PharmaCoNets of Droxidopa (SPCN: 24.29 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Droxidopahsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Droxidopahsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Droxidopahsa00500Starch and sucrose metabolism4.43E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Droxidopahsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Droxidopahsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Droxidopahsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Droxidopahsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Droxidopahsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Droxidopahsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Droxidopahsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Droxidopahsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Droxidopahsa03060Protein export3.28E-022Q15070, O76094OXA1L, SRP72More
Droxidopahsa03410Base excision repair7.59E-031P27695APEX1More
Droxidopahsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Droxidopahsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Droxidopahsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Droxidopahsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Droxidopahsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Droxidopahsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Droxidopahsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Droxidopahsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Droxidopahsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Droxidopahsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Droxidopahsa04621NOD-like receptor signaling pathway3.15E-0210Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Droxidopahsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Droxidopahsa04640Hematopoietic cell lineage1.67E-024P20023, P11836, P09693, P16871CR2, MS4A1, CD3G, IL7RMore
Droxidopahsa04650Natural killer cell mediated cytotoxicity6.40E-0510P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Droxidopahsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Droxidopahsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Droxidopahsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Droxidopahsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Droxidopahsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Droxidopahsa04742Taste transduction1.01E-021P30939HTR1FMore
Droxidopahsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Droxidopahsa04919Thyroid hormone signaling pathway4.44E-023P60709, Q09472, P01106ACTB, EP300, MYCMore
Droxidopahsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Droxidopahsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Droxidopahsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Droxidopahsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Droxidopahsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Droxidopahsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Droxidopahsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Droxidopahsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Droxidopahsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Droxidopahsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Droxidopahsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Droxidopahsa05133Pertussis4.20E-021P0C0L4C4AMore
Droxidopahsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Droxidopahsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Droxidopahsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Droxidopahsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Droxidopahsa05163Human cytomegalovirus infection4.07E-029P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Droxidopahsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Droxidopahsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Droxidopahsa05169Epstein-Barr virus infection1.42E-025P20023, P01106, P48551, P29728, P09693CR2, MYC, IFNAR2, OAS2, CD3GMore
Droxidopahsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Droxidopahsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Droxidopahsa05211Renal cell carcinoma1.67E-022Q09472, Q99814EP300, EPAS1More
Droxidopahsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Droxidopahsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Droxidopahsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Droxidopahsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Droxidopahsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Droxidopa (SDC: 3.09)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75475PSIP1PC4 and SFRS1Noneinteracting proteinPredicted00.33320.063800.2943
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P07101THTyrosine 3NonemonooxygenasePredicted00.04320.08880.49370.6929
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)