PharmaCoNets

PharmaCoNets of Entrectinib (S_PCN: 184.23 )

Entrectinib regulated-network (S_DN: 20.11)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Entrectinib

hsa00030

Pentose phosphate pathway

1.77E-04

P60891, P51854, P52209, P37837

PRPS1, TKTL1, PGD, TALDO1

Entrectinib

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Entrectinib

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Entrectinib

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Entrectinib

hsa00220

Arginine biosynthesis

3.58E-06

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Entrectinib

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Entrectinib

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Entrectinib

hsa00410

beta-Alanine metabolism

3.98E-02

Q6ZQY3

GADL1

Entrectinib

hsa00471

D-Glutamine and D-glutamate metabolism

3.98E-02

Q7Z3D6

C14orf159

Entrectinib

hsa00500

Starch and sucrose metabolism

6.81E-07

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Entrectinib

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Entrectinib

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Entrectinib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Entrectinib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Entrectinib

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Entrectinib

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Entrectinib

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Entrectinib

hsa00630

Glyoxylate and dicarboxylate metabolism

6.37E-05

P40925, P15104

MDH1, GLUL

Entrectinib

hsa00670

One carbon pool by folate

2.84E-05

O95954, P04818, Q99707

FTCD, TYMS, MTR

Entrectinib

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Entrectinib

hsa00750

Vitamin B6 metabolism

4.45E-02

O00764

PDXK

Entrectinib

hsa00770

Pantothenate and CoA biosynthesis

2.82E-05

O95498, Q6ZQY3, Q9NRN7

VNN2, GADL1, AASDHPPT

Entrectinib

hsa00830

Retinol metabolism

2.27E-03

P00325, P11766, P00352, Q9BPW9, O75911

ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3

Entrectinib

hsa00860

Porphyrin and chlorophyll metabolism

1.10E-03

P36551, P30043

CPOX, BLVRB

Entrectinib

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Entrectinib

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Entrectinib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Entrectinib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Entrectinib

hsa00983

Drug metabolism - other enzymes

2.45E-02

P20839, P32320, P05164

IMPDH1, CDA, MPO

Entrectinib

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Entrectinib

hsa01230

Biosynthesis of amino acids

1.74E-03

P51854, P60891, P05089, P15104, P37837

TKTL1, PRPS1, ARG1, GLUL, TALDO1

Entrectinib

hsa01240

Biosynthesis of cofactors

2.90E-03

P13716, P14618

ALAD, PKM2

Entrectinib

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Entrectinib

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Entrectinib

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Entrectinib

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Entrectinib

hsa03013

RNA transport

1.01E-07

O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, O14602, Q14152, O75822, P78345, Q14240, Q9BZI7, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF1AY, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9P289	STK26	Serine/threonine-protein kinase 26	O14980	XPO1	Exportin-1	0.781
Q9UBU7	DBF4	Protein DBF4 homolog A	O14980	XPO1	Exportin-1	0.943
Q07912	TNK2	Activated CDC42 kinase 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.701
Q9UBU7	DBF4	Protein DBF4 homolog A	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q07912	TNK2	Activated CDC42 kinase 1	O14893	GEMIN2	Gem-associated protein 2	-0.752
Q9P289	STK26	Serine/threonine-protein kinase 26	O14893	GEMIN2	Gem-associated protein 2	0.765
Q9UBU7	DBF4	Protein DBF4 homolog A	P61326	MAGOH	Protein mago nashi homolog	0.737
Q9P289	STK26	Serine/threonine-protein kinase 26	Q9H307	PNN	Pinin	0.716
Q9UBU7	DBF4	Protein DBF4 homolog A	Q9H307	PNN	Pinin	0.722
Q9UBU7	DBF4	Protein DBF4 homolog A	Q7Z3B4	NUP54	Nucleoporin p54	0.787
Q9P289	STK26	Serine/threonine-protein kinase 26	P35658	NUP214	Nuclear pore complex protein Nup214	-0.713
Q9UBU7	DBF4	Protein DBF4 homolog A	P35658	NUP214	Nuclear pore complex protein Nup214	-0.781
Q07912	TNK2	Activated CDC42 kinase 1	O14602	EIF1AY	Eukaryotic translation initiation factor 1A, Y-chromosomal	-0.826
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.902
Q9UBU7	DBF4	Protein DBF4 homolog A	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.83
Q07912	TNK2	Activated CDC42 kinase 1	P78345	RPP38	Ribonuclease P protein subunit p38	-0.717
Q9P289	STK26	Serine/threonine-protein kinase 26	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.703
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.867
Q9P289	STK26	Serine/threonine-protein kinase 26	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.732
Q9P289	STK26	Serine/threonine-protein kinase 26	Q06787	FMR1	Synaptic functional regulator FMR1	0.796
Q9UBU7	DBF4	Protein DBF4 homolog A	Q06787	FMR1	Synaptic functional regulator FMR1	0.772
Q9P289	STK26	Serine/threonine-protein kinase 26	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.803
Q9UBU7	DBF4	Protein DBF4 homolog A	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.854

Entrectinib

hsa03020

RNA polymerase

2.06E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Entrectinib

hsa03022

Basal transcription factors

2.68E-04

O00268, Q5H9L4, Q15544

TAF4, TAF7L, TAF11

Entrectinib

hsa03040

Spliceosome

4.08E-05

Q14562, O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Entrectinib

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Entrectinib

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Entrectinib

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Entrectinib

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Entrectinib

hsa03460

Fanconi anemia pathway

1.75E-02

P40692, O60673, Q9UNA4

MLH1, REV3L, POLI

Entrectinib

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Entrectinib

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Entrectinib

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Entrectinib

hsa04015

Rap1 signaling pathway

5.18E-04

P08069, P06213, O00522

IGF1R, INSR, KRIT1

Entrectinib

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Entrectinib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Entrectinib

hsa04062

Chemokine signaling pathway

4.01E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK

Entrectinib

hsa04064

NF-kappa B signaling pathway

2.30E-12

P10415, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q07912	TNK2	Activated CDC42 kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.7
P42681	TXK	Tyrosine-protein kinase TXK	P10415	BCL2	Apoptosis regulator Bcl-2	0.716
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P42681	TXK	Tyrosine-protein kinase TXK	O00463	TRAF5	TNF receptor-associated factor 5	0.827
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
Q07912	TNK2	Activated CDC42 kinase 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
Q07912	TNK2	Activated CDC42 kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.801
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16548	BCL2A1	Bcl-2-related protein A1	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q07912	TNK2	Activated CDC42 kinase 1	Q13315	ATM	Serine-protein kinase ATM	-0.755
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.758
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Entrectinib

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Entrectinib

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Entrectinib

hsa04070

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Entrectinib

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Entrectinib

hsa04110

Cell cycle

2.06E-02

Q9UBD5, P06493, Q14683, P30304, P33981, P01106

ORC3, CDK1, SMC1A, CDC25A, TTK, MYC

Entrectinib

hsa04114

Oocyte meiosis

1.45E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Entrectinib

hsa04115

p53 signaling pathway

2.54E-02

O15151, Q13315, P10415

MDM4, ATM, BCL2

Entrectinib

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Entrectinib

hsa04136

Autophagy - other

7.59E-03

O94817, Q9H1Y0

ATG12, ATG5

Entrectinib

hsa04140

Autophagy - animal

9.37E-03

P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759

IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Entrectinib

hsa04142

Lysosome

2.45E-03

Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Entrectinib

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Entrectinib

hsa04145

Phagosome

3.59E-03

O75015, Q15080, P14598, Q13509, P68371, Q99437, P05164, P78380, O60603, P35443, P13765, P25774

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS

Entrectinib

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Entrectinib

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Entrectinib

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Entrectinib

hsa04213

Longevity regulating pathway - multiple species

9.82E-04

P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Entrectinib

hsa04217

Necroptosis

1.26E-04

P01375, P48023, Q9NQC7, Q14765, P07900, P15104, P01584, Q99878, Q9H444

TNF, FASLG, CYLD, STAT4, HSP90AA1, GLUL, IL1B, H2AC14, CHMP4B

Entrectinib

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Entrectinib

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Entrectinib

hsa04340

Hedgehog signaling pathway

2.58E-03

P17612, P22694, Q13635, P10415

PRKACA, PRKACB, PTCH1, BCL2

Entrectinib

hsa04370

VEGF signaling pathway

9.46E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Entrectinib

hsa04380

Osteoclast differentiation

9.58E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Entrectinib

hsa04390

Hippo signaling pathway

3.73E-02

P35240, Q92796

NF2, DLG3

Entrectinib

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Entrectinib

hsa04510

Focal adhesion

9.45E-03

Q15942, P51636, P30281, P08069

ZYX, CAV2, CCND3, IGF1R

Entrectinib

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Entrectinib

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Entrectinib

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Entrectinib

hsa04540

Gap junction

7.81E-03

Q13509, P68371, Q9NRA1

TUBB3, TUBB2C, PDGFC

Entrectinib

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, Q02750, P08069, Q86SE9

BMPR2, MAP2K1, IGF1R, PCGF5

Entrectinib

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Entrectinib

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Entrectinib

hsa04612

Antigen processing and presentation

2.02E-03

P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF

Entrectinib

hsa04613

Neutrophil extracellular trap formation

8.84E-04

O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Entrectinib

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Entrectinib

hsa04621

NOD-like receptor signaling pathway

2.92E-02

P01584, P07900, P43490

IL1B, HSP90AA1, PBEF1

Entrectinib

hsa04623

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Entrectinib

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Entrectinib

hsa04640

Hematopoietic cell lineage

1.12E-06

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P15144	ANPEP	Aminopeptidase N	-0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P25063	CD24	Signal transducer CD24	-0.839
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Entrectinib

hsa04650

Natural killer cell mediated cytotoxicity

1.26E-09

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P42681	TXK	Tyrosine-protein kinase TXK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P42681	TXK	Tyrosine-protein kinase TXK	Q13241	KLRD1	Natural killer cells antigen CD94	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42681	TXK	Tyrosine-protein kinase TXK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.901
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P42681	TXK	Tyrosine-protein kinase TXK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.901
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943

Entrectinib

hsa04657

IL-17 signaling pathway

1.10E-05

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Entrectinib

hsa04658

Th1 and Th2 cell differentiation

2.79E-17

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P42681	TXK	Tyrosine-protein kinase TXK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Entrectinib

hsa04659

Th17 cell differentiation

1.13E-14

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Entrectinib

hsa04660

T cell receptor signaling pathway

3.27E-12

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42681	TXK	Tyrosine-protein kinase TXK	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.776
P42681	TXK	Tyrosine-protein kinase TXK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.857
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P42681	TXK	Tyrosine-protein kinase TXK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.847
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.9
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42681	TXK	Tyrosine-protein kinase TXK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733

Entrectinib

hsa04662

B cell receptor signaling pathway

2.54E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Entrectinib

hsa04664

Fc epsilon RI signaling pathway

2.20E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5

Entrectinib

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Entrectinib

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Entrectinib

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Entrectinib

hsa04720

Long-term potentiation

2.85E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Entrectinib

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Entrectinib

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Entrectinib

hsa04725

Cholinergic synapse

4.10E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Entrectinib

hsa04727

GABAergic synapse

1.82E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Entrectinib

hsa04728

Dopaminergic synapse

3.91E-02

P50151, P49841, Q16539, P49407, P48058

GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Entrectinib

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Entrectinib

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Entrectinib

hsa04750

Inflammatory mediator regulation of TRP channels

3.66E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Entrectinib

hsa04912

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Entrectinib

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Entrectinib

hsa04914

Progesterone-mediated oocyte maturation

2.23E-04

P08069, Q17RY0, Q9Y6D9, P51812, Q02750

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1

Entrectinib

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Entrectinib

hsa04922

Glucagon signaling pathway

4.18E-02

P14618, P06737

PKM2, PYGL

Entrectinib

hsa04923

Regulation of lipolysis in adipocytes

4.24E-03

P07550, P06213, P42338, Q9Y4H2

ADRB2, INSR, PIK3CB, IRS2

Entrectinib

hsa04926

Relaxin signaling pathway

5.70E-03

P42338, P63218, P50151, P49767, P49407

PIK3CB, GNG5, GNG10, VEGFC, ARRB1

Entrectinib

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Entrectinib

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Entrectinib

hsa04932

Non-alcoholic fatty liver disease

9.03E-06

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Entrectinib

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Entrectinib

hsa04960

Aldosterone-regulated sodium reabsorption

7.59E-03

O00141, P06213

SGK, INSR

Entrectinib

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Entrectinib

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Entrectinib

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Entrectinib

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Entrectinib

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Entrectinib

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Entrectinib

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Entrectinib

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Entrectinib

hsa05022

Pathways of neurodegeneration - multiple diseases

4.25E-03

P49841, Q16718, O14521, Q06055, Q13561, Q16539, Q08752, O15020

GSK3B, NDUFA5, SDHD, ATP5G2, DCTN2, MAPK14, PPID, SPTBN2

Entrectinib

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Entrectinib

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Entrectinib

hsa05110

Vibrio cholerae infection

1.86E-04

Q99437, P17612

ATP6V0B, PRKACA

Entrectinib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.40E-08

Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240

MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK

Entrectinib

hsa05131

Shigellosis

1.80E-02

Q13546, Q9UDY8, Q12778, Q13315, P10415

RIPK1, MALT1, FOXO1, ATM, BCL2

Entrectinib

hsa05132

Salmonella infection

4.85E-02

Q13546, P10415, Q13509, P68371

RIPK1, BCL2, TUBB3, TUBB2C

Entrectinib

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Entrectinib

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Entrectinib

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Entrectinib

hsa05140

Leishmaniasis

2.22E-04

P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74

Entrectinib

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Entrectinib

hsa05144

Malaria

8.73E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Entrectinib

hsa05146

Amoebiasis

1.89E-10

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P27930	IL1R2	Interleukin-1 receptor type 2	0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P42681	TXK	Tyrosine-protein kinase TXK	P05089	ARG1	Arginase-1	-0.739
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P05089	ARG1	Arginase-1	0.875
P42681	TXK	Tyrosine-protein kinase TXK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.878
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P12814	ACTN1	Alpha-actinin-1	0.794
P42681	TXK	Tyrosine-protein kinase TXK	P08311	CTSG	Cathepsin G	-0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P08311	CTSG	Cathepsin G	0.768

Entrectinib

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Entrectinib

hsa05152

Tuberculosis

4.16E-02

Q99437, P25774

ATP6V0B, CTSS

Entrectinib

hsa05160

Hepatitis C

1.16E-03

P52630, P60033, Q9NZJ5, P49841, P01375, P48023

STAT2, CD81, EIF2AK3, GSK3B, TNF, FASLG

Entrectinib

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Entrectinib

hsa05163

Human cytomegalovirus infection

1.66E-05

P01375, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

TNF, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P25025	CXCR2	C-X-C chemokine receptor type 2	0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735

Entrectinib

hsa05169

Epstein-Barr virus infection

1.01E-04

P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P42681	TXK	Tyrosine-protein kinase TXK	O00463	TRAF5	TNF receptor-associated factor 5	0.827
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42681	TXK	Tyrosine-protein kinase TXK	P10415	BCL2	Apoptosis regulator Bcl-2	0.716
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P42681	TXK	Tyrosine-protein kinase TXK	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.831
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Entrectinib

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Entrectinib

hsa05202

Transcriptional misregulation in cancer

9.99E-06

Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P41732	TSPAN7	Tetraspanin-7	-0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P42681	TXK	Tyrosine-protein kinase TXK	P14780	MMP9	Matrix metalloproteinase-9	-0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P42681	TXK	Tyrosine-protein kinase TXK	O15550	UTX	Lysine-specific demethylase 6A	-0.731
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P42681	TXK	Tyrosine-protein kinase TXK	P05164	MPO	Myeloperoxidase	-0.829
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P42681	TXK	Tyrosine-protein kinase TXK	P12838	DEFA4	Neutrophil defensin 4	-0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P42681	TXK	Tyrosine-protein kinase TXK	P08246	ELA2	Neutrophil elastase	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P42681	TXK	Tyrosine-protein kinase TXK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75

Entrectinib

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Entrectinib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Entrectinib

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Entrectinib

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Entrectinib

hsa05215

Prostate cancer

2.79E-03

P10415, Q12778, P08069, Q9NRA1

BCL2, FOXO1, IGF1R, PDGFC

Entrectinib

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Entrectinib

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Entrectinib

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Entrectinib

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Entrectinib

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Entrectinib

hsa05231

Choline metabolism in cancer

2.60E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Entrectinib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.20E-09

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42681	TXK	Tyrosine-protein kinase TXK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.857
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42681	TXK	Tyrosine-protein kinase TXK	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.776
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857

Entrectinib

hsa05310

Asthma

1.92E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Entrectinib

hsa05321

Inflammatory bowel disease

1.10E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Entrectinib

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Entrectinib

hsa05323

Rheumatoid arthritis

2.19E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Entrectinib

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Entrectinib

hsa05332

Graft-versus-host disease

3.71E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Entrectinib

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Entrectinib

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Entrectinib

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Entrectinib

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Entrectinib

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Entrectinib (S_DC: 9.16)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TNK2

Activated CDC42 kinase 1

Reported

0.009

0.3472

0.6988

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

Q9UBU7

DBF4

Protein DBF4 homolog A

Predicted

0.0075

0.1961

0.259

0.655

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

Q9P289

STK26

Serine/threonineNoneprotein kinase 26

Predicted

0.0285

0.2628

0.5399

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q9NZJ5

EIF2AK3

Eukaryotic translation initiation factor 2Nonealpha kinase 3

Predicted

0.0939

0.1574

0.6398

1.0015

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

P30530

AXL

TyrosineNoneprotein kinase receptor UFO

Predicted

0.3797

0.5365

0.1637

1.4264

P42226

STAT6

Signal transducer and activator of transcription 6

Predicted

0.3161

0.0353

0.509

0.7378

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P41240

CSK

TyrosineNoneprotein kinase CSK

Predicted

0.6986

0.3626

0.1023

1.1768

P09769

FGR

TyrosineNoneprotein kinase Fgr

Predicted

0.0622

0.3244

0.225

0.9049

P51813

BMX

Cytoplasmic tyrosineNoneprotein kinase BMX

Predicted

0.0597

0.3263

0.6825

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P42681

TXK

TyrosineNoneprotein kinase TXK

Predicted

0.2804

0.3026

0.1913

0.9367

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

PharmaCoNets of Entrectinib (SPCN: 184.23 )

Entrectinib regulated-network (SDN: 20.11)

Community members of Entrectinib (SDC: 9.16)

PharmaCoNets of Entrectinib (S_PCN: 184.23 )

Entrectinib regulated-network (S_DN: 20.11)

Community members of Entrectinib (S_DC: 9.16)