PharmaCoNets of Enoximone (SPCN: 77.91 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Enoximonehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Enoximonehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Enoximonehsa00190Oxidative phosphorylation1.85E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Enoximonehsa00500Starch and sucrose metabolism8.96E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Enoximonehsa00531Glycosaminoglycan degradation1.05E-032P15586, P34059GNS, GALNSMore
Enoximonehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.30E-021Q9Y2C2USTMore
Enoximonehsa00730Thiamine metabolism1.44E-032P05186, P24666ALPL, ACP1More
Enoximonehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Enoximonehsa00970Aminoacyl-tRNA biosynthesis9.57E-033O95363, P54136, P14868FARS2, RARS1, DARSMore
Enoximonehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Enoximonehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Enoximonehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Enoximonehsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Enoximonehsa03040Spliceosome2.09E-027Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5More
Enoximonehsa03050Proteasome1.53E-031P55036PSMD4More
Enoximonehsa04014Ras signaling pathway1.70E-027P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Enoximonehsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Enoximonehsa04020Calcium signaling pathway2.01E-026P17252, P19174, P0DP23, P20020, Q9NRA1, P49767PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Enoximonehsa04061Viral protein interaction with cytokine and cytokine receptor3.53E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, P14784, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL2RB, TNFMore
Enoximonehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Enoximonehsa04064NF-kappa B signaling pathway2.49E-0313P10415, Q13489, P14778, P29965, P19174, Q04759, Q9UDY8, P06239, Q8WV28, Q13315, P09341, P19875, Q06643BCL2, BIRC3, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, LCK, BLNK, ATM, CXCL1, CXCL2, LTBMore
Enoximonehsa04070Phosphatidylinositol signaling system3.82E-035P19174, P0DP23, Q14643, P23743, P17252PLCG1, CALM1, ITPR1, DGKA, PRKCAMore
Enoximonehsa04071Sphingolipid signaling pathway4.49E-024P17252, Q13362, Q9BX95, P10415PRKCA, PPP2R5C, SGPP1, BCL2More
Enoximonehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Enoximonehsa04080Neuroactive ligand-receptor interaction1.20E-028P08311, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318CTSG, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADMMore
Enoximonehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Enoximonehsa04142Lysosome1.67E-034P43234, P15586, P34059, P49281CTSO, GNS, GALNS, SLC11A2More
Enoximonehsa04145Phagosome2.99E-047Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Enoximonehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Enoximonehsa04210Apoptosis1.43E-024P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Enoximonehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Enoximonehsa04216Ferroptosis1.45E-022P04637, P49281TP53, SLC11A2More
Enoximonehsa04217Necroptosis3.83E-049P01568, Q13489, P42224, P08238, Q6FI13, Q93077, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Enoximonehsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Enoximonehsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Enoximonehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Enoximonehsa04540Gap junction5.38E-045P17252, Q13509, P68371, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, PDGFC, ITPR1More
Enoximonehsa04612Antigen processing and presentation1.03E-027P48382, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Enoximonehsa04613Neutrophil extracellular trap formation1.50E-0316P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Enoximonehsa04623Cytosolic DNA-sensing pathway3.29E-022P01568, P25963IFNA21, NFKBIAMore
Enoximonehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Enoximonehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Enoximonehsa04650Natural killer cell mediated cytotoxicity1.32E-0513P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Enoximonehsa04657IL-17 signaling pathway8.34E-0511P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, TNF, S100A9More
Enoximonehsa04658Th1 and Th2 cell differentiation8.66E-0611Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, TBX21, IL2RB, HLA-DOB, RUNX3More
Enoximonehsa04659Th17 cell differentiation3.15E-0511Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, CD3E, CD3G, CD247More
Enoximonehsa04660T cell receptor signaling pathway4.48E-0413P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6More
Enoximonehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Enoximonehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Enoximonehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Enoximonehsa04713Circadian entrainment2.17E-035P0DP23, P17252, P62873, Q14643, O15055CALM1, PRKCA, GNB1, ITPR1, PER2More
Enoximonehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Enoximonehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Enoximonehsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Enoximonehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Enoximonehsa04744Phototransduction1.20E-042P62873, P0DP23GNB1, CALM1More
Enoximonehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Enoximonehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Enoximonehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Enoximonehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Enoximonehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Enoximonehsa04933AGE-RAGE signaling pathway in diabetic complications6.00E-046P42224, P10415, Q12778, P49767, P17252, P19174STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1More
Enoximonehsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Enoximonehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Enoximonehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Enoximonehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Enoximonehsa05012Parkinson disease2.01E-037Q16718, O14521, Q14643, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, PLCG1, CALM1, TUBB3, TUBB2CMore
Enoximonehsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Enoximonehsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Enoximonehsa05022Pathways of neurodegeneration - multiple diseases3.71E-0411Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1More
Enoximonehsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Enoximonehsa05120Epithelial cell signaling in Helicobacter pylori infection3.46E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Enoximonehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Enoximonehsa05132Salmonella infection6.01E-0413P25963, P08238, Q9UJU2, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Enoximonehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Enoximonehsa05140Leishmaniasis2.18E-0510O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4More
Enoximonehsa05144Malaria9.23E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Enoximonehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Enoximonehsa05146Amoebiasis7.10E-0712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Enoximonehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Enoximonehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Enoximonehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Enoximonehsa05167Kaposi sarcoma-associated herpesvirus infection9.05E-0410P01568, P42224, P25963, P40189, P62873, P19174, Q14643, P04141, P0DP23, Q9UJU2IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, ITPR1, CSF2, CALM1, LEF1More
Enoximonehsa05168Herpes simplex virus 1 infection4.15E-0312P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212More
Enoximonehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Enoximonehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Enoximonehsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Enoximonehsa05200Pathways in cancer2.91E-0318P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Enoximonehsa05211Renal cell carcinoma9.88E-032Q06124, Q99814PTPN11, EPAS1More
Enoximonehsa05212Pancreatic cancer3.28E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05213Endometrial cancer3.28E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05214Glioma1.04E-036P0DP23, P17252, P04637, P19174, P24522, O75293CALM1, PRKCA, TP53, PLCG1, GADD45A, GADD45BMore
Enoximonehsa05216Thyroid cancer1.45E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05217Basal cell carcinoma2.60E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05218Melanoma1.45E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05220Chronic myeloid leukemia1.12E-023Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Enoximonehsa05223Non-small cell lung cancer4.01E-022P04637, P24522TP53, GADD45AMore
Enoximonehsa05225Hepatocellular carcinoma4.54E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Enoximonehsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Enoximonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.14E-0513P25963, P42338, P19174, P07766, P20963, P09693, P06239, P29350, P42224, O60603, P10747, Q04759, Q16539NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, STAT1, TLR2, CD28, PRKCQ, MAPK14More
Enoximonehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Enoximonehsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Enoximonehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Enoximonehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Enoximonehsa05415Diabetic cardiomyopathy1.23E-036P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Enoximonehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Enoximonehsa05418Fluid shear stress and atherosclerosis2.92E-047Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Enoximone (SDC: 4.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q99814EPAS1Endothelial PAS domainNonecontaining protein 1Predicted00.23220.0620.24910.4892
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)