PharmaCoNets of Eplerenone (SPCN: 39.19 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Eplerenonehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Eplerenonehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Eplerenonehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Eplerenonehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Eplerenonehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Eplerenonehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Eplerenonehsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Eplerenonehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Eplerenonehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Eplerenonehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Eplerenonehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Eplerenonehsa04064NF-kappa B signaling pathway2.19E-0719P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643, Q9UNE0BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTB, EDARMore
Eplerenonehsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Eplerenonehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Eplerenonehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Eplerenonehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Eplerenonehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Eplerenonehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Eplerenonehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Eplerenonehsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Eplerenonehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Eplerenonehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Eplerenonehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Eplerenonehsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Eplerenonehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Eplerenonehsa04621NOD-like receptor signaling pathway7.18E-0413Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4More
Eplerenonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Eplerenonehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Eplerenonehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Eplerenonehsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Eplerenonehsa04650Natural killer cell mediated cytotoxicity3.08E-038P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Eplerenonehsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Eplerenonehsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Eplerenonehsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Eplerenonehsa04660T cell receptor signaling pathway1.93E-0414P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Eplerenonehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Eplerenonehsa04668TNF signaling pathway1.83E-038P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Eplerenonehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Eplerenonehsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Eplerenonehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Eplerenonehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Eplerenonehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Eplerenonehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Eplerenonehsa05132Salmonella infection2.05E-0314P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Eplerenonehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Eplerenonehsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Eplerenonehsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Eplerenonehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Eplerenonehsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Eplerenonehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Eplerenonehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Eplerenonehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Eplerenonehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Eplerenonehsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Eplerenonehsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Eplerenonehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Eplerenonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Eplerenonehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Eplerenonehsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Eplerenonehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Eplerenonehsa05332Graft-versus-host disease9.31E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Eplerenonehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Eplerenonehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Eplerenone (SDC: 4.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08235NR3C2Mineralocorticoid receptorReported10.185510.01372.1064
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
NR3C2P08235IC50122
NR3C2P08235IC50135
NR3C2P08235IC50240