PharmaCoNets of Doxorubicin (SPCN: 37.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Doxorubicinhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Doxorubicinhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Doxorubicinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Doxorubicinhsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Doxorubicinhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Doxorubicinhsa00564Glycerophospholipid metabolism1.18E-034Q6P1A2, Q9Y259, P23743, P49619MBOAT5, CHKB, DGKA, DGKGMore
Doxorubicinhsa00630Glyoxylate and dicarboxylate metabolism3.73E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Doxorubicinhsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Doxorubicinhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Doxorubicinhsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Doxorubicinhsa03013RNA transport7.27E-0312O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1More
Doxorubicinhsa03040Spliceosome2.51E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Doxorubicinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Doxorubicinhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Doxorubicinhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Doxorubicinhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Doxorubicinhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Doxorubicinhsa04071Sphingolipid signaling pathway4.77E-037P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Doxorubicinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Doxorubicinhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Doxorubicinhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Doxorubicinhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Doxorubicinhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Doxorubicinhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Doxorubicinhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Doxorubicinhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Doxorubicinhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Doxorubicinhsa04657IL-17 signaling pathway5.03E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Doxorubicinhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Doxorubicinhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Doxorubicinhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Doxorubicinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Doxorubicinhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Doxorubicinhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Doxorubicinhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Doxorubicinhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Doxorubicinhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Doxorubicinhsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Doxorubicinhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Doxorubicinhsa04918Thyroid hormone synthesis1.16E-046P51828, P17252, Q99941, P18848, P27824, P02768ADCY7, PRKCA, CREBL1, ATF4, CANX, ALBMore
Doxorubicinhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Doxorubicinhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Doxorubicinhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Doxorubicinhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Doxorubicinhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Doxorubicinhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Doxorubicinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Doxorubicinhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Doxorubicinhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Doxorubicinhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Doxorubicinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Doxorubicinhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Doxorubicinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Doxorubicinhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Doxorubicinhsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Doxorubicinhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Doxorubicinhsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Doxorubicinhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Doxorubicinhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Doxorubicinhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Doxorubicinhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Doxorubicinhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Doxorubicinhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Doxorubicinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Doxorubicinhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Doxorubicinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Doxorubicinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Doxorubicinhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Doxorubicinhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Doxorubicinhsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Doxorubicinhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Doxorubicinhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Doxorubicinhsa05418Fluid shear stress and atherosclerosis2.84E-0310Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Doxorubicin (SDC: 4.10)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
TOP2AP11388IC50880
TOP2AP11388IC501000
TOP2AP11388IC503000