PharmaCoNets of Elvitegravir (SPCN: 37.77 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Elvitegravirhsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Elvitegravirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Elvitegravirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Elvitegravirhsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Elvitegravirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Elvitegravirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Elvitegravirhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Elvitegravirhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Elvitegravirhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Elvitegravirhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Elvitegravirhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Elvitegravirhsa04064NF-kappa B signaling pathway1.45E-0618P10415, Q13489, O00463, Q13546, P14778, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, EDARMore
Elvitegravirhsa04071Sphingolipid signaling pathway8.69E-057P17252, P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2More
Elvitegravirhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Elvitegravirhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Elvitegravirhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Elvitegravirhsa04145Phagosome2.29E-037O75015, Q15080, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Elvitegravirhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Elvitegravirhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Elvitegravirhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Elvitegravirhsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Elvitegravirhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Elvitegravirhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Elvitegravirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Elvitegravirhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Elvitegravirhsa04613Neutrophil extracellular trap formation1.63E-0418P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Elvitegravirhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Elvitegravirhsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Elvitegravirhsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Elvitegravirhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Elvitegravirhsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Elvitegravirhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Elvitegravirhsa04650Natural killer cell mediated cytotoxicity2.57E-0410P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Elvitegravirhsa04657IL-17 signaling pathway4.55E-025O00463, Q16539, P49841, P09341, P14780TRAF5, MAPK14, GSK3B, CXCL1, MMP9More
Elvitegravirhsa04658Th1 and Th2 cell differentiation7.66E-0712Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Elvitegravirhsa04659Th17 cell differentiation8.48E-0511Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Elvitegravirhsa04660T cell receptor signaling pathway1.09E-0412Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Elvitegravirhsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Elvitegravirhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Elvitegravirhsa04912GnRH signaling pathway3.14E-035P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Elvitegravirhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Elvitegravirhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Elvitegravirhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Elvitegravirhsa04928Parathyroid hormone synthesis, secretion and action4.10E-035Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Elvitegravirhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Elvitegravirhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Elvitegravirhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Elvitegravirhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Elvitegravirhsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Elvitegravirhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Elvitegravirhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Elvitegravirhsa05146Amoebiasis5.70E-059P09341, P19875, P14778, P27930, O60603, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, TLR2, PIK3CB, ITGAM, ARG1, ACTN1More
Elvitegravirhsa05152Tuberculosis1.26E-028Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14More
Elvitegravirhsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Elvitegravirhsa05202Transcriptional misregulation in cancer2.67E-0414Q12778, Q15532, Q13315, P41732, P14780, P27930, Q16548, Q13489, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Elvitegravirhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Elvitegravirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Elvitegravirhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Elvitegravirhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Elvitegravirhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Elvitegravirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.00E-0412P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Elvitegravirhsa05321Inflammatory bowel disease1.66E-045O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Elvitegravirhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Elvitegravirhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Elvitegravirhsa05332Graft-versus-host disease1.16E-044P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Elvitegravirhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Elvitegravir (SDC: 4.44)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)