PharmaCoNets of Elexacaftor (SPCN: 24.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Elexacaftorhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Elexacaftorhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Elexacaftorhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Elexacaftorhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Elexacaftorhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Elexacaftorhsa01230Biosynthesis of amino acids1.90E-034P60891, Q99707, P15104, P37837PRPS1, MTR, GLUL, TALDO1More
Elexacaftorhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Elexacaftorhsa03013RNA transport6.93E-0816O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, P20042, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF2S2, EIF4A2, EIF4B, TACC3More
Elexacaftorhsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Elexacaftorhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Elexacaftorhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Elexacaftorhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Elexacaftorhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Elexacaftorhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Elexacaftorhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Elexacaftorhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Elexacaftorhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Elexacaftorhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Elexacaftorhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Elexacaftorhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Elexacaftorhsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Elexacaftorhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Elexacaftorhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Elexacaftorhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Elexacaftorhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Elexacaftorhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Elexacaftorhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Elexacaftorhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Elexacaftorhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Elexacaftorhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Elexacaftorhsa04750Inflammatory mediator regulation of TRP channels7.62E-048P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQMore
Elexacaftorhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Elexacaftorhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Elexacaftorhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Elexacaftorhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Elexacaftorhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Elexacaftorhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Elexacaftorhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Elexacaftorhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Elexacaftorhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Elexacaftorhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Elexacaftorhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Elexacaftorhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Elexacaftorhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Elexacaftorhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Elexacaftorhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Elexacaftorhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore

Community members of Elexacaftor (SDC: 4.04)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)