PharmaCoNets of Dorzolamide (SPCN: 14.53 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dorzolamidehsa00030Pentose phosphate pathway1.09E-022P52209, P37837PGD, TALDO1More
Dorzolamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Dorzolamidehsa00220Arginine biosynthesis4.40E-021P15104GLULMore
Dorzolamidehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Dorzolamidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Dorzolamidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dorzolamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Dorzolamidehsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Dorzolamidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Dorzolamidehsa03020RNA polymerase2.51E-022P24928, P62487POLR2A, POLR2GMore
Dorzolamidehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Dorzolamidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dorzolamidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Dorzolamidehsa04217Necroptosis1.26E-049P01375, P48023, Q9NQC7, Q14765, P07900, P15104, P01584, Q99878, Q9H444TNF, FASLG, CYLD, STAT4, HSP90AA1, GLUL, IL1B, H2AC14, CHMP4BMore
Dorzolamidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Dorzolamidehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dorzolamidehsa04614Renin-angiotensin system2.52E-021P50052AGTR2More
Dorzolamidehsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Dorzolamidehsa04657IL-17 signaling pathway3.06E-038P07900, O00463, Q16539, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Dorzolamidehsa04664Fc epsilon RI signaling pathway2.18E-022P09917, P20292ALOX5, ALOX5APMore
Dorzolamidehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Dorzolamidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dorzolamidehsa04932Non-alcoholic fatty liver disease2.36E-036P01375, P49841, P48023, P01584, P12074, O15239TNF, GSK3B, FASLG, IL1B, COX6A1, NDUFA1More
Dorzolamidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dorzolamidehsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Dorzolamidehsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Dorzolamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Dorzolamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Dorzolamidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Dorzolamidehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dorzolamidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Dorzolamidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dorzolamidehsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Dorzolamidehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Dorzolamidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dorzolamidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Dorzolamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Dorzolamide (SDC: 3.09)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Reported00.00560.82670.16091.8171
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75493CA11Carbonic anhydraseNonerelated protein 11Predicted00.07450.061200.1597
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CA2P00918IC500.18
CA2P00918IC503.74
CA2P00918IC507.1
CA2P00918Ki0.199526
CA2P00918Ki0.28
CA2P00918Ki0.37
CA2P00918Kd0.043
CA4P22748IC5032
CA4P22748IC5043
CA4P22748Ki43
CA4P22748Ki8500
CA4P22748Ki8530