PharmaCoNets of Diphemanil (SPCN: 12.49 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diphemanilhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Diphemanilhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Diphemanilhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Diphemanilhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Diphemanilhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Diphemanilhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Diphemanilhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Diphemanilhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Diphemanilhsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Diphemanilhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Diphemanilhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Diphemanilhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Diphemanilhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Diphemanilhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Diphemanilhsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Diphemanilhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Diphemanilhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Diphemanilhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Diphemanilhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Diphemanilhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Diphemanilhsa05133Pertussis3.02E-031P0C0L4C4AMore
Diphemanilhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Diphemanilhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Diphemanilhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Diphemanilhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Diphemanilhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Diphemanilhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Diphemanilhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Diphemanilhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Diphemanilhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Diphemanilhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Diphemanil (SDC: 3.96)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)