PharmaCoNets of Dipyrithione (SPCN: 2.24 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dipyrithionehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Dipyrithionehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Dipyrithionehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Dipyrithionehsa03040Spliceosome4.87E-037O43143, P08579, P26368, Q13595, Q07955, P84103, Q13243DHX15, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS3, SFRS5More
Dipyrithionehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Dipyrithionehsa04217Necroptosis1.37E-026P01568, Q13489, P98170, P08238, P15104, P21796IFNA21, BIRC3, BIRC4, HSP90AB1, GLUL, VDAC1More
Dipyrithionehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Dipyrithionehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Dipyrithionehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Dipyrithionehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Dipyrithionehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Dipyrithionehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Dipyrithionehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Dipyrithionehsa04744Phototransduction6.94E-032P62873, P0DP23GNB1, CALM1More
Dipyrithionehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Dipyrithionehsa05034Alcoholism3.87E-037O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9More
Dipyrithionehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Dipyrithionehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Dipyrithionehsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Dipyrithionehsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Dipyrithionehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Dipyrithionehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Dipyrithionehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Dipyrithionehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Dipyrithionehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore

Community members of Dipyrithione (SDC: 0.61)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)