PharmaCoNets of Dolasetron (SPCN: 40.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dolasetronhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Dolasetronhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Dolasetronhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Dolasetronhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Dolasetronhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Dolasetronhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Dolasetronhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Dolasetronhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dolasetronhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Dolasetronhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Dolasetronhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Dolasetronhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Dolasetronhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Dolasetronhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Dolasetronhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Dolasetronhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dolasetronhsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Dolasetronhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Dolasetronhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Dolasetronhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Dolasetronhsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Dolasetronhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Dolasetronhsa04110Cell cycle1.44E-027P06493, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Dolasetronhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dolasetronhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Dolasetronhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Dolasetronhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Dolasetronhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dolasetronhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Dolasetronhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Dolasetronhsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Dolasetronhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dolasetronhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Dolasetronhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Dolasetronhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Dolasetronhsa04658Th1 and Th2 cell differentiation1.47E-0710Q04759, P07766, P20963, P19174, P01730, P06239, P42224, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, CD4, LCK, STAT1, TBX21, IL2RB, RUNX3More
Dolasetronhsa04659Th17 cell differentiation2.08E-0510Q04759, P19174, P01730, P06239, P42224, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, TBX21, CD3E, CD247More
Dolasetronhsa04660T cell receptor signaling pathway4.50E-0410Q04759, P42338, P19174, P16333, P07766, P20963, P01730, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, NCK1, CD3E, CD247, CD4, CD8A, CBLB, LCKMore
Dolasetronhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dolasetronhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dolasetronhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dolasetronhsa04742Taste transduction1.01E-021P30939HTR1FMore
Dolasetronhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Dolasetronhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dolasetronhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dolasetronhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Dolasetronhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dolasetronhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dolasetronhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dolasetronhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Dolasetronhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Dolasetronhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dolasetronhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dolasetronhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Dolasetronhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Dolasetronhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dolasetronhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Dolasetronhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dolasetronhsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Dolasetronhsa05231Choline metabolism in cancer4.24E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Dolasetronhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.41E-059P42338, P19174, P07766, P20963, P06239, P42224, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, PRKCQ, EML4, CD4More
Dolasetronhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dolasetronhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Dolasetronhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Dolasetronhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Dolasetron (SDC: 5.28)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)