PharmaCoNets of Encorafenib (SPCN: 21.73 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Encorafenibhsa00030Pentose phosphate pathway1.19E-022P52209, P37837PGD, TALDO1More
Encorafenibhsa00514Other types of O-glycan biosynthesis1.42E-022P15907, Q8N4A0ST6GAL1, GALNT4More
Encorafenibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Encorafenibhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Encorafenibhsa01522Endocrine resistance2.16E-021P04049RAF1More
Encorafenibhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Encorafenibhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Encorafenibhsa04014Ras signaling pathway3.65E-021P04049RAF1More
Encorafenibhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Encorafenibhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Encorafenibhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Encorafenibhsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Encorafenibhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Encorafenibhsa04071Sphingolipid signaling pathway2.16E-021P04049RAF1More
Encorafenibhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Encorafenibhsa04110Cell cycle2.06E-026Q9UBD5, P06493, Q14683, P30304, P33981, P01106ORC3, CDK1, SMC1A, CDC25A, TTK, MYCMore
Encorafenibhsa04140Autophagy - animal2.82E-021P04049RAF1More
Encorafenibhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Encorafenibhsa04210Apoptosis2.16E-021P04049RAF1More
Encorafenibhsa04218Cellular senescence2.49E-021P04049RAF1More
Encorafenibhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Encorafenibhsa04330Notch signaling pathway2.29E-022Q92769, Q92830HDAC2, KAT2AMore
Encorafenibhsa04340Hedgehog signaling pathway4.50E-022O43791, P30279SPOP, CCND2More
Encorafenibhsa04360Axon guidance2.49E-021P04049RAF1More
Encorafenibhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Encorafenibhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Encorafenibhsa04510Focal adhesion6.96E-034Q15942, P30281, P04049, Q9NQU5ZYX, CCND3, RAF1, PAK6More
Encorafenibhsa04540Gap junction1.33E-021P04049RAF1More
Encorafenibhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Encorafenibhsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Encorafenibhsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Encorafenibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Encorafenibhsa04650Natural killer cell mediated cytotoxicity1.82E-021P04049RAF1More
Encorafenibhsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Encorafenibhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Encorafenibhsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Encorafenibhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Encorafenibhsa04720Long-term potentiation1.66E-021P04049RAF1More
Encorafenibhsa04722Neurotrophin signaling pathway2.32E-021P04049RAF1More
Encorafenibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Encorafenibhsa04730Long-term depression1.16E-021P04049RAF1More
Encorafenibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Encorafenibhsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Encorafenibhsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Encorafenibhsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Encorafenibhsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Encorafenibhsa04916Melanogenesis1.33E-021P04049RAF1More
Encorafenibhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Encorafenibhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Encorafenibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Encorafenibhsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Encorafenibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Encorafenibhsa04929GnRH secretion4.98E-031P04049RAF1More
Encorafenibhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Encorafenibhsa05014Amyotrophic lateral sclerosis4.20E-025Q71U36, Q13148, P21796, P43243, P84103TUBA1A, TARDBP, VDAC1, MATR3, SFRS3More
Encorafenibhsa05034Alcoholism2.49E-021P04049RAF1More
Encorafenibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.75E-022Q99437, P41240ATP6V0B, CSKMore
Encorafenibhsa05132Salmonella infection4.98E-021P04049RAF1More
Encorafenibhsa05152Tuberculosis3.98E-021P04049RAF1More
Encorafenibhsa05160Hepatitis C1.99E-021P04049RAF1More
Encorafenibhsa05161Hepatitis B1.99E-021P04049RAF1More
Encorafenibhsa05162Measles3.34E-024P11142, Q13191, P30279, O43318HSPA8, CBLB, CCND2, MAP3K7More
Encorafenibhsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Encorafenibhsa05164Influenza A3.65E-021P04049RAF1More
Encorafenibhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Encorafenibhsa05169Epstein-Barr virus infection2.76E-025Q92769, O43318, P30101, Q13761, P30279HDAC2, MAP3K7, PDIA3, RUNX3, CCND2More
Encorafenibhsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Encorafenibhsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Encorafenibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Encorafenibhsa05210Colorectal cancer1.66E-021P04049RAF1More
Encorafenibhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Encorafenibhsa05212Pancreatic cancer1.16E-021P04049RAF1More
Encorafenibhsa05213Endometrial cancer9.95E-031P04049RAF1More
Encorafenibhsa05214Glioma9.95E-031P04049RAF1More
Encorafenibhsa05215Prostate cancer1.33E-021P04049RAF1More
Encorafenibhsa05218Melanoma6.63E-031P04049RAF1More
Encorafenibhsa05219Bladder cancer4.98E-031P04049RAF1More
Encorafenibhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Encorafenibhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Encorafenibhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Encorafenibhsa05224Breast cancer1.49E-021P04049RAF1More
Encorafenibhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Encorafenibhsa05226Gastric cancer8.29E-031P04049RAF1More
Encorafenibhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Encorafenibhsa05231Choline metabolism in cancer4.44E-034P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Encorafenibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More

Community members of Encorafenib (SDC: 2.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P30279CCND2G1/SNonespecific cyclinNoneD2Predicted00.04140.020611.0619
P30281CCND3G1/SNonespecific cyclinNoneD3Predicted00.15610.00690.94651.0384
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)