PharmaCoNets of Enflurane (SPCN: 21.44 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Enfluranehsa00053Ascorbate and aldarate metabolism5.61E-032P51648, Q9UEF7ALDH3A2, KLMore
Enfluranehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Enfluranehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Enfluranehsa00280Valine, leucine and isoleucine degradation4.55E-022P21953, P51648BCKDHB, ALDH3A2More
Enfluranehsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Enfluranehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Enfluranehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate4.32E-021Q9Y2C2USTMore
Enfluranehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Enfluranehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Enfluranehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Enfluranehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Enfluranehsa00970Aminoacyl-tRNA biosynthesis1.09E-022O95363, Q15046FARS2, KARSMore
Enfluranehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Enfluranehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Enfluranehsa03010Ribosome4.88E-0916P62753, P42677, P32969, P40429, P62917, P46776, P46777, Q9H0U6, Q07020, P62910, Q02878, P36578, P50914, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, RPL5, MRPL18, RPL18, RPL32, RPL6, RPL4, RPL14, RPLP1, RPS16, RPS3More
Enfluranehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Enfluranehsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Enfluranehsa03050Proteasome1.40E-021P55036PSMD4More
Enfluranehsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Enfluranehsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Enfluranehsa04024cAMP signaling pathway6.68E-0512P49019, P63092, P22694, P42338, P26678, P0DP23, P20020, P23634, P61586, Q16566, P48058, O15399HCAR3, GNAS, PRKACB, PIK3CB, PLN, CALM1, ATP2B1, ATP2B4, RHOA, CAMK4, GRIA4, GRIN2DMore
Enfluranehsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Enfluranehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Enfluranehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Enfluranehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Enfluranehsa04141Protein processing in endoplasmic reticulum9.57E-034P30101, P49257, P60604, Q9H173PDIA3, LMAN1, UBE2G2, SIL1More
Enfluranehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Enfluranehsa04150mTOR signaling pathway7.19E-033Q9NQL2, Q13322, Q93098RRAGD, GRB10, WNT8BMore
Enfluranehsa04217Necroptosis1.70E-025P01568, Q13489, P08238, O43633, Q08752IFNA21, BIRC3, HSP90AB1, CHMP2A, PPIDMore
Enfluranehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Enfluranehsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Enfluranehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Enfluranehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Enfluranehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Enfluranehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Enfluranehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Enfluranehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Enfluranehsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Enfluranehsa04713Circadian entrainment4.54E-059O15399, P0DP23, P17252, P62873, P63218, P50151, P48058, P22694, P63092GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, GRIA4, PRKACB, GNASMore
Enfluranehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Enfluranehsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Enfluranehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Enfluranehsa04723Retrograde endocannabinoid signaling1.47E-046P17252, P48169, P62873, P48058, P22694, Q16718PRKCA, GABRA4, GNB1, GRIA4, PRKACB, NDUFA5More
Enfluranehsa04724Glutamatergic synapse1.40E-048P48058, O15399, P63092, P22694, P17252, P62873, P63218, P50151GRIA4, GRIN2D, GNAS, PRKACB, PRKCA, GNB1, GNG5, GNG10More
Enfluranehsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Enfluranehsa04726Serotonergic synapse7.85E-059P63092, P22694, P17252, P31645, P62873, P63218, P50151, P33260, P09917GNAS, PRKACB, PRKCA, SLC6A4, GNB1, GNG5, GNG10, CYP2C18, ALOX5More
Enfluranehsa04727GABAergic synapse4.55E-022P50151, P15104GNG10, GLULMore
Enfluranehsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Enfluranehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Enfluranehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Enfluranehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Enfluranehsa04925Aldosterone synthesis and secretion8.50E-046P0DP23, P17252, Q16566, P22694, P20020, P23634CALM1, PRKCA, CAMK4, PRKACB, ATP2B1, ATP2B4More
Enfluranehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Enfluranehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Enfluranehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Enfluranehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Enfluranehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Enfluranehsa04972Pancreatic secretion1.29E-044P20020, P17252, P63092, P61586ATP2B1, PRKCA, GNAS, RHOAMore
Enfluranehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Enfluranehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Enfluranehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Enfluranehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Enfluranehsa05017Spinocerebellar ataxia8.69E-048Q8TB72, O15399, P42338, P28070, P43686, P05141, P12236, P21796PUM2, GRIN2D, PIK3CB, PSMB4, PSMC4, SLC25A5, SLC25A6, VDAC1More
Enfluranehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Enfluranehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Enfluranehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Enfluranehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Enfluranehsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Enfluranehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Enfluranehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Enfluranehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Enfluranehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Enfluranehsa05150Staphylococcus aureus infection1.61E-035P0C0L4, P13646, P59665, P59666, P12838C4A, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4More
Enfluranehsa05163Human cytomegalovirus infection3.23E-039P42338, P62873, P63218, P50151, P0DP23, P61586, P63092, P30101, P61769PIK3CB, GNB1, GNG5, GNG10, CALM1, RHOA, GNAS, PDIA3, B2MMore
Enfluranehsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Enfluranehsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Enfluranehsa05171Coronavirus disease - COVID-196.74E-0715P23396, P62753, P62249, P42677, P40429, Q9UHA3, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386, O14786RPS3, RPS6, RPS16, RPS27, RPL13A, RSL24D1, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1, NRP1More
Enfluranehsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Enfluranehsa05214Glioma2.09E-035P09619, P0DP23, Q16566, Q02750, P42338PDGFRB, CALM1, CAMK4, MAP2K1, PIK3CBMore
Enfluranehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Enfluranehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Enfluranehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Enfluranehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Enfluranehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Enfluranehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More

Community members of Enflurane (SDC: 2.26)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Reported00.01310.083500.1736
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Reported10.13960.505501.0809
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Reported00.28270.078500.2984
O95259KCNH1Potassium voltageNonegated channel subfamily H member 1Reported00.04250.046500.1143
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
Q8IZS8CACNA2D3VoltageNonedependent calcium channel subunit alphaNone2/deltaNone3Reported00.09430.040.32910.4562
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)