PharmaCoNets of Dipyridamole (SPCN: 21.08 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dipyridamolehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Dipyridamolehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Dipyridamolehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Dipyridamolehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Dipyridamolehsa00983Drug metabolism - other enzymes1.70E-043P04183, P32320, P05164TK1, CDA, MPOMore
Dipyridamolehsa01522Endocrine resistance4.07E-045P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Dipyridamolehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Dipyridamolehsa03050Proteasome4.83E-021P55036PSMD4More
Dipyridamolehsa04071Sphingolipid signaling pathway1.42E-046Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Dipyridamolehsa04137Mitophagy - animal3.55E-044Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Dipyridamolehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Dipyridamolehsa04146Peroxisome4.38E-034O43933, O96011, P56589, P33121PEX1, PEX11B, PEX3, ACSL1More
Dipyridamolehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Dipyridamolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Dipyridamolehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Dipyridamolehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Dipyridamolehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Dipyridamolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Dipyridamolehsa04613Neutrophil extracellular trap formation4.19E-0717P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P58876, Q16778, O60814, Q15080, P20160, P08311, P49913, O75015, P21730, P21462ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Dipyridamolehsa04621NOD-like receptor signaling pathway2.77E-038Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Dipyridamolehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Dipyridamolehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Dipyridamolehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Dipyridamolehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Dipyridamolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dipyridamolehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Dipyridamolehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Dipyridamolehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Dipyridamolehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Dipyridamolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dipyridamolehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Dipyridamolehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Dipyridamolehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Dipyridamolehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Dipyridamolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dipyridamolehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Dipyridamolehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Dipyridamolehsa04974Protein digestion and absorption3.53E-021Q03692COL10A1More
Dipyridamolehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Dipyridamolehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Dipyridamolehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Dipyridamolehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dipyridamolehsa05131Shigellosis3.32E-039P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P20810, O43524, P10415, Q96A32TNF, TRAF5, PRKCQ, MALT1, ATG5, CAST, FOXO3, BCL2, MYLPFMore
Dipyridamolehsa05144Malaria9.55E-044O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Dipyridamolehsa05150Staphylococcus aureus infection8.69E-045P21730, P21462, O75015, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA4, CAMPMore
Dipyridamolehsa05152Tuberculosis7.83E-047O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1More
Dipyridamolehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Dipyridamolehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Dipyridamolehsa05203Viral carcinogenesis5.38E-048Q99941, P18848, P27348, Q13547, P61978, P58876, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, HNRPK, H2BC5, HIST2H2BE, H2BC12More
Dipyridamolehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More

Community members of Dipyridamole (SDC: 3.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02763ORM1AlphaNone1Noneacid glycoprotein 1Reported10.05530.057900.1435
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P19652ORM2AlphaNone1Noneacid glycoprotein 2Predicted10.09380.057900.1628
Q9UKA8RCAN3CalcipressinNone3Predicted00.22030.004100.1183
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)