PharmaCoNets of Enprofylline (SPCN: 68.91 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Enprofyllinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Enprofyllinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Enprofyllinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Enprofyllinehsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Enprofyllinehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Enprofyllinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Enprofyllinehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Enprofyllinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Enprofyllinehsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Enprofyllinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Enprofyllinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Enprofyllinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Enprofyllinehsa00983Drug metabolism - other enzymes5.93E-053P04183, P32320, P05164TK1, CDA, MPOMore
Enprofyllinehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Enprofyllinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Enprofyllinehsa01230Biosynthesis of amino acids1.16E-034P51854, P60891, P15104, P37837TKTL1, PRPS1, GLUL, TALDO1More
Enprofyllinehsa01522Endocrine resistance5.79E-036P22694, Q02750, Q9UM47, P46527, P10415, Q13323PRKACB, MAP2K1, NOTCH3, CDKN1B, BCL2, BIKMore
Enprofyllinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Enprofyllinehsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Enprofyllinehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Enprofyllinehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Enprofyllinehsa03050Proteasome4.83E-021P55036PSMD4More
Enprofyllinehsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Enprofyllinehsa04014Ras signaling pathway4.04E-026Q02750, Q15389, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, PRKCA, NF1, GNB2, PRKACBMore
Enprofyllinehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Enprofyllinehsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Enprofyllinehsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Enprofyllinehsa04080Neuroactive ligand-receptor interaction4.68E-059P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Enprofyllinehsa04110Cell cycle1.35E-021P78527PRKDCMore
Enprofyllinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Enprofyllinehsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Enprofyllinehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Enprofyllinehsa04142Lysosome3.80E-034Q99437, P08311, P25774, Q9UPM8ATP6V0B, CTSG, CTSS, AP4E1More
Enprofyllinehsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Enprofyllinehsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Enprofyllinehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Enprofyllinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Enprofyllinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Enprofyllinehsa04261Adrenergic signaling in cardiomyocytes1.33E-037P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2DMore
Enprofyllinehsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Enprofyllinehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Enprofyllinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Enprofyllinehsa04540Gap junction1.57E-035P17252, P22694, P68371, Q02750, Q14643PRKCA, PRKACB, TUBB2C, MAP2K1, ITPR1More
Enprofyllinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Enprofyllinehsa04612Antigen processing and presentation4.24E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Enprofyllinehsa04613Neutrophil extracellular trap formation4.72E-023P05164, P20160, P08311MPO, AZU1, CTSGMore
Enprofyllinehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Enprofyllinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Enprofyllinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Enprofyllinehsa04650Natural killer cell mediated cytotoxicity4.40E-059P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Enprofyllinehsa04657IL-17 signaling pathway8.98E-047O00463, Q16539, P49841, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNFMore
Enprofyllinehsa04659Th17 cell differentiation8.77E-033Q04759, Q9HBE5, P84022PRKCQ, IL21R, SMAD3More
Enprofyllinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Enprofyllinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Enprofyllinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Enprofyllinehsa04720Long-term potentiation1.09E-024P17252, P51812, P22694, Q02750PRKCA, RPS6KA3, PRKACB, MAP2K1More
Enprofyllinehsa04725Cholinergic synapse3.43E-059P51828, P22694, Q14643, P17252, P62879, P18848, Q13557, P10415, Q02750ADCY7, PRKACB, ITPR1, PRKCA, GNB2, ATF4, CAMK2D, BCL2, MAP2K1More
Enprofyllinehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Enprofyllinehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Enprofyllinehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Enprofyllinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Enprofyllinehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Enprofyllinehsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Enprofyllinehsa04915Estrogen signaling pathway9.55E-049P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, P10415MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, BCL2More
Enprofyllinehsa04918Thyroid hormone synthesis6.10E-046P22694, P51828, Q99941, P18848, Q14643, P02768PRKACB, ADCY7, CREBL1, ATF4, ITPR1, ALBMore
Enprofyllinehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Enprofyllinehsa04924Renin secretion2.90E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Enprofyllinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Enprofyllinehsa04926Relaxin signaling pathway2.06E-036Q99941, P18848, P22694, P14780, P51828, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, GNA15More
Enprofyllinehsa04927Cortisol synthesis and secretion6.24E-075Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Enprofyllinehsa04928Parathyroid hormone synthesis, secretion and action9.97E-0610Q14643, P51828, P22694, P23771, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3ITPR1, ADCY7, PRKACB, GATA3, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFBMore
Enprofyllinehsa04934Cushing syndrome2.44E-047Q14643, Q99941, P18848, P51828, P22694, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY7, PRKACB, CAMK2D, WNT1More
Enprofyllinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Enprofyllinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Enprofyllinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Enprofyllinehsa04970Salivary secretion1.18E-045P07550, P22694, Q14643, P17252, P49913ADRB2, PRKACB, ITPR1, PRKCA, CAMPMore
Enprofyllinehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Enprofyllinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Enprofyllinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Enprofyllinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Enprofyllinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Enprofyllinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Enprofyllinehsa05144Malaria1.94E-046P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Enprofyllinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Enprofyllinehsa05150Staphylococcus aureus infection1.19E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Enprofyllinehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Enprofyllinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Enprofyllinehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Enprofyllinehsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Enprofyllinehsa05202Transcriptional misregulation in cancer1.24E-0313Q12778, Q15532, Q13315, P14780, Q15744, Q16548, O15550, P46527, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, CDKN1B, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Enprofyllinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Enprofyllinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Enprofyllinehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Enprofyllinehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Enprofyllinehsa05321Inflammatory bowel disease8.79E-057P01375, P13765, Q14765, Q9UL17, P23771, P84022, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, SMAD3, IL21RMore
Enprofyllinehsa05332Graft-versus-host disease1.83E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Enprofyllinehsa05340Primary immunodeficiency3.73E-022P11912, P16871CD79A, IL7RMore
Enprofyllinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Enprofyllinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Enprofylline (SDC: 5.20)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BReported00.02530.99460.222.2219
Q13231CHIT1ChitotriosidaseNone1Predicted00.03570.04290.19630.3
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q14790CASP8CaspaseNone8Predicted10.150.055811.1867
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PDE4BQ07343Ki43100