PharmaCoNets of Dyclonine (SPCN: 43.71 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dycloninehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dycloninehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Dycloninehsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Dycloninehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dycloninehsa00630Glyoxylate and dicarboxylate metabolism1.13E-022P40925, P15104MDH1, GLULMore
Dycloninehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Dycloninehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dycloninehsa00830Retinol metabolism1.36E-031P00325ADH1BMore
Dycloninehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Dycloninehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dycloninehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dycloninehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Dycloninehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Dycloninehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Dycloninehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dycloninehsa03040Spliceosome2.10E-0410O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1More
Dycloninehsa03050Proteasome1.21E-021P28074PSMB5More
Dycloninehsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Dycloninehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Dycloninehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dycloninehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Dycloninehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dycloninehsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Dycloninehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Dycloninehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Dycloninehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Dycloninehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dycloninehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dycloninehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Dycloninehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dycloninehsa04657IL-17 signaling pathway3.33E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Dycloninehsa04658Th1 and Th2 cell differentiation2.71E-025P07766, P06239, Q9UL17, P14784, Q13761CD3E, LCK, TBX21, IL2RB, RUNX3More
Dycloninehsa04659Th17 cell differentiation4.13E-037P06239, P14784, P14778, Q9UL17, Q13485, P08238, P07766LCK, IL2RB, IL1R1, TBX21, SMAD4, HSP90AB1, CD3EMore
Dycloninehsa04662B cell receptor signaling pathway4.07E-024P42338, P60033, P07948, Q8N149PIK3CB, CD81, LYN, LILRA2More
Dycloninehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dycloninehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dycloninehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Dycloninehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dycloninehsa04724Glutamatergic synapse2.22E-024O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Dycloninehsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Dycloninehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Dycloninehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dycloninehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Dycloninehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dycloninehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dycloninehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dycloninehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dycloninehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dycloninehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dycloninehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Dycloninehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dycloninehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Dycloninehsa05017Spinocerebellar ataxia1.80E-025Q92915, O15399, P42338, P28074, P21796FGF14, GRIN2D, PIK3CB, PSMB5, VDAC1More
Dycloninehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dycloninehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dycloninehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dycloninehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Dycloninehsa05140Leishmaniasis1.16E-0310O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Dycloninehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dycloninehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dycloninehsa05146Amoebiasis3.33E-039P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACBMore
Dycloninehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dycloninehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Dycloninehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Dycloninehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Dycloninehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dycloninehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Dycloninehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Dycloninehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Dycloninehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Dycloninehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dycloninehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dycloninehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Dycloninehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Dycloninehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Dyclonine (SDC: 4.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)