PharmaCoNets

PharmaCoNets of Ephedrine (S_PCN: 42.84 )

Ephedrine regulated-network (S_DN: 11.74)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

DL-Methylephedrine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

DL-Methylephedrine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

DL-Methylephedrine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

DL-Methylephedrine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

DL-Methylephedrine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

DL-Methylephedrine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

DL-Methylephedrine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

DL-Methylephedrine

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

DL-Methylephedrine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

DL-Methylephedrine

hsa03030

DNA replication

5.00E-02

P27694

RPA1

DL-Methylephedrine

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

DL-Methylephedrine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

DL-Methylephedrine

hsa04120

Ubiquitin mediated proteolysis

4.81E-03

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

DL-Methylephedrine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

DL-Methylephedrine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

DL-Methylephedrine

hsa04514

Cell adhesion molecules

1.22E-02

P23229, P30511

ITGA6, HLA-F

DL-Methylephedrine

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

DL-Methylephedrine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

DL-Methylephedrine

hsa04613

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

DL-Methylephedrine

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	1
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814

DL-Methylephedrine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

DL-Methylephedrine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

DL-Methylephedrine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q92618	ZNF516	Zinc finger protein 516	0.765
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	0.722
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P62753	RPS6	40S ribosomal protein S6	0.803
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.804
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712

DL-Methylephedrine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

DL-Methylephedrine

hsa04730

Long-term depression

5.00E-02

Q14344

GNA13

DL-Methylephedrine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

DL-Methylephedrine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

DL-Methylephedrine

hsa04810

Regulation of actin cytoskeleton

2.68E-02

P23229, Q14344

ITGA6, GNA13

DL-Methylephedrine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

DL-Methylephedrine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

DL-Methylephedrine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

DL-Methylephedrine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

DL-Methylephedrine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

DL-Methylephedrine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

DL-Methylephedrine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

DL-Methylephedrine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

DL-Methylephedrine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

DL-Methylephedrine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

DL-Methylephedrine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.776
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.83
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

DL-Methylephedrine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q96CV9	OPTN	Optineurin	-0.713
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.748
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P0DP24	CALM2	Calmodulin-2	0.708
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.844
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734

DL-Methylephedrine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

DL-Methylephedrine

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

DL-Methylephedrine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

DL-Methylephedrine

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

DL-Methylephedrine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

DL-Methylephedrine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

DL-Methylephedrine

hsa05163

Human cytomegalovirus infection

4.31E-02

P30511, Q14344

HLA-F, GNA13

DL-Methylephedrine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

DL-Methylephedrine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

DL-Methylephedrine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

DL-Methylephedrine

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

DL-Methylephedrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

DL-Methylephedrine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Ephedrine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Ephedrine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Ephedrine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Ephedrine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Ephedrine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Ephedrine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Ephedrine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Ephedrine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Ephedrine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Ephedrine

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Ephedrine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Ephedrine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Ephedrine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Ephedrine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Ephedrine

hsa04613

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Ephedrine

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	1
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814

Ephedrine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Ephedrine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Ephedrine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q92618	ZNF516	Zinc finger protein 516	0.765
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	0.722
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P62753	RPS6	40S ribosomal protein S6	0.803
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.804
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712

Ephedrine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Ephedrine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Ephedrine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Ephedrine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Ephedrine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Ephedrine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Ephedrine

hsa04932

Non-alcoholic fatty liver disease

3.62E-02

P49841, Q16718, O14521

GSK3B, NDUFA5, SDHD

Ephedrine

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Ephedrine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Ephedrine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Ephedrine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.776
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.83
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Ephedrine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q96CV9	OPTN	Optineurin	-0.713
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.748
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P0DP24	CALM2	Calmodulin-2	0.708
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.844
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734

Ephedrine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Ephedrine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Ephedrine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Ephedrine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Ephedrine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Ephedrine

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Ephedrine

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Ephedrine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Ephedrine

hsa05332

Graft-versus-host disease

8.79E-03

P01375, P26715, Q13241

TNF, KLRC1, KLRD1

Ephedrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Ephedrine

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Ephedrine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Pseudoephedrine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Pseudoephedrine

hsa00190

Oxidative phosphorylation

2.41E-03

P13073, Q16718, O15239, Q7KZN9, P05496, O14521

COX4I1, NDUFA5, NDUFA1, COX15, ATP5G1, SDHD

Pseudoephedrine

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

4.21E-02

O75752

B3GALNT1

Pseudoephedrine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.21E-02

O75752

B3GALNT1

Pseudoephedrine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Pseudoephedrine

hsa00750

Vitamin B6 metabolism

2.80E-02

O00764

PDXK

Pseudoephedrine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Pseudoephedrine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Pseudoephedrine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Pseudoephedrine

hsa01240

Biosynthesis of cofactors

3.54E-03

P48506, Q9BQB6, P14550, O00764

GCLC, VKORC1, AKR1A1, PDXK

Pseudoephedrine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Pseudoephedrine

hsa03010

Ribosome

1.14E-02

P62753, P32969, P62829, P46776, P61927, P61513, P36578, P23396

RPS6, RPL9, RPL23, RPL27A, RPL37, RPL37A, RPL4, RPS3

Pseudoephedrine

hsa03020

RNA polymerase

2.12E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Pseudoephedrine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Pseudoephedrine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Pseudoephedrine

hsa04022

cGMP-PKG signaling pathway

3.36E-02

Q13469

NFATC2

Pseudoephedrine

hsa04024

cAMP signaling pathway

4.24E-02

Q02930, P15498

CREB5, VAV1

Pseudoephedrine

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Pseudoephedrine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Pseudoephedrine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Pseudoephedrine

hsa04141

Protein processing in endoplasmic reticulum

6.42E-03

P18848, Q15437, Q15436, P11142, Q9NXW2, Q9H3Z4, P07900, P14625

ATF4, SEC23B, SEC23A, HSPA8, DNAJB12, DNAJC5, HSP90AA1, HSP90B1

Pseudoephedrine

hsa04151

PI3K-Akt signaling pathway

8.21E-03

Q5T1C6, P62879, Q16787, Q02930

THEM4, GNB2, LAMA3, CREB5

Pseudoephedrine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Pseudoephedrine

hsa04218

Cellular senescence

2.91E-02

Q13469

NFATC2

Pseudoephedrine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Pseudoephedrine

hsa04310

Wnt signaling pathway

1.57E-02

Q13469

NFATC2

Pseudoephedrine

hsa04360

Axon guidance

3.36E-02

Q13469

NFATC2

Pseudoephedrine

hsa04370

VEGF signaling pathway

6.73E-03

Q13469

NFATC2

Pseudoephedrine

hsa04380

Osteoclast differentiation

2.24E-02

Q13469

NFATC2

Pseudoephedrine

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Pseudoephedrine

hsa04612

Antigen processing and presentation

3.75E-04

P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Pseudoephedrine

hsa04613

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Pseudoephedrine

hsa04621

NOD-like receptor signaling pathway

2.27E-02

Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838

ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Pseudoephedrine

hsa04625

C-type lectin receptor signaling pathway

2.02E-02

Q13469

NFATC2

Pseudoephedrine

hsa04650

Natural killer cell mediated cytotoxicity

5.53E-06

Q13469, P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715

NFATC2, TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	Q13469	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2	1
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814

Pseudoephedrine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Pseudoephedrine

hsa04658

Th1 and Th2 cell differentiation

3.36E-02

Q13469

NFATC2

Pseudoephedrine

hsa04659

Th17 cell differentiation

3.14E-02

Q13469

NFATC2

Pseudoephedrine

hsa04660

T cell receptor signaling pathway

2.24E-02

Q13469

NFATC2

Pseudoephedrine

hsa04662

B cell receptor signaling pathway

1.35E-02

Q13469

NFATC2

Pseudoephedrine

hsa04666

Fc gamma R-mediated phagocytosis

4.75E-02

P15498, P29966

VAV1, MARCKS

Pseudoephedrine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Pseudoephedrine

hsa04714

Thermogenesis

3.43E-04

Q16539, Q92618, Q15418, P62753, P33121, P13073, Q7KZN9, O15239, Q16718, O14521, P05496

MAPK14, ZNF516, RPS6KA1, RPS6, ACSL1, COX4I1, COX15, NDUFA1, NDUFA5, SDHD, ATP5G1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q92618	ZNF516	Zinc finger protein 516	0.765
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	0.722
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P62753	RPS6	40S ribosomal protein S6	0.803
P31645	SLC6A4	Sodium-dependent serotonin transporter	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.804
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712

Pseudoephedrine

hsa04720

Long-term potentiation

2.22E-02

Q13557, P0DP24, Q15418, P18848

CAMK2D, CALM2, RPS6KA1, ATF4

Pseudoephedrine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Pseudoephedrine

hsa04725

Cholinergic synapse

2.45E-02

P62879, Q02930

GNB2, CREB5

Pseudoephedrine

hsa04728

Dopaminergic synapse

4.24E-02

P62879, Q02930

GNB2, CREB5

Pseudoephedrine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Pseudoephedrine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Pseudoephedrine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Pseudoephedrine

hsa04921

Oxytocin signaling pathway

2.69E-02

Q13469

NFATC2

Pseudoephedrine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Pseudoephedrine

hsa04926

Relaxin signaling pathway

2.51E-03

P62879, P18848, Q02930, P22694, P14780, P30679

GNB2, ATF4, CREB5, PRKACB, MMP9, GNA15

Pseudoephedrine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Pseudoephedrine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Pseudoephedrine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Pseudoephedrine

hsa04966

Collecting duct acid secretion

1.68E-02

P02730, P00918

SLC4A1, CA2

Pseudoephedrine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Pseudoephedrine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Pseudoephedrine

hsa05010

Alzheimer disease

6.51E-03

O15239, P05496, P13073, Q00535, P0DP24, P01584, P18848, P67870, P05141, P28070, P43686

NDUFA1, ATP5G1, COX4I1, CDK5, CALM2, IL1B, ATF4, CSNK2B, SLC25A5, PSMB4, PSMC4

Pseudoephedrine

hsa05012

Parkinson disease

8.81E-03

O15239, P13073, P05496, P05141, P18848, P28070, P43686, P0DP24, Q13557

NDUFA1, COX4I1, ATP5G1, SLC25A5, ATF4, PSMB4, PSMC4, CALM2, CAMK2D

Pseudoephedrine

hsa05014

Amyotrophic lateral sclerosis

3.15E-02

P20333, O15239, P13073, P05496, P18848, P28070, P43686, Q96CV9, P51991, Q9UBU9

TNFRSF1B, NDUFA1, COX4I1, ATP5G1, ATF4, PSMB4, PSMC4, OPTN, HNRPA3, NXF1

Pseudoephedrine

hsa05016

Huntington disease

2.68E-02

O15239, P13073, P05496, P24928, P30876, P62487, P05141, P28070, P43686

NDUFA1, COX4I1, ATP5G1, POLR2A, POLR2B, POLR2G, SLC25A5, PSMB4, PSMC4

Pseudoephedrine

hsa05020

Prion disease

2.93E-04

P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P18848, P05141, P28070, P43686, P49841, P67870, Q16539

IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, ATF4, SLC25A5, PSMB4, PSMC4, GSK3B, CSNK2B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.776
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.83
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Pseudoephedrine

hsa05022

Pathways of neurodegeneration - multiple diseases

6.80E-05

P49841, P67870, O15239, Q16718, O14521, P13073, P05496, Q96CV9, P18848, Q13561, P05141, P20333, Q16539, Q00535, P01584, Q08752, P0DP24, Q13557, P28070, P43686

GSK3B, CSNK2B, NDUFA1, NDUFA5, SDHD, COX4I1, ATP5G1, OPTN, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM2, CAMK2D, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.831
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.797
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.712
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q96CV9	OPTN	Optineurin	-0.713
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P05141	SLC25A5	ADP/ATP translocase 2	0.955
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.748
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P01584	IL1B	Interleukin-1 beta	0.749
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P0DP24	CALM2	Calmodulin-2	0.708
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.844
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.734

Pseudoephedrine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Pseudoephedrine

hsa05034

Alcoholism

3.76E-02

Q02930, P62879

CREB5, GNB2

Pseudoephedrine

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Pseudoephedrine

hsa05135

Yersinia infection

3.36E-02

Q13469

NFATC2

Pseudoephedrine

hsa05143

African trypanosomiasis

6.60E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Pseudoephedrine

hsa05144

Malaria

1.66E-04

P60033, P69905, P68871, P01375, P35443, P26718

CD81, HBA2, HBB, TNF, THBS4, KLRK1

Pseudoephedrine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Pseudoephedrine

hsa05150

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Pseudoephedrine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Pseudoephedrine

hsa05161

Hepatitis B

2.69E-02

Q13469

NFATC2

Pseudoephedrine

hsa05163

Human cytomegalovirus infection

4.71E-02

Q13469

NFATC2

Pseudoephedrine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.14E-02

Q13469

NFATC2

Pseudoephedrine

hsa05170

Human immunodeficiency virus 1 infection

3.81E-02

Q13469

NFATC2

Pseudoephedrine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Pseudoephedrine

hsa05218

Melanoma

1.07E-02

P09619, Q9GZP0, Q02750

PDGFRB, PDGFD, MAP2K1

Pseudoephedrine

hsa05231

Choline metabolism in cancer

9.39E-03

Q02750, P09619, Q9GZP0, O15245

MAP2K1, PDGFRB, PDGFD, SLC22A1

Pseudoephedrine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.02E-02

Q13469

NFATC2

Pseudoephedrine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Pseudoephedrine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Pseudoephedrine

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Pseudoephedrine

hsa05410

Hypertrophic cardiomyopathy

4.83E-02

Q8WZ42, P63261

TTN, ACTG1

Pseudoephedrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.10E-02

Q8IZS8, P54284, P13612

CACNA2D3, CACNB3, ITGA4

Pseudoephedrine

hsa05414

Dilated cardiomyopathy

2.69E-03

Q8IZS8, P54284, P13612, Q8WZ42, P26678, P63261

CACNA2D3, CACNB3, ITGA4, TTN, PLN, ACTG1

Pseudoephedrine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Community members of Ephedrine (S_DC: 3.65)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ADRB2

BetaNone2 adrenergic receptor

Reported

0.0071

0.2205

2.224

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

PharmaCoNets of Ephedrine (SPCN: 42.84 )

Ephedrine regulated-network (SDN: 11.74)

Community members of Ephedrine (SDC: 3.65)

PharmaCoNets of Ephedrine (S_PCN: 42.84 )

Ephedrine regulated-network (S_DN: 11.74)

Community members of Ephedrine (S_DC: 3.65)