PharmaCoNets of Dosulepin (SPCN: 48.77 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dosulepinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dosulepinhsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Dosulepinhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Dosulepinhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Dosulepinhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Dosulepinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dosulepinhsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Dosulepinhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Dosulepinhsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Dosulepinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dosulepinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dosulepinhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Dosulepinhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Dosulepinhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Dosulepinhsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Dosulepinhsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Dosulepinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dosulepinhsa03050Proteasome1.21E-021P28074PSMB5More
Dosulepinhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Dosulepinhsa03430Mismatch repair4.38E-021P20585MSH3More
Dosulepinhsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Dosulepinhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Dosulepinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dosulepinhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Dosulepinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dosulepinhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Dosulepinhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Dosulepinhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Dosulepinhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Dosulepinhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Dosulepinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dosulepinhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dosulepinhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Dosulepinhsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Dosulepinhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dosulepinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Dosulepinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dosulepinhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dosulepinhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Dosulepinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dosulepinhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dosulepinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Dosulepinhsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Dosulepinhsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Dosulepinhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dosulepinhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dosulepinhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dosulepinhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Dosulepinhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dosulepinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dosulepinhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Dosulepinhsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Dosulepinhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dosulepinhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Dosulepinhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dosulepinhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Dosulepinhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dosulepinhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dosulepinhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dosulepinhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dosulepinhsa05133Pertussis4.94E-021P0C0L4C4AMore
Dosulepinhsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Dosulepinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dosulepinhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dosulepinhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Dosulepinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dosulepinhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Dosulepinhsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Dosulepinhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Dosulepinhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dosulepinhsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Dosulepinhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dosulepinhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Dosulepinhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Dosulepinhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Dosulepinhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Dosulepinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Dosulepinhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dosulepinhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Dosulepinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dosulepinhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Dosulepinhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Dosulepinhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Dosulepinhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Dosulepinhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Dosulepin (SDC: 4.80)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)