| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Domperidone | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Domperidone | hsa00051 | Fructose and mannose metabolism | 3.35E-02 | 2 | P60174, P04075 | TPI1, ALDOA | More | | | Domperidone | hsa00052 | Galactose metabolism | 1.06E-03 | 2 | P06280, O43451 | GLA, MGAM | More | | | Domperidone | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Domperidone | hsa00190 | Oxidative phosphorylation | 5.52E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Domperidone | hsa00220 | Arginine biosynthesis | 3.21E-04 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Domperidone | hsa00230 | Purine metabolism | 1.97E-03 | 3 | P21589, P20839, Q16774 | NT5E, IMPDH1, GUK1 | More | | | Domperidone | hsa00240 | Pyrimidine metabolism | 1.81E-02 | 1 | P21589 | NT5E | More | | | Domperidone | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Domperidone | hsa00330 | Arginine and proline metabolism | 4.86E-02 | 1 | P17707 | AMD1 | More | | | Domperidone | hsa00340 | Histidine metabolism | 4.52E-02 | 1 | O95954 | FTCD | More | | | Domperidone | hsa00350 | Tyrosine metabolism | 3.40E-02 | 1 | P28332 | ADH6 | More | | | Domperidone | hsa00500 | Starch and sucrose metabolism | 1.56E-06 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Domperidone | hsa00520 | Amino sugar and nucleotide sugar metabolism | 1.59E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Domperidone | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 1.91E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Domperidone | hsa00564 | Glycerophospholipid metabolism | 9.70E-03 | 2 | Q9Y259, P49619 | CHKB, DGKG | More | | | Domperidone | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Domperidone | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Domperidone | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Domperidone | hsa00600 | Sphingolipid metabolism | 2.67E-04 | 4 | Q9BX95, Q8TCT0, Q06136, P15289 | SGPP1, CERK, FVT1, ARSA | More | | | Domperidone | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Domperidone | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 7.10E-03 | 2 | P06865, O75752 | HEXA, B3GALNT1 | More | | | Domperidone | hsa00630 | Glyoxylate and dicarboxylate metabolism | 4.84E-06 | 3 | P40925, P40926, P15104 | MDH1, MDH2, GLUL | More | | | Domperidone | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | | Domperidone | hsa00670 | One carbon pool by folate | 7.39E-04 | 3 | O95954, P04818, Q99707 | FTCD, TYMS, MTR | More | | | Domperidone | hsa00730 | Thiamine metabolism | 2.46E-06 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Domperidone | hsa00740 | Riboflavin metabolism | 4.77E-02 | 1 | P30043 | BLVRB | More | | | Domperidone | hsa00760 | Nicotinate and nicotinamide metabolism | 9.09E-03 | 1 | P21589 | NT5E | More | | | Domperidone | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Domperidone | hsa00785 | Lipoic acid metabolism | 4.32E-02 | 1 | Q9Y234 | LIPT1 | More | | | Domperidone | hsa00860 | Porphyrin and chlorophyll metabolism | 3.15E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Domperidone | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Domperidone | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Domperidone | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 8.40E-04 | 3 | P78417, P28332, P11712 | GSTO1, ADH6, CYP2C9 | More | | | Domperidone | hsa00982 | Drug metabolism - cytochrome P450 | 8.40E-04 | 3 | P11712, P78417, P28332 | CYP2C9, GSTO1, ADH6 | More | | | Domperidone | hsa00983 | Drug metabolism - other enzymes | 9.82E-04 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Domperidone | hsa01040 | Biosynthesis of unsaturated fatty acids | 2.92E-02 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | | Domperidone | hsa01100 | Metabolic pathways | 6.99E-03 | 30 | Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737 | MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q9Y259 | CHKB | Choline/ethanolamine kinase | -0.751 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q13956 | PDE6H | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0.703 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | P49619 | DGKG | Diacylglycerol kinase gamma | 0.926 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | O95954 | FTCD | Formimidoyltransferase-cyclodeaminase | -0.718 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q02318 | CYP27A1 | Sterol 26-hydroxylase, mitochondrial | -0.879 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q9UBX8 | B4GALT6 | Beta-1,4-galactosyltransferase 6 | 0.869 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | P35573 | AGL | Glycogen debranching enzyme | 0.759 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 |
| | Domperidone | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Domperidone | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.91E-02 | 1 | P50213 | IDH3A | More | | | Domperidone | hsa01212 | Fatty acid metabolism | 4.62E-02 | 2 | P33121, P11310 | ACSL1, ACADM | More | | | Domperidone | hsa01230 | Biosynthesis of amino acids | 5.98E-05 | 7 | P60174, P04075, P51854, P60891, O75390, P15104, P37837 | TPI1, ALDOA, TKTL1, PRPS1, CS, GLUL, TALDO1 | More | | | Domperidone | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 3.18E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa01522 | Endocrine resistance | 4.08E-03 | 6 | P22694, P04049, Q02750, Q9UM47, P46527, P08069 | PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1R | More | | | Domperidone | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Domperidone | hsa01524 | Platinum drug resistance | 1.79E-02 | 2 | O15392, P11388 | BIRC5, TOP2A | More | | | Domperidone | hsa02010 | ABC transporters | 1.11E-05 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Domperidone | hsa03013 | RNA transport | 1.92E-07 | 16 | O14980, Q09161, O14893, P61326, P38919, Q9H307, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, Q14240, Q9BZI7, Q06787, P51114 | XPO1, NCBP1, GEMIN2, MAGOH, EIF4A3, PNN, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, EIF4A2, UPF3B, FMR1, FXR1 | More | | | Domperidone | hsa03015 | mRNA surveillance pathway | 4.81E-02 | 2 | Q9BZI7, O94913 | UPF3B, PCF11 | More | | | Domperidone | hsa03018 | RNA degradation | 5.00E-02 | 1 | Q9NQT4 | EXOSC5 | More | | | Domperidone | hsa03020 | RNA polymerase | 5.59E-03 | 3 | P30876, P24928, P62487 | POLR2B, POLR2A, POLR2G | More | | | Domperidone | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Domperidone | hsa03040 | Spliceosome | 3.44E-06 | 14 | Q14562, O43143, O60508, P17844, P08579, O75940, P51991, P61978, O75494, Q07955, Q01130, Q13243, P11142, O43447 | DHX8, DHX15, CDC40, DDX5, SNRPB2, SMNDC1, HNRPA3, HNRPK, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIH | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.708 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.853 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.818 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.837 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.702 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75940 | SMNDC1 | Survival of motor neuron-related-splicing factor 30 | 0.786 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75494 | FUSIP1 | Serine/arginine-rich splicing factor 10 | 0.73 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.776 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.835 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.758 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.87 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.761 |
| | Domperidone | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Domperidone | hsa03320 | PPAR signaling pathway | 1.62E-02 | 2 | Q13133, Q02318 | NR1H3, CYP27A1 | More | | | Domperidone | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Domperidone | hsa03450 | Non-homologous end-joining | 3.17E-03 | 2 | Q9NP87, P13010 | POLM, XRCC5 | More | | | Domperidone | hsa03460 | Fanconi anemia pathway | 2.71E-02 | 1 | O94782 | USP1 | More | | | Domperidone | hsa04010 | MAPK signaling pathway | 1.69E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa04012 | ErbB signaling pathway | 1.36E-03 | 5 | Q13153, P16333, P19174, P01106, P04049 | PAK1, NCK1, PLCG1, MYC, RAF1 | More | | | Domperidone | hsa04014 | Ras signaling pathway | 4.45E-04 | 14 | Q02750, P04049, P20827, Q15389, Q9NRA1, P49767, P08069, P17252, P21359, P0DP23, P62873, P62879, P19174, P22694 | MAP2K1, RAF1, EFNA1, ANGPT1, PDGFC, VEGFC, IGF1R, PRKCA, NF1, CALM1, GNB1, GNB2, PLCG1, PRKACB | More | | | Domperidone | hsa04015 | Rap1 signaling pathway | 4.67E-04 | 10 | P04049, P20827, Q9NRA1, P49767, P08069, P06213, O00522, P0DP23, P17252, P19174 | RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, KRIT1, CALM1, PRKCA, PLCG1 | More | | | Domperidone | hsa04020 | Calcium signaling pathway | 2.54E-03 | 9 | P17252, P19174, P0DP24, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767 | PRKCA, PLCG1, CALM2, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFC | More | | | Domperidone | hsa04022 | cGMP-PKG signaling pathway | 3.15E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04024 | cAMP signaling pathway | 2.50E-04 | 9 | P51828, P42338, P0DP24, P0DP23, P23634, P04049, Q13370, Q13009, Q13153 | ADCY7, PIK3CB, CALM2, CALM1, ATP2B4, RAF1, PDE3B, TIAM1, PAK1 | More | | | Domperidone | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 2.43E-02 | 4 | P09341, P02775, P47992, Q9UBD3 | CXCL1, PPBP, XCL1, XCL2 | More | | | Domperidone | hsa04062 | Chemokine signaling pathway | 3.98E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04064 | NF-kappa B signaling pathway | 2.36E-04 | 14 | P10415, O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7 | BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD | More | | | Domperidone | hsa04066 | HIF-1 signaling pathway | 1.49E-02 | 5 | P08069, P17252, Q15389, Q02750, P46527 | IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1B | More | | | Domperidone | hsa04068 | FoxO signaling pathway | 3.80E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa04070 | Phosphatidylinositol signaling system | 5.35E-04 | 8 | P19174, P0DP23, P42338, P23743, Q86XP1, P27987, Q96DU7, P17252 | PLCG1, CALM1, PIK3CB, DGKA, DGKH, ITPKB, ITPKC, PRKCA | More | | | Domperidone | hsa04071 | Sphingolipid signaling pathway | 8.87E-07 | 10 | P04049, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | RAF1, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.704 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.841 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.809 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.787 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | | O95551 | TTRAP | Tyrosyl-DNA phosphodiesterase 2 | Q13510 | ASAH1 | Acid ceramidase | 0.82 | | O95551 | TTRAP | Tyrosyl-DNA phosphodiesterase 2 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.723 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.712 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.781 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | O95551 | TTRAP | Tyrosyl-DNA phosphodiesterase 2 | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.707 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.822 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | -0.866 |
| | Domperidone | hsa04072 | Phospholipase D signaling pathway | 2.82E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04080 | Neuroactive ligand-receptor interaction | 2.61E-03 | 10 | P08311, P28472, Q15722, P21453, Q9H228, P21462, P21730, Q16581, P07550, P35318 | CTSG, GABRB3, LTB4R, S1PR1, EDG8, FPR1, C5AR1, C3AR1, ADRB2, ADM | More | | | Domperidone | hsa04110 | Cell cycle | 1.01E-05 | 8 | Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106 | ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC | More | | | Domperidone | hsa04114 | Oocyte meiosis | 1.22E-04 | 10 | Q9Y6D9, P51812, Q02750, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362, P08069 | MAD1L1, RPS6KA3, MAP2K1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C, IGF1R | More | | | Domperidone | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Domperidone | hsa04140 | Autophagy - animal | 7.72E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Domperidone | hsa04141 | Protein processing in endoplasmic reticulum | 1.91E-03 | 6 | P18848, Q15437, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | | Domperidone | hsa04142 | Lysosome | 2.45E-03 | 9 | Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Domperidone | hsa04144 | Endocytosis | 2.89E-03 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Domperidone | hsa04145 | Phagosome | 1.69E-03 | 11 | Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, P35443, P13765, P25774 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, THBS4, HLA-DOB, CTSS | More | | | Domperidone | hsa04146 | Peroxisome | 1.43E-02 | 4 | O00623, P56589, Q9UKG9, P33121 | PEX12, PEX3, CROT, ACSL1 | More | | | Domperidone | hsa04150 | mTOR signaling pathway | 5.20E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Domperidone | hsa04151 | PI3K-Akt signaling pathway | 3.91E-03 | 7 | P62753, P27348, P07900, P22105, Q99941, P18848, O00141 | RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGK | More | | | Domperidone | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Domperidone | hsa04210 | Apoptosis | 3.64E-03 | 5 | O76075, P01375, Q9NR28, Q16548, P04049 | DFFB, TNF, DIABLO, BCL2A1, RAF1 | More | | | Domperidone | hsa04211 | Longevity regulating pathway | 5.33E-03 | 4 | P08069, P51828, Q99941, P18848 | IGF1R, ADCY7, CREBL1, ATF4 | More | | | Domperidone | hsa04213 | Longevity regulating pathway - multiple species | 8.54E-03 | 4 | P08069, Q08828, P51828, P0DMV8 | IGF1R, ADCY1, ADCY7, HSPA1A | More | | | Domperidone | hsa04217 | Necroptosis | 7.22E-05 | 13 | P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID | More | | | Domperidone | hsa04218 | Cellular senescence | 3.31E-03 | 5 | P04049, P01889, P10321, P05141, P12236 | RAF1, HLA-B, HLA-C, SLC25A5, SLC25A6 | More | | | Domperidone | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.86E-05 | 9 | P07550, P51828, P22694, Q99941, P18848, Q13362, P0DP24, Q13557, P23634 | ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2D, ATP2B4 | More | | | Domperidone | hsa04270 | Vascular smooth muscle contraction | 2.27E-03 | 7 | P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318 | CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Domperidone | hsa04310 | Wnt signaling pathway | 2.60E-02 | 3 | O15169, P17612, P67870 | AXIN1, PRKACA, CSNK2B | More | | | Domperidone | hsa04330 | Notch signaling pathway | 2.77E-02 | 2 | Q92542, P49768 | NCSTN, PSEN1 | More | | | Domperidone | hsa04340 | Hedgehog signaling pathway | 1.53E-04 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Domperidone | hsa04360 | Axon guidance | 5.48E-04 | 8 | P16333, P20827, O95631, P17252, P42338, P23528, P04049, P19174 | NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, RAF1, PLCG1 | More | | | Domperidone | hsa04370 | VEGF signaling pathway | 9.75E-04 | 4 | P16298, Q05397, Q02750, P04049 | PPP3CB, PTK2, MAP2K1, RAF1 | More | | | Domperidone | hsa04371 | Apelin signaling pathway | 2.65E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04380 | Osteoclast differentiation | 6.02E-04 | 7 | Q9UQC2, Q16539, P14778, P08637, O75015, P01375, Q8N149 | GAB2, MAPK14, IL1R1, FCGR3A, FCGR3B, TNF, LILRA2 | More | | | Domperidone | hsa04390 | Hippo signaling pathway | 6.38E-04 | 6 | P63261, O15105, P04628, Q9UJU2, O43623, Q13489 | ACTG1, SMAD7, WNT1, LEF1, SNAI2, BIRC3 | More | | | Domperidone | hsa04392 | Hippo signaling pathway - multiple species | 1.51E-02 | 1 | Q13153 | PAK1 | More | | | Domperidone | hsa04510 | Focal adhesion | 1.18E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Domperidone | hsa04530 | Tight junction | 3.60E-03 | 5 | P63261, P16989, P56750, Q92974, Q14247 | ACTG1, CSDA, CLDN17, ARHGEF2, CTTN | More | | | Domperidone | hsa04540 | Gap junction | 2.38E-04 | 7 | P17252, P22694, Q13509, P68371, Q02750, P04049, Q9NRA1 | PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, RAF1, PDGFC | More | | | Domperidone | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 3.80E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa04610 | Complement and coagulation cascades | 4.27E-06 | 1 | P0C0L4 | C4A | More | | | Domperidone | hsa04612 | Antigen processing and presentation | 1.54E-06 | 10 | P13765, P48382, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF | More | | | Domperidone | hsa04613 | Neutrophil extracellular trap formation | 4.21E-07 | 20 | P04049, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P08637, O75015, P21730, P21462, O43315, Q16539 | RAF1, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3A, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O60603 | TLR2 | Toll-like receptor 2 | 0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20160 | AZU1 | Azurocidin | 0.781 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08311 | CTSG | Cathepsin G | 0.829 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | Q96PH1 | NOX5 | NADPH oxidase 5 | P08637 | FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III-A | 0.833 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.852 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | Q96PH1 | NOX5 | NADPH oxidase 5 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.833 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.888 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.833 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O43315 | AQP9 | Aquaporin-9 | 0.897 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Domperidone | hsa04621 | NOD-like receptor signaling pathway | 1.52E-04 | 14 | Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838 | MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Domperidone | hsa04623 | Cytosolic DNA-sensing pathway | 1.16E-05 | 5 | P01584, P01568, Q13546, P25963, Q8NHW4 | IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2 | More | | | Domperidone | hsa04625 | C-type lectin receptor signaling pathway | 1.28E-03 | 6 | Q9ULY5, P04049, Q13153, P20749, P01375, Q16539 | CLEC4E, RAF1, PAK1, BCL3, TNF, MAPK14 | More | | | Domperidone | hsa04630 | JAK-STAT signaling pathway | 1.49E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04640 | Hematopoietic cell lineage | 4.95E-02 | 3 | P01730, P06127, P09564 | CD4, CD5, CD7 | More | | | Domperidone | hsa04650 | Natural killer cell mediated cytotoxicity | 1.59E-12 | 18 | P01375, P06239, O60880, P20963, Q29983, P10321, P01889, P04049, Q13153, Q13241, P26718, O14931, P08637, O75015, P26717, Q07444, Q14953, P26715 | TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3A, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.727 | | P67870 | CSNK2B | Casein kinase II subunit beta | Q29983 | MICA | MHC class I polypeptide-related sequence A | 0.705 | | P67870 | CSNK2B | Casein kinase II subunit beta | P10321 | HLA-C | HLA class I histocompatibility antigen, C alpha chain | 0.705 | | P67870 | CSNK2B | Casein kinase II subunit beta | P01889 | HLA-B | HLA class I histocompatibility antigen, B alpha chain | 0.705 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | 1 | | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.78 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.767 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.701 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.818 | | Q96PH1 | NOX5 | NADPH oxidase 5 | P08637 | FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III-A | 0.833 | | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | | Q96PH1 | NOX5 | NADPH oxidase 5 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.833 | | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.726 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.829 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.726 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 |
| | Domperidone | hsa04657 | IL-17 signaling pathway | 1.93E-08 | 13 | P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P19875, P14780, P04141, P80188, P01375, P06702 | NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.826 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.776 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.815 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09341 | CXCL1 | Growth-regulated alpha protein | 0.74 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.771 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.83 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.917 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.75 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.721 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P04141 | CSF2 | Granulocyte-macrophage colony-stimulating factor | 0.757 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.706 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.888 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | -0.757 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P06702 | S100A9 | Protein S100-A9 | -0.71 |
| | Domperidone | hsa04658 | Th1 and Th2 cell differentiation | 1.37E-08 | 11 | Q04759, P20963, P09693, Q16539, P06239, Q14765, P42226, P23771, Q9UL17, P13765, Q13761 | PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P07305 | H1-0 | Histone H1.0 | Q04759 | PRKCQ | Protein kinase C theta type | -0.706 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.734 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.812 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P07305 | H1-0 | Histone H1.0 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.716 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.736 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P42226 | STAT6 | Signal transducer and activator of transcription 6 | 0.852 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.753 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P07305 | H1-0 | Histone H1.0 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.772 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.849 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.738 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.705 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P07305 | H1-0 | Histone H1.0 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.859 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.73 |
| | Domperidone | hsa04659 | Th17 cell differentiation | 1.08E-05 | 13 | Q04759, Q16539, P06239, P42224, P42226, P14784, P13765, P40189, Q9UL17, P23771, P08238, P09693, P20963 | PRKCQ, MAPK14, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL6ST, TBX21, GATA3, HSP90AB1, CD3G, CD247 | More | | | Domperidone | hsa04660 | T cell receptor signaling pathway | 1.61E-09 | 20 | P01375, P04141, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P19174, Q13153, P16333, P20963, P09693, P01732, Q13191, P06239, P29350, P04049, Q16539, P49841 | TNF, CSF2, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PLCG1, PAK1, NCK1, CD247, CD3G, CD8A, CBLB, LCK, PTPN6, RAF1, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P04141 | CSF2 | Granulocyte-macrophage colony-stimulating factor | 0.757 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.734 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.758 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.73 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.737 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.8 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.752 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.739 | | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | 1 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P16333 | NCK1 | Cytoplasmic protein NCK1 | -0.703 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.812 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.72 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.763 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | -0.797 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.815 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 |
| | Domperidone | hsa04662 | B cell receptor signaling pathway | 8.00E-05 | 6 | P42338, P60033, P07948, P21854, Q8N149, P04049 | PIK3CB, CD81, LYN, CD72, LILRA2, RAF1 | More | | | Domperidone | hsa04664 | Fc epsilon RI signaling pathway | 4.48E-04 | 7 | P01375, Q16539, P42338, Q9UQC2, P07948, P04049, P09917 | TNF, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5 | More | | | Domperidone | hsa04666 | Fc gamma R-mediated phagocytosis | 1.87E-03 | 6 | P08637, O75015, P42338, P04049, P23528, P14598 | FCGR3A, FCGR3B, PIK3CB, RAF1, CFL1, NCF1 | More | | | Domperidone | hsa04668 | TNF signaling pathway | 2.12E-03 | 7 | P01375, O00463, Q16539, P18848, P19875, P20749, P14780 | TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9 | More | | | Domperidone | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | | Domperidone | hsa04713 | Circadian entrainment | 3.32E-02 | 4 | P0DP23, P17252, P62873, O15055 | CALM1, PRKCA, GNB1, PER2 | More | | | Domperidone | hsa04714 | Thermogenesis | 1.49E-04 | 8 | Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521 | MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD | More | | | Domperidone | hsa04720 | Long-term potentiation | 2.02E-05 | 9 | P17252, P16298, Q15418, P51812, P18848, P17612, P22694, Q02750, P04049 | PRKCA, PPP3CB, RPS6KA1, RPS6KA3, ATF4, PRKACA, PRKACB, MAP2K1, RAF1 | More | | | Domperidone | hsa04722 | Neurotrophin signaling pathway | 7.10E-03 | 4 | P04049, P49841, O43524, P48023 | RAF1, GSK3B, FOXO3, FASLG | More | | | Domperidone | hsa04723 | Retrograde endocannabinoid signaling | 2.60E-02 | 3 | P48169, P62873, P17612 | GABRA4, GNB1, PRKACA | More | | | Domperidone | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Domperidone | hsa04725 | Cholinergic synapse | 1.73E-05 | 12 | P51828, P17612, P22694, P17252, P62873, P62879, P63218, P50151, P18848, Q13557, P42338, Q02750 | ADCY7, PRKACA, PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, MAP2K1 | More | | | Domperidone | hsa04726 | Serotonergic synapse | 4.46E-03 | 5 | P22694, P17252, P62879, P04049, Q02750 | PRKACB, PRKCA, GNB2, RAF1, MAP2K1 | More | | | Domperidone | hsa04727 | GABAergic synapse | 1.27E-04 | 10 | P62873, P62879, P63218, P50151, P48169, P15104, P17612, P22694, O60296, P17252 | GNB1, GNB2, GNG5, GNG10, GABRA4, GLUL, PRKACA, PRKACB, TRAK2, PRKCA | More | | | Domperidone | hsa04728 | Dopaminergic synapse | 1.68E-03 | 6 | P17612, P62873, Q99941, P18848, Q13557, O15516 | PRKACA, GNB1, CREBL1, ATF4, CAMK2D, CLOCK | More | | | Domperidone | hsa04730 | Long-term depression | 1.25E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Domperidone | hsa04740 | Olfactory transduction | 2.08E-03 | 3 | P62873, Q9H255, P17612 | GNB1, OR51E2, PRKACA | More | | | Domperidone | hsa04742 | Taste transduction | 1.10E-04 | 3 | P48169, P30939, P17612 | GABRA4, HTR1F, PRKACA | More | | | Domperidone | hsa04744 | Phototransduction | 1.18E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Domperidone | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.01E-02 | 4 | P01584, Q08828, P51828, P0DP23 | IL1B, ADCY1, ADCY7, CALM1 | More | | | Domperidone | hsa04810 | Regulation of actin cytoskeleton | 3.81E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04910 | Insulin signaling pathway | 2.51E-03 | 4 | P22694, P06737, P04049, P49841 | PRKACB, PYGL, RAF1, GSK3B | More | | | Domperidone | hsa04911 | Insulin secretion | 4.03E-04 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Domperidone | hsa04912 | GnRH signaling pathway | 3.36E-03 | 4 | P51828, P18848, Q13557, P04049 | ADCY7, ATF4, CAMK2D, RAF1 | More | | | Domperidone | hsa04913 | Ovarian steroidogenesis | 5.67E-04 | 4 | P42330, P22694, P06213, P08069 | AKR1C3, PRKACB, INSR, IGF1R | More | | | Domperidone | hsa04914 | Progesterone-mediated oocyte maturation | 1.84E-04 | 9 | P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049 | IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1 | More | | | Domperidone | hsa04915 | Estrogen signaling pathway | 1.56E-04 | 10 | P04049, Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788 | RAF1, CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1 | More | | | Domperidone | hsa04916 | Melanogenesis | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04917 | Prolactin signaling pathway | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | | Domperidone | hsa04919 | Thyroid hormone signaling pathway | 1.07E-04 | 9 | P17252, P49841, P04049, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47 | PRKCA, GSK3B, RAF1, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3 | More | | | Domperidone | hsa04920 | Adipocytokine signaling pathway | 4.31E-02 | 2 | Q9Y478, Q96RR4 | PRKAB1, CAMKK2 | More | | | Domperidone | hsa04921 | Oxytocin signaling pathway | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa04923 | Regulation of lipolysis in adipocytes | 3.76E-02 | 1 | P06213 | INSR | More | | | Domperidone | hsa04924 | Renin secretion | 2.98E-03 | 4 | P22694, P07550, Q13370, P0DP23 | PRKACB, ADRB2, PDE3B, CALM1 | More | | | Domperidone | hsa04925 | Aldosterone synthesis and secretion | 5.96E-05 | 6 | Q99941, P18848, P51828, P0DP24, Q13557, P23634 | CREBL1, ATF4, ADCY7, CALM2, CAMK2D, ATP2B4 | More | | | Domperidone | hsa04926 | Relaxin signaling pathway | 1.14E-05 | 12 | P42338, P63218, P50151, Q99941, P18848, P22694, P49767, P14780, P51828, P04049, P30679, P49407 | PIK3CB, GNG5, GNG10, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY7, RAF1, GNA15, ARRB1 | More | | | Domperidone | hsa04927 | Cortisol synthesis and secretion | 2.72E-04 | 4 | Q99941, P18848, P51828, P22694 | CREBL1, ATF4, ADCY7, PRKACB | More | | | Domperidone | hsa04928 | Parathyroid hormone synthesis, secretion and action | 8.88E-04 | 8 | P51828, P22694, P04049, Q02750, P17252, Q99941, P18848, Q9Y5Q3 | ADCY7, PRKACB, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, MAFB | More | | | Domperidone | hsa04929 | GnRH secretion | 3.50E-03 | 3 | P42338, P49407, P04049 | PIK3CB, ARRB1, RAF1 | More | | | Domperidone | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Domperidone | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Domperidone | hsa04932 | Non-alcoholic fatty liver disease | 7.01E-05 | 11 | P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521 | TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD | More | | | Domperidone | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.72E-02 | 5 | P42224, Q12778, P49767, P17252, P19174 | STAT1, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Domperidone | hsa04934 | Cushing syndrome | 6.81E-05 | 6 | Q99941, P18848, P51828, P17612, O15169, Q13557 | CREBL1, ATF4, ADCY7, PRKACA, AXIN1, CAMK2D | More | | | Domperidone | hsa04935 | Growth hormone synthesis, secretion and action | 5.33E-03 | 4 | P51828, P04049, Q99941, P18848 | ADCY7, RAF1, CREBL1, ATF4 | More | | | Domperidone | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Domperidone | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Domperidone | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 2.09E-02 | 2 | P23634, P62491 | ATP2B4, RAB11A | More | | | Domperidone | hsa04962 | Vasopressin-regulated water reabsorption | 1.80E-02 | 2 | P62491, P46459 | RAB11A, NSF | More | | | Domperidone | hsa04964 | Proximal tubule bicarbonate reclamation | 2.17E-03 | 1 | P00918 | CA2 | More | | | Domperidone | hsa04966 | Collecting duct acid secretion | 2.17E-03 | 1 | P00918 | CA2 | More | | | Domperidone | hsa04970 | Salivary secretion | 5.20E-06 | 9 | P07550, Q08828, P51828, P22694, P23634, P17252, P0DP24, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM2, CALM1, CAMP | More | | | Domperidone | hsa04972 | Pancreatic secretion | 4.94E-03 | 3 | P23634, P51828, P62491 | ATP2B4, ADCY7, RAB11A | More | | | Domperidone | hsa04976 | Bile secretion | 1.90E-04 | 6 | O43315, Q08828, P51828, P22694, P08183, Q14032 | AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | | Domperidone | hsa05010 | Alzheimer disease | 9.83E-03 | 7 | P13073, P18848, O15169, P67870, P05141, P12236, P28070 | COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4 | More | | | Domperidone | hsa05012 | Parkinson disease | 2.43E-03 | 12 | Q16718, O14521, P13073, P05141, P12236, P17612, P18848, P28070, P19174, P0DP23, Q13509, P68371 | NDUFA5, SDHD, COX4I1, SLC25A5, SLC25A6, PRKACA, ATF4, PSMB4, PLCG1, CALM1, TUBB3, TUBB2C | More | | | Domperidone | hsa05016 | Huntington disease | 2.46E-02 | 9 | O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12 | More | | | Domperidone | hsa05020 | Prion disease | 5.07E-05 | 13 | P17612, Q16718, O14521, P13073, Q92736, P18848, P05141, P12236, P28070, O60282, P49841, P67870, Q16539 | PRKACA, NDUFA5, SDHD, COX4I1, RYR2, ATF4, SLC25A5, SLC25A6, PSMB4, KIF5C, GSK3B, CSNK2B, MAPK14 | More | | | Domperidone | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.39E-04 | 18 | Q13509, P68371, P49841, P67870, Q16718, O14521, P13073, P18848, Q13561, P19174, P05141, P12236, P17252, Q16539, O15169, Q08752, P0DP23, P28070 | TUBB3, TUBB2C, GSK3B, CSNK2B, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, PLCG1, SLC25A5, SLC25A6, PRKCA, MAPK14, AXIN1, PPID, CALM1, PSMB4 | More | | | Domperidone | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Domperidone | hsa05031 | Amphetamine addiction | 8.84E-04 | 5 | Q13557, P22694, Q99941, P18848, Q13547 | CAMK2D, PRKACB, CREBL1, ATF4, HDAC1 | More | | | Domperidone | hsa05032 | Morphine addiction | 1.01E-02 | 3 | P17612, P62873, P48169 | PRKACA, GNB1, GABRA4 | More | | | Domperidone | hsa05034 | Alcoholism | 1.91E-05 | 9 | P17612, P18848, P62873, P04049, Q93077, P62807, O60814, P84243, P68431 | PRKACA, ATF4, GNB1, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Domperidone | hsa05100 | Bacterial invasion of epithelial cells | 4.54E-02 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Domperidone | hsa05110 | Vibrio cholerae infection | 2.60E-03 | 4 | Q13488, Q99437, P17252, P19174 | TCIRG1, ATP6V0B, PRKCA, PLCG1 | More | | | Domperidone | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 3.10E-03 | 5 | Q16539, Q13153, P09341, P25024, P25025 | MAPK14, PAK1, CXCL1, CXCR1, CXCR2 | More | | | Domperidone | hsa05131 | Shigellosis | 2.93E-02 | 6 | Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315 | RRAGD, UBB, SEPT6, ELMO2, PTK2, ATM | More | | | Domperidone | hsa05132 | Salmonella infection | 2.30E-05 | 14 | P25963, P08238, P04049, Q9UJU2, O00471, Q13546, Q13489, P04406, O75369, Q13561, O60282, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, RAF1, LEF1, EXOC5, RIPK1, BIRC3, GAPDH, FLNB, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41 | More | | | Domperidone | hsa05133 | Pertussis | 3.02E-03 | 1 | P0C0L4 | C4A | More | | | Domperidone | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | | | Domperidone | hsa05140 | Leishmaniasis | 2.86E-05 | 13 | P13612, P08637, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080 | ITGA4, FCGR3A, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4 | More | | | Domperidone | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Domperidone | hsa05144 | Malaria | 1.94E-04 | 6 | P60033, P69905, P68871, P01375, P35443, P26718 | CD81, HBA2, HBB, TNF, THBS4, KLRK1 | More | | | Domperidone | hsa05146 | Amoebiasis | 5.02E-05 | 11 | P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG | More | | | Domperidone | hsa05150 | Staphylococcus aureus infection | 5.18E-07 | 13 | P0C0L4, P21730, P21462, P08637, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P12838, P49913 | C4A, C5AR1, FPR1, FCGR3A, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Domperidone | hsa05152 | Tuberculosis | 4.65E-03 | 3 | P04049, Q99437, P25774 | RAF1, ATP6V0B, CTSS | More | | | Domperidone | hsa05160 | Hepatitis C | 1.40E-03 | 5 | P60033, P04049, P49841, P01375, P48023 | CD81, RAF1, GSK3B, TNF, FASLG | More | | | Domperidone | hsa05161 | Hepatitis B | 5.33E-03 | 4 | P04049, Q99941, P18848, P27348 | RAF1, CREBL1, ATF4, YWHAQ | More | | | Domperidone | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Domperidone | hsa05163 | Human cytomegalovirus infection | 5.24E-05 | 21 | P04049, P01375, P01889, P10321, P62873, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P17612, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463 | RAF1, TNF, HLA-B, HLA-C, GNB1, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACA, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | | P67870 | CSNK2B | Casein kinase II subunit beta | P01889 | HLA-B | HLA class I histocompatibility antigen, B alpha chain | 0.705 | | P67870 | CSNK2B | Casein kinase II subunit beta | P10321 | HLA-C | HLA class I histocompatibility antigen, C alpha chain | 0.705 | | P67870 | CSNK2B | Casein kinase II subunit beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.704 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | P67870 | CSNK2B | Casein kinase II subunit beta | P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | 0.75 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | | P67870 | CSNK2B | Casein kinase II subunit beta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.733 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 |
| | Domperidone | hsa05164 | Influenza A | 3.65E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05165 | Human papillomavirus infection | 4.71E-03 | 10 | P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315 | CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM | More | | | Domperidone | hsa05166 | Human T-cell leukemia virus 1 infection | 7.39E-03 | 7 | Q9Y490, P01889, P10321, P05141, P12236, P17612, P18848 | TLN1, HLA-B, HLA-C, SLC25A5, SLC25A6, PRKACA, ATF4 | More | | | Domperidone | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.42E-04 | 12 | P01568, P42224, P25963, P40189, P01889, P10321, P62873, P19174, P04049, Q29983, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, IL6ST, HLA-B, HLA-C, GNB1, PLCG1, RAF1, MICA, CSF2, CALM1 | More | | | Domperidone | hsa05168 | Herpes simplex virus 1 infection | 4.15E-06 | 23 | O00463, O60603, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q16629, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415 | TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.711 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | O60603 | TLR2 | Toll-like receptor 2 | -0.776 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.825 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P01568 | IFNA21 | Interferon alpha-21 | 0.729 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Q05823 | RNASEL | 2-5A-dependent ribonuclease | -0.739 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q9GZY0 | NXF2; NXF2B | Nuclear RNA export factor 2 | 0.704 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.912 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.776 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.703 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.758 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.781 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.87 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Q16629 | SFRS7 | Serine/arginine-rich splicing factor 7 | 0.752 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Q9Y2A4 | ZNF443 | Zinc finger protein 443 | 0.731 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q13398 | ZNF211 | Zinc finger protein 211 | -0.759 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P51522 | ZNF83 | Zinc finger protein 83 | 0.851 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Q9NR11 | ZNF302 | Zinc finger protein 302 | 0.734 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | P17097 | ZNF7 | Zinc finger protein 7 | 0.798 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P17038 | ZNF43 | Zinc finger protein 43 | 0.718 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q03923 | ZNF85 | Zinc finger protein 85 | 0.79 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Q03923 | ZNF85 | Zinc finger protein 85 | 0.838 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P52738 | ZNF140 | Zinc finger protein 140 | 0.717 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | P52738 | ZNF140 | Zinc finger protein 140 | 0.71 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75820 | ZNF189 | Zinc finger protein 189 | 0.715 | | Q13627 | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | O75820 | ZNF189 | Zinc finger protein 189 | 0.768 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q9UDV6 | ZNF212 | Zinc finger protein 212 | -0.808 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Q9UDV6 | ZNF212 | Zinc finger protein 212 | -0.713 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 | | Q8IVH8 | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.72 |
| | Domperidone | hsa05169 | Epstein-Barr virus infection | 6.15E-03 | 17 | P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963 | HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247 | More | | | Domperidone | hsa05170 | Human immunodeficiency virus 1 infection | 1.21E-02 | 6 | P04049, Q02750, P62879, P16298, Q05397, Q13315 | RAF1, MAP2K1, GNB2, PPP3CB, PTK2, ATM | More | | | Domperidone | hsa05171 | Coronavirus disease - COVID-19 | 1.36E-02 | 7 | P25963, P42224, P01568, P40189, P04141, P19174, P17252 | NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA | More | | | Domperidone | hsa05200 | Pathways in cancer | 2.27E-03 | 16 | P42338, P08238, P42224, P25963, P19174, P17252, P43246, P14923, P49767, Q12778, P62873, O75293, P0DP23, P01568, P14784, P40189 | PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, JUP, VEGFC, FOXO1, GNB1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.826 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.912 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.739 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.739 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P17252 | PRKCA | Protein kinase C alpha type | 0.832 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.768 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P14923 | JUP | Junction plakoglobin | 0.735 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P49767 | VEGFC | Vascular endothelial growth factor C | 0.761 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q12778 | FOXO1 | Forkhead box protein O1 | 0.753 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.833 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.713 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P0DP23 | CALM1 | Calmodulin-1 | -0.761 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P01568 | IFNA21 | Interferon alpha-21 | 0.729 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | P40189 | IL6ST | Interleukin-6 receptor subunit beta | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Domperidone | hsa05202 | Transcriptional misregulation in cancer | 1.03E-06 | 20 | Q12778, Q15532, Q13315, P14780, P27930, Q15744, Q16548, Q13077, Q15652, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, JMJD1C, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q13315 | ATM | Serine-protein kinase ATM | Q12778 | FOXO1 | Forkhead box protein O1 | 0.821 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15532 | SS18 | Protein SSXT | -0.772 | | Q13315 | ATM | Serine-protein kinase ATM | Q13315 | ATM | Serine-protein kinase ATM | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.917 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.881 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | Q13315 | ATM | Serine-protein kinase ATM | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.709 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.967 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.783 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15652 | JMJD1C | Probable JmjC domain-containing histone demethylation protein 2C | 0.754 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O15550 | UTX | Lysine-specific demethylase 6A | 0.724 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q13315 | ATM | Serine-protein kinase ATM | P46527 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | 0.708 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q13315 | ATM | Serine-protein kinase ATM | P05164 | MPO | Myeloperoxidase | -0.725 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P12838 | DEFA4 | Neutrophil defensin 4 | 0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q13315 | ATM | Serine-protein kinase ATM | P08246 | ELA2 | Neutrophil elastase | -0.742 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.742 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | Q13315 | ATM | Serine-protein kinase ATM | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.741 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.847 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 |
| | Domperidone | hsa05203 | Viral carcinogenesis | 5.35E-05 | 10 | Q99941, P18848, P27348, Q15283, P01889, P10321, P61978, P17612, P62807, O60814 | CREBL1, ATF4, YWHAQ, RASA2, HLA-B, HLA-C, HNRPK, PRKACA, HIST1H2BC, H2BC12 | More | | | Domperidone | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Domperidone | hsa05205 | Proteoglycans in cancer | 2.86E-03 | 7 | P04049, P14780, P01375, P08069, P23588, Q13635, P22694 | RAF1, MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB | More | | | Domperidone | hsa05206 | MicroRNAs in cancer | 1.19E-02 | 7 | P46527, Q9UM47, P16070, Q13315, P17252, P04049, Q02750 | CDKN1B, NOTCH3, CD44, ATM, PRKCA, RAF1, MAP2K1 | More | | | Domperidone | hsa05210 | Colorectal cancer | 1.66E-02 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05211 | Renal cell carcinoma | 3.93E-04 | 2 | Q13153, P04049 | PAK1, RAF1 | More | | | Domperidone | hsa05212 | Pancreatic cancer | 2.44E-03 | 4 | P42338, P04049, P42224, O75293 | PIK3CB, RAF1, STAT1, GADD45B | More | | | Domperidone | hsa05213 | Endometrial cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05214 | Glioma | 9.33E-06 | 7 | P08069, P0DP23, P17252, P04049, P42338, P19174, O75293 | IGF1R, CALM1, PRKCA, RAF1, PIK3CB, PLCG1, GADD45B | More | | | Domperidone | hsa05215 | Prostate cancer | 1.65E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Domperidone | hsa05217 | Basal cell carcinoma | 2.53E-03 | 5 | Q13635, P04628, P49841, Q9UJU2, P24522 | PTCH1, WNT1, GSK3B, LEF1, GADD45A | More | | | Domperidone | hsa05218 | Melanoma | 3.85E-05 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Domperidone | hsa05219 | Bladder cancer | 5.65E-03 | 3 | P14780, P04637, P04049 | MMP9, TP53, RAF1 | More | | | Domperidone | hsa05220 | Chronic myeloid leukemia | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05221 | Acute myeloid leukemia | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05223 | Non-small cell lung cancer | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05224 | Breast cancer | 2.75E-03 | 6 | P04049, P08069, P49841, Q92837, P04637, P24522 | RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Domperidone | hsa05225 | Hepatocellular carcinoma | 1.65E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Domperidone | hsa05226 | Gastric cancer | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05230 | Central carbon metabolism in cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Domperidone | hsa05231 | Choline metabolism in cancer | 2.56E-06 | 7 | P04049, Q9NRA1, Q9Y259, P19174, P23743, P49619, P17252 | RAF1, PDGFC, CHKB, PLCG1, DGKA, DGKG, PRKCA | More | | | Domperidone | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.45E-05 | 14 | P25963, O95267, P19174, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, P01730 | NFKBIA, RASGRP1, PLCG1, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4 | More | | | Domperidone | hsa05310 | Asthma | 1.64E-03 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Domperidone | hsa05321 | Inflammatory bowel disease | 5.32E-07 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3 | More | | | Domperidone | hsa05322 | Systemic lupus erythematosus | 1.35E-06 | 10 | P08637, O75015, P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814 | FCGR3A, FCGR3B, CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1 | More | | | Domperidone | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Domperidone | hsa05332 | Graft-versus-host disease | 1.36E-04 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Domperidone | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 2.17E-03 | 1 | P54284 | CACNB3 | More | | | Domperidone | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Domperidone | hsa05415 | Diabetic cardiomyopathy | 4.43E-05 | 9 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P14780, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, GAPDH | More | | | Domperidone | hsa05418 | Fluid shear stress and atherosclerosis | 1.56E-05 | 12 | Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1 | More | |
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