PharmaCoNets of Dutasteride (SPCN: 40.71 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dutasteridehsa00030Pentose phosphate pathway7.84E-032P06744, P37837GPI, TALDO1More
Dutasteridehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Dutasteridehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Dutasteridehsa00500Starch and sucrose metabolism8.89E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Dutasteridehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Dutasteridehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Dutasteridehsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Dutasteridehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Dutasteridehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Dutasteridehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Dutasteridehsa01200Carbon metabolism7.69E-033P06744, P37837, P40926GPI, TALDO1, MDH2More
Dutasteridehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Dutasteridehsa04014Ras signaling pathway1.74E-023Q15283, P61586, P62873RASA2, RHOA, GNB1More
Dutasteridehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Dutasteridehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Dutasteridehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Dutasteridehsa04064NF-kappa B signaling pathway1.13E-0514P10415, O00463, P14778, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643BCL2, TRAF5, IL1R1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTBMore
Dutasteridehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Dutasteridehsa04071Sphingolipid signaling pathway7.26E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Dutasteridehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Dutasteridehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Dutasteridehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Dutasteridehsa04210Apoptosis4.11E-039Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1More
Dutasteridehsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Dutasteridehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Dutasteridehsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Dutasteridehsa04612Antigen processing and presentation2.20E-036P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Dutasteridehsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Dutasteridehsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Dutasteridehsa04650Natural killer cell mediated cytotoxicity3.08E-048P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Dutasteridehsa04657IL-17 signaling pathway5.03E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Dutasteridehsa04658Th1 and Th2 cell differentiation1.77E-0912Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Dutasteridehsa04659Th17 cell differentiation7.76E-0711Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Dutasteridehsa04660T cell receptor signaling pathway3.19E-0511Q9UDY8, Q04759, P10747, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239MALT1, PRKCQ, CD28, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Dutasteridehsa04710Circadian rhythm2.43E-021O15516CLOCKMore
Dutasteridehsa04723Retrograde endocannabinoid signaling2.68E-022P48169, P62873GABRA4, GNB1More
Dutasteridehsa04727GABAergic synapse3.69E-022P62873, P48169GNB1, GABRA4More
Dutasteridehsa04742Taste transduction4.80E-021P48169GABRA4More
Dutasteridehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dutasteridehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dutasteridehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Dutasteridehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Dutasteridehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Dutasteridehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dutasteridehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Dutasteridehsa05032Morphine addiction1.42E-022P62873, P48169GNB1, GABRA4More
Dutasteridehsa05033Nicotine addiction2.43E-021P48169GABRA4More
Dutasteridehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Dutasteridehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Dutasteridehsa05146Amoebiasis1.32E-037P09341, P14778, P27930, O60603, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSGMore
Dutasteridehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Dutasteridehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Dutasteridehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Dutasteridehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Dutasteridehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Dutasteridehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.15E-0410O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Dutasteridehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Dutasteridehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Dutasteridehsa05332Graft-versus-host disease3.63E-044P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Dutasteridehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Dutasteridehsa05414Dilated cardiomyopathy2.68E-022P09493, P26678TPM1, PLNMore
Dutasteridehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Dutasteride (SDC: 4.90)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)