PharmaCoNets

PharmaCoNets of Dobutamine (S_PCN: 131.26 )

Dobutamine regulated-network (S_DN: 20.07)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dobutamine

hsa00030

Pentose phosphate pathway

3.13E-06

P60891, P51854, P52209, P11413, P37837

PRPS1, TKTL1, PGD, G6PD, TALDO1

Dobutamine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Dobutamine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Dobutamine

hsa00310

Lysine degradation

4.57E-02

Q96KQ7, Q02809

EHMT2, PLOD1

Dobutamine

hsa00480

Glutathione metabolism

1.35E-02

P11413

G6PD

Dobutamine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Dobutamine

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Dobutamine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Dobutamine

hsa00630

Glyoxylate and dicarboxylate metabolism

2.15E-03

P40925, P40926, P15104

MDH1, MDH2, GLUL

Dobutamine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Dobutamine

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Dobutamine

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Dobutamine

hsa00983

Drug metabolism - other enzymes

3.50E-02

P04183, P32320, P05164

TK1, CDA, MPO

Dobutamine

hsa01200

Carbon metabolism

2.23E-02

P51854, P11413, P37837, P60891

TKTL1, G6PD, TALDO1, PRPS1

Dobutamine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Dobutamine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Dobutamine

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Dobutamine

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Dobutamine

hsa03013

RNA transport

3.98E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Dobutamine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Dobutamine

hsa03040

Spliceosome

5.76E-08

Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Dobutamine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Dobutamine

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Dobutamine

hsa04012

ErbB signaling pathway

2.00E-02

P16333, P17252, P19174, P42338

NCK1, PRKCA, PLCG1, PIK3CB

Dobutamine

hsa04014

Ras signaling pathway

5.57E-05

P42338, P20827, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Dobutamine

hsa04015

Rap1 signaling pathway

3.30E-05

P20827, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174

EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11215	ITGAM	Integrin alpha-M	-0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Dobutamine

hsa04020

Calcium signaling pathway

4.34E-02

P27987, P17252, O15399, P19174, P0DP23, P49767

ITPKB, PRKCA, GRIN2D, PLCG1, CALM1, VEGFC

Dobutamine

hsa04024

cAMP signaling pathway

4.34E-02

P42338, P0DP23, Q13370, O15399, P25963, Q13009

PIK3CB, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1

Dobutamine

hsa04062

Chemokine signaling pathway

4.05E-04

P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43250	GRK6	G protein-coupled receptor kinase 6	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14598	NCF1	Neutrophil cytosol factor 1	0.908
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Dobutamine

hsa04064

NF-kappa B signaling pathway

1.60E-02

P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1

Dobutamine

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Dobutamine

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Dobutamine

hsa04070

Phosphatidylinositol signaling system

3.29E-03

P19174, P0DP23, P42338, P23743, P27987, P17252

PLCG1, CALM1, PIK3CB, DGKA, ITPKB, PRKCA

Dobutamine

hsa04071

Sphingolipid signaling pathway

7.02E-07

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q15722	LTB4R	Leukotriene B4 receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.832
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.733
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.773
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863

Dobutamine

hsa04080

Neuroactive ligand-receptor interaction

2.16E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Dobutamine

hsa04114

Oocyte meiosis

3.19E-03

P51812, Q02750, P16298, Q17RY0, P08069

RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Dobutamine

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Dobutamine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Dobutamine

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Dobutamine

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Dobutamine

hsa04141

Protein processing in endoplasmic reticulum

1.91E-03

P18848, Q15437, Q99941, P11142, P07900, Q9NR31

ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A

Dobutamine

hsa04145

Phagosome

1.81E-02

O75015, Q15080, Q13488, P05164, O60603, P35443, P13765

FCGR3B, NCF4, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Dobutamine

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Dobutamine

hsa04150

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Dobutamine

hsa04151

PI3K-Akt signaling pathway

7.36E-05

P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P17252, O00141, P30281

RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, PRKCA, SGK, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P16144	ITGB4	Integrin beta-4	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O15335	CHAD	Chondroadherin	-0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Dobutamine

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Dobutamine

hsa04210

Apoptosis

3.77E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Dobutamine

hsa04211

Longevity regulating pathway

5.33E-03

P08069, P51828, Q99941, P18848

IGF1R, ADCY7, CREBL1, ATF4

Dobutamine

hsa04213

Longevity regulating pathway - multiple species

2.83E-03

P08069, Q9Y4H2, Q13547

IGF1R, IRS2, HDAC1

Dobutamine

hsa04217

Necroptosis

2.97E-03

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, O43633

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP2A

Dobutamine

hsa04261

Adrenergic signaling in cardiomyocytes

1.33E-03

P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557

ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2D

Dobutamine

hsa04360

Axon guidance

5.10E-04

P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1

Dobutamine

hsa04370

VEGF signaling pathway

1.04E-04

P19174, P16298, P42338, P17252, Q05397, Q02750

PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1

Dobutamine

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Dobutamine

hsa04510

Focal adhesion

2.69E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P08069, P49767

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, IGF1R, VEGFC

Dobutamine

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Dobutamine

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Dobutamine

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Dobutamine

hsa04530

Tight junction

1.38E-04

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Dobutamine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Dobutamine

hsa04610

Complement and coagulation cascades

1.03E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Dobutamine

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Dobutamine

hsa04612

Antigen processing and presentation

2.09E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Dobutamine

hsa04613

Neutrophil extracellular trap formation

2.31E-07

P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Dobutamine

hsa04623

Cytosolic DNA-sensing pathway

4.57E-02

P01568, P25963

IFNA21, NFKBIA

Dobutamine

hsa04650

Natural killer cell mediated cytotoxicity

3.52E-05

P16298, P50591, P01375, P20963, Q02750, Q13241, P26718, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Dobutamine

hsa04657

IL-17 signaling pathway

4.27E-03

O00463, Q16539, P19875, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, CXCL2, MMP9, ANAPC5, LCN2, TNF

Dobutamine

hsa04659

Th17 cell differentiation

2.10E-03

P25963, P19174, P42224, P14784, P14778, P40189, P84022, Q13485, P08238, P07766

NFKBIA, PLCG1, STAT1, IL2RB, IL1R1, IL6ST, SMAD3, SMAD4, HSP90AB1, CD3E

Dobutamine

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Dobutamine

hsa04664

Fc epsilon RI signaling pathway

1.23E-04

P42338, P17252, P07948, P19174, P09917, P20292

PIK3CB, PRKCA, LYN, PLCG1, ALOX5, ALOX5AP

Dobutamine

hsa04666

Fc gamma R-mediated phagocytosis

8.08E-03

P42338, P19174, P23528, P14598, P17252

PIK3CB, PLCG1, CFL1, NCF1, PRKCA

Dobutamine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Dobutamine

hsa04713

Circadian entrainment

1.24E-02

O15399, P0DP23, P17252, P62873, P50151

GRIN2D, CALM1, PRKCA, GNB1, GNG10

Dobutamine

hsa04714

Thermogenesis

6.01E-04

Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521

MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD

Dobutamine

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Dobutamine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Dobutamine

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Dobutamine

hsa04724

Glutamatergic synapse

8.08E-03

O15399, P17252, P62873, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG10, GLUL

Dobutamine

hsa04725

Cholinergic synapse

5.91E-04

P51828, P22694, Q14643, P17252, P62873, P50151, P18848, Q13557, P42338, P10415

ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG10, ATF4, CAMK2D, PIK3CB, BCL2

Dobutamine

hsa04726

Serotonergic synapse

2.54E-02

P17252, P62873, P50151, P33260, P09917

PRKCA, GNB1, GNG10, CYP2C18, ALOX5

Dobutamine

hsa04727

GABAergic synapse

1.23E-02

P62873, P50151, P15104, P17252

GNB1, GNG10, GLUL, PRKCA

Dobutamine

hsa04728

Dopaminergic synapse

4.78E-02

Q99941, P18848, Q13557

CREBL1, ATF4, CAMK2D

Dobutamine

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Dobutamine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Dobutamine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Dobutamine

hsa04744

Phototransduction

1.67E-02

P62873, P0DP23

GNB1, CALM1

Dobutamine

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Dobutamine

hsa04911

Insulin secretion

4.03E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Dobutamine

hsa04912

GnRH signaling pathway

6.52E-04

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, PRKACB

Dobutamine

hsa04913

Ovarian steroidogenesis

7.72E-03

P42330, P22694, P08069

AKR1C3, PRKACB, IGF1R

Dobutamine

hsa04914

Progesterone-mediated oocyte maturation

7.03E-04

P08069, Q17RY0, P42338, Q13370, Q9UJX4, P30304, P08238, P51812, Q02750

IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Dobutamine

hsa04915

Estrogen signaling pathway

9.55E-04

P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, P10415

MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, BCL2

Dobutamine

hsa04918

Thyroid hormone synthesis

6.10E-04

P22694, P51828, Q99941, P18848, Q14643, P02768

PRKACB, ADCY7, CREBL1, ATF4, ITPR1, ALB

Dobutamine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Dobutamine

hsa04925

Aldosterone synthesis and secretion

1.69E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Dobutamine

hsa04926

Relaxin signaling pathway

1.15E-04

P25963, P42338, P62873, P50151, Q99941, P18848, P22694, P49767, P14780, P51828, P17252, P30679

NFKBIA, PIK3CB, GNB1, GNG10, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY7, PRKCA, GNA15

Dobutamine

hsa04927

Cortisol synthesis and secretion

1.11E-05

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Dobutamine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.22E-04

Q14643, P51828, P22694, P23771, P17252, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, PRKCA, CREBL1, ATF4, BCL2

Dobutamine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Dobutamine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.76E-03

P84022, Q13485, P42224, P42338, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, PIK3CB, VEGFC, PRKCA, PLCG1

Dobutamine

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Dobutamine

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Dobutamine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Dobutamine

hsa04962

Vasopressin-regulated water reabsorption

2.18E-02

P52566, P62491

ARHGDIB, RAB11A

Dobutamine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Dobutamine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Dobutamine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Dobutamine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Dobutamine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Dobutamine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Dobutamine

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Dobutamine

hsa05031

Amphetamine addiction

8.84E-04

Q13557, P22694, Q99941, P18848, Q13547

CAMK2D, PRKACB, CREBL1, ATF4, HDAC1

Dobutamine

hsa05032

Morphine addiction

1.24E-02

P62873, P50151, Q13370, P17252, P43250

GNB1, GNG10, PDE3B, PRKCA, GRK6

Dobutamine

hsa05034

Alcoholism

2.10E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Dobutamine

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Dobutamine

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Dobutamine

hsa05133

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Dobutamine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Dobutamine

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Dobutamine

hsa05145

Toxoplasmosis

3.45E-02

P25963, Q13489, P42224, P09917, Q13751, P11142

NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8

Dobutamine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Dobutamine

hsa05152

Tuberculosis

1.26E-02

Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14

Dobutamine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Dobutamine

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Dobutamine

hsa05163

Human cytomegalovirus infection

1.62E-02

P42338, P25963, P62873, P50151, P0DP23, P17252, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG10, CALM1, PRKCA, PDIA3, IFNA21

Dobutamine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.54E-04

P01568, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q02750, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, MAP2K1, CALM1, UBB

Dobutamine

hsa05168

Herpes simplex virus 1 infection

6.31E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212

Dobutamine

hsa05170

Human immunodeficiency virus 1 infection

1.54E-04

P42338, Q02750, P62873, P62879, P50151, P16298, P0DP23, Q05397, P17252, P30101, P01568, P25963, P19174, P23528, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1, TNFRSF1B

Dobutamine

hsa05171

Coronavirus disease - COVID-19

3.30E-02

P25963, P42224, P01568, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA

Dobutamine

hsa05200

Pathways in cancer

5.83E-06

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, Q13547, P10826, P14923, P30281, Q13489, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, RARB, JUP, CCND3, BIRC3, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Dobutamine

hsa05202

Transcriptional misregulation in cancer

6.64E-08

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Dobutamine

hsa05203

Viral carcinogenesis

5.38E-04

Q99941, P18848, P27348, Q13547, P61978, P58876, Q16778, O60814

CREBL1, ATF4, YWHAQ, HDAC1, HNRPK, H2BC5, HIST2H2BE, H2BC12

Dobutamine

hsa05205

Proteoglycans in cancer

1.09E-02

P14780, P01375, P08069, P23588, Q13635, P22694

MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB

Dobutamine

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Dobutamine

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Dobutamine

hsa05214

Glioma

4.14E-04

P08069, P0DP23, P17252, P42338, P19174, O75293

IGF1R, CALM1, PRKCA, PIK3CB, PLCG1, GADD45B

Dobutamine

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Dobutamine

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Dobutamine

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Dobutamine

hsa05222

Small cell lung cancer

1.10E-02

P10826, P42338, Q13751, Q13489, P25963, O75293

RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B

Dobutamine

hsa05223

Non-small cell lung cancer

4.91E-03

P17252, P42338, P19174, P10826, O75293

PRKCA, PIK3CB, PLCG1, RARB, GADD45B

Dobutamine

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Dobutamine

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Dobutamine

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Dobutamine

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Dobutamine

hsa05231

Choline metabolism in cancer

4.91E-03

P42338, Q9Y259, P19174, P23743, P17252

PIK3CB, CHKB, PLCG1, DGKA, PRKCA

Dobutamine

hsa05321

Inflammatory bowel disease

1.30E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Dobutamine

hsa05322

Systemic lupus erythematosus

1.18E-02

P58876, Q16778, O60814

H2BC5, HIST2H2BE, H2BC12

Dobutamine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Dobutamine

hsa05332

Graft-versus-host disease

8.27E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Dobutamine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Dobutamine

hsa05415

Diabetic cardiomyopathy

4.92E-03

Q16718, O14521, Q16539, P49841, P11413

NDUFA5, SDHD, MAPK14, GSK3B, G6PD

Community members of Dobutamine (S_DC: 6.54)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ADRB2

BetaNone2 adrenergic receptor

Reported

0.0071

0.2205

2.224

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P52209

PGD

6Nonephosphogluconate dehydrogenase, decarboxylating

Predicted

0.195

0.1454

0.2642

0.6525

P11413

G6PD

GlucoseNone6Nonephosphate 1Nonedehydrogenase

Predicted

0.4435

0.6369

0.2929

1.7884

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

PharmaCoNets of Dobutamine (SPCN: 131.26 )

Dobutamine regulated-network (SDN: 20.07)

Community members of Dobutamine (SDC: 6.54)

PharmaCoNets of Dobutamine (S_PCN: 131.26 )

Dobutamine regulated-network (S_DN: 20.07)

Community members of Dobutamine (S_DC: 6.54)