PharmaCoNets of Dronedarone (SPCN: 13.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dronedaronehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dronedaronehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Dronedaronehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Dronedaronehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Dronedaronehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dronedaronehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Dronedaronehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Dronedaronehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Dronedaronehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Dronedaronehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Dronedaronehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Dronedaronehsa00770Pantothenate and CoA biosynthesis5.15E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Dronedaronehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Dronedaronehsa01100Metabolic pathways5.95E-0330P05089, O95455, P21953, P15144, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P42330, Q13093, Q08477, P15907, Q9NY28, Q9UNP4, Q9BX95, P09960, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737, Q16718ARG1, TGDS, BCKDHB, ANPEP, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, AKR1C3, PLA2G7, CYP4F3, ST6GAL1, GALNT8, ST3GAL5, SGPP1, LTA4H, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGL, NDUFA5More
Dronedaronehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dronedaronehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dronedaronehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Dronedaronehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Dronedaronehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Dronedaronehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Dronedaronehsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Dronedaronehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Dronedaronehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Dronedaronehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Dronedaronehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dronedaronehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dronedaronehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Dronedaronehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Dronedaronehsa04217Necroptosis1.12E-039P01375, P01568, P48023, Q13489, Q14765, P08238, Q99878, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT4, HSP90AB1, H2AC14, CHMP2A, PPIDMore
Dronedaronehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Dronedaronehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Dronedaronehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Dronedaronehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dronedaronehsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Dronedaronehsa04650Natural killer cell mediated cytotoxicity3.65E-059P01375, P17252, O60880, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, PRKCA, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dronedaronehsa04657IL-17 signaling pathway7.22E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Dronedaronehsa04659Th17 cell differentiation4.12E-024P06239, P14784, P14778, P07766LCK, IL2RB, IL1R1, CD3EMore
Dronedaronehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Dronedaronehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dronedaronehsa04713Circadian entrainment1.69E-023P17252, P48058, P22694PRKCA, GRIA4, PRKACBMore
Dronedaronehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Dronedaronehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Dronedaronehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dronedaronehsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Dronedaronehsa04724Glutamatergic synapse1.31E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Dronedaronehsa04726Serotonergic synapse2.62E-023P22694, P17252, P31645PRKACB, PRKCA, SLC6A4More
Dronedaronehsa04730Long-term depression3.52E-021Q14344GNA13More
Dronedaronehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dronedaronehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dronedaronehsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Dronedaronehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Dronedaronehsa04913Ovarian steroidogenesis6.39E-042P42330, P22694AKR1C3, PRKACBMore
Dronedaronehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Dronedaronehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dronedaronehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Dronedaronehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dronedaronehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dronedaronehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Dronedaronehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dronedaronehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dronedaronehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Dronedaronehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Dronedaronehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Dronedaronehsa04970Salivary secretion3.56E-045P07550, P22694, P20020, P17252, P49913ADRB2, PRKACB, ATP2B1, PRKCA, CAMPMore
Dronedaronehsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Dronedaronehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Dronedaronehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Dronedaronehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Dronedaronehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Dronedaronehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Dronedaronehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Dronedaronehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Dronedaronehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Dronedaronehsa05031Amphetamine addiction1.94E-035P48058, P22694, P18848, P17252, Q13547GRIA4, PRKACB, ATF4, PRKCA, HDAC1More
Dronedaronehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Dronedaronehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Dronedaronehsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Dronedaronehsa05140Leishmaniasis2.47E-025P13612, O75015, P01375, P49006, Q16539ITGA4, FCGR3B, TNF, MARCKSL1, MAPK14More
Dronedaronehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dronedaronehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dronedaronehsa05146Amoebiasis3.03E-038P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACBMore
Dronedaronehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Dronedaronehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dronedaronehsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Dronedaronehsa05171Coronavirus disease - COVID-191.08E-0413P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1More
Dronedaronehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dronedaronehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Dronedaronehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Dronedaronehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Dronedaronehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Dronedaronehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Dronedaronehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dronedaronehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dronedaronehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Dronedaronehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More
Dronedaronehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Dronedarone (SDC: 1.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)