PharmaCoNets

PharmaCoNets of Empagliflozin (S_PCN: 2.03 )

Empagliflozin regulated-network (S_DN: 3.39)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Empagliflozin

hsa00030

Pentose phosphate pathway

6.81E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Empagliflozin

hsa00510

N-Glycan biosynthesis

3.61E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Empagliflozin

hsa01100

Metabolic pathways

3.32E-02

Q9NR34, P05089, O14521, P15144, O14732, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, O60701, Q9HCC0, P33121, P42330, P51854, Q08477, Q96EB6, P15907, Q9UNP4, Q9BX95, P37837, P32321, P60891, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q16718

MAN1C1, ARG1, SDHD, ANPEP, IMPA2, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, UGDH, MCCC2, ACSL1, AKR1C3, TKTL1, CYP4F3, SIRT1, ST6GAL1, ST3GAL5, SGPP1, TALDO1, DCTD, PRPS1, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16548	BCL2A1	Bcl-2-related protein A1	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.723
Q16548	BCL2A1	Bcl-2-related protein A1	P05089	ARG1	Arginase-1	0.842
Q16548	BCL2A1	Bcl-2-related protein A1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.709
Q16548	BCL2A1	Bcl-2-related protein A1	P15144	ANPEP	Aminopeptidase N	0.864
Q16548	BCL2A1	Bcl-2-related protein A1	O14732	IMPA2	Inositol monophosphatase 2	0.844
Q16548	BCL2A1	Bcl-2-related protein A1	P32320	CDA	Cytidine deaminase	0.852
Q16548	BCL2A1	Bcl-2-related protein A1	P22748	CA4	Carbonic anhydrase 4	0.833
Q16548	BCL2A1	Bcl-2-related protein A1	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.827
Q16548	BCL2A1	Bcl-2-related protein A1	P06280	GLA	Alpha-galactosidase A	0.903
Q16548	BCL2A1	Bcl-2-related protein A1	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.889
Q16548	BCL2A1	Bcl-2-related protein A1	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.78
Q16548	BCL2A1	Bcl-2-related protein A1	O43451	MGAM	Maltase-glucoamylase	0.845
Q16548	BCL2A1	Bcl-2-related protein A1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.889
Q16548	BCL2A1	Bcl-2-related protein A1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.863
Q16548	BCL2A1	Bcl-2-related protein A1	O60701	UGDH	UDP-glucose 6-dehydrogenase	-0.701
Q16548	BCL2A1	Bcl-2-related protein A1	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.922
Q16548	BCL2A1	Bcl-2-related protein A1	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.933
Q16548	BCL2A1	Bcl-2-related protein A1	P42330	AKR1C3	Aldo-keto reductase family 1 member C3	-0.701
Q16548	BCL2A1	Bcl-2-related protein A1	P51854	TKTL1	Transketolase-like protein 1	-0.7
Q16548	BCL2A1	Bcl-2-related protein A1	Q08477	CYP4F3	Cytochrome P450 4F3	0.729
Q16548	BCL2A1	Bcl-2-related protein A1	Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	-0.718
Q16548	BCL2A1	Bcl-2-related protein A1	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.768
Q16548	BCL2A1	Bcl-2-related protein A1	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.789
Q16548	BCL2A1	Bcl-2-related protein A1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.822
Q16548	BCL2A1	Bcl-2-related protein A1	P37837	TALDO1	Transaldolase	0.795
Q16548	BCL2A1	Bcl-2-related protein A1	P32321	DCTD	Deoxycytidylate deaminase	-0.718
Q16548	BCL2A1	Bcl-2-related protein A1	P60891	PRPS1	Ribose-phosphate pyrophosphokinase 1	-0.742
Q16548	BCL2A1	Bcl-2-related protein A1	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.773
Q16548	BCL2A1	Bcl-2-related protein A1	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.827
Q16548	BCL2A1	Bcl-2-related protein A1	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.867
Q16548	BCL2A1	Bcl-2-related protein A1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.958
Q16548	BCL2A1	Bcl-2-related protein A1	P46976	GYG1	Glycogenin-1	0.756
Q16548	BCL2A1	Bcl-2-related protein A1	P06737	PYGL	Glycogen phosphorylase, liver form	0.967
Q16548	BCL2A1	Bcl-2-related protein A1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.729

Empagliflozin

hsa04064

NF-kappa B signaling pathway

4.25E-02

P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341

BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Empagliflozin

hsa04071

Sphingolipid signaling pathway

8.29E-03

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Empagliflozin

hsa04340

Hedgehog signaling pathway

2.76E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Empagliflozin

hsa04612

Antigen processing and presentation

1.64E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Empagliflozin

hsa04621

NOD-like receptor signaling pathway

4.27E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Empagliflozin

hsa04657

IL-17 signaling pathway

2.81E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Empagliflozin

hsa04658

Th1 and Th2 cell differentiation

7.47E-03

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Empagliflozin

hsa04660

T cell receptor signaling pathway

2.52E-02

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3B

Empagliflozin

hsa04714

Thermogenesis

4.80E-02

P22694, Q16539, Q969G3, P33121, Q16718, O14521

PRKACB, MAPK14, SMARCE1, ACSL1, NDUFA5, SDHD

Empagliflozin

hsa04912

GnRH signaling pathway

4.72E-02

Q16539, Q9Y6R4, Q14643, P22694

MAPK14, MAP3K4, ITPR1, PRKACB

Empagliflozin

hsa05140

Leishmaniasis

4.80E-02

O75015, P13765, O60603, P01375, Q16539, Q15080

FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4

Empagliflozin

hsa05144

Malaria

1.54E-02

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Empagliflozin

hsa05145

Toxoplasmosis

3.96E-02

P28068, Q16787

HLA-DMB, LAMA3

Empagliflozin

hsa05146

Amoebiasis

2.81E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Empagliflozin

hsa05150

Staphylococcus aureus infection

2.30E-02

P21730, P21462, O75015, P13765, Q16581, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4

Empagliflozin

hsa05165

Human papillomavirus infection

2.01E-02

Q16787, Q02930, Q13315

LAMA3, CREB5, ATM

Empagliflozin

hsa05166

Human T-cell leukemia virus 1 infection

2.91E-02

Q02930, P28068, Q13315

CREB5, HLA-DMB, ATM

Empagliflozin

hsa05217

Basal cell carcinoma

4.72E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Empagliflozin

hsa05310

Asthma

2.34E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Empagliflozin

hsa05321

Inflammatory bowel disease

2.22E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Empagliflozin

hsa05332

Graft-versus-host disease

2.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Community members of Empagliflozin (S_DC: 0.60)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

Q16548

BCL2A1

BclNone2Nonerelated protein A1

Predicted

0.0306

0.0336

0.4687

0.5512

P13866

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

PharmaCoNets of Empagliflozin (SPCN: 2.03 )

Empagliflozin regulated-network (SDN: 3.39)

Community members of Empagliflozin (SDC: 0.60)

PharmaCoNets of Empagliflozin (S_PCN: 2.03 )

Empagliflozin regulated-network (S_DN: 3.39)

Community members of Empagliflozin (S_DC: 0.60)