PharmaCoNets of Epinastine (SPCN: 199.88 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Epinastinehsa00030Pentose phosphate pathway3.89E-083P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Epinastinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Epinastinehsa00190Oxidative phosphorylation4.38E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Epinastinehsa00220Arginine biosynthesis1.85E-032P05089, P49448ARG1, GLUD2More
Epinastinehsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Epinastinehsa00310Lysine degradation2.60E-033Q8NEZ4, Q13029, Q02809MLL3, PRDM2, PLOD1More
Epinastinehsa00500Starch and sucrose metabolism1.16E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Epinastinehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Epinastinehsa00520Amino sugar and nucleotide sugar metabolism1.57E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Epinastinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Epinastinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Epinastinehsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Epinastinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.02E-032P06865, O75752HEXA, B3GALNT1More
Epinastinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Epinastinehsa00670One carbon pool by folate3.73E-033O95954, P04818, Q99707FTCD, TYMS, MTRMore
Epinastinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Epinastinehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Epinastinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Epinastinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Epinastinehsa00860Porphyrin and chlorophyll metabolism3.73E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Epinastinehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Epinastinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Epinastinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Epinastinehsa00983Drug metabolism - other enzymes9.66E-044P04183, P20839, P32320, P05164TK1, IMPDH1, CDA, MPOMore
Epinastinehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Epinastinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Epinastinehsa01230Biosynthesis of amino acids1.47E-034P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Epinastinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Epinastinehsa01522Endocrine resistance1.49E-025P22694, Q02750, Q9UM47, P46527, P08069PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1RMore
Epinastinehsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Epinastinehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Epinastinehsa03013RNA transport4.61E-0718P62826, O14980, Q09161, O14893, P61326, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, Q14240, Q9BZI7, Q14232, Q06787, P51114RAN, XPO1, NCBP1, GEMIN2, MAGOH, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, EIF4A2, UPF3B, EIF2B1, FMR1, FXR1More
Epinastinehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Epinastinehsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Epinastinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Epinastinehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Epinastinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Epinastinehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Epinastinehsa04014Ras signaling pathway1.64E-027Q02750, Q15389, P08069, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, IGF1R, PRKCA, NF1, GNB2, PRKACBMore
Epinastinehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Epinastinehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Epinastinehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Epinastinehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Epinastinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Epinastinehsa04061Viral protein interaction with cytokine and cytokine receptor1.83E-049Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Epinastinehsa04062Chemokine signaling pathway4.01E-0413P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITKMore
Epinastinehsa04064NF-kappa B signaling pathway6.64E-1223P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Epinastinehsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Epinastinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Epinastinehsa04070Phosphatidylinositol signaling system1.00E-037P0DP23, Q14643, O14986, P23743, Q16760, P48426, P17252CALM1, ITPR1, PIP5K1B, DGKA, DGKD, PIP4K2A, PRKCAMore
Epinastinehsa04071Sphingolipid signaling pathway1.61E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Epinastinehsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Epinastinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Epinastinehsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Epinastinehsa04114Oocyte meiosis7.39E-0611Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Epinastinehsa04115p53 signaling pathway1.69E-022P31350, P06493RRM2, CDK1More
Epinastinehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Epinastinehsa04140Autophagy - animal7.25E-0411P08069, P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Epinastinehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Epinastinehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Epinastinehsa04145Phagosome3.12E-0411O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Epinastinehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Epinastinehsa04151PI3K-Akt signaling pathway7.38E-0311P25116, P49767, Q13362, P62873, P16144, P02452, P24821, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, COL1A1, TNC, TLR2, IFNA21, BCL2, PRKCAMore
Epinastinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Epinastinehsa04211Longevity regulating pathway5.00E-035P31751, P08069, Q08828, P51828, P18848AKT2, IGF1R, ADCY1, ADCY7, ATF4More
Epinastinehsa04213Longevity regulating pathway - multiple species1.22E-049P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Epinastinehsa04217Necroptosis1.24E-0412P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPIDMore
Epinastinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Epinastinehsa04261Adrenergic signaling in cardiomyocytes6.17E-0612P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2More
Epinastinehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Epinastinehsa04340Hedgehog signaling pathway3.93E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Epinastinehsa04370VEGF signaling pathway3.17E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Epinastinehsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Epinastinehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Epinastinehsa04390Hippo signaling pathway2.41E-022P04628, O43623WNT1, SNAI2More
Epinastinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Epinastinehsa04512ECM-receptor interaction7.53E-032P02452, P24821COL1A1, TNCMore
Epinastinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Epinastinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Epinastinehsa04540Gap junction8.27E-046P17252, P22694, Q13509, P68371, Q02750, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, ITPR1More
Epinastinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Epinastinehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Epinastinehsa04612Antigen processing and presentation1.45E-069P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Epinastinehsa04613Neutrophil extracellular trap formation3.41E-0414P17252, O60603, P08246, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Epinastinehsa04620Toll-like receptor signaling pathway1.84E-045Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Epinastinehsa04622RIG-I-like receptor signaling pathway6.07E-032P01568, Q13546IFNA21, RIPK1More
Epinastinehsa04623Cytosolic DNA-sensing pathway2.23E-085P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Epinastinehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Epinastinehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Epinastinehsa04640Hematopoietic cell lineage6.16E-0917P13612, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Epinastinehsa04650Natural killer cell mediated cytotoxicity8.21E-1316P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Epinastinehsa04657IL-17 signaling pathway8.98E-047O00463, Q16539, P49841, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNFMore
Epinastinehsa04658Th1 and Th2 cell differentiation3.70E-1714Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Epinastinehsa04659Th17 cell differentiation5.45E-1314Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Epinastinehsa04660T cell receptor signaling pathway1.99E-1217P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Epinastinehsa04662B cell receptor signaling pathway4.78E-021P13164IFITM1More
Epinastinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Epinastinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Epinastinehsa04672Intestinal immune network for IgA production3.36E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Epinastinehsa04713Circadian entrainment2.85E-036P0DP23, P17252, P62873, Q14643, Q08828, P51828CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Epinastinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Epinastinehsa04720Long-term potentiation8.82E-079P17252, P16298, P0DP23, P51812, P18848, P22694, Q08828, Q02750, Q14643PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, PRKACB, ADCY1, MAP2K1, ITPR1More
Epinastinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Epinastinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Epinastinehsa04725Cholinergic synapse5.34E-0511Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P18848, P31751, P10415, Q02750ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, ATF4, AKT2, BCL2, MAP2K1More
Epinastinehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Epinastinehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Epinastinehsa04728Dopaminergic synapse1.17E-0413Q14643, P17252, P62873, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23, P48058ITPR1, PRKCA, GNB1, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1, GRIA4More
Epinastinehsa04730Long-term depression1.16E-021P08069IGF1RMore
Epinastinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Epinastinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Epinastinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Epinastinehsa04750Inflammatory mediator regulation of TRP channels2.58E-059P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Epinastinehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Epinastinehsa04912GnRH signaling pathway1.52E-036P17252, Q08828, P51828, P18848, Q14643, P0DP23PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1More
Epinastinehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Epinastinehsa04914Progesterone-mediated oocyte maturation3.30E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Epinastinehsa04915Estrogen signaling pathway2.01E-037P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Epinastinehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Epinastinehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Epinastinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Epinastinehsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Epinastinehsa04924Renin secretion7.38E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Epinastinehsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Epinastinehsa04926Relaxin signaling pathway1.56E-037P31751, P18848, P22694, P14780, Q08828, P51828, P30679AKT2, ATF4, PRKACB, MMP9, ADCY1, ADCY7, GNA15More
Epinastinehsa04927Cortisol synthesis and secretion7.43E-044P18848, Q08828, P51828, P22694ATF4, ADCY1, ADCY7, PRKACBMore
Epinastinehsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Epinastinehsa04932Non-alcoholic fatty liver disease2.20E-0613P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Epinastinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Epinastinehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Epinastinehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Epinastinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Epinastinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Epinastinehsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Epinastinehsa04970Salivary secretion1.36E-057P07550, Q08828, P51828, P22694, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMPMore
Epinastinehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Epinastinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Epinastinehsa04974Protein digestion and absorption2.78E-021P02452COL1A1More
Epinastinehsa04976Bile secretion1.26E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Epinastinehsa05010Alzheimer disease7.57E-0415Q16718, O95298, O14521, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P31751, P05141, Q08752, P28070NDUFA5, NDUFC2, SDHD, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, AKT2, SLC25A5, PPID, PSMB4More
Epinastinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Epinastinehsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Epinastinehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Epinastinehsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Epinastinehsa05022Pathways of neurodegeneration - multiple diseases1.17E-0520Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Epinastinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Epinastinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Epinastinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.05E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Epinastinehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Epinastinehsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Epinastinehsa05133Pertussis3.51E-021P0C0L4C4AMore
Epinastinehsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Epinastinehsa05140Leishmaniasis3.51E-049P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, NCF4More
Epinastinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Epinastinehsa05144Malaria6.75E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Epinastinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Epinastinehsa05146Amoebiasis2.57E-1013P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Epinastinehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Epinastinehsa05152Tuberculosis1.23E-0410Q13488, Q15075, P0DP23, P42224, O60603, P10415, P13765, Q13651, P01568, Q9UDY8TCIRG1, EEA1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IL10RA, IFNA21, MALT1More
Epinastinehsa05160Hepatitis C1.19E-036Q13546, P01568, P60033, P49841, P01375, P48023RIPK1, IFNA21, CD81, GSK3B, TNF, FASLGMore
Epinastinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Epinastinehsa05163Human cytomegalovirus infection1.71E-0716P31751, P01375, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Epinastinehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Epinastinehsa05165Human papillomavirus infection1.76E-0517P46527, Q02750, P16144, P02452, P24821, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, P04628, Q13315CDKN1B, MAP2K1, ITGB4, COL1A1, TNC, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, WNT1, ATMMore
Epinastinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Epinastinehsa05167Kaposi sarcoma-associated herpesvirus infection3.04E-0310P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1More
Epinastinehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Epinastinehsa05169Epstein-Barr virus infection8.38E-0515P20023, P13765, P01106, Q13547, Q92769, O00463, P10415, P07948, Q13761, P24522, O60603, P29728, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, BCL2, LYN, RUNX3, GADD45A, TLR2, OAS2, CD3E, CD3G, CD247More
Epinastinehsa05170Human immunodeficiency virus 1 infection8.44E-0514Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Epinastinehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Epinastinehsa05202Transcriptional misregulation in cancer2.86E-0517Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Epinastinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Epinastinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Epinastinehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Epinastinehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Epinastinehsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Epinastinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Epinastinehsa05214Glioma9.95E-031P08069IGF1RMore
Epinastinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Epinastinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Epinastinehsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Epinastinehsa05218Melanoma6.63E-031P08069IGF1RMore
Epinastinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Epinastinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Epinastinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Epinastinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Epinastinehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Epinastinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.34E-0913P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Epinastinehsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Epinastinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Epinastinehsa05321Inflammatory bowel disease8.85E-097O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Epinastinehsa05322Systemic lupus erythematosus4.80E-0610P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Epinastinehsa05323Rheumatoid arthritis7.16E-045P13765, Q13488, P10747, P09341, O60603HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Epinastinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Epinastinehsa05332Graft-versus-host disease5.96E-096P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Epinastinehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Epinastinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Epinastinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Epinastinehsa05415Diabetic cardiomyopathy1.58E-037P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3BMore
Epinastinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Epinastinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Epinastine (SDC: 8.07)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)