PharmaCoNets of Enalaprilat (SPCN: 36.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Enalaprilathsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Enalaprilathsa00190Oxidative phosphorylation4.56E-064Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Enalaprilathsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Enalaprilathsa00500Starch and sucrose metabolism1.02E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Enalaprilathsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Enalaprilathsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Enalaprilathsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Enalaprilathsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Enalaprilathsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Enalaprilathsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Enalaprilathsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Enalaprilathsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Enalaprilathsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Enalaprilathsa04015Rap1 signaling pathway2.05E-034P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Enalaprilathsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Enalaprilathsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Enalaprilathsa04060Cytokine-cytokine receptor interaction3.95E-0211P27930, P08476, Q13651, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Enalaprilathsa04061Viral protein interaction with cytokine and cytokine receptor1.31E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Enalaprilathsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Enalaprilathsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Enalaprilathsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Enalaprilathsa04217Necroptosis2.87E-038P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Enalaprilathsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Enalaprilathsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Enalaprilathsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Enalaprilathsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Enalaprilathsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Enalaprilathsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Enalaprilathsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Enalaprilathsa04611Platelet activation7.40E-065P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Enalaprilathsa04612Antigen processing and presentation1.81E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Enalaprilathsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Enalaprilathsa04640Hematopoietic cell lineage2.20E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Enalaprilathsa04650Natural killer cell mediated cytotoxicity2.19E-059P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Enalaprilathsa04657IL-17 signaling pathway3.52E-026O00463, Q16539, P09341, P14780, P80188, P01375TRAF5, MAPK14, CXCL1, MMP9, LCN2, TNFMore
Enalaprilathsa04658Th1 and Th2 cell differentiation4.23E-0510Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Enalaprilathsa04659Th17 cell differentiation1.22E-0311P25963, Q04759, Q16539, P06239, P13765, Q9UL17, P23771, P84022, Q13485, P09693, P20963NFKBIA, PRKCQ, MAPK14, LCK, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247More
Enalaprilathsa04660T cell receptor signaling pathway1.65E-0411P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Enalaprilathsa04668TNF signaling pathway1.81E-027P01375, O00463, Q16539, P18848, P09341, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL1, BCL3, MMP9More
Enalaprilathsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Enalaprilathsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Enalaprilathsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Enalaprilathsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Enalaprilathsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Enalaprilathsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Enalaprilathsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Enalaprilathsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Enalaprilathsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Enalaprilathsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Enalaprilathsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Enalaprilathsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Enalaprilathsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Enalaprilathsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Enalaprilathsa05140Leishmaniasis2.18E-046P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Enalaprilathsa05144Malaria1.85E-034P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Enalaprilathsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Enalaprilathsa05146Amoebiasis9.15E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Enalaprilathsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Enalaprilathsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Enalaprilathsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Enalaprilathsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Enalaprilathsa05202Transcriptional misregulation in cancer1.95E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Enalaprilathsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Enalaprilathsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Enalaprilathsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Enalaprilathsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Enalaprilathsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Enalaprilathsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Enalaprilathsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.52E-026O95267, P20963, P09693, P06239, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, PRKCQ, MAPK14More
Enalaprilathsa05310Asthma4.57E-044P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Enalaprilathsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Enalaprilathsa05321Inflammatory bowel disease6.19E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Enalaprilathsa05322Systemic lupus erythematosus4.08E-027O75015, P08246, P08311, P01375, P13765, Q16778, P12814FCGR3B, ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Enalaprilathsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Enalaprilathsa05332Graft-versus-host disease1.32E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Enalaprilathsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Enalaprilathsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Enalaprilathsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Enalaprilathsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Enalaprilat (SDC: 3.17)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P05089ARG1ArginaseNone1Predicted10.46310.01790.29750.5648
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)