PharmaCoNets of Dotatate-gallium-ga-68 (SPCN: 4.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dotatate-gallium-Ga-68hsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Dotatate-gallium-Ga-68hsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Dotatate-gallium-Ga-68hsa04060Cytokine-cytokine receptor interaction1.74E-027Q9UHF4, P16871, Q9UBD3, P47992, P02775, P32248, P51684IL20RA, IL7R, XCL2, XCL1, PPBP, CCR7, CCR6More
Dotatate-gallium-Ga-68hsa04061Viral protein interaction with cytokine and cytokine receptor7.74E-046P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4CCR6, CCR7, PPBP, XCL1, XCL2, IL20RAMore
Dotatate-gallium-Ga-68hsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Dotatate-gallium-Ga-68hsa04110Cell cycle2.06E-026Q9UJX4, O60566, Q09472, P24522, P04637, P49918ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1CMore
Dotatate-gallium-Ga-68hsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Dotatate-gallium-Ga-68hsa04210Apoptosis2.44E-0410P04637, P10415, O75460, P24522, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643TP53, BCL2, ERN1, GADD45A, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Dotatate-gallium-Ga-68hsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Dotatate-gallium-Ga-68hsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Dotatate-gallium-Ga-68hsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Dotatate-gallium-Ga-68hsa04613Neutrophil extracellular trap formation2.17E-0213O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dotatate-gallium-Ga-68hsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Dotatate-gallium-Ga-68hsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Dotatate-gallium-Ga-68hsa04640Hematopoietic cell lineage2.52E-029P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNFMore
Dotatate-gallium-Ga-68hsa04650Natural killer cell mediated cytotoxicity1.88E-029P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Dotatate-gallium-Ga-68hsa04657IL-17 signaling pathway2.81E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Dotatate-gallium-Ga-68hsa04658Th1 and Th2 cell differentiation7.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Dotatate-gallium-Ga-68hsa04659Th17 cell differentiation3.13E-028Q04759, Q16539, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Dotatate-gallium-Ga-68hsa04660T cell receptor signaling pathway8.00E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Dotatate-gallium-Ga-68hsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Dotatate-gallium-Ga-68hsa04912GnRH signaling pathway4.72E-024Q16539, Q9Y6R4, Q14643, P22694MAPK14, MAP3K4, ITPR1, PRKACBMore
Dotatate-gallium-Ga-68hsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Dotatate-gallium-Ga-68hsa04932Non-alcoholic fatty liver disease2.05E-035O43521, P18848, O75460, P01584, P13073BCL2L11, ATF4, ERN1, IL1B, COX4I1More
Dotatate-gallium-Ga-68hsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Dotatate-gallium-Ga-68hsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Dotatate-gallium-Ga-68hsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Dotatate-gallium-Ga-68hsa05022Pathways of neurodegeneration - multiple diseases1.98E-027P13073, O75460, P18848, P05141, P20333, P01584, P0DP24COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2More
Dotatate-gallium-Ga-68hsa05140Leishmaniasis1.31E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Dotatate-gallium-Ga-68hsa05144Malaria1.54E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Dotatate-gallium-Ga-68hsa05146Amoebiasis7.47E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Dotatate-gallium-Ga-68hsa05169Epstein-Barr virus infection2.71E-026P13765, P04637, P10415, P24522, P29728, P09693HLA-DOB, TP53, BCL2, GADD45A, OAS2, CD3GMore
Dotatate-gallium-Ga-68hsa05200Pathways in cancer4.87E-029P04637, Q9UJU2, Q09472, P14923, P10415, Q13077, O95267, P24522, P16871TP53, LEF1, EP300, JUP, BCL2, TRAF1, RASGRP1, GADD45A, IL7RMore
Dotatate-gallium-Ga-68hsa05202Transcriptional misregulation in cancer2.12E-0419Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Dotatate-gallium-Ga-68hsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Dotatate-gallium-Ga-68hsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Dotatate-gallium-Ga-68hsa05213Endometrial cancer1.91E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Dotatate-gallium-Ga-68hsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Dotatate-gallium-Ga-68hsa05216Thyroid cancer5.28E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Dotatate-gallium-Ga-68hsa05217Basal cell carcinoma1.34E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Dotatate-gallium-Ga-68hsa05222Small cell lung cancer1.94E-024P10415, Q13077, P04637, P24522BCL2, TRAF1, TP53, GADD45AMore
Dotatate-gallium-Ga-68hsa05224Breast cancer4.32E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Dotatate-gallium-Ga-68hsa05226Gastric cancer8.86E-035Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Dotatate-gallium-Ga-68hsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Dotatate-gallium-Ga-68hsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Dotatate-gallium-Ga-68hsa05332Graft-versus-host disease2.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Dotatate-gallium-ga-68 (SDC: 0.65)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)