PharmaCoNets of Diphenidol (SPCN: 169.41 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diphenidolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Diphenidolhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Diphenidolhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Diphenidolhsa00190Oxidative phosphorylation1.03E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Diphenidolhsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Diphenidolhsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Diphenidolhsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Diphenidolhsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Diphenidolhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Diphenidolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Diphenidolhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Diphenidolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Diphenidolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Diphenidolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Diphenidolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Diphenidolhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Diphenidolhsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Diphenidolhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Diphenidolhsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Diphenidolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Diphenidolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Diphenidolhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Diphenidolhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Diphenidolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Diphenidolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Diphenidolhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Diphenidolhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Diphenidolhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Diphenidolhsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Diphenidolhsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Diphenidolhsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Diphenidolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Diphenidolhsa03030DNA replication5.00E-021P27694RPA1More
Diphenidolhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Diphenidolhsa03050Proteasome1.21E-021P28074PSMB5More
Diphenidolhsa03060Protein export3.28E-021Q15070OXA1LMore
Diphenidolhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Diphenidolhsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Diphenidolhsa04061Viral protein interaction with cytokine and cytokine receptor2.43E-024P09341, P02775, P47992, Q9UBD3CXCL1, PPBP, XCL1, XCL2More
Diphenidolhsa04064NF-kappa B signaling pathway1.60E-0414P10415, Q13489, O00463, Q13546, P14778, P29965, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, IL1R1, CD40LG, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1, EDARMore
Diphenidolhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Diphenidolhsa04071Sphingolipid signaling pathway4.64E-0611P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCEMore
Diphenidolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Diphenidolhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Diphenidolhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Diphenidolhsa04120Ubiquitin mediated proteolysis4.81E-034Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Diphenidolhsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Diphenidolhsa04145Phagosome1.50E-0410Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Diphenidolhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Diphenidolhsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Diphenidolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Diphenidolhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Diphenidolhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Diphenidolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Diphenidolhsa04217Necroptosis8.71E-0714P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Diphenidolhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Diphenidolhsa04261Adrenergic signaling in cardiomyocytes2.31E-038P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2More
Diphenidolhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Diphenidolhsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Diphenidolhsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Diphenidolhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Diphenidolhsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Diphenidolhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Diphenidolhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Diphenidolhsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Diphenidolhsa04612Antigen processing and presentation2.31E-049P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Diphenidolhsa04613Neutrophil extracellular trap formation3.12E-0624P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Diphenidolhsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Diphenidolhsa04621NOD-like receptor signaling pathway6.46E-0314Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CXCL1, DEFA4More
Diphenidolhsa04622RIG-I-like receptor signaling pathway1.28E-033P01568, Q13546, Q12933IFNA21, RIPK1, TRAF2More
Diphenidolhsa04623Cytosolic DNA-sensing pathway2.63E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Diphenidolhsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Diphenidolhsa04640Hematopoietic cell lineage1.75E-038P21926, P20023, P11836, P07766, P09693, P01730, P09564, P16871CD9, CR2, MS4A1, CD3E, CD3G, CD4, CD7, IL7RMore
Diphenidolhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Diphenidolhsa04657IL-17 signaling pathway7.11E-058O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Diphenidolhsa04658Th1 and Th2 cell differentiation9.02E-049Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Diphenidolhsa04659Th17 cell differentiation3.71E-037P25963, Q04759, P06239, P13765, P23771, P84022, Q13485NFKBIA, PRKCQ, LCK, HLA-DOB, GATA3, SMAD3, SMAD4More
Diphenidolhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Diphenidolhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Diphenidolhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Diphenidolhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Diphenidolhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Diphenidolhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Diphenidolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Diphenidolhsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Diphenidolhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Diphenidolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Diphenidolhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Diphenidolhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Diphenidolhsa04725Cholinergic synapse1.90E-037Q14643, P17252, P62873, P63218, P50151, P42338, P10415ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2More
Diphenidolhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Diphenidolhsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Diphenidolhsa04730Long-term depression5.00E-021Q14344GNA13More
Diphenidolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Diphenidolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Diphenidolhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Diphenidolhsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Diphenidolhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Diphenidolhsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Diphenidolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Diphenidolhsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Diphenidolhsa04919Thyroid hormone signaling pathway8.92E-047P49841, P22694, P60709, Q09472, O60244, Q9NVC6, P01106GSK3B, PRKACB, ACTB, EP300, MED14, MED17, MYCMore
Diphenidolhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Diphenidolhsa04924Renin secretion7.38E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Diphenidolhsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Diphenidolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Diphenidolhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Diphenidolhsa04930Type II diabetes mellitus2.47E-021Q02156PRKCEMore
Diphenidolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Diphenidolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Diphenidolhsa04933AGE-RAGE signaling pathway in diabetic complications5.84E-047P84022, Q13485, P42224, P10415, Q12778, P49767, P17252SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Diphenidolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Diphenidolhsa04964Proximal tubule bicarbonate reclamation4.53E-032P00918, P49448CA2, GLUD2More
Diphenidolhsa04966Collecting duct acid secretion2.07E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Diphenidolhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Diphenidolhsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Diphenidolhsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Diphenidolhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Diphenidolhsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Diphenidolhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Diphenidolhsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Diphenidolhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Diphenidolhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Diphenidolhsa05022Pathways of neurodegeneration - multiple diseases2.00E-0412Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1More
Diphenidolhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Diphenidolhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diphenidolhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Diphenidolhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Diphenidolhsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Diphenidolhsa05132Salmonella infection3.94E-0511P25963, Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371NFKBIA, LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Diphenidolhsa05133Pertussis4.24E-031P0C0L4C4AMore
Diphenidolhsa05140Leishmaniasis8.52E-0712P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Diphenidolhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Diphenidolhsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Diphenidolhsa05145Toxoplasmosis1.02E-037P25963, P10415, Q13489, P42224, P13765, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Diphenidolhsa05146Amoebiasis4.97E-0410P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Diphenidolhsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Diphenidolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Diphenidolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Diphenidolhsa05163Human cytomegalovirus infection8.32E-039P30511, Q14643, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463HLA-F, ITPR1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Diphenidolhsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Diphenidolhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Diphenidolhsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Diphenidolhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Diphenidolhsa05169Epstein-Barr virus infection1.83E-0311P20023, P01106, Q13547, P42338, P07948, Q13761, O75293, P48551, P29728, P07766, P09693CR2, MYC, HDAC1, PIK3CB, LYN, RUNX3, GADD45B, IFNAR2, OAS2, CD3E, CD3GMore
Diphenidolhsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Diphenidolhsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Diphenidolhsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Diphenidolhsa05202Transcriptional misregulation in cancer4.33E-0315P14780, P27930, Q15744, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Diphenidolhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Diphenidolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Diphenidolhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Diphenidolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Diphenidolhsa05211Renal cell carcinoma1.67E-022Q09472, Q99814EP300, EPAS1More
Diphenidolhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Diphenidolhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Diphenidolhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Diphenidolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Diphenidolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Diphenidolhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Diphenidolhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Diphenidolhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Diphenidolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.94E-038O95267, P07766, P09693, P06239, O60603, Q16539, Q9HC35, P01730RASGRP1, CD3E, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
Diphenidolhsa05310Asthma1.64E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Diphenidolhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Diphenidolhsa05321Inflammatory bowel disease2.16E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Diphenidolhsa05322Systemic lupus erythematosus2.33E-0712P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diphenidolhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Diphenidolhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Diphenidolhsa05332Graft-versus-host disease1.36E-045P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Diphenidolhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Diphenidolhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Diphenidolhsa05415Diabetic cardiomyopathy5.60E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Diphenidolhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Diphenidolhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Diphenidol (SDC: 7.89)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P07101THTyrosine 3NonemonooxygenasePredicted00.04320.08880.49370.6929
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)