PharmaCoNets of Dipivefrin (SPCN: 42.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dipivefrinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dipivefrinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dipivefrinhsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Dipivefrinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dipivefrinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dipivefrinhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Dipivefrinhsa01522Endocrine resistance1.69E-024P22694, P04049, P10415, Q13323PRKACB, RAF1, BCL2, BIKMore
Dipivefrinhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Dipivefrinhsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Dipivefrinhsa04014Ras signaling pathway9.62E-034P04049, Q15311, P0DP23, P17612RAF1, RALBP1, CALM1, PRKACAMore
Dipivefrinhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Dipivefrinhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Dipivefrinhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Dipivefrinhsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Dipivefrinhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Dipivefrinhsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Dipivefrinhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Dipivefrinhsa04080Neuroactive ligand-receptor interaction2.95E-048P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Dipivefrinhsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Dipivefrinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dipivefrinhsa04140Autophagy - animal2.81E-024P04049, P22694, Q14643, P10415RAF1, PRKACB, ITPR1, BCL2More
Dipivefrinhsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Dipivefrinhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Dipivefrinhsa04210Apoptosis2.16E-021P04049RAF1More
Dipivefrinhsa04217Necroptosis3.67E-048P01375, P23458, P48023, Q9NQC7, Q14765, Q99878, Q9H444, O75351TNF, JAK1, FASLG, CYLD, STAT4, H2AC14, CHMP4B, VPS4BMore
Dipivefrinhsa04218Cellular senescence2.49E-021P04049RAF1More
Dipivefrinhsa04261Adrenergic signaling in cardiomyocytes2.61E-036P07550, P17612, P22694, P18848, Q13362, P0DP23ADRB2, PRKACA, PRKACB, ATF4, PPP2R5C, CALM1More
Dipivefrinhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Dipivefrinhsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Dipivefrinhsa04360Axon guidance2.49E-021P04049RAF1More
Dipivefrinhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Dipivefrinhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Dipivefrinhsa04510Focal adhesion3.48E-021P04049RAF1More
Dipivefrinhsa04540Gap junction5.06E-034P22694, P68371, P04049, Q14643PRKACB, TUBB2C, RAF1, ITPR1More
Dipivefrinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Dipivefrinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dipivefrinhsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Dipivefrinhsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Dipivefrinhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Dipivefrinhsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dipivefrinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Dipivefrinhsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Dipivefrinhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Dipivefrinhsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Dipivefrinhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Dipivefrinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dipivefrinhsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Dipivefrinhsa04720Long-term potentiation5.58E-033P0DP23, P17612, P04049CALM1, PRKACA, RAF1More
Dipivefrinhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Dipivefrinhsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Dipivefrinhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Dipivefrinhsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Dipivefrinhsa04730Long-term depression1.16E-021P04049RAF1More
Dipivefrinhsa04740Olfactory transduction4.53E-043Q9H255, P0DP23, P17612OR51E2, CALM1, PRKACAMore
Dipivefrinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Dipivefrinhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Dipivefrinhsa04910Insulin signaling pathway4.09E-033P0DP23, P17612, P04049CALM1, PRKACA, RAF1More
Dipivefrinhsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Dipivefrinhsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Dipivefrinhsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Dipivefrinhsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Dipivefrinhsa04916Melanogenesis2.88E-033P17612, P0DP23, P04049PRKACA, CALM1, RAF1More
Dipivefrinhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Dipivefrinhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Dipivefrinhsa04921Oxytocin signaling pathway2.25E-034P0DP23, P17612, P04049, Q96RR4CALM1, PRKACA, RAF1, CAMKK2More
Dipivefrinhsa04924Renin secretion9.81E-065P17612, P22694, P07550, Q14643, P0DP23PRKACA, PRKACB, ADRB2, ITPR1, CALM1More
Dipivefrinhsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Dipivefrinhsa04927Cortisol synthesis and secretion1.27E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Dipivefrinhsa04928Parathyroid hormone synthesis, secretion and action2.75E-035Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Dipivefrinhsa04929GnRH secretion4.98E-031P04049RAF1More
Dipivefrinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dipivefrinhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Dipivefrinhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Dipivefrinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dipivefrinhsa04970Salivary secretion5.87E-056P07550, P17612, P22694, Q14643, P0DP23, P49913ADRB2, PRKACA, PRKACB, ITPR1, CALM1, CAMPMore
Dipivefrinhsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Dipivefrinhsa04976Bile secretion2.20E-022P17612, Q14032PRKACA, BAATMore
Dipivefrinhsa05031Amphetamine addiction3.10E-035P0DP23, P17612, P22694, P18848, Q13547CALM1, PRKACA, PRKACB, ATF4, HDAC1More
Dipivefrinhsa05034Alcoholism1.98E-034P17612, P0DP23, Q96RR4, P04049PRKACA, CALM1, CAMKK2, RAF1More
Dipivefrinhsa05132Salmonella infection4.98E-021P04049RAF1More
Dipivefrinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dipivefrinhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dipivefrinhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Dipivefrinhsa05152Tuberculosis3.98E-021P04049RAF1More
Dipivefrinhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Dipivefrinhsa05161Hepatitis B1.99E-021P04049RAF1More
Dipivefrinhsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Dipivefrinhsa05164Influenza A3.65E-021P04049RAF1More
Dipivefrinhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Dipivefrinhsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Dipivefrinhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dipivefrinhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Dipivefrinhsa05210Colorectal cancer1.66E-021P04049RAF1More
Dipivefrinhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Dipivefrinhsa05212Pancreatic cancer2.37E-033P04049, Q15311, P23458RAF1, RALBP1, JAK1More
Dipivefrinhsa05213Endometrial cancer9.95E-031P04049RAF1More
Dipivefrinhsa05214Glioma9.95E-031P04049RAF1More
Dipivefrinhsa05215Prostate cancer1.33E-021P04049RAF1More
Dipivefrinhsa05218Melanoma6.63E-031P04049RAF1More
Dipivefrinhsa05219Bladder cancer4.98E-031P04049RAF1More
Dipivefrinhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Dipivefrinhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Dipivefrinhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Dipivefrinhsa05224Breast cancer1.49E-021P04049RAF1More
Dipivefrinhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Dipivefrinhsa05226Gastric cancer8.29E-031P04049RAF1More
Dipivefrinhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Dipivefrinhsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Dipivefrinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Dipivefrinhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dipivefrinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dipivefrinhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More

Community members of Dipivefrin (SDC: 2.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)