PharmaCoNets of Duvelisib (SPCN: 364.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Duvelisibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Duvelisibhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Duvelisibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Duvelisibhsa00051Fructose and mannose metabolism2.84E-045P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Duvelisibhsa00052Galactose metabolism8.55E-065P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Duvelisibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Duvelisibhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Duvelisibhsa00190Oxidative phosphorylation4.50E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Duvelisibhsa00220Arginine biosynthesis2.20E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Duvelisibhsa00230Purine metabolism4.93E-021P21589NT5EMore
Duvelisibhsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Duvelisibhsa00310Lysine degradation2.26E-045Q96KQ7, Q8NEZ4, Q13029, Q02809, P51648EHMT2, MLL3, PRDM2, PLOD1, ALDH3A2More
Duvelisibhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Duvelisibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Duvelisibhsa00500Starch and sucrose metabolism1.36E-064O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Duvelisibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Duvelisibhsa00520Amino sugar and nucleotide sugar metabolism1.75E-063Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Duvelisibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Duvelisibhsa00562Inositol phosphate metabolism2.37E-045Q14642, P27987, P19174, P42338, Q02252INPP5A, ITPKB, PLCG1, PIK3CB, ALDH6A1More
Duvelisibhsa00564Glycerophospholipid metabolism8.47E-045P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Duvelisibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Duvelisibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Duvelisibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Duvelisibhsa00600Sphingolipid metabolism2.67E-044Q9BX95, Q8TCT0, Q06136, P15289SGPP1, CERK, FVT1, ARSAMore
Duvelisibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Duvelisibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Duvelisibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Duvelisibhsa00630Glyoxylate and dicarboxylate metabolism6.22E-073P40925, P40926, P15104MDH1, MDH2, GLULMore
Duvelisibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Duvelisibhsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Duvelisibhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Duvelisibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Duvelisibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Duvelisibhsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Duvelisibhsa00770Pantothenate and CoA biosynthesis4.29E-042O95498, Q9NRN7VNN2, AASDHPPTMore
Duvelisibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Duvelisibhsa00830Retinol metabolism1.66E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Duvelisibhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Duvelisibhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Duvelisibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Duvelisibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Duvelisibhsa00983Drug metabolism - other enzymes1.06E-043P04183, P32320, P05164TK1, CDA, MPOMore
Duvelisibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Duvelisibhsa01100Metabolic pathways3.69E-0446Q9NR34, Q9Y234, P35790, Q9Y259, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, Q13956, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, P49619, O95861, O95954, Q9HCC0, P33121, Q02318, Q86VZ5, P48651, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P14927MAN1C1, LIPT1, CHKA, CHKB, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, PDE6H, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKG, BPNT1, FTCD, MCCC2, ACSL1, CYP27A1, SGMS1, PTDSS1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, UQCRBMore
Duvelisibhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Duvelisibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Duvelisibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Duvelisibhsa01230Biosynthesis of amino acids1.42E-058P60174, P04075, P51854, P60891, Q99707, O75390, P50213, P37837TPI1, ALDOA, TKTL1, PRPS1, MTR, CS, IDH3A, TALDO1More
Duvelisibhsa01240Biosynthesis of cofactors3.44E-035Q969G6, P36551, P22557, O60701, Q9Y234RFK, CPOX, ALAS2, UGDH, LIPT1More
Duvelisibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Duvelisibhsa01522Endocrine resistance4.08E-036P22694, P04049, Q02750, Q9UM47, P46527, P08069PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1RMore
Duvelisibhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Duvelisibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Duvelisibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Duvelisibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Duvelisibhsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Duvelisibhsa03013RNA transport3.97E-1221O14980, P52298, Q09161, O14893, P61326, P38919, Q9H307, P37198, Q7Z3B4, P35658, O14602, Q14152, P55884, O75822, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, PNN, NUP62, NUP54, NUP214, EIF1AY, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1More
Duvelisibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Duvelisibhsa03020RNA polymerase1.56E-053P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Duvelisibhsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Duvelisibhsa03040Spliceosome1.37E-0717Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Duvelisibhsa03050Proteasome4.83E-021P55036PSMD4More
Duvelisibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Duvelisibhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Duvelisibhsa03430Mismatch repair4.38E-021P20585MSH3More
Duvelisibhsa03450Non-homologous end-joining1.58E-043Q9NP87, P78527, P13010POLM, PRKDC, XRCC5More
Duvelisibhsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Duvelisibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Duvelisibhsa04012ErbB signaling pathway3.94E-078Q13153, P16333, Q13191, P17252, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PRKCA, PLCG1, PIK3CB, MYC, RAF1More
Duvelisibhsa04014Ras signaling pathway4.34E-0618Q02750, P04049, P31751, P42338, P20827, Q15389, P49767, P08069, Q13009, P17252, P14921, P21359, P0DP23, P62873, P62879, P50151, P19174, P22694MAP2K1, RAF1, AKT2, PIK3CB, EFNA1, ANGPT1, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, NF1, CALM1, GNB1, GNB2, GNG10, PLCG1, PRKACBMore
Duvelisibhsa04015Rap1 signaling pathway7.98E-0613P04049, P20827, P49767, P08069, P06213, P11215, Q13009, O00522, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Duvelisibhsa04020Calcium signaling pathway4.34E-026P27987, P17252, O15399, P19174, P0DP23, P49767ITPKB, PRKCA, GRIN2D, PLCG1, CALM1, VEGFCMore
Duvelisibhsa04022cGMP-PKG signaling pathway2.62E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Duvelisibhsa04024cAMP signaling pathway3.01E-049P42338, P31751, P0DP23, P04049, Q13370, O15399, P25963, Q13009, Q13153PIK3CB, AKT2, CALM1, RAF1, PDE3B, GRIN2D, NFKBIA, TIAM1, PAK1More
Duvelisibhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Duvelisibhsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Duvelisibhsa04062Chemokine signaling pathway9.32E-0619P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Duvelisibhsa04064NF-kappa B signaling pathway1.15E-1324P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Duvelisibhsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Duvelisibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Duvelisibhsa04070Phosphatidylinositol signaling system3.50E-059P19174, P0DP23, Q14643, P42338, P23743, Q86XP1, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, DGKA, DGKH, ITPKB, ITPKC, PRKCAMore
Duvelisibhsa04071Sphingolipid signaling pathway5.70E-069P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Duvelisibhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Duvelisibhsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Duvelisibhsa04110Cell cycle4.04E-0811Q9UBD5, P06493, O60566, P78527, Q14683, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, BUB1B, PRKDC, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Duvelisibhsa04114Oocyte meiosis1.32E-056Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Duvelisibhsa04115p53 signaling pathway3.63E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Duvelisibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Duvelisibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Duvelisibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Duvelisibhsa04140Autophagy - animal3.50E-0310P08069, Q9Y4H2, P42338, P04049, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, IRS2, PIK3CB, RAF1, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Duvelisibhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Duvelisibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Duvelisibhsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Duvelisibhsa04145Phagosome5.62E-0511O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Duvelisibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Duvelisibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Duvelisibhsa04151PI3K-Akt signaling pathway6.80E-0523P62753, P42338, P25116, P27348, P20827, P49767, Q13362, P07900, P08238, P62873, P50151, P16144, O15335, Q13751, P22105, O60603, P14784, P01568, Q99941, P18848, P10415, P17252, O00141RPS6, PIK3CB, F2R, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, TNXB, TLR2, IL2RB, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGKMore
Duvelisibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Duvelisibhsa04210Apoptosis5.97E-0411Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1More
Duvelisibhsa04211Longevity regulating pathway5.33E-034P08069, P51828, Q99941, P18848IGF1R, ADCY7, CREBL1, ATF4More
Duvelisibhsa04213Longevity regulating pathway - multiple species1.94E-068P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Duvelisibhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Duvelisibhsa04217Necroptosis9.98E-0818P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, PPIDMore
Duvelisibhsa04218Cellular senescence1.14E-047P31751, P04049, P0DP23, P01889, P10321, P05141, P12236AKT2, RAF1, CALM1, HLA-B, HLA-C, SLC25A5, SLC25A6More
Duvelisibhsa04261Adrenergic signaling in cardiomyocytes2.00E-0512P09493, P07550, P51828, P22694, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415TPM1, ADRB2, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2More
Duvelisibhsa04270Vascular smooth muscle contraction2.48E-047P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Duvelisibhsa04310Wnt signaling pathway1.48E-033O15169, P17612, P67870AXIN1, PRKACA, CSNK2BMore
Duvelisibhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Duvelisibhsa04340Hedgehog signaling pathway1.39E-045P49841, P17612, P22694, O43791, P30279GSK3B, PRKACA, PRKACB, SPOP, CCND2More
Duvelisibhsa04360Axon guidance1.30E-038P16333, P20827, O95631, P17252, P42338, P23528, P04049, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, RAF1, PLCG1More
Duvelisibhsa04370VEGF signaling pathway7.99E-108P19174, P16298, P31751, P42338, P17252, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1More
Duvelisibhsa04371Apelin signaling pathway1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Duvelisibhsa04380Osteoclast differentiation5.19E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Duvelisibhsa04390Hippo signaling pathway3.80E-058P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Duvelisibhsa04392Hippo signaling pathway - multiple species7.65E-042Q13153, Q6V0I7PAK1, FAT4More
Duvelisibhsa04510Focal adhesion8.44E-0411P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P04049, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, RAF1, IGF1R, VEGFCMore
Duvelisibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Duvelisibhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Duvelisibhsa04540Gap junction5.13E-068P17252, P22694, Q13509, P68371, Q02750, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, RAF1, PDGFC, ITPR1More
Duvelisibhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Duvelisibhsa04610Complement and coagulation cascades5.97E-092P00734, P0C0L4F2, C4AMore
Duvelisibhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Duvelisibhsa04612Antigen processing and presentation2.18E-0812P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Duvelisibhsa04613Neutrophil extracellular trap formation1.55E-0625P19174, P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PLCG1, PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Duvelisibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Duvelisibhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Duvelisibhsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Duvelisibhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Duvelisibhsa04623Cytosolic DNA-sensing pathway1.92E-055P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Duvelisibhsa04625C-type lectin receptor signaling pathway9.74E-0713Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Duvelisibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Duvelisibhsa04640Hematopoietic cell lineage1.77E-0816P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Duvelisibhsa04650Natural killer cell mediated cytotoxicity2.24E-1520P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Duvelisibhsa04657IL-17 signaling pathway2.00E-0710P07900, O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Duvelisibhsa04658Th1 and Th2 cell differentiation3.95E-1916Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Duvelisibhsa04659Th17 cell differentiation8.11E-1822P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Duvelisibhsa04660T cell receptor signaling pathway1.03E-1319P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, Q13153, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Duvelisibhsa04662B cell receptor signaling pathway2.18E-077P31751, P42338, P60033, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Duvelisibhsa04664Fc epsilon RI signaling pathway4.24E-0711P01375, P31751, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Duvelisibhsa04666Fc gamma R-mediated phagocytosis7.95E-036P42338, P19174, P04049, P23528, P14598, P17252PIK3CB, PLCG1, RAF1, CFL1, NCF1, PRKCAMore
Duvelisibhsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Duvelisibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Duvelisibhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Duvelisibhsa04713Circadian entrainment8.46E-046O15399, P0DP23, P17252, P62873, P50151, Q14643GRIN2D, CALM1, PRKCA, GNB1, GNG10, ITPR1More
Duvelisibhsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Duvelisibhsa04720Long-term potentiation5.69E-0811P17252, P16298, P0DP23, Q15418, P51812, P18848, P17612, P22694, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, PRKACA, PRKACB, MAP2K1, RAF1, ITPR1More
Duvelisibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Duvelisibhsa04722Neurotrophin signaling pathway7.07E-068Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1More
Duvelisibhsa04723Retrograde endocannabinoid signaling1.43E-036Q14643, P17252, P48169, P62873, P17612, Q16718ITPR1, PRKCA, GABRA4, GNB1, PRKACA, NDUFA5More
Duvelisibhsa04724Glutamatergic synapse9.69E-066O15399, P17252, P62873, P63218, P50151, P15104GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLULMore
Duvelisibhsa04725Cholinergic synapse4.37E-0814P51828, P17612, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P18848, Q13557, P42338, P10415, Q02750ADCY7, PRKACA, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2, MAP2K1More
Duvelisibhsa04726Serotonergic synapse2.79E-049P22694, P17252, P62873, P62879, P50151, P33260, P09917, P04049, Q02750PRKACB, PRKCA, GNB1, GNB2, GNG10, CYP2C18, ALOX5, RAF1, MAP2K1More
Duvelisibhsa04727GABAergic synapse1.39E-0610P62873, P62879, P63218, P50151, P48169, P15104, P17612, P22694, O60296, P17252GNB1, GNB2, GNG5, GNG10, GABRA4, GLUL, PRKACA, PRKACB, TRAK2, PRKCAMore
Duvelisibhsa04728Dopaminergic synapse1.80E-0511P17612, Q14643, P17252, P62873, P31751, Q99941, P18848, Q13557, Q13362, P0DP23, O15516PRKACA, ITPR1, PRKCA, GNB1, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1, CLOCKMore
Duvelisibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Duvelisibhsa04740Olfactory transduction1.85E-033P62873, P0DP23, P17612GNB1, CALM1, PRKACAMore
Duvelisibhsa04742Taste transduction2.53E-042P48169, P17612GABRA4, PRKACAMore
Duvelisibhsa04744Phototransduction6.96E-052P62873, P0DP23GNB1, CALM1More
Duvelisibhsa04750Inflammatory mediator regulation of TRP channels4.34E-0713P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Duvelisibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Duvelisibhsa04910Insulin signaling pathway1.39E-069Q14642, P0DP23, P22694, P06737, P04049, P31751, P49841, Q13191, Q9Y4H2INPP5A, CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3B, CBLB, IRS2More
Duvelisibhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Duvelisibhsa04912GnRH signaling pathway4.30E-0411P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Duvelisibhsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Duvelisibhsa04914Progesterone-mediated oocyte maturation7.24E-0711P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Duvelisibhsa04915Estrogen signaling pathway8.72E-0615P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, NCOA1, BCL2More
Duvelisibhsa04916Melanogenesis1.47E-032P0DP23, P04049CALM1, RAF1More
Duvelisibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Duvelisibhsa04918Thyroid hormone synthesis1.47E-047P22694, P51828, Q99941, P18848, Q14643, P02768, P05543PRKACB, ADCY7, CREBL1, ATF4, ITPR1, ALB, SERPINA7More
Duvelisibhsa04919Thyroid hormone signaling pathway1.07E-049P17252, P49841, P04049, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47PRKCA, GSK3B, RAF1, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3More
Duvelisibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Duvelisibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Duvelisibhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Duvelisibhsa04923Regulation of lipolysis in adipocytes6.26E-045P07550, P06213, P42338, Q9Y4H2, P31751ADRB2, INSR, PIK3CB, IRS2, AKT2More
Duvelisibhsa04924Renin secretion1.57E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Duvelisibhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Duvelisibhsa04926Relaxin signaling pathway9.12E-0715P25963, P42338, P62873, P63218, P50151, Q99941, P18848, P22694, P49767, P14780, P51828, P04049, P17252, P30679, P49407NFKBIA, PIK3CB, GNB1, GNG5, GNG10, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY7, RAF1, PRKCA, GNA15, ARRB1More
Duvelisibhsa04927Cortisol synthesis and secretion1.11E-055Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Duvelisibhsa04928Parathyroid hormone synthesis, secretion and action9.81E-0511Q14643, P51828, P22694, P23771, P04049, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3ITPR1, ADCY7, PRKACB, GATA3, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFBMore
Duvelisibhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Duvelisibhsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Duvelisibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Duvelisibhsa04932Non-alcoholic fatty liver disease9.03E-0612P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Duvelisibhsa04933AGE-RAGE signaling pathway in diabetic complications8.02E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Duvelisibhsa04934Cushing syndrome6.81E-056Q99941, P18848, P51828, P17612, O15169, Q13557CREBL1, ATF4, ADCY7, PRKACA, AXIN1, CAMK2DMore
Duvelisibhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Duvelisibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Duvelisibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Duvelisibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Duvelisibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Duvelisibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Duvelisibhsa04970Salivary secretion6.70E-057P07550, Q08828, P51828, P22694, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMPMore
Duvelisibhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Duvelisibhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Duvelisibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Duvelisibhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Duvelisibhsa04976Bile secretion1.90E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Duvelisibhsa05010Alzheimer disease3.97E-0516Q16718, O14521, P13073, Q14643, Q00535, P0DP23, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P12236, Q08752, P28070NDUFA5, SDHD, COX4I1, ITPR1, CDK5, CALM1, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, SLC25A6, PPID, PSMB4More
Duvelisibhsa05012Parkinson disease1.58E-0312Q16718, O14521, P13073, P05141, P12236, P17612, P18848, P28070, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, SLC25A6, PRKACA, ATF4, PSMB4, ITPR1, CALM1, TUBB3, TUBB2CMore
Duvelisibhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Duvelisibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Duvelisibhsa05020Prion disease1.20E-0618P17612, Q16718, O14521, P13073, Q92736, Q14643, P18848, P05141, P12236, P28070, O60282, Q13509, P68371, P49841, P67870, P14598, Q15080, Q16539PRKACA, NDUFA5, SDHD, COX4I1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, KIF5C, TUBB3, TUBB2C, GSK3B, CSNK2B, NCF1, NCF4, MAPK14More
Duvelisibhsa05022Pathways of neurodegeneration - multiple diseases5.53E-0622Q14643, Q13509, P68371, P49841, P67870, P10415, Q16718, O14521, P13073, Q06055, P18848, Q13561, P05141, P12236, P17252, Q16539, Q00535, O15169, Q08752, O15020, P0DP23, P28070ITPR1, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA5, SDHD, COX4I1, ATP5G2, ATF4, DCTN2, SLC25A5, SLC25A6, PRKCA, MAPK14, CDK5, AXIN1, PPID, SPTBN2, CALM1, PSMB4More
Duvelisibhsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Duvelisibhsa05031Amphetamine addiction1.45E-046P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Duvelisibhsa05032Morphine addiction3.40E-047P17612, P62873, P50151, Q13370, P48169, P17252, P43250PRKACA, GNB1, GNG10, PDE3B, GABRA4, PRKCA, GRK6More
Duvelisibhsa05034Alcoholism1.68E-0610P17612, P18848, Q96RR4, P62873, P04049, Q93077, P62807, O60814, P84243, P68431PRKACA, ATF4, CAMKK2, GNB1, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Duvelisibhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Duvelisibhsa05110Vibrio cholerae infection5.33E-045Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Duvelisibhsa05120Epithelial cell signaling in Helicobacter pylori infection3.54E-067Q16539, Q13153, P09341, P19875, P19174, P25024, P25025MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Duvelisibhsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Duvelisibhsa05131Shigellosis2.61E-0516Q13546, P68431, Q05655, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Duvelisibhsa05132Salmonella infection4.36E-0815P25963, P04049, Q9UJU2, P84095, O00471, Q13546, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371NFKBIA, RAF1, LEF1, RHOG, EXOC5, RIPK1, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Duvelisibhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Duvelisibhsa05134Legionellosis2.28E-077P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Duvelisibhsa05135Yersinia infection4.39E-024P06239, P19174, P42338, P01732LCK, PLCG1, PIK3CB, CD8AMore
Duvelisibhsa05140Leishmaniasis8.36E-0814P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Duvelisibhsa05143African trypanosomiasis8.39E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Duvelisibhsa05144Malaria9.68E-068P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Duvelisibhsa05145Toxoplasmosis1.41E-0410P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LGMore
Duvelisibhsa05146Amoebiasis4.50E-1214P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Duvelisibhsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Duvelisibhsa05152Tuberculosis1.60E-0410P04049, Q13488, P0DP23, P42224, O60603, P31751, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1More
Duvelisibhsa05160Hepatitis C1.58E-047P52630, P60033, Q9NZJ5, P04049, P49841, P01375, P48023STAT2, CD81, EIF2AK3, RAF1, GSK3B, TNF, FASLGMore
Duvelisibhsa05161Hepatitis B1.14E-048P04049, Q99941, P18848, P25963, Q13485, P10415, P27348, P84022RAF1, CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Duvelisibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Duvelisibhsa05163Human cytomegalovirus infection1.63E-0628P31751, P42338, P04049, P01375, P01889, P10321, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P17612, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, RAF1, TNF, HLA-B, HLA-C, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACA, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Duvelisibhsa05164Influenza A3.65E-021P04049RAF1More
Duvelisibhsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Duvelisibhsa05166Human T-cell leukemia virus 1 infection7.39E-037Q9Y490, P01889, P10321, P05141, P12236, P17612, P18848TLN1, HLA-B, HLA-C, SLC25A5, SLC25A6, PRKACA, ATF4More
Duvelisibhsa05167Kaposi sarcoma-associated herpesvirus infection2.17E-0616P01568, P31751, P42224, P25963, P42338, P40189, P01889, P10321, P62873, P50151, P19174, Q14643, P04049, Q29983, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, HLA-B, HLA-C, GNB1, GNG10, PLCG1, ITPR1, RAF1, MICA, CALM1, LEF1More
Duvelisibhsa05168Herpes simplex virus 1 infection1.19E-0424O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Duvelisibhsa05169Epstein-Barr virus infection5.94E-0412P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247More
Duvelisibhsa05170Human immunodeficiency virus 1 infection2.93E-0721P31751, P42338, P04049, Q02750, P62873, P62879, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2More
Duvelisibhsa05171Coronavirus disease - COVID-194.35E-0314P01584, P25963, P42224, P01568, P62753, P36578, P62888, P61927, P61513, P62829, P40189, P42338, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23, IL6ST, PIK3CB, PLCG1, PRKCAMore
Duvelisibhsa05200Pathways in cancer3.72E-0626Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P10826, P14923, P10415, Q13489, P49767, P14921, Q12778, P31751, P25116, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, RARB, JUP, BCL2, BIRC3, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Duvelisibhsa05202Transcriptional misregulation in cancer3.90E-0722Q12778, Q15532, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Duvelisibhsa05203Viral carcinogenesis1.94E-0612Q99941, P18848, P30279, P27348, Q13547, Q15283, P01889, P10321, P61978, P17612, P62807, O60814CREBL1, ATF4, CCND2, YWHAQ, HDAC1, RASA2, HLA-B, HLA-C, HNRPK, PRKACA, HIST1H2BC, H2BC12More
Duvelisibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Duvelisibhsa05205Proteoglycans in cancer2.86E-037P04049, P14780, P01375, P08069, P23588, Q13635, P22694RAF1, MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Duvelisibhsa05206MicroRNAs in cancer6.92E-0411P46527, P30279, Q9Y4H2, Q9UM47, P16070, Q13547, Q13315, P17252, P19174, P04049, Q02750CDKN1B, CCND2, IRS2, NOTCH3, CD44, HDAC1, ATM, PRKCA, PLCG1, RAF1, MAP2K1More
Duvelisibhsa05210Colorectal cancer1.46E-046Q9UKG1, P84022, Q13485, P04049, P10415, P37173APPL1, SMAD3, SMAD4, RAF1, BCL2, TGFBR2More
Duvelisibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Duvelisibhsa05212Pancreatic cancer4.19E-044P31751, P04049, P84022, Q13485AKT2, RAF1, SMAD3, SMAD4More
Duvelisibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Duvelisibhsa05214Glioma7.98E-078P08069, P0DP23, P17252, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Duvelisibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Duvelisibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Duvelisibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Duvelisibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Duvelisibhsa05220Chronic myeloid leukemia5.12E-055Q13485, P25963, P84022, P31751, P04049SMAD4, NFKBIA, SMAD3, AKT2, RAF1More
Duvelisibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Duvelisibhsa05222Small cell lung cancer7.32E-058P10826, P31751, P42338, Q13751, Q13489, P10415, P25963, O75293RARB, AKT2, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, GADD45BMore
Duvelisibhsa05223Non-small cell lung cancer2.63E-068P17252, P31751, P42338, P19174, P10826, P04049, Q9HC35, O75293PRKCA, AKT2, PIK3CB, PLCG1, RARB, RAF1, EML4, GADD45BMore
Duvelisibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Duvelisibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Duvelisibhsa05226Gastric cancer8.56E-055P04049, P31751, P84022, Q13485, P10415RAF1, AKT2, SMAD3, SMAD4, BCL2More
Duvelisibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Duvelisibhsa05231Choline metabolism in cancer8.99E-077P04049, P42338, Q9Y259, P19174, P23743, P49619, P17252RAF1, PIK3CB, CHKB, PLCG1, DGKA, DGKG, PRKCAMore
Duvelisibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.59E-1015P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Duvelisibhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Duvelisibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Duvelisibhsa05321Inflammatory bowel disease6.92E-088O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Duvelisibhsa05322Systemic lupus erythematosus4.80E-0610P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Duvelisibhsa05323Rheumatoid arthritis1.59E-037Q06643, P13765, Q13488, P10747, P09341, P19875, O60603LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Duvelisibhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Duvelisibhsa05332Graft-versus-host disease1.73E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Duvelisibhsa05340Primary immunodeficiency2.95E-044P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Duvelisibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Duvelisibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Duvelisibhsa05415Diabetic cardiomyopathy2.31E-0510P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P49841, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, TGFBR2More
Duvelisibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Duvelisibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Duvelisib (SDC: 11.89)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q96SW2CRBNProtein cereblonPredicted00.2490.042700.2099
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P67870CSNK2BCasein kinase II subunit betaPredicted00.76770.02730.52970.9682
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)