PharmaCoNets of Dopamine (SPCN: 27.92 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dopaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dopaminehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Dopaminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Dopaminehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Dopaminehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Dopaminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Dopaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dopaminehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Dopaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dopaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dopaminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Dopaminehsa02010ABC transporters1.20E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Dopaminehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Dopaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dopaminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Dopaminehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Dopaminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Dopaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dopaminehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Dopaminehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Dopaminehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Dopaminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dopaminehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Dopaminehsa04340Hedgehog signaling pathway3.01E-021Q9Y496KIF3AMore
Dopaminehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Dopaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dopaminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dopaminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dopaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Dopaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dopaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dopaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dopaminehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Dopaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dopaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dopaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dopaminehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Dopaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dopaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dopaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dopaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dopaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dopaminehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Dopaminehsa04966Collecting duct acid secretion1.38E-032P02730, P00918SLC4A1, CA2More
Dopaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dopaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dopaminehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Dopaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dopaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dopaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dopaminehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Dopaminehsa05133Pertussis4.24E-031P0C0L4C4AMore
Dopaminehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dopaminehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Dopaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Dopaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dopaminehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Dopaminehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dopaminehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Dopaminehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Dopaminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Dopaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dopaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dopaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Dopaminehsa05412Arrhythmogenic right ventricular cardiomyopathy5.12E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Dopaminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Dopaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Dopamine (SDC: 3.75)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P00441SOD1Superoxide dismutase [CuNoneZn]Reported10.53850.07130.48710.8991
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC500.000008
DRD2P14416IC501000
DRD2P14416IC50100000
DRD2P14416Ki1.9
DRD2P14416Ki2
DRD2P14416Ki2.9
SLC6A4P31645IC50>30000
SLC6A4P31645Ki>1100000