PharmaCoNets

PharmaCoNets of Dioxybenzone (S_PCN: 139.88 )

Dioxybenzone regulated-network (S_DN: 24.04)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dioxybenzone

hsa00190

Oxidative phosphorylation

1.94E-02

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Dioxybenzone

hsa00220

Arginine biosynthesis

8.30E-04

P05089, P49448

ARG1, GLUD2

Dioxybenzone

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Dioxybenzone

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Dioxybenzone

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Dioxybenzone

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Dioxybenzone

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Dioxybenzone

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Dioxybenzone

hsa00630

Glyoxylate and dicarboxylate metabolism

9.62E-04

P40925, P40926, P15104

MDH1, MDH2, GLUL

Dioxybenzone

hsa00750

Vitamin B6 metabolism

3.56E-02

O00764

PDXK

Dioxybenzone

hsa00830

Retinol metabolism

2.17E-03

P00325, P00352, Q9BPW9, O75911

ADH1B, ALDH1A1, DHRS9, DHRS3

Dioxybenzone

hsa00900

Terpenoid backbone biosynthesis

3.05E-02

Q01581

HMGCS1

Dioxybenzone

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Dioxybenzone

hsa00980

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Dioxybenzone

hsa00982

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Dioxybenzone

hsa00983

Drug metabolism - other enzymes

1.78E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Dioxybenzone

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Dioxybenzone

hsa01210

2-Oxocarboxylic acid metabolism

3.56E-02

P50213

IDH3A

Dioxybenzone

hsa01521

EGFR tyrosine kinase inhibitor resistance

4.79E-03

P49841, P42338, P04049

GSK3B, PIK3CB, RAF1

Dioxybenzone

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Dioxybenzone

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Dioxybenzone

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Dioxybenzone

hsa03008

Ribosome biogenesis in eukaryotes

2.99E-02

P78345, Q9BVP2

RPP38, GNL3

Dioxybenzone

hsa03013

RNA transport

5.78E-05

O14980, P52298, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798

Dioxybenzone

hsa03020

RNA polymerase

2.94E-07

P24928, P62487, Q9GZM3, P52435

POLR2A, POLR2G, POLR2J2, POLR2J

Dioxybenzone

hsa03022

Basal transcription factors

3.50E-02

P20226, O00268, Q15544

TBP, TAF4, TAF11

Dioxybenzone

hsa03040

Spliceosome

4.48E-04

Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8

Dioxybenzone

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Dioxybenzone

hsa04012

ErbB signaling pathway

4.79E-03

P49841, P42338, P04049

GSK3B, PIK3CB, RAF1

Dioxybenzone

hsa04014

Ras signaling pathway

3.82E-03

P04049, Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174

RAF1, PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Dioxybenzone

hsa04015

Rap1 signaling pathway

2.99E-02

P04049

RAF1

Dioxybenzone

hsa04022

cGMP-PKG signaling pathway

3.15E-02

P04049

RAF1

Dioxybenzone

hsa04024

cAMP signaling pathway

2.49E-02

P04049

RAF1

Dioxybenzone

hsa04060

Cytokine-cytokine receptor interaction

1.40E-05

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, O75509, P01375, P09341, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNFRSF21, TNF, CXCL1, IL1RN, CD4, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P51531	SMARCA2	Probable global transcription activator SNF2L2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P51531	SMARCA2	Probable global transcription activator SNF2L2	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P08311	CTSG	Cathepsin G	P08476	INHBA	Inhibin beta A chain	0.848
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P08311	CTSG	Cathepsin G	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.736
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P51531	SMARCA2	Probable global transcription activator SNF2L2	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.715
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P08311	CTSG	Cathepsin G	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P08311	CTSG	Cathepsin G	P47992	XCL1	Lymphotactin	-0.823
P51531	SMARCA2	Probable global transcription activator SNF2L2	O75509	TNFRSF21	Tumor necrosis factor receptor superfamily member 21	-0.81
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P08311	CTSG	Cathepsin G	P18510	IL1RN	Interleukin-1 receptor antagonist protein	0.73
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P08311	CTSG	Cathepsin G	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	-0.782

Dioxybenzone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.57E-03

P09341, P25024, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB, TNF

Dioxybenzone

hsa04062

Chemokine signaling pathway

1.00E-06

P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963, P49841

CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIA, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51531	SMARCA2	Probable global transcription activator SNF2L2	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.715
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P51531	SMARCA2	Probable global transcription activator SNF2L2	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49407	ARRB1	Beta-arrestin-1	0.75
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P51531	SMARCA2	Probable global transcription activator SNF2L2	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.81

Dioxybenzone

hsa04064

NF-kappa B signaling pathway

1.79E-09

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846

Dioxybenzone

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Dioxybenzone

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Dioxybenzone

hsa04071

Sphingolipid signaling pathway

1.65E-04

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Dioxybenzone

hsa04072

Phospholipase D signaling pathway

2.93E-03

P04049, P42338, Q9UQC2, P25024

RAF1, PIK3CB, GAB2, CXCR1

Dioxybenzone

hsa04080

Neuroactive ligand-receptor interaction

8.25E-05

P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, P14416, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, DRD2, ADRB2

Dioxybenzone

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Dioxybenzone

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Dioxybenzone

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Dioxybenzone

hsa04120

Ubiquitin mediated proteolysis

2.89E-02

O95071, P0CG47

UBR5, UBB

Dioxybenzone

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Dioxybenzone

hsa04140

Autophagy - animal

2.95E-02

P04049, P22694, Q14643, P10415, Q04759

RAF1, PRKACB, ITPR1, BCL2, PRKCQ

Dioxybenzone

hsa04141

Protein processing in endoplasmic reticulum

1.22E-04

P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3

Dioxybenzone

hsa04145

Phagosome

7.52E-05

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Dioxybenzone

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Dioxybenzone

hsa04150

mTOR signaling pathway

7.13E-04

P42338, P04049, Q02750, Q9NQL2, P51812, P49841

PIK3CB, RAF1, MAP2K1, RRAGD, RPS6KA3, GSK3B

Dioxybenzone

hsa04151

PI3K-Akt signaling pathway

3.91E-03

P62753, P27348, P07900, P22105, Q99941, P18848, O00141

RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGK

Dioxybenzone

hsa04210

Apoptosis

2.38E-04

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P04049

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, RAF1

Dioxybenzone

hsa04211

Longevity regulating pathway

2.40E-03

Q08828, P51828, Q99941, P18848, Q96RR4

ADCY1, ADCY7, CREBL1, ATF4, CAMKK2

Dioxybenzone

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Dioxybenzone

hsa04261

Adrenergic signaling in cardiomyocytes

1.46E-02

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Dioxybenzone

hsa04270

Vascular smooth muscle contraction

1.29E-04

P0DP24, P04049, Q08828, P35579, P35318

CALM2, RAF1, ADCY1, MYH9, ADM

Dioxybenzone

hsa04340

Hedgehog signaling pathway

1.76E-03

P49841, P22694, Q13635, P49407, P10415

GSK3B, PRKACB, PTCH1, ARRB1, BCL2

Dioxybenzone

hsa04360

Axon guidance

3.26E-03

P20827, P23528, P04049, Q06124

EFNA1, CFL1, RAF1, PTPN11

Dioxybenzone

hsa04370

VEGF signaling pathway

1.79E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Dioxybenzone

hsa04371

Apelin signaling pathway

3.46E-04

P62873, P63218, P50151, P04049, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, RAF1, PDE3B, GNA13, SMAD3, CALM1

Dioxybenzone

hsa04380

Osteoclast differentiation

3.38E-03

Q9UQC2, P42338, P14778, Q8N149

GAB2, PIK3CB, IL1R1, LILRA2

Dioxybenzone

hsa04390

Hippo signaling pathway

2.30E-02

P63261, P04628, O43623

ACTG1, WNT1, SNAI2

Dioxybenzone

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Dioxybenzone

hsa04540

Gap junction

2.22E-03

Q13509, P68371, Q71U36, P04049, Q9NRA1

TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC

Dioxybenzone

hsa04550

Signaling pathways regulating pluripotency of stem cells

2.53E-03

P04628, P40189, P04049, P14653

WNT1, IL6ST, RAF1, HOXB1

Dioxybenzone

hsa04612

Antigen processing and presentation

8.19E-05

P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF

Dioxybenzone

hsa04613

Neutrophil extracellular trap formation

2.63E-05

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Dioxybenzone

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Dioxybenzone

hsa04623

Cytosolic DNA-sensing pathway

2.59E-02

P01568, P25963

IFNA21, NFKBIA

Dioxybenzone

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Dioxybenzone

hsa04630

JAK-STAT signaling pathway

3.67E-03

P48551, P40189, Q06124, P04049

IFNAR2, IL6ST, PTPN11, RAF1

Dioxybenzone

hsa04640

Hematopoietic cell lineage

1.05E-05

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Dioxybenzone

hsa04650

Natural killer cell mediated cytotoxicity

2.77E-08

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Dioxybenzone

hsa04657

IL-17 signaling pathway

2.29E-02

O00463, P09341, P14780, P80188, P01375

TRAF5, CXCL1, MMP9, LCN2, TNF

Dioxybenzone

hsa04658

Th1 and Th2 cell differentiation

2.83E-11

Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Dioxybenzone

hsa04659

Th17 cell differentiation

6.90E-10

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Dioxybenzone

hsa04660

T cell receptor signaling pathway

7.91E-09

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Dioxybenzone

hsa04662

B cell receptor signaling pathway

2.64E-04

P49841, P42338, Q8N149, P04049

GSK3B, PIK3CB, LILRA2, RAF1

Dioxybenzone

hsa04664

Fc epsilon RI signaling pathway

2.82E-06

P04141, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292

CSF2, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5AP

Dioxybenzone

hsa04666

Fc gamma R-mediated phagocytosis

9.11E-03

P42338, P04049, Q9UQC2

PIK3CB, RAF1, GAB2

Dioxybenzone

hsa04668

TNF signaling pathway

2.59E-02

P01375, O00463, Q13489, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9

Dioxybenzone

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Dioxybenzone

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Dioxybenzone

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Dioxybenzone

hsa04720

Long-term potentiation

2.17E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Dioxybenzone

hsa04722

Neurotrophin signaling pathway

2.32E-02

P04049

RAF1

Dioxybenzone

hsa04724

Glutamatergic synapse

1.57E-02

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Dioxybenzone

hsa04725

Cholinergic synapse

2.17E-02

P51828, P18848, Q13557

ADCY7, ATF4, CAMK2D

Dioxybenzone

hsa04726

Serotonergic synapse

5.74E-03

P62873, P63218, P50151, P09917, P04049

GNB1, GNG5, GNG10, ALOX5, RAF1

Dioxybenzone

hsa04727

GABAergic synapse

4.18E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Dioxybenzone

hsa04728

Dopaminergic synapse

2.30E-03

P14416, P49841, Q99941, P18848, Q13557, P49407

DRD2, GSK3B, CREBL1, ATF4, CAMK2D, ARRB1

Dioxybenzone

hsa04730

Long-term depression

1.95E-02

Q14344, P04049, P07948

GNA13, RAF1, LYN

Dioxybenzone

hsa04744

Phototransduction

9.21E-03

P62873, P0DP23

GNB1, CALM1

Dioxybenzone

hsa04750

Inflammatory mediator regulation of TRP channels

4.88E-02

P14778, P42338

IL1R1, PIK3CB

Dioxybenzone

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Dioxybenzone

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Dioxybenzone

hsa04911

Insulin secretion

4.03E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Dioxybenzone

hsa04912

GnRH signaling pathway

3.36E-03

P51828, P18848, Q13557, P04049

ADCY7, ATF4, CAMK2D, RAF1

Dioxybenzone

hsa04914

Progesterone-mediated oocyte maturation

5.89E-03

Q17RY0, P51812, Q02750, P04049

CPEB4, RPS6KA3, MAP2K1, RAF1

Dioxybenzone

hsa04915

Estrogen signaling pathway

4.99E-04

P04049, Q99941, P18848, P51828, P07900, P11142

RAF1, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8

Dioxybenzone

hsa04916

Melanogenesis

2.96E-03

P49841, Q01726, P04049

GSK3B, MC1R, RAF1

Dioxybenzone

hsa04917

Prolactin signaling pathway

1.31E-03

P42338, P04049, P49841

PIK3CB, RAF1, GSK3B

Dioxybenzone

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Dioxybenzone

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Dioxybenzone

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Dioxybenzone

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Dioxybenzone

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Dioxybenzone

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Dioxybenzone

hsa04925

Aldosterone synthesis and secretion

1.15E-04

Q99941, P18848, Q08828, P51828, P0DP24, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D

Dioxybenzone

hsa04926

Relaxin signaling pathway

7.01E-03

Q99941, P18848, P51828, P04049

CREBL1, ATF4, ADCY7, RAF1

Dioxybenzone

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Dioxybenzone

hsa04928

Parathyroid hormone synthesis, secretion and action

1.06E-03

Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2

Dioxybenzone

hsa04929

GnRH secretion

2.72E-04

P42338, P49407, P04049

PIK3CB, ARRB1, RAF1

Dioxybenzone

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Dioxybenzone

hsa04935

Growth hormone synthesis, secretion and action

5.33E-03

P51828, P04049, Q99941, P18848

ADCY7, RAF1, CREBL1, ATF4

Dioxybenzone

hsa04960

Aldosterone-regulated sodium reabsorption

8.43E-03

P42338, P48048

PIK3CB, KCNJ1

Dioxybenzone

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Dioxybenzone

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Dioxybenzone

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Dioxybenzone

hsa04971

Gastric acid secretion

3.46E-02

P48048, P78508

KCNJ1, KCNJ10

Dioxybenzone

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Dioxybenzone

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Dioxybenzone

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Dioxybenzone

hsa05016

Huntington disease

2.46E-05

Q9GZM3, P52435, Q9NYC9

POLR2J2, POLR2J, DNAH9

Dioxybenzone

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Dioxybenzone

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Dioxybenzone

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Dioxybenzone

hsa05034

Alcoholism

3.36E-03

Q96RR4, P04049, P84243

CAMKK2, RAF1, H3F3A

Dioxybenzone

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Dioxybenzone

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Dioxybenzone

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Dioxybenzone

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Dioxybenzone

hsa05132

Salmonella infection

1.96E-03

P51617, P25963, P01375, P08238, P04049, Q9UJU2, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Dioxybenzone

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Dioxybenzone

hsa05140

Leishmaniasis

1.55E-03

P14598, P11215, P42224, P13765, O60603, P25963, P01375, P51617, Q15080

NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4

Dioxybenzone

hsa05145

Toxoplasmosis

7.78E-03

P51617, P25963, P01375, P10415, Q13489, P28068, P13765, Q16787, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DMB, HLA-DOB, LAMA3, TLR2

Dioxybenzone

hsa05146

Amoebiasis

1.45E-05

P09341, P14778, P27930, P01375, P42338, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, PIK3CB, ARG1, PRKACB, ACTN1, CTSG

Dioxybenzone

hsa05150

Staphylococcus aureus infection

4.02E-03

P21462, O75015, Q14532, P59665, P59666, P12838

FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Dioxybenzone

hsa05152

Tuberculosis

1.41E-02

P04049, Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

RAF1, TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Dioxybenzone

hsa05160

Hepatitis C

1.99E-02

P04049

RAF1

Dioxybenzone

hsa05161

Hepatitis B

5.07E-04

P17252, P04049, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4

Dioxybenzone

hsa05163

Human cytomegalovirus infection

3.19E-05

P42338, P04049, P25963, P62873, P63218, P50151, P0DP23, P0DP24, Q14344, Q08828, P23458, P49841, P14778, P61073, Q99941, P30101, P01568

PIK3CB, RAF1, NFKBIA, GNB1, GNG5, GNG10, CALM1, CALM2, GNA13, ADCY1, JAK1, GSK3B, IL1R1, CXCR4, CREBL1, PDIA3, IFNA21

Dioxybenzone

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Dioxybenzone

hsa05165

Human papillomavirus infection

2.01E-02

Q16787, Q02930, Q13315

LAMA3, CREB5, ATM

Dioxybenzone

hsa05166

Human T-cell leukemia virus 1 infection

2.91E-02

Q02930, P28068, Q13315

CREB5, HLA-DMB, ATM

Dioxybenzone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.32E-06

P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, P04049, Q02750, P07948, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, RAF1, MAP2K1, LYN, CSF2, CALM1, UBB

Dioxybenzone

hsa05168

Herpes simplex virus 1 infection

3.79E-02

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189

Dioxybenzone

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Dioxybenzone

hsa05170

Human immunodeficiency virus 1 infection

3.00E-07

P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5, P20333

RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Dioxybenzone

hsa05200

Pathways in cancer

1.99E-03

P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Dioxybenzone

hsa05202

Transcriptional misregulation in cancer

4.58E-07

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Dioxybenzone

hsa05203

Viral carcinogenesis

1.75E-03

Q12933, Q99941, P18848, P42229, P27348, Q15283, P61978

TRAF2, CREBL1, ATF4, STAT5A, YWHAQ, RASA2, HNRPK

Dioxybenzone

hsa05204

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Dioxybenzone

hsa05205

Proteoglycans in cancer

3.48E-02

P04049

RAF1

Dioxybenzone

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Dioxybenzone

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Dioxybenzone

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Dioxybenzone

hsa05212

Pancreatic cancer

9.52E-03

P04049, P42224, P84022, O75293

RAF1, STAT1, SMAD3, GADD45B

Dioxybenzone

hsa05213

Endometrial cancer

2.80E-04

O15169, P49841, P42338, Q02750, P04049

AXIN1, GSK3B, PIK3CB, MAP2K1, RAF1

Dioxybenzone

hsa05214

Glioma

7.45E-03

P0DP23, P04049, P19174, O75293

CALM1, RAF1, PLCG1, GADD45B

Dioxybenzone

hsa05215

Prostate cancer

6.80E-04

P49841, P42338, P04049, P27930

GSK3B, PIK3CB, RAF1, IL1R2

Dioxybenzone

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Dioxybenzone

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Dioxybenzone

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Dioxybenzone

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Dioxybenzone

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Dioxybenzone

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Dioxybenzone

hsa05224

Breast cancer

5.52E-03

P04049, P42338, P49841

RAF1, PIK3CB, GSK3B

Dioxybenzone

hsa05225

Hepatocellular carcinoma

2.35E-03

P04049, P42338, P49841, P51531

RAF1, PIK3CB, GSK3B, SMARCA2

Dioxybenzone

hsa05226

Gastric cancer

3.26E-03

P04049, Q02750, O15169

RAF1, MAP2K1, AXIN1

Dioxybenzone

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Dioxybenzone

hsa05231

Choline metabolism in cancer

1.33E-02

P04049

RAF1

Dioxybenzone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.31E-05

O95267, P07766, P20963, P09693, P06239, P04049, O60603, P10747, Q04759, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, CD28, PRKCQ, CD4

Dioxybenzone

hsa05310

Asthma

3.13E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dioxybenzone

hsa05321

Inflammatory bowel disease

3.29E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Dioxybenzone

hsa05322

Systemic lupus erythematosus

4.90E-03

P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSB

Dioxybenzone

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Dioxybenzone

hsa05332

Graft-versus-host disease

1.46E-06

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Dioxybenzone

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Dioxybenzone

hsa05416

Viral myocarditis

2.30E-02

P10747, P63261

CD28, ACTG1

Dioxybenzone

hsa05418

Fluid shear stress and atherosclerosis

2.02E-02

P42338, P14778, P27930

PIK3CB, IL1R1, IL1R2

Community members of Dioxybenzone (S_DC: 5.82)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P13866

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

P07384

CAPN1

CalpainNone1 catalytic subunit

Predicted

0.023

0.1489

0.6038

0.9131

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

O43521

BCL2L11

BclNone2Nonelike protein 11

Predicted

0.5059

0.0495

0.631

0.9829

P51531

SMARCA2

Probable global transcription activator SNF2L2

Predicted

0.2231

0.045

0.1375

0.3391

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

PharmaCoNets of Dioxybenzone (SPCN: 139.88 )

Dioxybenzone regulated-network (SDN: 24.04)

Community members of Dioxybenzone (SDC: 5.82)

PharmaCoNets of Dioxybenzone (S_PCN: 139.88 )

Dioxybenzone regulated-network (S_DN: 24.04)

Community members of Dioxybenzone (S_DC: 5.82)