PharmaCoNets of Doxepin (SPCN: 49.71 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Doxepinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Doxepinhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Doxepinhsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Doxepinhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Doxepinhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Doxepinhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Doxepinhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Doxepinhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Doxepinhsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Doxepinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Doxepinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Doxepinhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Doxepinhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Doxepinhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Doxepinhsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Doxepinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Doxepinhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Doxepinhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Doxepinhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Doxepinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Doxepinhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Doxepinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Doxepinhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Doxepinhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Doxepinhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Doxepinhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Doxepinhsa04610Complement and coagulation cascades5.18E-061P0C0L4C4AMore
Doxepinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Doxepinhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Doxepinhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Doxepinhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Doxepinhsa04650Natural killer cell mediated cytotoxicity3.19E-0610P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Doxepinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Doxepinhsa04660T cell receptor signaling pathway2.78E-027P01375, Q08881, P20963, Q13191, P06239, Q16539, P49841TNF, ITK, CD247, CBLB, LCK, MAPK14, GSK3BMore
Doxepinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Doxepinhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Doxepinhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Doxepinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Doxepinhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Doxepinhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Doxepinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Doxepinhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Doxepinhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Doxepinhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Doxepinhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Doxepinhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Doxepinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Doxepinhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Doxepinhsa04966Collecting duct acid secretion1.29E-032P02730, P00918SLC4A1, CA2More
Doxepinhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Doxepinhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Doxepinhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Doxepinhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Doxepinhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Doxepinhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Doxepinhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Doxepinhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Doxepinhsa05133Pertussis3.60E-031P0C0L4C4AMore
Doxepinhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Doxepinhsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Doxepinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Doxepinhsa05144Malaria1.06E-034P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Doxepinhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Doxepinhsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Doxepinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Doxepinhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Doxepinhsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Doxepinhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Doxepinhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Doxepinhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Doxepinhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Doxepinhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Doxepinhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Doxepinhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Doxepinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Doxepinhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Doxepinhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Doxepinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Doxepinhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Doxepinhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Doxepinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.71E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Doxepinhsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Doxepinhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Doxepinhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Doxepin (SDC: 4.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)