PharmaCoNets of Edoxaban (SPCN: 10.06 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Edoxabanhsa00190Oxidative phosphorylation1.10E-033Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Edoxabanhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Edoxabanhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Edoxabanhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Edoxabanhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Edoxabanhsa03040Spliceosome1.26E-026P17844, P51991, P61978, Q15365, Q01130, P11142DDX5, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8More
Edoxabanhsa03060Protein export3.37E-022P37108, Q15005SRP14, SPCS2More
Edoxabanhsa04141Protein processing in endoplasmic reticulum6.04E-038P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Edoxabanhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Edoxabanhsa04151PI3K-Akt signaling pathway9.80E-0310O43521, P27348, Q13362, P07900, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1More
Edoxabanhsa04211Longevity regulating pathway4.57E-024P51828, Q99941, P18848, Q96RR4ADCY7, CREBL1, ATF4, CAMKK2More
Edoxabanhsa04217Necroptosis5.00E-037P23458, Q9NQC7, P07900, P05141, P01584, Q9H444, O75351JAK1, CYLD, HSP90AA1, SLC25A5, IL1B, CHMP4B, VPS4BMore
Edoxabanhsa04261Adrenergic signaling in cardiomyocytes1.26E-026P67936, P51828, Q99941, P18848, Q13362, P23634TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4More
Edoxabanhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Edoxabanhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Edoxabanhsa04621NOD-like receptor signaling pathway2.39E-025P01584, P07900, P23458, Q9H3M7, P43490IL1B, HSP90AA1, JAK1, TXNIP, PBEF1More
Edoxabanhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Edoxabanhsa04911Insulin secretion4.85E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Edoxabanhsa04915Estrogen signaling pathway1.65E-026Q99941, P18848, P51828, P07900, P11142, Q15788CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, NCOA1More
Edoxabanhsa04918Thyroid hormone synthesis2.50E-024P51828, Q99941, P18848, P05543ADCY7, CREBL1, ATF4, SERPINA7More
Edoxabanhsa04925Aldosterone synthesis and secretion2.50E-024Q99941, P18848, P51828, P23634CREBL1, ATF4, ADCY7, ATP2B4More
Edoxabanhsa04927Cortisol synthesis and secretion3.29E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Edoxabanhsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Edoxabanhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Edoxabanhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Edoxabanhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Edoxabanhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Edoxabanhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Edoxabanhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Edoxabanhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Edoxabanhsa05163Human cytomegalovirus infection4.52E-027P51828, P23458, P01584, P61073, Q13651, Q99941, P18848ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Edoxabanhsa05203Viral carcinogenesis1.26E-026Q99941, P18848, P23458, P27348, Q7KZF4, P61978CREBL1, ATF4, JAK1, YWHAQ, SND1, HNRPKMore
Edoxabanhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Edoxaban (SDC: 2.38)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P22891PROZVitamin KNonedependent protein ZPredicted00.79810.016800.4327
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)