PharmaCoNets of Edoxudine (SPCN: 17.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Edoxudinehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Edoxudinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Edoxudinehsa00471D-Glutamine and D-glutamate metabolism2.41E-021P49448GLUD2More
Edoxudinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Edoxudinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Edoxudinehsa01040Biosynthesis of unsaturated fatty acids4.77E-021O00767SCDMore
Edoxudinehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Edoxudinehsa01521EGFR tyrosine kinase inhibitor resistance1.80E-022P17252, Q9GZP0PRKCA, PDGFDMore
Edoxudinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Edoxudinehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Edoxudinehsa04010MAPK signaling pathway5.69E-034P17252, O95267, P09603, Q9GZP0PRKCA, RASGRP1, CSF1, PDGFDMore
Edoxudinehsa04014Ras signaling pathway2.60E-034P09603, Q9GZP0, P17252, O95267CSF1, PDGFD, PRKCA, RASGRP1More
Edoxudinehsa04015Rap1 signaling pathway1.84E-045P09603, Q9GZP0, P25116, P08514, P17252CSF1, PDGFD, F2R, ITGA2B, PRKCAMore
Edoxudinehsa04020Calcium signaling pathway1.21E-023P17252, P25116, Q9GZP0PRKCA, F2R, PDGFDMore
Edoxudinehsa04061Viral protein interaction with cytokine and cytokine receptor4.28E-027P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Edoxudinehsa04064NF-kappa B signaling pathway2.37E-0411P10415, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Edoxudinehsa04071Sphingolipid signaling pathway9.29E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Edoxudinehsa04072Phospholipase D signaling pathway7.75E-033P25116, P17252, Q9GZP0F2R, PRKCA, PDGFDMore
Edoxudinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Edoxudinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Edoxudinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Edoxudinehsa04151PI3K-Akt signaling pathway4.16E-035P25116, P09603, Q9GZP0, P08514, P17252F2R, CSF1, PDGFD, ITGA2B, PRKCAMore
Edoxudinehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Edoxudinehsa04350TGF-beta signaling pathway3.68E-022Q14766, Q15583LTBP1, TGIF1More
Edoxudinehsa04510Focal adhesion2.93E-023P08514, P17252, Q9GZP0ITGA2B, PRKCA, PDGFDMore
Edoxudinehsa04540Gap junction2.22E-022P17252, Q9GZP0PRKCA, PDGFDMore
Edoxudinehsa04610Complement and coagulation cascades2.67E-022P25116, Q9Y279F2R, VSIG4More
Edoxudinehsa04611Platelet activation4.53E-033P25116, O95267, P08514F2R, RASGRP1, ITGA2BMore
Edoxudinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Edoxudinehsa04613Neutrophil extracellular trap formation1.02E-0214O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Edoxudinehsa04621NOD-like receptor signaling pathway4.83E-0210Q16539, Q14643, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P49913, P12838MAPK14, ITPR1, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4More
Edoxudinehsa04640Hematopoietic cell lineage1.75E-023P08514, P11836, P09603ITGA2B, MS4A1, CSF1More
Edoxudinehsa04650Natural killer cell mediated cytotoxicity1.56E-023P17252, P26717, P26715PRKCA, KLRC2, KLRC1More
Edoxudinehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Edoxudinehsa04658Th1 and Th2 cell differentiation8.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Edoxudinehsa04660T cell receptor signaling pathway2.57E-0311P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14More
Edoxudinehsa04810Regulation of actin cytoskeleton1.21E-023P08514, Q9GZP0, P25116ITGA2B, PDGFD, F2RMore
Edoxudinehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Edoxudinehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Edoxudinehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Edoxudinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Edoxudinehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Edoxudinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Edoxudinehsa05146Amoebiasis3.11E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Edoxudinehsa05150Staphylococcus aureus infection2.53E-026P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Edoxudinehsa05152Tuberculosis1.16E-0310O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1More
Edoxudinehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Edoxudinehsa05170Human immunodeficiency virus 1 infection4.82E-0211P01375, O00463, Q14643, Q16539, O60603, Q13315, P09693, P20963, P10415, Q93034, Q9Y6Q5TNF, TRAF5, ITPR1, MAPK14, TLR2, ATM, CD3G, CD247, BCL2, CUL5, AP1M2More
Edoxudinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Edoxudinehsa05202Transcriptional misregulation in cancer1.01E-0315Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Edoxudinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Edoxudinehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Edoxudinehsa05231Choline metabolism in cancer2.22E-022Q9GZP0, P17252PDGFD, PRKCAMore
Edoxudinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.11E-027O95267, P20963, P09693, O60603, P10747, Q04759, Q16539RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14More
Edoxudinehsa05310Asthma1.68E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Edoxudinehsa05321Inflammatory bowel disease2.47E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Edoxudinehsa05322Systemic lupus erythematosus4.61E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Edoxudinehsa05323Rheumatoid arthritis2.84E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Edoxudinehsa05332Graft-versus-host disease3.93E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Edoxudinehsa05415Diabetic cardiomyopathy7.11E-035P05141, O15239, P13073, Q13557, P11413SLC25A5, NDUFA1, COX4I1, CAMK2D, G6PDMore

Community members of Edoxudine (SDC: 1.80)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P07998RNASE1Ribonuclease pancreaticPredicted10.1320.018700.1033
P32320CDACytidine deaminasePredicted00.05160.05690.16530.3049
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)