PharmaCoNets of Eltrombopag (SPCN: 21.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Eltrombopaghsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Eltrombopaghsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Eltrombopaghsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Eltrombopaghsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Eltrombopaghsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Eltrombopaghsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Eltrombopaghsa00920Sulfur metabolism2.29E-021Q16762TSTMore
Eltrombopaghsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Eltrombopaghsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Eltrombopaghsa03013RNA transport3.98E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Eltrombopaghsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Eltrombopaghsa04120Ubiquitin mediated proteolysis2.89E-022O95071, P0CG47UBR5, UBBMore
Eltrombopaghsa04122Sulfur relay system2.29E-021Q16762TSTMore
Eltrombopaghsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Eltrombopaghsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Eltrombopaghsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Eltrombopaghsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Eltrombopaghsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Eltrombopaghsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Eltrombopaghsa04512ECM-receptor interaction2.00E-022P07359, P08514GP1BA, ITGA2BMore
Eltrombopaghsa04514Cell adhesion molecules3.82E-022P16109, O00501SELP, CLDN5More
Eltrombopaghsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Eltrombopaghsa04611Platelet activation2.25E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Eltrombopaghsa04613Neutrophil extracellular trap formation3.17E-0612P16109, P11215, Q13547, Q99878, Q93077, P58876, P62807, Q16778, O60814, P68431, P08514, P07359SELP, ITGAM, HDAC1, H2AC14, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BAMore
Eltrombopaghsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Eltrombopaghsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Eltrombopaghsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Eltrombopaghsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Eltrombopaghsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Eltrombopaghsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Eltrombopaghsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Eltrombopaghsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Eltrombopaghsa04921Oxytocin signaling pathway4.91E-022Q15746, Q8WYR1MYLK, PIK3R5More
Eltrombopaghsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Eltrombopaghsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Eltrombopaghsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Eltrombopaghsa05132Salmonella infection2.53E-0312P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Eltrombopaghsa05150Staphylococcus aureus infection3.32E-022Q14532, P16109KRT32, SELPMore
Eltrombopaghsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Eltrombopaghsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Eltrombopaghsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Eltrombopaghsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Eltrombopaghsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Eltrombopaghsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Eltrombopaghsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Eltrombopaghsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Eltrombopag (SDC: 4.13)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)