Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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Epinastine | hsa00030 | Pentose phosphate pathway | 3.89E-08 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | Epinastine | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | Epinastine | hsa00190 | Oxidative phosphorylation | 4.38E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | Epinastine | hsa00220 | Arginine biosynthesis | 1.85E-03 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | Epinastine | hsa00240 | Pyrimidine metabolism | 3.59E-03 | 2 | P31350, P04818 | RRM2, TYMS | More | | Epinastine | hsa00310 | Lysine degradation | 2.60E-03 | 3 | Q8NEZ4, Q13029, Q02809 | MLL3, PRDM2, PLOD1 | More | | Epinastine | hsa00500 | Starch and sucrose metabolism | 1.16E-04 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | Epinastine | hsa00510 | N-Glycan biosynthesis | 3.15E-02 | 2 | P15907, Q9NR34 | ST6GAL1, MAN1C1 | More | | Epinastine | hsa00520 | Amino sugar and nucleotide sugar metabolism | 1.57E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | Epinastine | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | Epinastine | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | Epinastine | hsa00600 | Sphingolipid metabolism | 2.77E-02 | 3 | Q9BX95, Q8TCT0, P15289 | SGPP1, CERK, ARSA | More | | Epinastine | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 7.02E-03 | 2 | P06865, O75752 | HEXA, B3GALNT1 | More | | Epinastine | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | Epinastine | hsa00670 | One carbon pool by folate | 3.73E-03 | 3 | O95954, P04818, Q99707 | FTCD, TYMS, MTR | More | | Epinastine | hsa00730 | Thiamine metabolism | 2.27E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | Epinastine | hsa00740 | Riboflavin metabolism | 4.77E-02 | 1 | P30043 | BLVRB | More | | Epinastine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | Epinastine | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | Epinastine | hsa00860 | Porphyrin and chlorophyll metabolism | 3.73E-03 | 3 | P36551, P53004, P30043 | CPOX, BLVRA, BLVRB | More | | Epinastine | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | Epinastine | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Epinastine | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | Epinastine | hsa00983 | Drug metabolism - other enzymes | 9.66E-04 | 4 | P04183, P20839, P32320, P05164 | TK1, IMPDH1, CDA, MPO | More | | Epinastine | hsa01040 | Biosynthesis of unsaturated fatty acids | 2.92E-02 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | Epinastine | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | Epinastine | hsa01230 | Biosynthesis of amino acids | 1.47E-03 | 4 | P51854, P60891, P05089, P37837 | TKTL1, PRPS1, ARG1, TALDO1 | More | | Epinastine | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa01522 | Endocrine resistance | 1.49E-02 | 5 | P22694, Q02750, Q9UM47, P46527, P08069 | PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1R | More | | Epinastine | hsa01523 | Antifolate resistance | 1.43E-03 | 2 | Q92820, P04818 | GGH, TYMS | More | | Epinastine | hsa02010 | ABC transporters | 1.98E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | Epinastine | hsa03013 | RNA transport | 4.61E-07 | 18 | P62826, O14980, Q09161, O14893, P61326, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, Q14240, Q9BZI7, Q14232, Q06787, P51114 | RAN, XPO1, NCBP1, GEMIN2, MAGOH, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, EIF4A2, UPF3B, EIF2B1, FMR1, FXR1 | More | | Epinastine | hsa03015 | mRNA surveillance pathway | 4.81E-02 | 2 | Q9BZI7, O94913 | UPF3B, PCF11 | More | | Epinastine | hsa03020 | RNA polymerase | 6.63E-05 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | Epinastine | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | Epinastine | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | Epinastine | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | Epinastine | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04014 | Ras signaling pathway | 1.64E-02 | 7 | Q02750, Q15389, P08069, P17252, P21359, P62879, P22694 | MAP2K1, ANGPT1, IGF1R, PRKCA, NF1, GNB2, PRKACB | More | | Epinastine | hsa04015 | Rap1 signaling pathway | 2.99E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04020 | Calcium signaling pathway | 4.83E-02 | 4 | Q08828, P0DP23, P05141, P51828 | ADCY1, CALM1, SLC25A5, ADCY7 | More | | Epinastine | hsa04022 | cGMP-PKG signaling pathway | 4.38E-03 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | Epinastine | hsa04024 | cAMP signaling pathway | 3.94E-02 | 4 | Q08828, P51828, P31751, P0DP23 | ADCY1, ADCY7, AKT2, CALM1 | More | | Epinastine | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | Epinastine | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.83E-04 | 9 | Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784 | CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB | More | | Epinastine | hsa04062 | Chemokine signaling pathway | 4.01E-04 | 13 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK | More | | Epinastine | hsa04064 | NF-kappa B signaling pathway | 6.64E-12 | 23 | P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P42681 | TXK | Tyrosine-protein kinase TXK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.716 | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.744 | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | P42681 | TXK | Tyrosine-protein kinase TXK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.827 | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.945 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.735 | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | P17252 | PRKCA | Protein kinase C alpha type | P29965 | CD40LG | CD40 ligand | 0.788 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | P42681 | TXK | Tyrosine-protein kinase TXK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.742 | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | P17252 | PRKCA | Protein kinase C alpha type | Q8WV28 | BLNK | B-cell linker protein | 0.838 | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.758 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P42681 | TXK | Tyrosine-protein kinase TXK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.881 | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.802 | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P09341 | CXCL1 | Growth-regulated alpha protein | 0.78 | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| Epinastine | hsa04066 | HIF-1 signaling pathway | 1.49E-02 | 5 | P08069, P17252, Q15389, Q02750, P46527 | IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1B | More | | Epinastine | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04070 | Phosphatidylinositol signaling system | 1.00E-03 | 7 | P0DP23, Q14643, O14986, P23743, Q16760, P48426, P17252 | CALM1, ITPR1, PIP5K1B, DGKA, DGKD, PIP4K2A, PRKCA | More | | Epinastine | hsa04071 | Sphingolipid signaling pathway | 1.61E-03 | 7 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2 | More | | Epinastine | hsa04072 | Phospholipase D signaling pathway | 4.96E-04 | 11 | P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760 | AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | Epinastine | hsa04080 | Neuroactive ligand-receptor interaction | 1.97E-02 | 5 | P28472, P21453, Q9H228, P21730, P07550 | GABRB3, S1PR1, EDG8, C5AR1, ADRB2 | More | | Epinastine | hsa04110 | Cell cycle | 1.97E-05 | 7 | P06493, O60566, O75293, P30304, P33981, P42773, P01106 | CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | Epinastine | hsa04114 | Oocyte meiosis | 7.39E-06 | 11 | Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069 | MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R | More | | Epinastine | hsa04115 | p53 signaling pathway | 1.69E-02 | 2 | P31350, P06493 | RRM2, CDK1 | More | | Epinastine | hsa04120 | Ubiquitin mediated proteolysis | 1.08E-03 | 6 | Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669 | SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12 | More | | Epinastine | hsa04140 | Autophagy - animal | 7.25E-04 | 11 | P08069, P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9 | IGF1R, AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8 | More | | Epinastine | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | Epinastine | hsa04144 | Endocytosis | 1.67E-02 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | Epinastine | hsa04145 | Phagosome | 3.12E-04 | 11 | O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB | More | | Epinastine | hsa04150 | mTOR signaling pathway | 7.74E-03 | 4 | P08069, Q02750, Q9NQL2, P51812 | IGF1R, MAP2K1, RRAGD, RPS6KA3 | More | | Epinastine | hsa04151 | PI3K-Akt signaling pathway | 7.38E-03 | 11 | P25116, P49767, Q13362, P62873, P16144, P02452, P24821, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, COL1A1, TNC, TLR2, IFNA21, BCL2, PRKCA | More | | Epinastine | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04211 | Longevity regulating pathway | 5.00E-03 | 5 | P31751, P08069, Q08828, P51828, P18848 | AKT2, IGF1R, ADCY1, ADCY7, ATF4 | More | | Epinastine | hsa04213 | Longevity regulating pathway - multiple species | 1.22E-04 | 9 | P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | | Epinastine | hsa04217 | Necroptosis | 1.24E-04 | 12 | P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPID | More | | Epinastine | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | Epinastine | hsa04261 | Adrenergic signaling in cardiomyocytes | 6.17E-06 | 12 | P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415 | TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2 | More | | Epinastine | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | Epinastine | hsa04340 | Hedgehog signaling pathway | 3.93E-02 | 3 | P22694, Q13635, P10415 | PRKACB, PTCH1, BCL2 | More | | Epinastine | hsa04370 | VEGF signaling pathway | 3.17E-05 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | Epinastine | hsa04371 | Apelin signaling pathway | 3.94E-02 | 4 | P31751, Q08828, P51828, P0DP23 | AKT2, ADCY1, ADCY7, CALM1 | More | | Epinastine | hsa04380 | Osteoclast differentiation | 5.27E-04 | 10 | Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149 | CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2 | More | | Epinastine | hsa04390 | Hippo signaling pathway | 2.41E-02 | 2 | P04628, O43623 | WNT1, SNAI2 | More | | Epinastine | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04512 | ECM-receptor interaction | 7.53E-03 | 2 | P02452, P24821 | COL1A1, TNC | More | | Epinastine | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | Epinastine | hsa04540 | Gap junction | 8.27E-04 | 6 | P17252, P22694, Q13509, P68371, Q02750, Q14643 | PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, ITPR1 | More | | Epinastine | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04610 | Complement and coagulation cascades | 1.91E-03 | 1 | P0C0L4 | C4A | More | | Epinastine | hsa04612 | Antigen processing and presentation | 1.45E-06 | 9 | P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P48382 | RFX5 | DNA-binding protein RFX5 | 0.826 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | P07195 | LDHB | L-lactate dehydrogenase B chain | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.779 | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.943 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 | P07195 | LDHB | L-lactate dehydrogenase B chain | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.779 | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.943 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.806 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.852 | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | P07195 | LDHB | L-lactate dehydrogenase B chain | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.792 | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.812 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 |
| Epinastine | hsa04613 | Neutrophil extracellular trap formation | 3.41E-04 | 14 | P17252, O60603, P08246, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539 | PRKCA, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14 | More | | Epinastine | hsa04620 | Toll-like receptor signaling pathway | 1.84E-04 | 5 | Q13546, P01568, P01584, P31751, Q8NHW4 | RIPK1, IFNA21, IL1B, AKT2, CCL4L2 | More | | Epinastine | hsa04622 | RIG-I-like receptor signaling pathway | 6.07E-03 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | Epinastine | hsa04623 | Cytosolic DNA-sensing pathway | 2.23E-08 | 5 | P01584, P01568, Q13546, Q9Y535, Q8NHW4 | IL1B, IFNA21, RIPK1, POLR3H, CCL4L2 | More | | Epinastine | hsa04625 | C-type lectin receptor signaling pathway | 1.14E-03 | 8 | Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14 | More | | Epinastine | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | Epinastine | hsa04640 | Hematopoietic cell lineage | 6.16E-09 | 17 | P13612, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375 | ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07195 | LDHB | L-lactate dehydrogenase B chain | P13612 | ITGA4 | Integrin alpha-4 | 0.866 | P06239 | LCK | Tyrosine-protein kinase Lck | P13612 | ITGA4 | Integrin alpha-4 | 0.732 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13612 | ITGA4 | Integrin alpha-4 | 0.774 | P52732 | KIF11 | Kinesin-like protein KIF11 | P21926 | CD9 | CD9 antigen | -0.787 | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P15144 | ANPEP | Aminopeptidase N | -0.757 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20023 | CR2 | Complement receptor type 2 | 0.742 | P07195 | LDHB | L-lactate dehydrogenase B chain | P11836 | MS4A1 | B-lymphocyte antigen CD20 | 0.822 | P06239 | LCK | Tyrosine-protein kinase Lck | P25063 | CD24 | Signal transducer CD24 | -0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P25063 | CD24 | Signal transducer CD24 | -0.839 | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | P07195 | LDHB | L-lactate dehydrogenase B chain | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.792 | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | P06239 | LCK | Tyrosine-protein kinase Lck | P09564 | CD7 | T-cell antigen CD7 | 0.84 | P52732 | KIF11 | Kinesin-like protein KIF11 | P09564 | CD7 | T-cell antigen CD7 | -0.886 | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 |
| Epinastine | hsa04650 | Natural killer cell mediated cytotoxicity | 8.21E-13 | 16 | P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715 | PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | P11511 | CYP19A1 | Aromatase | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.701 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P42681 | TXK | Tyrosine-protein kinase TXK | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.881 | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.862 | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.727 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | P42681 | TXK | Tyrosine-protein kinase TXK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.888 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.806 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.852 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | P42681 | TXK | Tyrosine-protein kinase TXK | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.869 | P07195 | LDHB | L-lactate dehydrogenase B chain | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.816 | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.922 | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.701 | P07195 | LDHB | L-lactate dehydrogenase B chain | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.739 | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.778 | P42681 | TXK | Tyrosine-protein kinase TXK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.901 | P07195 | LDHB | L-lactate dehydrogenase B chain | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.779 | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.943 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | P42681 | TXK | Tyrosine-protein kinase TXK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.901 | P07195 | LDHB | L-lactate dehydrogenase B chain | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.779 | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.943 | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 |
| Epinastine | hsa04657 | IL-17 signaling pathway | 8.98E-04 | 7 | O00463, Q16539, P49841, P19875, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNF | More | | Epinastine | hsa04658 | Th1 and Th2 cell differentiation | 3.70E-17 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | P42681 | TXK | Tyrosine-protein kinase TXK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.771 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.904 | P42681 | TXK | Tyrosine-protein kinase TXK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.856 | P07195 | LDHB | L-lactate dehydrogenase B chain | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.778 | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | P42681 | TXK | Tyrosine-protein kinase TXK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.849 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.786 | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| Epinastine | hsa04659 | Th17 cell differentiation | 5.45E-13 | 14 | Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963 | PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.713 | P42681 | TXK | Tyrosine-protein kinase TXK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.849 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.786 | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | P42681 | TXK | Tyrosine-protein kinase TXK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.856 | P07195 | LDHB | L-lactate dehydrogenase B chain | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.778 | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 |
| Epinastine | hsa04660 | T cell receptor signaling pathway | 1.99E-12 | 17 | P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P42681 | TXK | Tyrosine-protein kinase TXK | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.776 | P42681 | TXK | Tyrosine-protein kinase TXK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.857 | P07195 | LDHB | L-lactate dehydrogenase B chain | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.925 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.925 | P42681 | TXK | Tyrosine-protein kinase TXK | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.847 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.817 | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 1 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | P42681 | TXK | Tyrosine-protein kinase TXK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.9 | P07195 | LDHB | L-lactate dehydrogenase B chain | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.792 | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | P42681 | TXK | Tyrosine-protein kinase TXK | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.716 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.761 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.811 | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.733 |
| Epinastine | hsa04662 | B cell receptor signaling pathway | 4.78E-02 | 1 | P13164 | IFITM1 | More | | Epinastine | hsa04664 | Fc epsilon RI signaling pathway | 3.98E-02 | 3 | P01375, Q16539, Q9UQC2 | TNF, MAPK14, GAB2 | More | | Epinastine | hsa04668 | TNF signaling pathway | 2.12E-03 | 7 | P01375, O00463, Q16539, P18848, P19875, P20749, P14780 | TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9 | More | | Epinastine | hsa04672 | Intestinal immune network for IgA production | 3.36E-04 | 4 | P29965, P10747, P13765, P13612 | CD40LG, CD28, HLA-DOB, ITGA4 | More | | Epinastine | hsa04713 | Circadian entrainment | 2.85E-03 | 6 | P0DP23, P17252, P62873, Q14643, Q08828, P51828 | CALM1, PRKCA, GNB1, ITPR1, ADCY1, ADCY7 | More | | Epinastine | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | Epinastine | hsa04720 | Long-term potentiation | 8.82E-07 | 9 | P17252, P16298, P0DP23, P51812, P18848, P22694, Q08828, Q02750, Q14643 | PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, PRKACB, ADCY1, MAP2K1, ITPR1 | More | | Epinastine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | Epinastine | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | Epinastine | hsa04725 | Cholinergic synapse | 5.34E-05 | 11 | Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P18848, P31751, P10415, Q02750 | ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, ATF4, AKT2, BCL2, MAP2K1 | More | | Epinastine | hsa04726 | Serotonergic synapse | 2.43E-02 | 4 | P22694, P17252, P62879, Q02750 | PRKACB, PRKCA, GNB2, MAP2K1 | More | | Epinastine | hsa04727 | GABAergic synapse | 2.03E-02 | 4 | P62879, P22694, O60296, P17252 | GNB2, PRKACB, TRAK2, PRKCA | More | | Epinastine | hsa04728 | Dopaminergic synapse | 1.17E-04 | 13 | Q14643, P17252, P62873, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23, P48058 | ITPR1, PRKCA, GNB1, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1, GRIA4 | More | | Epinastine | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | Epinastine | hsa04742 | Taste transduction | 1.01E-02 | 1 | P30939 | HTR1F | More | | Epinastine | hsa04744 | Phototransduction | 1.02E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | Epinastine | hsa04750 | Inflammatory mediator regulation of TRP channels | 2.58E-05 | 9 | P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | Epinastine | hsa04911 | Insulin secretion | 2.40E-02 | 3 | Q08828, P51828, P18848 | ADCY1, ADCY7, ATF4 | More | | Epinastine | hsa04912 | GnRH signaling pathway | 1.52E-03 | 6 | P17252, Q08828, P51828, P18848, Q14643, P0DP23 | PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1 | More | | Epinastine | hsa04913 | Ovarian steroidogenesis | 7.72E-03 | 3 | P42330, P22694, P08069 | AKR1C3, PRKACB, IGF1R | More | | Epinastine | hsa04914 | Progesterone-mediated oocyte maturation | 3.30E-04 | 5 | P08069, Q17RY0, Q9Y6D9, P51812, Q02750 | IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1 | More | | Epinastine | hsa04915 | Estrogen signaling pathway | 2.01E-03 | 7 | P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788 | ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1 | More | | Epinastine | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | Epinastine | hsa04919 | Thyroid hormone signaling pathway | 2.22E-02 | 5 | P17252, Q02750, P22694, Q12778, Q9UM47 | PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3 | More | | Epinastine | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | Epinastine | hsa04923 | Regulation of lipolysis in adipocytes | 2.89E-04 | 6 | Q08828, P51828, P07550, P42338, Q9Y4H2, P31751 | ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2 | More | | Epinastine | hsa04924 | Renin secretion | 7.38E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | Epinastine | hsa04925 | Aldosterone synthesis and secretion | 9.86E-03 | 4 | P18848, Q08828, P51828, P0DP23 | ATF4, ADCY1, ADCY7, CALM1 | More | | Epinastine | hsa04926 | Relaxin signaling pathway | 1.56E-03 | 7 | P31751, P18848, P22694, P14780, Q08828, P51828, P30679 | AKT2, ATF4, PRKACB, MMP9, ADCY1, ADCY7, GNA15 | More | | Epinastine | hsa04927 | Cortisol synthesis and secretion | 7.43E-04 | 4 | P18848, Q08828, P51828, P22694 | ATF4, ADCY1, ADCY7, PRKACB | More | | Epinastine | hsa04928 | Parathyroid hormone synthesis, secretion and action | 4.48E-02 | 4 | P22694, Q02750, P17252, Q9Y5Q3 | PRKACB, MAP2K1, PRKCA, MAFB | More | | Epinastine | hsa04932 | Non-alcoholic fatty liver disease | 2.20E-06 | 13 | P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521 | AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD | More | | Epinastine | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | Epinastine | hsa04934 | Cushing syndrome | 4.54E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | Epinastine | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | Epinastine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | Epinastine | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | Epinastine | hsa04966 | Collecting duct acid secretion | 1.95E-03 | 3 | Q13488, P00918, Q9Y666 | TCIRG1, CA2, SLC12A7 | More | | Epinastine | hsa04970 | Salivary secretion | 1.36E-05 | 7 | P07550, Q08828, P51828, P22694, P17252, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMP | More | | Epinastine | hsa04971 | Gastric acid secretion | 2.54E-03 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | Epinastine | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | Epinastine | hsa04974 | Protein digestion and absorption | 2.78E-02 | 1 | P02452 | COL1A1 | More | | Epinastine | hsa04976 | Bile secretion | 1.26E-04 | 5 | O43315, Q08828, P51828, P08183, Q14032 | AQP9, ADCY1, ADCY7, ABCB1, BAAT | More | | Epinastine | hsa05010 | Alzheimer disease | 7.57E-04 | 15 | Q16718, O95298, O14521, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P31751, P05141, Q08752, P28070 | NDUFA5, NDUFC2, SDHD, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, AKT2, SLC25A5, PPID, PSMB4 | More | | Epinastine | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | Epinastine | hsa05016 | Huntington disease | 1.76E-03 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | | Epinastine | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | Epinastine | hsa05020 | Prion disease | 1.31E-03 | 9 | Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14 | More | | Epinastine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.17E-05 | 20 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4 | More | | Epinastine | hsa05031 | Amphetamine addiction | 4.32E-02 | 3 | P22694, P18848, Q13547 | PRKACB, ATF4, HDAC1 | More | | Epinastine | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | Epinastine | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.05E-04 | 6 | Q16539, P09341, P19875, P19174, P25024, P25025 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | Epinastine | hsa05131 | Shigellosis | 2.27E-02 | 8 | P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | Epinastine | hsa05132 | Salmonella infection | 1.11E-02 | 8 | Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371 | LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | Epinastine | hsa05133 | Pertussis | 3.51E-02 | 1 | P0C0L4 | C4A | More | | Epinastine | hsa05134 | Legionellosis | 8.80E-04 | 7 | P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | Epinastine | hsa05140 | Leishmaniasis | 3.51E-04 | 9 | P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, NCF4 | More | | Epinastine | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | Epinastine | hsa05144 | Malaria | 6.75E-04 | 5 | P60033, O60603, P01375, P35443, P26718 | CD81, TLR2, TNF, THBS4, KLRK1 | More | | Epinastine | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | Epinastine | hsa05146 | Amoebiasis | 2.57E-10 | 13 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG | More | | Epinastine | hsa05150 | Staphylococcus aureus infection | 1.16E-03 | 6 | P0C0L4, P13646, Q14532, P59665, P59666, P49913 | C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMP | More | | Epinastine | hsa05152 | Tuberculosis | 1.23E-04 | 10 | Q13488, Q15075, P0DP23, P42224, O60603, P10415, P13765, Q13651, P01568, Q9UDY8 | TCIRG1, EEA1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IL10RA, IFNA21, MALT1 | More | | Epinastine | hsa05160 | Hepatitis C | 1.19E-03 | 6 | Q13546, P01568, P60033, P49841, P01375, P48023 | RIPK1, IFNA21, CD81, GSK3B, TNF, FASLG | More | | Epinastine | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | Epinastine | hsa05163 | Human cytomegalovirus infection | 1.71E-07 | 16 | P31751, P01375, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463 | AKT2, TNF, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.766 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.733 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | -0.797 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.774 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.735 |
| Epinastine | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | Epinastine | hsa05165 | Human papillomavirus infection | 1.76E-05 | 17 | P46527, Q02750, P16144, P02452, P24821, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, P04628, Q13315 | CDKN1B, MAP2K1, ITGB4, COL1A1, TNC, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, WNT1, ATM | More | | Epinastine | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | Epinastine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 3.04E-03 | 10 | P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2 | IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1 | More | | Epinastine | hsa05168 | Herpes simplex virus 1 infection | 4.79E-02 | 8 | P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820 | NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189 | More | | Epinastine | hsa05169 | Epstein-Barr virus infection | 8.38E-05 | 15 | P20023, P13765, P01106, Q13547, Q92769, O00463, P10415, P07948, Q13761, P24522, O60603, P29728, P07766, P09693, P20963 | CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, BCL2, LYN, RUNX3, GADD45A, TLR2, OAS2, CD3E, CD3G, CD247 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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P07195 | LDHB | L-lactate dehydrogenase B chain | P20023 | CR2 | Complement receptor type 2 | 0.742 | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | P06239 | LCK | Tyrosine-protein kinase Lck | P01106 | MYC | Myc proto-oncogene protein | 0.719 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13547 | HDAC1 | Histone deacetylase 1 | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | Q92769 | HDAC2 | Histone deacetylase 2 | 0.759 | P42681 | TXK | Tyrosine-protein kinase TXK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.827 | P07195 | LDHB | L-lactate dehydrogenase B chain | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | P42681 | TXK | Tyrosine-protein kinase TXK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.716 | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | P07195 | LDHB | L-lactate dehydrogenase B chain | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.758 | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | P42681 | TXK | Tyrosine-protein kinase TXK | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | 0.831 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 |
| Epinastine | hsa05170 | Human immunodeficiency virus 1 infection | 8.44E-05 | 14 | Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333 | MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B | More | | Epinastine | hsa05200 | Pathways in cancer | 4.99E-02 | 12 | P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568 | STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21 | More | | Epinastine | hsa05202 | Transcriptional misregulation in cancer | 2.86E-05 | 17 | Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522 | FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13315 | ATM | Serine-protein kinase ATM | Q12778 | FOXO1 | Forkhead box protein O1 | 0.821 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | Q13315 | ATM | Serine-protein kinase ATM | Q13315 | ATM | Serine-protein kinase ATM | 1 | P42681 | TXK | Tyrosine-protein kinase TXK | P41732 | TSPAN7 | Tetraspanin-7 | -0.719 | P42681 | TXK | Tyrosine-protein kinase TXK | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.762 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.855 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.833 | Q13315 | ATM | Serine-protein kinase ATM | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.709 | P42681 | TXK | Tyrosine-protein kinase TXK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | P42681 | TXK | Tyrosine-protein kinase TXK | O15550 | UTX | Lysine-specific demethylase 6A | -0.731 | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | Q13315 | ATM | Serine-protein kinase ATM | P46527 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | 0.708 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | P42681 | TXK | Tyrosine-protein kinase TXK | P05164 | MPO | Myeloperoxidase | -0.829 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P05164 | MPO | Myeloperoxidase | -0.811 | Q13315 | ATM | Serine-protein kinase ATM | P05164 | MPO | Myeloperoxidase | -0.725 | P42681 | TXK | Tyrosine-protein kinase TXK | P12838 | DEFA4 | Neutrophil defensin 4 | -0.707 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P12838 | DEFA4 | Neutrophil defensin 4 | -0.86 | P42681 | TXK | Tyrosine-protein kinase TXK | P08246 | ELA2 | Neutrophil elastase | -0.756 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P08246 | ELA2 | Neutrophil elastase | -0.782 | Q13315 | ATM | Serine-protein kinase ATM | P08246 | ELA2 | Neutrophil elastase | -0.742 | P42681 | TXK | Tyrosine-protein kinase TXK | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.874 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.9 | Q13315 | ATM | Serine-protein kinase ATM | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.741 | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 |
| Epinastine | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | Epinastine | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | Epinastine | hsa05205 | Proteoglycans in cancer | 1.09E-02 | 6 | P14780, P01375, P08069, P23588, Q13635, P22694 | MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB | More | | Epinastine | hsa05206 | MicroRNAs in cancer | 3.66E-02 | 6 | P46527, Q9UM47, P16070, Q13315, P17252, Q02750 | CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1 | More | | Epinastine | hsa05212 | Pancreatic cancer | 2.40E-02 | 3 | P31751, Q15311, P23458 | AKT2, RALBP1, JAK1 | More | | Epinastine | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | Epinastine | hsa05214 | Glioma | 9.95E-03 | 1 | P08069 | IGF1R | More | | Epinastine | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa05216 | Thyroid cancer | 3.80E-02 | 2 | P01106, O75293 | MYC, GADD45B | More | | Epinastine | hsa05217 | Basal cell carcinoma | 2.83E-02 | 3 | Q13635, Q9UJU2, P24522 | PTCH1, LEF1, GADD45A | More | | Epinastine | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | Epinastine | hsa05223 | Non-small cell lung cancer | 1.39E-02 | 3 | P10826, Q9HC35, O75293 | RARB, EML4, GADD45B | More | | Epinastine | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | Epinastine | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | Epinastine | hsa05231 | Choline metabolism in cancer | 3.38E-02 | 3 | P31751, Q16760, O14986 | AKT2, DGKD, PIP5K1B | More | | Epinastine | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.34E-09 | 13 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4 | More | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | P42681 | TXK | Tyrosine-protein kinase TXK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.857 | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | P52732 | KIF11 | Kinesin-like protein KIF11 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.721 | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | P42681 | TXK | Tyrosine-protein kinase TXK | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.776 | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | P52732 | KIF11 | Kinesin-like protein KIF11 | Q9HC35 | EML4 | Echinoderm microtubule-associated protein-like 4 | 0.794 | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 |
| Epinastine | hsa05310 | Asthma | 1.92E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | Epinastine | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | Epinastine | hsa05321 | Inflammatory bowel disease | 8.85E-09 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | Epinastine | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 10 | P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431 | ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | Epinastine | hsa05323 | Rheumatoid arthritis | 7.16E-04 | 5 | P13765, Q13488, P10747, P09341, O60603 | HLA-DOB, TCIRG1, CD28, CXCL1, TLR2 | More | | Epinastine | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | Epinastine | hsa05332 | Graft-versus-host disease | 5.96E-09 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | Epinastine | hsa05340 | Primary immunodeficiency | 1.31E-04 | 5 | P01730, P01732, P11912, P07766, P06239 | CD4, CD8A, CD79A, CD3E, LCK | More | | Epinastine | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | Epinastine | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | Epinastine | hsa05415 | Diabetic cardiomyopathy | 1.58E-03 | 7 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B | More | | Epinastine | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | Epinastine | hsa05418 | Fluid shear stress and atherosclerosis | 1.08E-03 | 7 | Q16539, Q14145, P10599, P14780, P01375, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2 | More | | |