PharmaCoNets of Doxercalciferol (SPCN: 49.33 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Doxercalciferolhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Doxercalciferolhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Doxercalciferolhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Doxercalciferolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Doxercalciferolhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Doxercalciferolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Doxercalciferolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Doxercalciferolhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Doxercalciferolhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Doxercalciferolhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Doxercalciferolhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Doxercalciferolhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Doxercalciferolhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Doxercalciferolhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Doxercalciferolhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Doxercalciferolhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Doxercalciferolhsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Doxercalciferolhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Doxercalciferolhsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Doxercalciferolhsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Doxercalciferolhsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Doxercalciferolhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Doxercalciferolhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Doxercalciferolhsa04070Phosphatidylinositol signaling system2.96E-023P19174, P49619, P27987PLCG1, DGKG, ITPKBMore
Doxercalciferolhsa04110Cell cycle1.65E-048Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Doxercalciferolhsa04114Oocyte meiosis1.45E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Doxercalciferolhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Doxercalciferolhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Doxercalciferolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Doxercalciferolhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Doxercalciferolhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Doxercalciferolhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Doxercalciferolhsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Doxercalciferolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Doxercalciferolhsa04370VEGF signaling pathway9.46E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Doxercalciferolhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Doxercalciferolhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Doxercalciferolhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Doxercalciferolhsa04520Adherens junction8.29E-031P08069IGF1RMore
Doxercalciferolhsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, Q02750, P08069, Q86SE9BMPR2, MAP2K1, IGF1R, PCGF5More
Doxercalciferolhsa04613Neutrophil extracellular trap formation1.56E-025P19174, P11215, Q13547, P62807, Q16778PLCG1, ITGAM, HDAC1, HIST1H2BC, HIST2H2BEMore
Doxercalciferolhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Doxercalciferolhsa04650Natural killer cell mediated cytotoxicity3.73E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Doxercalciferolhsa04658Th1 and Th2 cell differentiation1.01E-077P07766, P19174, P01730, P06239, P42224, P14784, Q13761CD3E, PLCG1, CD4, LCK, STAT1, IL2RB, RUNX3More
Doxercalciferolhsa04659Th17 cell differentiation6.83E-069P25963, P19174, P01730, P06239, P42224, P14784, P84022, Q13485, P07766NFKBIA, PLCG1, CD4, LCK, STAT1, IL2RB, SMAD3, SMAD4, CD3EMore
Doxercalciferolhsa04660T cell receptor signaling pathway4.08E-025P19174, P16333, P07766, P01730, P06239PLCG1, NCK1, CD3E, CD4, LCKMore
Doxercalciferolhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Doxercalciferolhsa04730Long-term depression1.16E-021P08069IGF1RMore
Doxercalciferolhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Doxercalciferolhsa04914Progesterone-mediated oocyte maturation2.23E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Doxercalciferolhsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Doxercalciferolhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Doxercalciferolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Doxercalciferolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Doxercalciferolhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Doxercalciferolhsa05034Alcoholism4.79E-023Q13547, P62807, Q16778HDAC1, HIST1H2BC, HIST2H2BEMore
Doxercalciferolhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Doxercalciferolhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Doxercalciferolhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Doxercalciferolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Doxercalciferolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Doxercalciferolhsa05169Epstein-Barr virus infection3.66E-025P01106, Q13547, Q13761, P42224, P07766MYC, HDAC1, RUNX3, STAT1, CD3EMore
Doxercalciferolhsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Doxercalciferolhsa05203Viral carcinogenesis9.16E-035Q13547, P12814, P06493, P62807, Q16778HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BEMore
Doxercalciferolhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Doxercalciferolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Doxercalciferolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Doxercalciferolhsa05214Glioma9.95E-031P08069IGF1RMore
Doxercalciferolhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Doxercalciferolhsa05218Melanoma6.63E-031P08069IGF1RMore
Doxercalciferolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Doxercalciferolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Doxercalciferolhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Doxercalciferolhsa05224Breast cancer1.49E-021P08069IGF1RMore
Doxercalciferolhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Doxercalciferolhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Doxercalciferolhsa05231Choline metabolism in cancer1.14E-043Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Doxercalciferolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.21E-066P19174, P07766, P06239, P42224, Q9HC35, P01730PLCG1, CD3E, LCK, STAT1, EML4, CD4More
Doxercalciferolhsa05322Systemic lupus erythematosus2.75E-023P62807, Q16778, P12814HIST1H2BC, HIST2H2BE, ACTN1More
Doxercalciferolhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore

Community members of Doxercalciferol (SDC: 4.69)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)