PharmaCoNets of Emedastine (SPCN: 46.26 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Emedastinehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Emedastinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Emedastinehsa00500Starch and sucrose metabolism2.32E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Emedastinehsa00730Thiamine metabolism2.53E-042P05186, P24666ALPL, ACP1More
Emedastinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Emedastinehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Emedastinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Emedastinehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Emedastinehsa03020RNA polymerase3.03E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Emedastinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Emedastinehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Emedastinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Emedastinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Emedastinehsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Emedastinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Emedastinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Emedastinehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Emedastinehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Emedastinehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Emedastinehsa04210Apoptosis4.66E-037O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4More
Emedastinehsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Emedastinehsa04217Necroptosis3.89E-049P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4BMore
Emedastinehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Emedastinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Emedastinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Emedastinehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Emedastinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Emedastinehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Emedastinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Emedastinehsa04657IL-17 signaling pathway1.27E-035O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Emedastinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Emedastinehsa04668TNF signaling pathway1.56E-038P01375, O00463, Q16539, P18848, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, IL1B, BCL3, MMP9, TNFRSF1BMore
Emedastinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Emedastinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Emedastinehsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Emedastinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Emedastinehsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Emedastinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Emedastinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Emedastinehsa04932Non-alcoholic fatty liver disease6.81E-0712P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Emedastinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Emedastinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Emedastinehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Emedastinehsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Emedastinehsa04976Bile secretion1.90E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Emedastinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Emedastinehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Emedastinehsa05016Huntington disease3.74E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Emedastinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Emedastinehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Emedastinehsa05133Pertussis3.51E-021P0C0L4C4AMore
Emedastinehsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Emedastinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Emedastinehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Emedastinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Emedastinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Emedastinehsa05163Human cytomegalovirus infection2.22E-0313P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5More
Emedastinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Emedastinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Emedastinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Emedastinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Emedastinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Emedastinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Emedastine (SDC: 5.91)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)