PharmaCoNets of Epinephrine (SPCN: 84.56 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Epinephrinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Epinephrinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Epinephrinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Epinephrinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Epinephrinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Epinephrinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Epinephrinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Epinephrinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Epinephrinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Epinephrinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Epinephrinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Epinephrinehsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Epinephrinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Epinephrinehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Epinephrinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Epinephrinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Epinephrinehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Epinephrinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Epinephrinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Epinephrinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Epinephrinehsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Epinephrinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Epinephrinehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Epinephrinehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Epinephrinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Epinephrinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Epinephrinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Epinephrinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Epinephrinehsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Epinephrinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Epinephrinehsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Epinephrinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Epinephrinehsa04210Apoptosis2.16E-021P04049RAF1More
Epinephrinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Epinephrinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Epinephrinehsa04218Cellular senescence2.49E-021P04049RAF1More
Epinephrinehsa04261Adrenergic signaling in cardiomyocytes1.73E-049P07550, P51828, P22694, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Epinephrinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Epinephrinehsa04360Axon guidance2.49E-021P04049RAF1More
Epinephrinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Epinephrinehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Epinephrinehsa04510Focal adhesion3.48E-021P04049RAF1More
Epinephrinehsa04540Gap junction1.33E-021P04049RAF1More
Epinephrinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Epinephrinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Epinephrinehsa04612Antigen processing and presentation3.75E-048P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Epinephrinehsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Epinephrinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Epinephrinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Epinephrinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Epinephrinehsa04650Natural killer cell mediated cytotoxicity3.52E-0610P01375, O60880, P20963, P04049, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH2D1A, CD247, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Epinephrinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Epinephrinehsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Epinephrinehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Epinephrinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Epinephrinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Epinephrinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Epinephrinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Epinephrinehsa04720Long-term potentiation1.66E-021P04049RAF1More
Epinephrinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Epinephrinehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Epinephrinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Epinephrinehsa04728Dopaminergic synapse3.20E-036Q99941, P18848, Q13557, Q13362, Q14738, P0DP23CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Epinephrinehsa04730Long-term depression1.16E-021P04049RAF1More
Epinephrinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Epinephrinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Epinephrinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Epinephrinehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Epinephrinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Epinephrinehsa04912GnRH signaling pathway3.36E-034P51828, P18848, Q13557, P04049ADCY7, ATF4, CAMK2D, RAF1More
Epinephrinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Epinephrinehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Epinephrinehsa04915Estrogen signaling pathway4.99E-046P04049, Q99941, P18848, P51828, P07900, P11142RAF1, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Epinephrinehsa04916Melanogenesis1.33E-021P04049RAF1More
Epinephrinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Epinephrinehsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Epinephrinehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Epinephrinehsa04921Oxytocin signaling pathway4.61E-034P0DP23, P04049, Q96RR4, Q13469CALM1, RAF1, CAMKK2, NFATC2More
Epinephrinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Epinephrinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Epinephrinehsa04926Relaxin signaling pathway5.73E-047Q99941, P18848, P22694, P14780, P51828, P04049, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, RAF1, GNA15More
Epinephrinehsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Epinephrinehsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Epinephrinehsa04929GnRH secretion4.98E-031P04049RAF1More
Epinephrinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Epinephrinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Epinephrinehsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Epinephrinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Epinephrinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Epinephrinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Epinephrinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Epinephrinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Epinephrinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Epinephrinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Epinephrinehsa05034Alcoholism2.49E-021P04049RAF1More
Epinephrinehsa05132Salmonella infection4.98E-021P04049RAF1More
Epinephrinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Epinephrinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Epinephrinehsa05144Malaria1.94E-046P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Epinephrinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Epinephrinehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Epinephrinehsa05152Tuberculosis3.98E-021P04049RAF1More
Epinephrinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Epinephrinehsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Epinephrinehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Epinephrinehsa05164Influenza A3.65E-021P04049RAF1More
Epinephrinehsa05167Kaposi sarcoma-associated herpesvirus infection1.06E-024P23458, Q13469, P04049, P0DP23JAK1, NFATC2, RAF1, CALM1More
Epinephrinehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Epinephrinehsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Epinephrinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Epinephrinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Epinephrinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Epinephrinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Epinephrinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Epinephrinehsa05212Pancreatic cancer4.13E-033P04049, Q15311, P23458RAF1, RALBP1, JAK1More
Epinephrinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Epinephrinehsa05214Glioma9.95E-031P04049RAF1More
Epinephrinehsa05215Prostate cancer3.72E-033P18848, P14625, P04049ATF4, HSP90B1, RAF1More
Epinephrinehsa05218Melanoma6.63E-031P04049RAF1More
Epinephrinehsa05219Bladder cancer4.98E-031P04049RAF1More
Epinephrinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Epinephrinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Epinephrinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Epinephrinehsa05224Breast cancer1.49E-021P04049RAF1More
Epinephrinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Epinephrinehsa05226Gastric cancer8.29E-031P04049RAF1More
Epinephrinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Epinephrinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Epinephrinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Epinephrinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Epinephrinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Epinephrinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Epinephrinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Norepinephrinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Norepinephrinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Norepinephrinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Norepinephrinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Norepinephrinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Norepinephrinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Norepinephrinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Norepinephrinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Norepinephrinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Norepinephrinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Norepinephrinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Norepinephrinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Norepinephrinehsa03010Ribosome3.92E-0610P62753, P62906, P46776, P46777, Q07020, P61513, P27635, P50914, P62249, P23396RPS6, RPL10A, RPL27A, RPL5, RPL18, RPL37A, RPL10, RPL14, RPS16, RPS3More
Norepinephrinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Norepinephrinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Norepinephrinehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Norepinephrinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Norepinephrinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Norepinephrinehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Norepinephrinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Norepinephrinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Norepinephrinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Norepinephrinehsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Norepinephrinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Norepinephrinehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Norepinephrinehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Norepinephrinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Norepinephrinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Norepinephrinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Norepinephrinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Norepinephrinehsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Norepinephrinehsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Norepinephrinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Norepinephrinehsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Norepinephrinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Norepinephrinehsa04210Apoptosis2.16E-021P04049RAF1More
Norepinephrinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Norepinephrinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Norepinephrinehsa04218Cellular senescence2.49E-021P04049RAF1More
Norepinephrinehsa04261Adrenergic signaling in cardiomyocytes1.73E-049P07550, P51828, P22694, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Norepinephrinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Norepinephrinehsa04360Axon guidance2.49E-021P04049RAF1More
Norepinephrinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Norepinephrinehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Norepinephrinehsa04510Focal adhesion3.48E-021P04049RAF1More
Norepinephrinehsa04540Gap junction1.33E-021P04049RAF1More
Norepinephrinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Norepinephrinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Norepinephrinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Norepinephrinehsa04613Neutrophil extracellular trap formation4.48E-036P04049, P04908, Q93077, P68431, O43315, Q16539RAF1, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Norepinephrinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Norepinephrinehsa04630JAK-STAT signaling pathway9.31E-045P01106, Q09472, P48551, P16871, P04049MYC, EP300, IFNAR2, IL7R, RAF1More
Norepinephrinehsa04640Hematopoietic cell lineage1.67E-024P20023, P11836, P09693, P16871CR2, MS4A1, CD3G, IL7RMore
Norepinephrinehsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Norepinephrinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Norepinephrinehsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Norepinephrinehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Norepinephrinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Norepinephrinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Norepinephrinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Norepinephrinehsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Norepinephrinehsa04720Long-term potentiation1.66E-021P04049RAF1More
Norepinephrinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Norepinephrinehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Norepinephrinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Norepinephrinehsa04728Dopaminergic synapse3.20E-036Q99941, P18848, Q13557, Q13362, Q14738, P0DP23CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Norepinephrinehsa04730Long-term depression1.16E-021P04049RAF1More
Norepinephrinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Norepinephrinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Norepinephrinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Norepinephrinehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Norepinephrinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Norepinephrinehsa04912GnRH signaling pathway3.36E-034P51828, P18848, Q13557, P04049ADCY7, ATF4, CAMK2D, RAF1More
Norepinephrinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Norepinephrinehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Norepinephrinehsa04915Estrogen signaling pathway4.99E-046P04049, Q99941, P18848, P51828, P07900, P11142RAF1, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Norepinephrinehsa04916Melanogenesis1.33E-021P04049RAF1More
Norepinephrinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Norepinephrinehsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Norepinephrinehsa04919Thyroid hormone signaling pathway5.80E-034P04049, P60709, Q09472, P01106RAF1, ACTB, EP300, MYCMore
Norepinephrinehsa04921Oxytocin signaling pathway4.61E-034P0DP23, P04049, Q96RR4, Q13469CALM1, RAF1, CAMKK2, NFATC2More
Norepinephrinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Norepinephrinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Norepinephrinehsa04926Relaxin signaling pathway5.73E-047Q99941, P18848, P22694, P14780, P51828, P04049, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, RAF1, GNA15More
Norepinephrinehsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Norepinephrinehsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Norepinephrinehsa04929GnRH secretion4.98E-031P04049RAF1More
Norepinephrinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Norepinephrinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Norepinephrinehsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Norepinephrinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Norepinephrinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Norepinephrinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Norepinephrinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Norepinephrinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Norepinephrinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Norepinephrinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Norepinephrinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Norepinephrinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Norepinephrinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Norepinephrinehsa05034Alcoholism2.49E-021P04049RAF1More
Norepinephrinehsa05132Salmonella infection4.98E-021P04049RAF1More
Norepinephrinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Norepinephrinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Norepinephrinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Norepinephrinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Norepinephrinehsa05152Tuberculosis3.98E-021P04049RAF1More
Norepinephrinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Norepinephrinehsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Norepinephrinehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Norepinephrinehsa05164Influenza A3.28E-035Q09472, P48551, P29728, P04049, P60709EP300, IFNAR2, OAS2, RAF1, ACTBMore
Norepinephrinehsa05167Kaposi sarcoma-associated herpesvirus infection1.06E-024P23458, Q13469, P04049, P0DP23JAK1, NFATC2, RAF1, CALM1More
Norepinephrinehsa05169Epstein-Barr virus infection1.42E-025P20023, P01106, P48551, P29728, P09693CR2, MYC, IFNAR2, OAS2, CD3GMore
Norepinephrinehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Norepinephrinehsa05171Coronavirus disease - COVID-198.52E-0612P48551, P29728, P23396, P62753, P62249, P62906, P46777, P27635, Q07020, P46776, P61513, P50914IFNAR2, OAS2, RPS3, RPS6, RPS16, RPL10A, RPL5, RPL10, RPL18, RPL27A, RPL37A, RPL14More
Norepinephrinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Norepinephrinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Norepinephrinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Norepinephrinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Norepinephrinehsa05211Renal cell carcinoma2.76E-033Q09472, Q99814, P04049EP300, EPAS1, RAF1More
Norepinephrinehsa05212Pancreatic cancer4.13E-033P04049, Q15311, P23458RAF1, RALBP1, JAK1More
Norepinephrinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Norepinephrinehsa05214Glioma9.95E-031P04049RAF1More
Norepinephrinehsa05215Prostate cancer3.72E-033P18848, P14625, P04049ATF4, HSP90B1, RAF1More
Norepinephrinehsa05218Melanoma6.63E-031P04049RAF1More
Norepinephrinehsa05219Bladder cancer4.98E-031P04049RAF1More
Norepinephrinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Norepinephrinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Norepinephrinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Norepinephrinehsa05224Breast cancer1.49E-021P04049RAF1More
Norepinephrinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Norepinephrinehsa05226Gastric cancer8.29E-031P04049RAF1More
Norepinephrinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Norepinephrinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Norepinephrinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Norepinephrinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Norepinephrinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Norepinephrinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Norepinephrinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Norepinephrinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Epinephrine (SDC: 4.58)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P01375TNFTumor necrosis factorReported10.18650.55112.1953
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki3300
ADRB2P07550Ki96700
ADRB2P07550Kd3980
ADRB2P07550Kd3981
ADRB2P07550Ki360
ADRB2P07550Kd630
ADRB2P07550Kd631