hsa05231

Choline metabolism in cancer

2.02E-03

P31751, Q9Y259, P19174, P49619, Q16760, O14986

AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1B

Erdafitinib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.32E-03

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Erdafitinib

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Erdafitinib

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Erdafitinib

hsa05332

Graft-versus-host disease

3.75E-03

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Erdafitinib

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Erdafitinib

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Erdafitinib

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Erdafitinib

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Erdafitinib

hsa05418

Fluid shear stress and atherosclerosis

2.60E-05

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Erdafitinib (S_DC: 7.76)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PDGFRB

PlateletNonederived growth factor receptor beta

Reported

0.0496

0.9444

0.7408

2.6543

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

Q13315

ATM

SerineNoneprotein kinase ATM

Predicted

0.7747

0.2014

0.9391

1.7293

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

Q07912

TNK2

Activated CDC42 kinase 1

Predicted

0.009

0.3472

0.6988

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

Q16769

QPCT

GlutaminylNonepeptide cyclotransferase

Predicted

0.0245

0.2416

0.4954

PharmaCoNets of Erdafitinib (SPCN: 192.67 )

Erdafitinib regulated-network (SDN: 24.83)

Community members of Erdafitinib (SDC: 7.76)

PharmaCoNets of Erdafitinib (S_PCN: 192.67 )

Erdafitinib regulated-network (S_DN: 24.83)

Community members of Erdafitinib (S_DC: 7.76)