PharmaCoNets of Diphenylpyraline (SPCN: 172.77 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diphenylpyralinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Diphenylpyralinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Diphenylpyralinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Diphenylpyralinehsa00190Oxidative phosphorylation1.03E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Diphenylpyralinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Diphenylpyralinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Diphenylpyralinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Diphenylpyralinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Diphenylpyralinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Diphenylpyralinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Diphenylpyralinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Diphenylpyralinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Diphenylpyralinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Diphenylpyralinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Diphenylpyralinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Diphenylpyralinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Diphenylpyralinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Diphenylpyralinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Diphenylpyralinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Diphenylpyralinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Diphenylpyralinehsa01522Endocrine resistance8.11E-033P04637, P42773, P08069TP53, CDKN2C, IGF1RMore
Diphenylpyralinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Diphenylpyralinehsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Diphenylpyralinehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Diphenylpyralinehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Diphenylpyralinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Diphenylpyralinehsa03030DNA replication5.00E-021P27694RPA1More
Diphenylpyralinehsa03050Proteasome1.21E-021P28074PSMB5More
Diphenylpyralinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Diphenylpyralinehsa03430Mismatch repair4.38E-021P20585MSH3More
Diphenylpyralinehsa04010MAPK signaling pathway1.23E-033P08069, Q9H2K8, Q12933IGF1R, TAOK3, TRAF2More
Diphenylpyralinehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Diphenylpyralinehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Diphenylpyralinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Diphenylpyralinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Diphenylpyralinehsa04064NF-kappa B signaling pathway2.49E-0313P10415, Q13489, P14778, P29965, P19174, Q04759, Q9UDY8, P06239, Q8WV28, Q13315, P09341, P19875, Q06643BCL2, BIRC3, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, LCK, BLNK, ATM, CXCL1, CXCL2, LTBMore
Diphenylpyralinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Diphenylpyralinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Diphenylpyralinehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Diphenylpyralinehsa04071Sphingolipid signaling pathway9.77E-0610P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCEMore
Diphenylpyralinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Diphenylpyralinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Diphenylpyralinehsa04110Cell cycle2.75E-049P30260, P06493, O75293, P04637, P49918, P30304, P33981, P42773, P01106CDC27, CDK1, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYCMore
Diphenylpyralinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Diphenylpyralinehsa04120Ubiquitin mediated proteolysis4.81E-034Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Diphenylpyralinehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Diphenylpyralinehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Diphenylpyralinehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Diphenylpyralinehsa04151PI3K-Akt signaling pathway7.73E-0312P25116, P04637, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252, Q96BR1, P56279F2R, TP53, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA, SGK3, TCL1AMore
Diphenylpyralinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Diphenylpyralinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Diphenylpyralinehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Diphenylpyralinehsa04213Longevity regulating pathway - multiple species1.14E-035P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Diphenylpyralinehsa04217Necroptosis7.46E-0613P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Diphenylpyralinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Diphenylpyralinehsa04261Adrenergic signaling in cardiomyocytes2.31E-038P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2More
Diphenylpyralinehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Diphenylpyralinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Diphenylpyralinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Diphenylpyralinehsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Diphenylpyralinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Diphenylpyralinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Diphenylpyralinehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Diphenylpyralinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Diphenylpyralinehsa04610Complement and coagulation cascades1.15E-081P0C0L4C4AMore
Diphenylpyralinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Diphenylpyralinehsa04613Neutrophil extracellular trap formation6.17E-0618P17252, P11215, O60603, P08246, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, ELA2, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Diphenylpyralinehsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Diphenylpyralinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Diphenylpyralinehsa04640Hematopoietic cell lineage1.54E-039P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7More
Diphenylpyralinehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Diphenylpyralinehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Diphenylpyralinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Diphenylpyralinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Diphenylpyralinehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Diphenylpyralinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Diphenylpyralinehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Diphenylpyralinehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Diphenylpyralinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Diphenylpyralinehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Diphenylpyralinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Diphenylpyralinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Diphenylpyralinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Diphenylpyralinehsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Diphenylpyralinehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Diphenylpyralinehsa04730Long-term depression3.01E-032Q14344, P08069GNA13, IGF1RMore
Diphenylpyralinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Diphenylpyralinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Diphenylpyralinehsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Diphenylpyralinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Diphenylpyralinehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Diphenylpyralinehsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Diphenylpyralinehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Diphenylpyralinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Diphenylpyralinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Diphenylpyralinehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Diphenylpyralinehsa04924Renin secretion7.38E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Diphenylpyralinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Diphenylpyralinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Diphenylpyralinehsa04930Type II diabetes mellitus1.28E-032P06213, Q02156INSR, PRKCEMore
Diphenylpyralinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Diphenylpyralinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Diphenylpyralinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Diphenylpyralinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Diphenylpyralinehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Diphenylpyralinehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Diphenylpyralinehsa04966Collecting duct acid secretion5.21E-064Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Diphenylpyralinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Diphenylpyralinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Diphenylpyralinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Diphenylpyralinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Diphenylpyralinehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Diphenylpyralinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Diphenylpyralinehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Diphenylpyralinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Diphenylpyralinehsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Diphenylpyralinehsa05022Pathways of neurodegeneration - multiple diseases2.00E-0412Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1More
Diphenylpyralinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Diphenylpyralinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diphenylpyralinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Diphenylpyralinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Diphenylpyralinehsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Diphenylpyralinehsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Diphenylpyralinehsa05133Pertussis3.47E-041P0C0L4C4AMore
Diphenylpyralinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Diphenylpyralinehsa05140Leishmaniasis1.06E-047P14598, P42224, P13765, O60603, P25963, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, NCF4More
Diphenylpyralinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Diphenylpyralinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Diphenylpyralinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Diphenylpyralinehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Diphenylpyralinehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Diphenylpyralinehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Diphenylpyralinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Diphenylpyralinehsa05163Human cytomegalovirus infection4.31E-022P30511, Q14344HLA-F, GNA13More
Diphenylpyralinehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Diphenylpyralinehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Diphenylpyralinehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Diphenylpyralinehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Diphenylpyralinehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Diphenylpyralinehsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Diphenylpyralinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Diphenylpyralinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Diphenylpyralinehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Diphenylpyralinehsa05214Glioma9.95E-031P08069IGF1RMore
Diphenylpyralinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Diphenylpyralinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Diphenylpyralinehsa05218Melanoma9.63E-044P08069, P09619, Q9GZP0, Q02750IGF1R, PDGFRB, PDGFD, MAP2K1More
Diphenylpyralinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Diphenylpyralinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Diphenylpyralinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Diphenylpyralinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Diphenylpyralinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.99E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4More
Diphenylpyralinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Diphenylpyralinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Diphenylpyralinehsa05322Systemic lupus erythematosus2.33E-0712P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diphenylpyralinehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Diphenylpyralinehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Diphenylpyralinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Diphenylpyralinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Diphenylpyralinehsa05412Arrhythmogenic right ventricular cardiomyopathy6.71E-043Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Diphenylpyralinehsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Diphenylpyralinehsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Diphenylpyralinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Diphenylpyraline (SDC: 7.64)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)