PharmaCoNets

PharmaCoNets of Disulfiram (S_PCN: 13.85 )

Disulfiram regulated-network (S_DN: 10.49)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Disulfiram

hsa00040

Pentose and glucuronate interconversions

2.31E-02

Q9UEF7, O60701

KL, UGDH

Disulfiram

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Disulfiram

hsa00190

Oxidative phosphorylation

2.74E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Disulfiram

hsa00220

Arginine biosynthesis

1.43E-02

P05089, P49448

ARG1, GLUD2

Disulfiram

hsa00250

Alanine, aspartate and glutamate metabolism

4.51E-02

P51649

ALDH5A1

Disulfiram

hsa00280

Valine, leucine and isoleucine degradation

2.20E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Disulfiram

hsa00531

Glycosaminoglycan degradation

3.97E-05

P15586, P34059

GNS, GALNS

Disulfiram

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

2.92E-02

Q9Y2C2

UST

Disulfiram

hsa00630

Glyoxylate and dicarboxylate metabolism

3.01E-05

P40925, P15104

MDH1, GLUL

Disulfiram

hsa00980

Metabolism of xenobiotics by cytochrome P450

3.10E-02

P78417, P11712

GSTO1, CYP2C9

Disulfiram

hsa00982

Drug metabolism - cytochrome P450

3.10E-02

P11712, P78417

CYP2C9, GSTO1

Disulfiram

hsa01524

Platinum drug resistance

5.40E-03

P04637, Q13489, P98170, P48023, P78417, P43246

TP53, BIRC3, BIRC4, FASLG, GSTO1, MSH2

Disulfiram

hsa03008

Ribosome biogenesis in eukaryotes

2.06E-02

Q9NYH9, Q9BVP2

UTP6, GNL3

Disulfiram

hsa03040

Spliceosome

4.38E-06

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P78417	GSTO1	Glutathione S-transferase omega-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.794
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P78417	GSTO1	Glutathione S-transferase omega-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.741
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P78417	GSTO1	Glutathione S-transferase omega-1	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P78417	GSTO1	Glutathione S-transferase omega-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.735
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P78417	GSTO1	Glutathione S-transferase omega-1	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.763
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P78417	GSTO1	Glutathione S-transferase omega-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.715

Disulfiram

hsa04014

Ras signaling pathway

4.12E-02

P20827, P49767, Q14644, P0DP23, P63218

EFNA1, VEGFC, RASA3, CALM1, GNG5

Disulfiram

hsa04020

Calcium signaling pathway

3.36E-03

Q16566, P30679, O15399, P0DP23, P23634, P49767

CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFC

Disulfiram

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Disulfiram

hsa04062

Chemokine signaling pathway

3.81E-02

P07948, P62873, P63218, P50151, P43250, Q13009

LYN, GNB1, GNG5, GNG10, GRK6, TIAM1

Disulfiram

hsa04068

FoxO signaling pathway

6.45E-03

P48023, Q96BR1

FASLG, SGK3

Disulfiram

hsa04070

Phosphatidylinositol signaling system

4.86E-02

P0DP23, P42338, P27987

CALM1, PIK3CB, ITPKB

Disulfiram

hsa04142

Lysosome

1.14E-02

P43234, P15586, P34059

CTSO, GNS, GALNS

Disulfiram

hsa04151

PI3K-Akt signaling pathway

4.21E-03

P48023, P04637, Q96BR1

FASLG, TP53, SGK3

Disulfiram

hsa04210

Apoptosis

9.18E-03

P04637, P24522, P43234, P63261

TP53, GADD45A, CTSO, ACTG1

Disulfiram

hsa04217

Necroptosis

1.37E-02

P01568, Q13489, P98170, P08238, P15104, P21796

IFNA21, BIRC3, BIRC4, HSP90AB1, GLUL, VDAC1

Disulfiram

hsa04360

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Disulfiram

hsa04371

Apelin signaling pathway

5.99E-05

P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1

Disulfiram

hsa04610

Complement and coagulation cascades

4.48E-02

P01042, P09871, P11215

KNG1, C1S, ITGAM

Disulfiram

hsa04612

Antigen processing and presentation

8.21E-03

P26715, P26717, Q07444, Q13241, P01732

KLRC1, KLRC2, KLRC3, KLRD1, CD8A

Disulfiram

hsa04622

RIG-I-like receptor signaling pathway

3.49E-02

P01568, P25963, Q9H1Y0, Q13546

IFNA21, NFKBIA, ATG5, RIPK1

Disulfiram

hsa04623

Cytosolic DNA-sensing pathway

3.47E-03

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Disulfiram

hsa04650

Natural killer cell mediated cytotoxicity

1.37E-05

P06239, P20963, P48023, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715

LCK, CD247, FASLG, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1

Disulfiram

hsa04658

Th1 and Th2 cell differentiation

7.09E-05

Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761

PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3

Disulfiram

hsa04659

Th17 cell differentiation

3.49E-04

Q04759, P06239, P42224, P14784, P40189, Q9UL17, P23771, P08238, P09693, P20963

PRKCQ, LCK, STAT1, IL2RB, IL6ST, TBX21, GATA3, HSP90AB1, CD3G, CD247

Disulfiram

hsa04660

T cell receptor signaling pathway

8.49E-04

Q04759, O95267, Q08881, P20963, P09693, P01732, P06239

PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCK

Disulfiram

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Disulfiram

hsa04713

Circadian entrainment

1.78E-03

O15399, P0DP23, P62873, P63218, P50151

GRIN2D, CALM1, GNB1, GNG5, GNG10

Disulfiram

hsa04720

Long-term potentiation

9.60E-04

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Disulfiram

hsa04722

Neurotrophin signaling pathway

2.27E-02

P48023, P04637

FASLG, TP53

Disulfiram

hsa04724

Glutamatergic synapse

1.66E-04

O15399, P62873, P63218, P50151, P15104, Q9NSB8

GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2

Disulfiram

hsa04725

Cholinergic synapse

9.51E-03

P62873, P63218, P50151, Q16566

GNB1, GNG5, GNG10, CAMK4

Disulfiram

hsa04726

Serotonergic synapse

2.38E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Disulfiram

hsa04727

GABAergic synapse

2.45E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Disulfiram

hsa04744

Phototransduction

1.89E-04

P62873, P0DP23

GNB1, CALM1

Disulfiram

hsa04914

Progesterone-mediated oocyte maturation

3.92E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Disulfiram

hsa04916

Melanogenesis

3.49E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Disulfiram

hsa04924

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Disulfiram

hsa04925

Aldosterone synthesis and secretion

3.44E-02

P0DP23, Q16566, P23634

CALM1, CAMK4, ATP2B4

Disulfiram

hsa05032

Morphine addiction

1.34E-02

P62873, P63218, P50151, P43250

GNB1, GNG5, GNG10, GRK6

Disulfiram

hsa05034

Alcoholism

1.28E-04

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079, O60814, P68431

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Disulfiram

hsa05132

Salmonella infection

3.43E-04

P25963, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P49754

NFKBIA, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, VPS41

Disulfiram

hsa05133

Pertussis

1.70E-03

P11215, P0DP23, P23528, P09871

ITGAM, CALM1, CFL1, C1S

Disulfiram

hsa05146

Amoebiasis

2.73E-02

P09341, P05089, P12814, P08311

CXCL1, ARG1, ACTN1, CTSG

Disulfiram

hsa05152

Tuberculosis

1.14E-02

Q13488, Q15075, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8

TCIRG1, EEA1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1

Disulfiram

hsa05160

Hepatitis C

3.81E-02

P04637, P48023

TP53, FASLG

Disulfiram

hsa05163

Human cytomegalovirus infection

2.00E-02

P62873, P63218, P50151, P0DP23, P30101, P01568

GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21

Disulfiram

hsa05164

Influenza A

3.48E-02

Q9GZY0, P48023

NXF2; NXF2B, FASLG

Disulfiram

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.00E-02

P01568, P62873, P63218, P50151, P07948, P0DP23

IFNA21, GNB1, GNG5, GNG10, LYN, CALM1

Disulfiram

hsa05168

Herpes simplex virus 1 infection

1.67E-05

O60603, P25963, P01568, P04637, Q9GZY0, P42224, Q07955, Q01130, P84103, Q13243, P48023, Q13489, P30101, P42338, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, O75820, P98182, Q9NZL3, Q9UDV6, P10415

TLR2, NFKBIA, IFNA21, TP53, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, FASLG, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF189, ZNF200, ZNF224, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	-0.759
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.82
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13398	ZNF211	Zinc finger protein 211	-0.886
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13398	ZNF211	Zinc finger protein 211	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51522	ZNF83	Zinc finger protein 83	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9NR11	ZNF302	Zinc finger protein 302	0.808
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCX3	ZNF304	Zinc finger protein 304	0.701
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17097	ZNF7	Zinc finger protein 7	0.744
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q03923	ZNF85	Zinc finger protein 85	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75820	ZNF189	Zinc finger protein 189	0.753
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P98182	ZNF200	Zinc finger protein 200	0.747
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q9NZL3	ZNF224	Zinc finger protein 224	-0.762
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849

Disulfiram

hsa05170

Human immunodeficiency virus 1 infection

1.55E-03

P62873, P63218, P50151, P0DP23, P17252, Q13546, P30101, P01568, P25963, O60603, P23528, P10415, Q13619, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, PRKCA, RIPK1, PDIA3, IFNA21, NFKBIA, TLR2, CFL1, BCL2, CUL4A, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889

Disulfiram

hsa05200

Pathways in cancer

7.68E-05

Q13751, P42338, P08238, P42224, P43246, P84022, Q13485, P14923, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042

LAMB3, PIK3CB, HSP90AB1, STAT1, MSH2, SMAD3, SMAD4, JUP, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Disulfiram

hsa05204

Chemical carcinogenesis

4.92E-02

P78417, P11712

GSTO1, CYP2C9

Disulfiram

hsa05205

Proteoglycans in cancer

4.43E-02

P63261, P04637, Q06124

ACTG1, TP53, PTPN11

Disulfiram

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Disulfiram

hsa05211

Renal cell carcinoma

7.75E-03

Q06124, Q99814

PTPN11, EPAS1

Disulfiram

hsa05212

Pancreatic cancer

1.12E-04

P42338, P42224, P84022, Q13485, P04637, P24522, O75293

PIK3CB, STAT1, SMAD3, SMAD4, TP53, GADD45A, GADD45B

Disulfiram

hsa05213

Endometrial cancer

2.60E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05214

Glioma

1.12E-04

P0DP23, Q16566, P42338, P04637, P24522, O75293

CALM1, CAMK4, PIK3CB, TP53, GADD45A, GADD45B

Disulfiram

hsa05216

Thyroid cancer

1.14E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05217

Basal cell carcinoma

2.06E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05218

Melanoma

1.14E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05219

Bladder cancer

4.51E-02

P04637

TP53

Disulfiram

hsa05220

Chronic myeloid leukemia

7.90E-03

Q06124, P04637, P24522

PTPN11, TP53, GADD45A

Disulfiram

hsa05222

Small cell lung cancer

2.60E-03

P10826, Q13751, Q13489, P98170, P10415, P25963, Q13077, O75293

RARB, LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, GADD45B

Disulfiram

hsa05223

Non-small cell lung cancer

3.19E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05224

Breast cancer

4.51E-02

P04637, P24522

TP53, GADD45A

Disulfiram

hsa05225

Hepatocellular carcinoma

3.30E-02

P04637, P24522, P63261

TP53, GADD45A, ACTG1

Disulfiram

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.88E-03

O95267, P20963, P09693, P06239, Q04759

RASGRP1, CD247, CD3G, LCK, PRKCQ

Disulfiram

hsa05322

Systemic lupus erythematosus

1.57E-02

P08311, P62807, Q16778, P12814

CTSG, HIST1H2BC, HIST2H2BE, ACTN1

Disulfiram

hsa05418

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Community members of Disulfiram (S_DC: 1.32)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

Q9Y4K0

LOXL2

Lysyl oxidase homolog 2

Predicted

0.0269

0.1198

0.253

P78417

GSTO1

Glutathione SNonetransferase omegaNone1

Predicted

0.4109

0.1399

0.425

0.9103

P00352

ALDH1A1

Aldehyde dehydrogenase 1A1

Predicted

0.3208

0.2925

0.1543

0.8998

P51649

ALDH5A1

SuccinateNonesemialdehyde dehydrogenase, mitochondrial

Predicted

0.173

0.0778

0.152

0.394

Q02252

ALDH6A1

MethylmalonateNonesemialdehyde dehydrogenase [acylating], mitochondrial

Predicted

0.4334

0.0148

0.2428

0.4891

PharmaCoNets of Disulfiram (SPCN: 13.85 )

Disulfiram regulated-network (SDN: 10.49)

Community members of Disulfiram (SDC: 1.32)

PharmaCoNets of Disulfiram (S_PCN: 13.85 )

Disulfiram regulated-network (S_DN: 10.49)

Community members of Disulfiram (S_DC: 1.32)