PharmaCoNets of Disopyramide (SPCN: 38.32 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Disopyramidehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Disopyramidehsa00190Oxidative phosphorylation7.38E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Disopyramidehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Disopyramidehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Disopyramidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Disopyramidehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Disopyramidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Disopyramidehsa00983Drug metabolism - other enzymes2.07E-033P04183, P32320, P05164TK1, CDA, MPOMore
Disopyramidehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Disopyramidehsa01522Endocrine resistance4.07E-045P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Disopyramidehsa03010Ribosome4.27E-0717P62753, P42677, P25398, P32969, P40429, P62917, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPS12, RPL9, RPL13A, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL6, RPL4, RPLP1, RPS16, RPS3More
Disopyramidehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Disopyramidehsa03020RNA polymerase3.25E-064P30876, P62487, Q9GZM3, P52435POLR2B, POLR2G, POLR2J2, POLR2JMore
Disopyramidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Disopyramidehsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Disopyramidehsa04071Sphingolipid signaling pathway1.70E-035Q9H228, P01375, Q13362, Q9BX95, P10415EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Disopyramidehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Disopyramidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Disopyramidehsa04137Mitophagy - animal3.55E-044Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Disopyramidehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Disopyramidehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Disopyramidehsa04146Peroxisome4.38E-034O43933, O96011, P56589, P33121PEX1, PEX11B, PEX3, ACSL1More
Disopyramidehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Disopyramidehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Disopyramidehsa04217Necroptosis4.25E-0818P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Disopyramidehsa04261Adrenergic signaling in cardiomyocytes4.22E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Disopyramidehsa04613Neutrophil extracellular trap formation4.19E-0717P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P58876, Q16778, O60814, Q15080, P20160, P08311, P49913, O75015, P21730, P21462ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Disopyramidehsa04621NOD-like receptor signaling pathway2.77E-038Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Disopyramidehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Disopyramidehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Disopyramidehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Disopyramidehsa04713Circadian entrainment1.69E-023P17252, P48058, P22694PRKCA, GRIA4, PRKACBMore
Disopyramidehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Disopyramidehsa04721Synaptic vesicle cycle6.59E-042Q13488, P31645TCIRG1, SLC6A4More
Disopyramidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Disopyramidehsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Disopyramidehsa04724Glutamatergic synapse1.31E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Disopyramidehsa04726Serotonergic synapse2.62E-023P22694, P17252, P31645PRKACB, PRKCA, SLC6A4More
Disopyramidehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Disopyramidehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Disopyramidehsa04742Taste transduction1.01E-021P30939HTR1FMore
Disopyramidehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Disopyramidehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Disopyramidehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Disopyramidehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Disopyramidehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Disopyramidehsa04932Non-alcoholic fatty liver disease6.43E-047P01375, P49841, P18848, P48023, P01584, P13073, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1More
Disopyramidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Disopyramidehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Disopyramidehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Disopyramidehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Disopyramidehsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Disopyramidehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Disopyramidehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Disopyramidehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Disopyramidehsa05012Parkinson disease1.67E-038O15239, P13073, P05141, P12236, P18848, P28070, P43686, Q13557NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4, CAMK2DMore
Disopyramidehsa05016Huntington disease4.79E-058O15239, P13073, Q9GZM3, P30876, P62487, P52435, P05141, Q9NYC9NDUFA1, COX4I1, POLR2J2, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9More
Disopyramidehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Disopyramidehsa05020Prion disease1.94E-0513P13591, P01584, P46531, P11142, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Disopyramidehsa05022Pathways of neurodegeneration - multiple diseases7.72E-0517P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, P01584, Q08752, Q13557, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, IL1B, PPID, CAMK2D, PSMB4, PSMC4More
Disopyramidehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Disopyramidehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Disopyramidehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Disopyramidehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Disopyramidehsa05131Shigellosis3.32E-039P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P20810, O43524, P10415, Q96A32TNF, TRAF5, PRKCQ, MALT1, ATG5, CAST, FOXO3, BCL2, MYLPFMore
Disopyramidehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Disopyramidehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Disopyramidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Disopyramidehsa05144Malaria9.55E-044O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Disopyramidehsa05150Staphylococcus aureus infection8.69E-045P21730, P21462, O75015, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA4, CAMPMore
Disopyramidehsa05152Tuberculosis7.83E-047O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1More
Disopyramidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Disopyramidehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Disopyramidehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Disopyramidehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Disopyramidehsa05171Coronavirus disease - COVID-194.28E-0617P01584, P23396, P62753, P25398, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P18077, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23More
Disopyramidehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Disopyramidehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Disopyramidehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Disopyramidehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Disopyramidehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Disopyramidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Disopyramidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Disopyramidehsa05415Diabetic cardiomyopathy1.14E-0410P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDHMore

Community members of Disopyramide (SDC: 3.74)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P19652ORM2AlphaNone1Noneacid glycoprotein 2Reported10.09380.057900.1628
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P02763ORM1AlphaNone1Noneacid glycoprotein 1Predicted10.05530.057900.1435
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)