PharmaCoNets

PharmaCoNets of Enoxacin (S_PCN: 233.33 )

Enoxacin regulated-network (S_DN: 26.88)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Enoxacin

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Enoxacin

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Enoxacin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Enoxacin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Enoxacin

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Enoxacin

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Enoxacin

hsa00983

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Enoxacin

hsa01100

Metabolic pathways

2.25E-02

Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573

CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.829
P19784	CSNK2A2	Casein kinase II subunit alpha'	P35790	CHKA	Choline kinase alpha	-0.778
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q16772	GSTA3	Glutathione S-transferase A3	-0.791
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P19784	CSNK2A2	Casein kinase II subunit alpha'	P30041	PRDX6	Peroxiredoxin-6	0.893
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P19784	CSNK2A2	Casein kinase II subunit alpha'	P19367	HK1	Hexokinase-1	0.777
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.745
P19784	CSNK2A2	Casein kinase II subunit alpha'	P22557	ALAS2	5-aminolevulinate synthase, erythroid-specific, mitochondrial	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P19784	CSNK2A2	Casein kinase II subunit alpha'	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.828
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P19784	CSNK2A2	Casein kinase II subunit alpha'	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P19784	CSNK2A2	Casein kinase II subunit alpha'	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.82
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
P19784	CSNK2A2	Casein kinase II subunit alpha'	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	-0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.795
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48651	PTDSS1	Phosphatidylserine synthase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q969G6	RFK	Riboflavin kinase	0.797
P19784	CSNK2A2	Casein kinase II subunit alpha'	P14927	UQCRB	Cytochrome b-c1 complex subunit 7	0.721
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731

Enoxacin

hsa03320

PPAR signaling pathway

1.62E-02

Q13133, Q02318

NR1H3, CYP27A1

Enoxacin

hsa04064

NF-kappa B signaling pathway

1.60E-02

P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Enoxacin

hsa04070

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Enoxacin

hsa04071

Sphingolipid signaling pathway

2.96E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Enoxacin

hsa04080

Neuroactive ligand-receptor interaction

3.22E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Enoxacin

hsa04110

Cell cycle

3.57E-02

Q9UBD5, P06493, P33981

ORC3, CDK1, TTK

Enoxacin

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Enoxacin

hsa04210

Apoptosis

3.77E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Enoxacin

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Enoxacin

hsa04612

Antigen processing and presentation

3.21E-02

P13765, P48382, P26715, P26717, Q13241, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Enoxacin

hsa04613

Neutrophil extracellular trap formation

1.73E-02

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Enoxacin

hsa04725

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Enoxacin

hsa04915

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Enoxacin

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Enoxacin

hsa04927

Cortisol synthesis and secretion

8.60E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Enoxacin

hsa04928

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Enoxacin

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Enoxacin

hsa05202

Transcriptional misregulation in cancer

1.77E-02

Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799

Enoxacin

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Enoxacin

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Enoxacin

hsa05231

Choline metabolism in cancer

2.00E-02

Q9Y259, P49619

CHKB, DGKG

Enoxacin

hsa05321

Inflammatory bowel disease

2.29E-02

P13765, Q14765, P23771, Q9HBE5

HLA-DOB, STAT4, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763

Enoxacin

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P08311	CTSG	Cathepsin G	Q16778	HIST2H2BE	Histone H2B type 2-E	0.786
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Enoxacin

hsa05332

Graft-versus-host disease

7.89E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812

Ozenoxacin

hsa00030

Pentose phosphate pathway

1.03E-03

P60891, P52209, P37837

PRPS1, PGD, TALDO1

Ozenoxacin

hsa00051

Fructose and mannose metabolism

3.92E-03

P15121, P19367, P08237

AKR1B1, HK1, PFKM

Ozenoxacin

hsa00052

Galactose metabolism

3.77E-04

P06280, P08237, O43451, P15121, P19367

GLA, PFKM, MGAM, AKR1B1, HK1

Ozenoxacin

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Ozenoxacin

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Ozenoxacin

hsa00310

Lysine degradation

1.85E-04

Q96KQ7, Q8NEZ4, Q13029, Q02809, P51648

EHMT2, MLL3, PRDM2, PLOD1, ALDH3A2

Ozenoxacin

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Ozenoxacin

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Ozenoxacin

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Ozenoxacin

hsa00520

Amino sugar and nucleotide sugar metabolism

7.84E-04

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Ozenoxacin

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Ozenoxacin

hsa00564

Glycerophospholipid metabolism

3.56E-02

P48651, Q9Y6K0, P35790

PTDSS1, CEPT1, CHKA

Ozenoxacin

hsa00565

Ether lipid metabolism

2.42E-02

Q8N661

TMEM86B

Ozenoxacin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Ozenoxacin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Ozenoxacin

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

7.02E-03

P06865, O75752

HEXA, B3GALNT1

Ozenoxacin

hsa00630

Glyoxylate and dicarboxylate metabolism

2.22E-07

P40925, P15104

MDH1, GLUL

Ozenoxacin

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Ozenoxacin

hsa00670

One carbon pool by folate

3.15E-02

O95954, Q99707

FTCD, MTR

Ozenoxacin

hsa00730

Thiamine metabolism

1.38E-05

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Ozenoxacin

hsa00740

Riboflavin metabolism

2.80E-03

P30043, P24666

BLVRB, ACP1

Ozenoxacin

hsa00790

Folate biosynthesis

1.04E-02

Q92820, P05186, P42330

GGH, ALPL, AKR1C3

Ozenoxacin

hsa00860

Porphyrin and chlorophyll metabolism

3.73E-03

P36551, P53004, P30043

CPOX, BLVRA, BLVRB

Ozenoxacin

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Ozenoxacin

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Ozenoxacin

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Ozenoxacin

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Ozenoxacin

hsa00983

Drug metabolism - other enzymes

2.09E-04

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Ozenoxacin

hsa01100

Metabolic pathways

3.86E-05

Q9NR34, Q9Y234, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6, Q969G6, P14927, Q9NVH6

MAN1C1, LIPT1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, MCCC2, ACSL1, AMACR, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1, RFK, UQCRB, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.829
P19784	CSNK2A2	Casein kinase II subunit alpha'	P35790	CHKA	Choline kinase alpha	-0.778
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q16772	GSTA3	Glutathione S-transferase A3	-0.791
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P19784	CSNK2A2	Casein kinase II subunit alpha'	P30041	PRDX6	Peroxiredoxin-6	0.893
O95931	CBX7	Chromobox protein homolog 7	P30041	PRDX6	Peroxiredoxin-6	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P19784	CSNK2A2	Casein kinase II subunit alpha'	P19367	HK1	Hexokinase-1	0.777
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.745
P19784	CSNK2A2	Casein kinase II subunit alpha'	P22557	ALAS2	5-aminolevulinate synthase, erythroid-specific, mitochondrial	0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P19784	CSNK2A2	Casein kinase II subunit alpha'	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.828
O95931	CBX7	Chromobox protein homolog 7	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P19784	CSNK2A2	Casein kinase II subunit alpha'	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	0.732
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P19784	CSNK2A2	Casein kinase II subunit alpha'	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.82
O95931	CBX7	Chromobox protein homolog 7	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.702
O95931	CBX7	Chromobox protein homolog 7	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.726
P19784	CSNK2A2	Casein kinase II subunit alpha'	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	-0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
O95931	CBX7	Chromobox protein homolog 7	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.798
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.795
O95931	CBX7	Chromobox protein homolog 7	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.762
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P19784	CSNK2A2	Casein kinase II subunit alpha'	P48651	PTDSS1	Phosphatidylserine synthase 1	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P19784	CSNK2A2	Casein kinase II subunit alpha'	Q969G6	RFK	Riboflavin kinase	0.797
P19784	CSNK2A2	Casein kinase II subunit alpha'	P14927	UQCRB	Cytochrome b-c1 complex subunit 7	0.721
O95931	CBX7	Chromobox protein homolog 7	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.731

Ozenoxacin

hsa01240

Biosynthesis of cofactors

4.63E-02

Q969G6, P22557, Q9Y234

RFK, ALAS2, LIPT1

Ozenoxacin

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Ozenoxacin

hsa01522

Endocrine resistance

6.02E-04

P17612, Q9UM47, P08069

PRKACA, NOTCH3, IGF1R

Ozenoxacin

hsa01523

Antifolate resistance

2.54E-03

P41440, Q92820, P04818, P01375

SLC19A1, GGH, TYMS, TNF

Ozenoxacin

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Ozenoxacin

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Ozenoxacin

hsa03013

RNA transport

2.90E-07

P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114

RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q9UBU7	DBF4	Protein DBF4 homolog A	O14980	XPO1	Exportin-1	0.943
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q9UBU7	DBF4	Protein DBF4 homolog A	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P49759	CLK1	Dual specificity protein kinase CLK1	O14893	GEMIN2	Gem-associated protein 2	0.76
Q9UBU7	DBF4	Protein DBF4 homolog A	P61326	MAGOH	Protein mago nashi homolog	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q9UBU7	DBF4	Protein DBF4 homolog A	Q9H307	PNN	Pinin	0.722
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q9UBU7	DBF4	Protein DBF4 homolog A	Q7Z3B4	NUP54	Nucleoporin p54	0.787
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q9UBU7	DBF4	Protein DBF4 homolog A	P35658	NUP214	Nuclear pore complex protein Nup214	-0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.902
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q9UBU7	DBF4	Protein DBF4 homolog A	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.83
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
Q9UBU7	DBF4	Protein DBF4 homolog A	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.867
P49759	CLK1	Dual specificity protein kinase CLK1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.704
P49759	CLK1	Dual specificity protein kinase CLK1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.758
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9UBU7	DBF4	Protein DBF4 homolog A	Q06787	FMR1	Synaptic functional regulator FMR1	0.772
P49759	CLK1	Dual specificity protein kinase CLK1	Q06787	FMR1	Synaptic functional regulator FMR1	0.793
Q9UBU7	DBF4	Protein DBF4 homolog A	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.854

Ozenoxacin

hsa03015

mRNA surveillance pathway

4.81E-02

Q9BZI7, O94913

UPF3B, PCF11

Ozenoxacin

hsa03020

RNA polymerase

6.63E-05

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Ozenoxacin

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Ozenoxacin

hsa03040

Spliceosome

3.31E-05

Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761

Ozenoxacin

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Ozenoxacin

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Ozenoxacin

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Ozenoxacin

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Ozenoxacin

hsa04014

Ras signaling pathway

3.82E-03

Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Ozenoxacin

hsa04015

Rap1 signaling pathway

3.24E-03

P08069, P25116, Q8TEU7, P08514

IGF1R, F2R, RAPGEF6, ITGA2B

Ozenoxacin

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Ozenoxacin

hsa04022

cGMP-PKG signaling pathway

1.12E-04

P24844, P18848, Q8WYR1, P31751, Q08828, P51828, P05141, Q15746, P0DP23

MYL9, ATF4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, MYLK, CALM1

Ozenoxacin

hsa04024

cAMP signaling pathway

3.22E-04

Q08828, P51828, P42338, P31751, P0DP23, Q13370, P48058, P25116, P24844, Q13009

ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIA4, F2R, MYL9, TIAM1

Ozenoxacin

hsa04060

Cytokine-cytokine receptor interaction

5.39E-03

P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038

IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25

Ozenoxacin

hsa04061

Viral protein interaction with cytokine and cytokine receptor

6.22E-05

Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Ozenoxacin

hsa04062

Chemokine signaling pathway

2.53E-05

P25024, P25025, P09341, P19875, Q99731, P07948, P42338, P19174, P62873, P63218, P50151, Q13009, P14598, P17612, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, CCL19, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, PRKACA, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q01433	AMPD2	AMP deaminase 2	Q99731	CCL19	C-C motif chemokine 19	0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
Q01433	AMPD2	AMP deaminase 2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Ozenoxacin

hsa04064

NF-kappa B signaling pathway

9.65E-11

P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Ozenoxacin

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Ozenoxacin

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Ozenoxacin

hsa04070

Phosphatidylinositol signaling system

1.00E-05

P19174, P0DP23, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7

PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC

Ozenoxacin

hsa04071

Sphingolipid signaling pathway

9.39E-03

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Ozenoxacin

hsa04072

Phospholipase D signaling pathway

4.96E-04

P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Ozenoxacin

hsa04080

Neuroactive ligand-receptor interaction

3.57E-04

P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P07550, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Ozenoxacin

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Ozenoxacin

hsa04114

Oocyte meiosis

1.72E-04

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R

Ozenoxacin

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Ozenoxacin

hsa04140

Autophagy - animal

4.41E-03

P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9

IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8

Ozenoxacin

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Ozenoxacin

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Ozenoxacin

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Ozenoxacin

hsa04145

Phagosome

5.26E-04

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Ozenoxacin

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Ozenoxacin

hsa04151

PI3K-Akt signaling pathway

2.49E-02

P02452, P24821, P01568

COL1A1, TNC, IFNA21

Ozenoxacin

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Ozenoxacin

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Ozenoxacin

hsa04211

Longevity regulating pathway

5.00E-03

P31751, P08069, Q08828, P51828, P18848

AKT2, IGF1R, ADCY1, ADCY7, ATF4

Ozenoxacin

hsa04213

Longevity regulating pathway - multiple species

1.22E-04

P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Ozenoxacin

hsa04217

Necroptosis

4.47E-02

P01568, Q13546

IFNA21, RIPK1

Ozenoxacin

hsa04261

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Ozenoxacin

hsa04270

Vascular smooth muscle contraction

1.25E-04

Q15746, P24844, P24723, Q04759, Q14643, P0DP23, Q08828, P51828, P22694, P35579, P35749, P35318

MYLK, MYL9, PRKCH, PRKCQ, ITPR1, CALM1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADM

Ozenoxacin

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Ozenoxacin

hsa04330

Notch signaling pathway

7.49E-03

Q92542, P49768

NCSTN, PSEN1

Ozenoxacin

hsa04340

Hedgehog signaling pathway

1.42E-03

P17612

PRKACA

Ozenoxacin

hsa04360

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Ozenoxacin

hsa04370

VEGF signaling pathway

5.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Ozenoxacin

hsa04371

Apelin signaling pathway

1.20E-05

P62873, P63218, P50151, P31751, Q08828, P51828, P17612, Q13370, Q14344, Q9UM47, P84022, P0DP23

GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PRKACA, PDE3B, GNA13, NOTCH3, SMAD3, CALM1

Ozenoxacin

hsa04380

Osteoclast differentiation

5.27E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Ozenoxacin

hsa04390

Hippo signaling pathway

2.41E-02

P04628, O43623

WNT1, SNAI2

Ozenoxacin

hsa04510

Focal adhesion

5.64E-03

P08514, Q15746, P24844, P08069

ITGA2B, MYLK, MYL9, IGF1R

Ozenoxacin

hsa04512

ECM-receptor interaction

4.79E-04

P02452, P24821, P07359, P08514

COL1A1, TNC, GP1BA, ITGA2B

Ozenoxacin

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Ozenoxacin

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Ozenoxacin

hsa04530

Tight junction

1.51E-05

Q8TEU7, P17612, P16989, P56750, O00501, Q71U36, Q14247, P24844

RAPGEF6, PRKACA, CSDA, CLDN17, CLDN5, TUBA1A, CTTN, MYL9

Ozenoxacin

hsa04540

Gap junction

6.46E-04

P17612, Q13509, P68371, Q71U36, Q9NRA1

PRKACA, TUBB3, TUBB2C, TUBA1A, PDGFC

Ozenoxacin

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Ozenoxacin

hsa04610

Complement and coagulation cascades

1.21E-06

P25116, P00734, P0C0L4, P10909

F2R, F2, C4A, CLU

Ozenoxacin

hsa04611

Platelet activation

1.07E-06

P25116, Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359

F2R, TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BA

Ozenoxacin

hsa04612

Antigen processing and presentation

3.08E-05

P13765, P48382, P26715, P26717, Q07444, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Ozenoxacin

hsa04613

Neutrophil extracellular trap formation

2.55E-05

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Ozenoxacin

hsa04620

Toll-like receptor signaling pathway

1.84E-04

Q13546, P01568, P01584, P31751, Q8NHW4

RIPK1, IFNA21, IL1B, AKT2, CCL4L2

Ozenoxacin

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Ozenoxacin

hsa04622

RIG-I-like receptor signaling pathway

6.07E-03

P01568, Q13546

IFNA21, RIPK1

Ozenoxacin

hsa04623

Cytosolic DNA-sensing pathway

1.70E-09

P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2

Ozenoxacin

hsa04625

C-type lectin receptor signaling pathway

1.14E-03

Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Ozenoxacin

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Ozenoxacin

hsa04640

Hematopoietic cell lineage

1.15E-06

P13612, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13612	ITGA4	Integrin alpha-4	0.735
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P15144	ANPEP	Aminopeptidase N	-0.765
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25063	CD24	Signal transducer CD24	-0.838
P08311	CTSG	Cathepsin G	P25063	CD24	Signal transducer CD24	0.902
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Ozenoxacin

hsa04650

Natural killer cell mediated cytotoxicity

2.47E-09

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867

Ozenoxacin

hsa04657

IL-17 signaling pathway

1.10E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Ozenoxacin

hsa04658

Th1 and Th2 cell differentiation

6.55E-11

Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13761	RUNX3	Runt-related transcription factor 3	0.702

Ozenoxacin

hsa04659

Th17 cell differentiation

1.21E-09

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Ozenoxacin

hsa04660

T cell receptor signaling pathway

1.86E-08

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.808
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.795
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816

Ozenoxacin

hsa04662

B cell receptor signaling pathway

1.49E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Ozenoxacin

hsa04664

Fc epsilon RI signaling pathway

3.51E-06

P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917, P20292

TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Ozenoxacin

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Ozenoxacin

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Ozenoxacin

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Ozenoxacin

hsa04672

Intestinal immune network for IgA production

4.27E-02

P13765, P13612

HLA-DOB, ITGA4

Ozenoxacin

hsa04713

Circadian entrainment

2.39E-03

P0DP23, P62873, P63218, P50151, Q08828, P51828

CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7

Ozenoxacin

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Ozenoxacin

hsa04720

Long-term potentiation

4.68E-03

P16298, P0DP23, P51812, P18848, Q08828, Q02750

PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1

Ozenoxacin

hsa04724

Glutamatergic synapse

2.62E-05

P48058, O15399, P62873, P63218, P50151, P15104, Q9NSB8

GRIA4, GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2

Ozenoxacin

hsa04725

Cholinergic synapse

1.34E-03

Q08828, P51828, P63218, P50151, P18848, P42338, P31751

ADCY1, ADCY7, GNG5, GNG10, ATF4, PIK3CB, AKT2

Ozenoxacin

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Ozenoxacin

hsa04727

GABAergic synapse

1.66E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Ozenoxacin

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Ozenoxacin

hsa04730

Long-term depression

1.95E-02

Q14344, P08069, P07948

GNA13, IGF1R, LYN

Ozenoxacin

hsa04740

Olfactory transduction

4.78E-02

P17612

PRKACA

Ozenoxacin

hsa04742

Taste transduction

1.42E-03

P17612

PRKACA

Ozenoxacin

hsa04744

Phototransduction

9.21E-03

P62873, P0DP23

GNB1, CALM1

Ozenoxacin

hsa04750

Inflammatory mediator regulation of TRP channels

2.58E-05

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Ozenoxacin

hsa04810

Regulation of actin cytoskeleton

1.38E-03

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Ozenoxacin

hsa04911

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Ozenoxacin

hsa04912

GnRH signaling pathway

1.39E-02

Q08828, P51828, P18848, P0DP23

ADCY1, ADCY7, ATF4, CALM1

Ozenoxacin

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Ozenoxacin

hsa04914

Progesterone-mediated oocyte maturation

5.56E-04

P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750

IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1

Ozenoxacin

hsa04915

Estrogen signaling pathway

2.01E-03

P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788

ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1

Ozenoxacin

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Ozenoxacin

hsa04919

Thyroid hormone signaling pathway

7.96E-04

P26678, P17612, P08237, Q9UM47

PLN, PRKACA, PFKM, NOTCH3

Ozenoxacin

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Ozenoxacin

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Ozenoxacin

hsa04923

Regulation of lipolysis in adipocytes

2.89E-04

Q08828, P51828, P07550, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2

Ozenoxacin

hsa04924

Renin secretion

1.94E-03

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Ozenoxacin

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Ozenoxacin

hsa04926

Relaxin signaling pathway

3.95E-04

P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P49407

AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, ARRB1

Ozenoxacin

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Ozenoxacin

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Ozenoxacin

hsa04932

Non-alcoholic fatty liver disease

3.16E-05

P31751, P49841, O43521, P18848, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

AKT2, GSK3B, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Ozenoxacin

hsa04934

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Ozenoxacin

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Ozenoxacin

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Ozenoxacin

hsa04962

Vasopressin-regulated water reabsorption

2.18E-02

P52566, P62491

ARHGDIB, RAB11A

Ozenoxacin

hsa04964

Proximal tubule bicarbonate reclamation

2.61E-03

P22748, P00918, P49448

CA4, CA2, GLUD2

Ozenoxacin

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Ozenoxacin

hsa04970

Salivary secretion

2.94E-04

Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913

ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Ozenoxacin

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Ozenoxacin

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Ozenoxacin

hsa04974

Protein digestion and absorption

2.78E-02

P02452

COL1A1

Ozenoxacin

hsa04976

Bile secretion

1.26E-04

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Ozenoxacin

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Ozenoxacin

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Ozenoxacin

hsa05016

Huntington disease

1.76E-03

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Ozenoxacin

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Ozenoxacin

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Ozenoxacin

hsa05022

Pathways of neurodegeneration - multiple diseases

4.63E-04

P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Ozenoxacin

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Ozenoxacin

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Ozenoxacin

hsa05110

Vibrio cholerae infection

1.86E-04

Q99437, P17612

ATP6V0B, PRKACA

Ozenoxacin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

6.09E-06

Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Ozenoxacin

hsa05130

Pathogenic Escherichia coli infection

3.29E-03

Q71U36, Q14247, O00501, P16333, Q13509, P68371, P25116, Q14344, P25963

TUBA1A, CTTN, CLDN5, NCK1, TUBB3, TUBB2C, F2R, GNA13, NFKBIA

Ozenoxacin

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Ozenoxacin

hsa05132

Salmonella infection

2.78E-03

P51617, P25963, P01375, P08238, Q9UJU2, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Ozenoxacin

hsa05133

Pertussis

2.35E-03

P0DP23, P0C0L4

CALM1, C4A

Ozenoxacin

hsa05134

Legionellosis

1.05E-04

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Ozenoxacin

hsa05140

Leishmaniasis

1.31E-04

O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080

FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Ozenoxacin

hsa05143

African trypanosomiasis

2.81E-03

P69905, P68871

HBA2, HBB

Ozenoxacin

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Ozenoxacin

hsa05146

Amoebiasis

4.97E-08

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09341	CXCL1	Growth-regulated alpha protein	-0.927
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05089	ARG1	Arginase-1	-0.905
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.894
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1

Ozenoxacin

hsa05150

Staphylococcus aureus infection

1.16E-03

P0C0L4, P13646, Q14532, P59665, P59666, P49913

C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Ozenoxacin

hsa05152

Tuberculosis

2.07E-02

Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Ozenoxacin

hsa05160

Hepatitis C

3.23E-02

Q13546, P01568

RIPK1, IFNA21

Ozenoxacin

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Ozenoxacin

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Ozenoxacin

hsa05163

Human cytomegalovirus infection

5.64E-09

P31751, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568

AKT2, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Ozenoxacin

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Ozenoxacin

hsa05165

Human papillomavirus infection

1.20E-03

P02452, P24821, P01568, P04628

COL1A1, TNC, IFNA21, WNT1

Ozenoxacin

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Ozenoxacin

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.62E-05

P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Ozenoxacin

hsa05168

Herpes simplex virus 1 infection

2.66E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776

Ozenoxacin

hsa05169

Epstein-Barr virus infection

3.36E-03

P20023, P13765, Q13547, Q92769, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963

CR2, HLA-DOB, HDAC1, HDAC2, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247

Ozenoxacin

hsa05170

Human immunodeficiency virus 1 infection

4.52E-05

P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2

Ozenoxacin

hsa05200

Pathways in cancer

2.98E-04

P42338, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P14923, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, JUP, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Ozenoxacin

hsa05202

Transcriptional misregulation in cancer

3.98E-08

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799

Ozenoxacin

hsa05203

Viral carcinogenesis

6.22E-03

Q12933, P42229, Q15283, P62807, O60814

TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12

Ozenoxacin

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Ozenoxacin

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Ozenoxacin

hsa05212

Pancreatic cancer

1.31E-04

P42338, P31751, Q15311, P23458, P42224, P84022, O75293

PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, GADD45B

Ozenoxacin

hsa05214

Glioma

3.23E-04

P08069, P0DP23, P42338, P19174, O75293

IGF1R, CALM1, PIK3CB, PLCG1, GADD45B

Ozenoxacin

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Ozenoxacin

hsa05217

Basal cell carcinoma

2.83E-02

Q13635, Q9UJU2, P24522

PTCH1, LEF1, GADD45A

Ozenoxacin

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Ozenoxacin

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Ozenoxacin

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Ozenoxacin

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Ozenoxacin

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Ozenoxacin

hsa05231

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Ozenoxacin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.56E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Ozenoxacin

hsa05310

Asthma

1.39E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Ozenoxacin

hsa05321

Inflammatory bowel disease

1.19E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763

Ozenoxacin

hsa05322

Systemic lupus erythematosus

3.22E-06

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P08311	CTSG	Cathepsin G	Q16778	HIST2H2BE	Histone H2B type 2-E	0.786
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Ozenoxacin

hsa05332

Graft-versus-host disease

1.78E-06

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812